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WO1994023732A1 - Preparations therapeutiques contenant des extraits de cypres et procedes d'utilisation - Google Patents

Preparations therapeutiques contenant des extraits de cypres et procedes d'utilisation Download PDF

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Publication number
WO1994023732A1
WO1994023732A1 PCT/AU1993/000513 AU9300513W WO9423732A1 WO 1994023732 A1 WO1994023732 A1 WO 1994023732A1 AU 9300513 W AU9300513 W AU 9300513W WO 9423732 A1 WO9423732 A1 WO 9423732A1
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
extract
cypress
tree
cypress tree
Prior art date
Application number
PCT/AU1993/000513
Other languages
English (en)
Inventor
John Kambourakis
Efstathios Kambourakis
Jack Kambourakis
Chreus Kambourakis
Original Assignee
Kambourakis Medicinal Solutions Pty. Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU36827/93A external-priority patent/AU3682793A/en
Application filed by Kambourakis Medicinal Solutions Pty. Limited filed Critical Kambourakis Medicinal Solutions Pty. Limited
Publication of WO1994023732A1 publication Critical patent/WO1994023732A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress

Definitions

  • This invention relates to a therapeutic preparation, a method of preparing it and to a method of treating diseased mammals.
  • This invention is based upon the discovery that an extract from Cypress trees is capable of treating, or, in some cases, curing, a range of diseases and conditions. These include psoriasis and other itching diseases, radiation or radiotherapy skin damage, leprosy, cancer and leukaemia.
  • this invention provides a therapeutic preparatio comprising an effective amount of Cypress tree extract.
  • the therapeutic preparation of the invention preferably is undiluted and not combined with a carrier.
  • this invention does include within its scope suitable diluents and suitable carriers for the preparation.
  • the preparation may be applied topically or internally as is well known in the art.
  • the preparation takes the form of an oil which is administered in that form, or, if to be taken internally, in the form of a gelatine capsule containing the preparation of the invention.
  • the preparation of the invention has been found to be effective in the case of psoriasis and other itching conditions, and in the case of skin damage and lesions caused by radiation or radiotherapy, if the preparation is applied topically. It is also believed that internal application can assist in treatment of these conditions.
  • SUBSTITUTE SHEET In the case of leprosy, cancer and the like, internal application is suitable.
  • the preparation of the invention may have efficacy in relation to many forms of cancer in its various stages, such as stages I, II and III, but not usually to stage IV cancer.
  • the effective amount of the preparation of the invention will depend on a number of factors, especially the age and body weight of the mammal to be treated, and the severity of the disease or condition.
  • Cropress is applied to various types of trees, including the following:
  • the Cypress tree from which the extract is taken is a relatively mature specimen.
  • the extract is preferably derived from the trunk of the tree.
  • This invention also provides a method of producing a therapeutic preparation, comprising deriving from a Cypress tree an effective amount of extract.
  • the extract is derived from the Cypress tree by distillation.
  • other methods of extraction ma be suitable and are not excluded from the scope of this invention.
  • This invention also provides a method of treating a diseased mammal, comprising administering to the diseased mammal a pharmaceutically effective amount of Cypress tree extract.
  • Drops of this oil were administered topically to an adult female human suffering from psoriasis.
  • the quantity required was that sufficient to cover the affected areas.
  • the oil prepared as in Example 1 was administered to humans suffering from various types of cancer.
  • the single daily dosage was 1 drop of the oil for every year of age.
  • the single daily dosage was 15 to 45 drops.
  • the most suitable dosage for individuals in this second group depended on body weight, body structure and the severity of the disease. The appropriate dosage was determined experimentally for each person. However, the maximum dosage of 45 drops per day was not exceeded in any case,
  • Example 1 The preparation of Example 1 was applied topically every day to lesions caused by radiotherapy treatment. After a few weeks, the lesions had healed completely.
  • Example 1 The preparation of Example 1 was diluted with methanol and analysed via gas chromatography/ mass spectro etry, by Australian Government Analytical Laboratories ("AGAL”) , of 1 Suarkin Street, Py ble, New South Wales.
  • AGAL Australian Government Analytical Laboratories
  • the identification was based on a computer search of a 130,000 compound library. Identifications with a match quality of less than 85 are to be treated with caution and matches of less than 50 are usually incorrect. (For absolute identi ication of each component, the analysis of an authentic standard would be required. )
  • Table 1 shows the approximate composition of the major components:
  • a therapeutic preparation comprising an effective amount of Cypress tree extract.
  • a therapeutic preparation as claimed in claim 1 wherein the extract is from a tree of the genus Cupressus Sempervirens.

