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WO1994020598A1 - Produits ophtalmologiques contenant un additif de pheromone et son procede d'utilisation - Google Patents

Produits ophtalmologiques contenant un additif de pheromone et son procede d'utilisation

Info

Publication number
WO1994020598A1
WO1994020598A1 PCT/US1994/002575 US9402575W WO9420598A1 WO 1994020598 A1 WO1994020598 A1 WO 1994020598A1 US 9402575 W US9402575 W US 9402575W WO 9420598 A1 WO9420598 A1 WO 9420598A1
Authority
WO
WIPO (PCT)
Prior art keywords
care product
contact lens
eye
eye care
pheromone
Prior art date
Application number
PCT/US1994/002575
Other languages
English (en)
Inventor
Timothy R. Willis
Original Assignee
Allergan, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan, Inc. filed Critical Allergan, Inc.
Priority to JP6520297A priority Critical patent/JPH08507884A/ja
Priority to EP94911527A priority patent/EP0688357A1/fr
Priority to AU64012/94A priority patent/AU6401294A/en
Publication of WO1994020598A1 publication Critical patent/WO1994020598A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005—Other compounding ingredients characterised by their effect
    • C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/384—Animal products
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
    • G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
    • G02B1/041—Lenses
    • G02B1/043—Contact lenses