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention concerne une préparation thérapeutique comprenant une quantité efficace d'extrait de cyprès. L'extrait provient de préférence d'un cyprès choisi dans le groupe comprenant: (a) tout conifère du genre Cupressus, de la famille Cupressaceae; (b) Chamaecyparis lawsoniana; (c) le cyprès des marais; et (d) tout conifère du genre Callitrus, de la famille Cupressaceae. L'invention concerne également un procédé pour produire une telle préparation thérapeutique et son utilisation.
PCT/AU1993/000513 1993-04-08 1993-10-07 Preparations therapeutiques contenant des extraits de cypres et procedes d'utilisation WO1994023732A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU36827/93 1993-04-08
AU36827/93A AU3682793A (en) 1992-04-08 1993-04-08 Therapeutic preparation and method

Publications (1)

Publication Number Publication Date
WO1994023732A1 true WO1994023732A1 (fr) 1994-10-27

Family

ID=3723996

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU1993/000513 WO1994023732A1 (fr) 1993-04-08 1993-10-07 Preparations therapeutiques contenant des extraits de cypres et procedes d'utilisation

Country Status (1)

Country Link
WO (1) WO1994023732A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005107694A1 (fr) * 2004-05-11 2005-11-17 Lelee Mehregani Preparation topique contre les vergetures a base d'huile essentielle de cypres,
WO2007048985A2 (fr) * 2005-10-28 2007-05-03 Engelhard Lyon Substance pour restaurer une co-expression et une interaction normales entre les proteines lox et nrage
AU2005239762B2 (en) * 2004-05-11 2009-12-03 Lelee Mehregani Topical cypress essential oil composition for stretch marks
ES2330989A1 (es) * 2008-03-17 2009-12-17 Diego Cervetto Bravo Formula natural de uso externo para piel, articulaciones, musculos y huesos.

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2274313A2 (fr) * 1973-07-20 1976-01-09 Biologie Appliquee Sarl Remede a base de leucoanthocyanes retires des galbules frais de cypres
DE2529294A1 (de) * 1974-07-01 1976-01-15 Comtadine D Extraction S A Neues verfahren zum fraktionieren von aus schwerfluechtigen feststoffen bestehenden gemischen, sowie anwendung des verfahrens auf die fraktionierung von kondensierten tanninen
JPS6117509A (ja) * 1984-07-03 1986-01-25 Yokoyama Mokuzai:Kk ヒノキ香を有する入浴剤
JPS6150916A (ja) * 1984-08-20 1986-03-13 Mitsubishi Chem Ind Ltd 抗腫瘍剤
JPS62111913A (ja) * 1985-11-08 1987-05-22 Emiko Tomobe 桧材に係る浴槽に投入する温浴剤
JPS63150208A (ja) * 1986-12-12 1988-06-22 Shiseido Co Ltd 皮膚外用剤
JPH01175918A (ja) * 1987-12-29 1989-07-12 Koichi Hirata 美容パック材
JPH01186824A (ja) * 1988-01-19 1989-07-26 Horiuchiitarou Shoten:Kk 外皮投与用組成物及び経皮吸収を促進する方法
JPH01283215A (ja) * 1988-05-07 1989-11-14 Nori Oomura 入浴用薬用的効果物品および入浴剤
JPH02115106A (ja) * 1988-10-22 1990-04-27 Matsushita Electric Works Ltd 抗生物剤の製法
WO1990013304A1 (fr) * 1989-05-12 1990-11-15 Institut Des Substances Vegetales Composition a base de proanthocyanidols; leur application pharmacologique
JPH0390036A (ja) * 1989-08-31 1991-04-16 Daicel Chem Ind Ltd スギ及びヒノキ花粉症用ワクチン
AU3682793A (en) * 1992-04-08 1993-10-14 Kambourakis Medicinal Solutions Pty Limited Therapeutic preparation and method