Definitions

  • the present invention generally relates to eye care products containing a pheromone additive and more particularly relates to eye care products such as contact lenses, contact lens care solutions, and eye care formulations which contain a pheromone additive which enables the user of the eye care products to feel good and to achieve a sense of comfort, well-being and satisfaction.
  • Some contact lens wearers have allergic reaction to the presence of contact tenses in their eyes. As a consequence irritations in the eye or the eye lids have been observed.
  • Some lid scrub solutions have been developed to alleviate such adverse allergic reactions caused by contact lenses. They can be used to wash and disinfect eye lids such that irritation or infection may be prevented.
  • the present invention discloses a method of adding a pheromone additive into a variety of eye care products such as contact lenses, contact lens care solutions, and eye care solutions such as a lid scrub solution so that the contact lens wearer would experience a good feeling and sensation of comfort, well being and satisfaction when such pheromone containing eye care product is placed in the eye.
  • vomeronasal organ i.e., a chemosensory organ in the nasal cavity tied to the hypothalamus
  • U.S. Patent No. 4,456,587 to Keith discloses a pheromone delivery system in which emulsion polymers are used as carriers of pheromone for slow release when the aqueous mixture is sprayed onto the leaves of cotton plants for the control of cotton tree insects.
  • U.S. Patent No. 4,923, 1 1 9 to Yamamoto, et al. discloses a bag-like dispenser which contains a sex pheromone compound of insects used for sustained release of the pheromone compound at a uniform emission rate over a long period of time.
  • the bag-like dispenser body is formed of a specific polymeric laminated film having at least two or three layers in which one of the layers is a film of polyvinylidene chloride.
  • Yamamoto, et al. compared their bag-like dispenser with other types of sustained release dispensers and claimed superiority over other types of dispensers such as microcapsuies and capillary tube-type dispensers.
  • U.S. Patent No. 4,959,353 to Brown, et al. discloses a method of promotion of corneal stroma wound healing with human epidermal growth factor prepared from recombinant DNA.
  • Brown, et al.'s method for treating corneal stroma wounds is to promote regeneration of the affected tissue by the incorporation of a polypeptide in ointment or cream to be used in the eye.
  • Brown, et al. did not use an additive of pheromone and did not attempt to make the user of their ointment or cream to have a sense of good feeling.
  • U.S. Patent No. 4,855,1 27 to Abrutyn, et al. discloses solid compositions wherein a non-cosmetic functional material is entrapped in a lattice of a crosslinked polymer during in situ polymerization of the monomers forming the polymer lattice. It provides a method for converting solid or liquid products into solid, free-flowing forms by the entrapment of the functional materials in a hydrophobic polymer lattice.
  • Abrutyn, et al. do not teach the use of pheromone in a hydrophilic polymer which is the base material used in most soft contact lenses. Furthermore, Abrutyn, et al.
  • the resulting polymer made by Williams contains entrapped active ingredient which tends not to exude from the polymer during storage yet is gradually released when the polymer is exposed to the atmosphere such as in the case of an air-freshener.
  • the purpose of Williams' invention was to replace a portion of the hydrophilic monomer with a particular type of lipophilic polymer such that the undesirable exudation process which normally results in a greasy or wet surface can be avoided.
  • U.S. Patent No. 4,310,397 to Kaetsu, et al. discloses polymer compositions containing a physiologically active substance. The polymer is polymerized by the irradiation of light or an ionizing source while maintaining the system in an anhydrous and airless condition. The Kaetsu, et al. method would not work in a soft contact lens composition made with hydrophilic polymers since the Kaetsu, et al.'s method only works in an anhydrous condition.
  • an eye care solution such as a lid scrub solution containing a pheromone
  • a pheromone can be used as an additional ingredient into the polymerization process of a hydrophilic contact lens such that the pheromone is incorporated in situ with the hydrophilic polymer structure.
  • the pheromone is volatile in nature and can be controlled to release through a process of sustained slow release. This enables the user of the contact lens to have a comfortable and good feeling every time the lens is inserted into the eye. It is believed that the pheromone is in the water portion of the lens matrix with some pheromone bound to the matrix polymer. Pheromone slow releases by a diffusion process over a predetermined period of time depending upon how it is bound to the matrix polymer.
  • the amount of the pheromone incorporated into the polymerization process is relatively small compared to the total content of the monomer. As a result, the pheromone does not interfere with the polymerization process.
  • a suitable pheromones for the present invention is androsterone. However, any other pheromone capable of producing a sense of good feeling and well-being in the user may also be used.
  • a pheromone is incorporated into contact lens care solutions such as those used for cleaning, disinfecting, storing, rinsing, and neutralizing.
  • a small amount of pheromone is added to the solution such that every time the contact lens user uses the solution to treat the lenses and then inserts the lenses into the eyes, the user achieves a sense of comfort, good feeling, and satisfaction.
  • a suitable amount of pheromone is added to the solution, it is believed that this sense of good feeling and well-being can last for extended period of time.
  • a pheromone is added to an eye care solution such as a lid scrub formulation.
  • an eye care solution such as a lid scrub formulation.
  • the present invention is also directed to a method of using a pheromone in eye care products such as contact lenses, contact lens care solutions, and other eye care formulations.