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2274313A2 (fr) * 1973-07-20 1976-01-09 Biologie Appliquee Sarl Remede a base de leucoanthocyanes retires des galbules frais de cypres
DE2529294A1 (de) * 1974-07-01 1976-01-15 Comtadine D Extraction S A Neues verfahren zum fraktionieren von aus schwerfluechtigen feststoffen bestehenden gemischen, sowie anwendung des verfahrens auf die fraktionierung von kondensierten tanninen
DE2559722A1 (de) * 1974-07-01 1977-09-29 Comtadine D Extraction S A Arzneimittel
JPS6117509A (ja) * 1984-07-03 1986-01-25 Yokoyama Mokuzai:Kk ヒノキ香を有する入浴剤
JPS6150916A (ja) * 1984-08-20 1986-03-13 Mitsubishi Chem Ind Ltd 抗腫瘍剤
JPS62111913A (ja) * 1985-11-08 1987-05-22 Emiko Tomobe 桧材に係る浴槽に投入する温浴剤
JPS63150208A (ja) * 1986-12-12 1988-06-22 Shiseido Co Ltd 皮膚外用剤
JPH01175918A (ja) * 1987-12-29 1989-07-12 Koichi Hirata 美容パック材
JPH01186824A (ja) * 1988-01-19 1989-07-26 Horiuchiitarou Shoten:Kk 外皮投与用組成物及び経皮吸収を促進する方法
JPH01283215A (ja) * 1988-05-07 1989-11-14 Nori Oomura 入浴用薬用的効果物品および入浴剤
JPH02115106A (ja) * 1988-10-22 1990-04-27 Matsushita Electric Works Ltd 抗生物剤の製法
WO1990013304A1 (fr) * 1989-05-12 1990-11-15 Institut Des Substances Vegetales Composition a base de proanthocyanidols; leur application pharmacologique
JPH0390036A (ja) * 1989-08-31 1991-04-16 Daicel Chem Ind Ltd スギ及びヒノキ花粉症用ワクチン
AU3682793A (en) * 1992-04-08 1993-10-14 Kambourakis Medicinal Solutions Pty Limited Therapeutic preparation and method

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
A.B. AND J.W. CRIBB, "Wild Medicine in Australia", published 1988, by WILLIAM COLLINS PTY. LTD. (SYDNEY), page 59. *
DERWENT ABSTRACT, Accession No. 86-109201/17, Class B05, C03; & JP,A,61 050 916 (MITSUBISHI CHEM IND KK), 13 March 1986. *
J. ISAACS, "Bush Food: Aboriginal Food and Herbal Medicine", published 1989, by WELDON PUBLISHING (SYDNEY), pages 206, 232. *
PATENT ABSTRACTS OF JAPAN, C-353, page 35; & JP,A,61 017 509 (YOKOYAMA MOKUZAI K.K.), 25 January 1986. *
PATENT ABSTRACTS OF JAPAN, C-454, page 50; & JP,A,62 111 913 (EMIKO TOMOBE), 22 May 1987. *
PATENT ABSTRACTS OF JAPAN, C-540, page 135; & JP,A,63 150 208 (SHISEIDO CO. LTD.), 22 June 1988. *
PATENT ABSTRACTS OF JAPAN, C-644, page 3; & JP,A,1 175 918 (KOICHI HIRATA), 12 July 1989. *
PATENT ABSTRACTS OF JAPAN, C-647, page 158; & JP,A,1 186 824 (HORIUCHIITAROU SHOTEN K.K.), 26 July 1989. *
PATENT ABSTRACTS OF JAPAN, C-684, page 19; & JP,A,1 283 215 (NORI OOMURA), 14 November 1989. *
PATENT ABSTRACTS OF JAPAN, C-739, page 119; & JP,A,2 115 106 (MATSUSHITA ELECTRIC WORKS LTD.), 27 April 1990. *
PATENT ABSTRACTS OF JAPAN, C-847, page 80; & JP,A,3 090 036 (DAICEL CHEM IND. LTD.), 16 April 1991. *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005107694A1 (fr) * 2004-05-11 2005-11-17 Lelee Mehregani Preparation topique contre les vergetures a base d'huile essentielle de cypres,
AU2005239762B2 (en) * 2004-05-11 2009-12-03 Lelee Mehregani Topical cypress essential oil composition for stretch marks
WO2007048985A2 (fr) * 2005-10-28 2007-05-03 Engelhard Lyon Substance pour restaurer une co-expression et une interaction normales entre les proteines lox et nrage
WO2007048985A3 (fr) * 2005-10-28 2008-04-10 Engelhard Lyon Substance pour restaurer une co-expression et une interaction normales entre les proteines lox et nrage
EP2345405A1 (fr) * 2005-10-28 2011-07-20 BASF Beauty Care Solutions France SAS Substance pour restaurer une co-expression et une interaction normales entre les protéines LOX et NRAGE
US9308161B2 (en) 2005-10-28 2016-04-12 Basf Beauty Care Solutions France S.A.S. Substance for restoring normal co-expression and interaction between the LOX and NRAGE proteins
ES2330989A1 (es) * 2008-03-17 2009-12-17 Diego Cervetto Bravo Formula natural de uso externo para piel, articulaciones, musculos y huesos.

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