  • the method comprises the step of adding a pheromone into a polymerization process for contact lenses such that the pheromone is incorporated into the polymer in-situ or adding a pheromone to contact lens care solutions or eye care formulations by a small amount, i.e., from about 0.0001 % to about 1 5% (w/v).
  • the contact lenses and the eye care formulations can then be used in the eye, or contact lenses can be treated with contact lens care solutions containing pheromone for a suitable length of time before they are inserted into the eyes.
  • the present invention is directed to new and improved eye care products that incorporates a pheromone as an additive or as a base solution.
  • the present invention is also directed to a method of using such eye care products.
  • the pheromone specifically androsterone, acts in conjunction with the vomeronasal organ, i.e., a chemosensory organ in the nasal cavity connected to the hypothalamus, provides the user with a sense of good feeling, comfort and satisfaction when the lenses or the eye care formulations touch the eyes.
  • Androsterone may exist in several chemical forms such as
  • Crystals of androsterone can be obtained from acetone-ether. It has a melting point of 1 85-185.5° C. and it sublimes in high vacuum.
  • a pheromone is added to the contact lens polymer by the incorporation of a pheromone in an in-situ polymerization process.
  • This in-situ polymerization process can be readily employed with all kinds of materials for contact lenses such as that for conventional hard, soft, gas permeable and silicon lenses.
  • it is especially suitable for soft contact lenses of hydrophilic base such as those commonly referred to as hydrogel lenses prepared by monomers such as hydroxyethyl methacrylate, hydroxyethyl methyl methacrylate, vinylpyrrolidone, glyceromethacrylate, methacrylate esters and the like.
  • a suitable amount of androsterone i.e., between about 0.0001 % to about 1 5% by weight, is blended with the polymerization monomers before the monomers are poured into a mold and cured by irradiation with electron beams or radioactive rays.
  • Producing the lens by polymerization and shaping is well known in the art. Any of the well known techniques may be used.
  • One such method teaching the manufacture of soft contact lenses not containing androsterone is described in U.S.P.N. 4,966,924 to Hyon, et al. which is incorporated hereby by reference.
  • PVA polyvinyl alcohol
  • a mixture of solvents containing 20% by weight of water and 80% by weight of dimethyl sulfoxide are added so as to obtain a solution containing 10% by weight of PVA and 1 % by weight of androsterone.
  • the solution is poured into a mold and allowed to stand for 1 hour in a freezer kept at -20° C.
  • a pheromone is incorporated into contact lens care solutions.
  • a pheromone of androsterone is added to a lens care solution for contact lens disinfection containing sodium chlorite and polyvinyl pyrrolidone (PVP).
  • PVP polyvinyl pyrrolidone
  • the amount of androsterone used is 0.3% and 0.6% (w/v), respectively.
  • a preferred amount of pheromone to be used is between about 0.0001 % to 1 5 % (w/v).
  • a more preferred amount of pheromone to be used is between about 0.01 % to 5% (w/v).
  • a pheromone of androsterone is blended with contact lens disinfecting solutions containing sodium chlorite and polyvinyl pyrrolidone.
  • Androsterone is blended with contact lens disinfecting solutions containing sodium chlorite and polyvinyl pyrrolidone.
  • PVP is used in ophthalmic preparations in order to increase the viscosity of the solution. In some eye drops PVP is used to prolong the therapeutic action of substances such as pilocarpine and to promote the bioavailability of drugs. PVP is also used in solutions for contact lenses. Various grades of PVP are commercially available from BASF Aktiegensellschaft of Ludwigshafen, Germany under the name of Kollidon ® .
  • K-1 2 PF molecular weight « 2,900
  • K-1 7 PF molecular weight « 9,000
  • K-30 molecular weight « 45,000
  • a pheromone of androsterone is added to a lens care solution for contact lens cleaning and disinfecting containing a non-ionic surfactant and a triquaternary phosphate ester.
  • the amount of androsterone used in Examples 3 and 4 was 0.8% and 1 .6% (w/v), respectively. However, it is believed that any other suitable amount in between 0.0001 % to 15% (w/v) may also be used to achieve the same desirable result.
  • Example 3 A cleaning, disinfecting, and rinsing solution for contact lenses containing 30 androsterone is prepared with the following composition:
  • a new and improved cleaning, disinfecting, and rinsing solution for contact lenses containing androsterone is prepared by the following composition.
  • a suitable family of surfactants for use in Examples 3 and 4 can be obtained commercially from the BASF Corporation under the trade name of Pluronic ® surfactants.
  • This family of block copolymers can be generally described as polyoxyethylene/polyoxypropylene condensation polymers terminated in primary hydroxyl groups.
  • Phospholipid ® PTC is a microbiocidal agent of a triquatemary phosphate ester of cocoamidopropyl PG dimonium chloride phosphate. It is commercially available from Mona Industries.
  • a pheromone is added to a variety of eye care products.
  • An illustrative example is shown below in which androsterone is added to a lid scrub formulation.
  • a suitable percentage of androsterone to be used is between about 0.0001 % to about 1 5 % (w/v).
  • Example 5 and Example 6 each shows a non-irritating liquid cleansing composition for cleaning eye lids.
  • Either composition can be used to alleviate or prevent the symptoms of Blepharitis, a common chronic inflammation of the eye lids characterized by a scaly crust on the lid margins. This condition is frequently caused by a bacteria infection, an allergic reaction, or associated with seborrhea of the face and scalp.
  • Blepharitis a common chronic inflammation of the eye lids characterized by a scaly crust on the lid margins. This condition is frequently caused by a bacteria infection, an allergic reaction, or associated with seborrhea of the face and scalp.
  • the lid scrub formulations disclosed in Examples 5 and 6 contain a major ingredient of a mixture of surfactants marketed by Miranol Chemical Company (Dayton, N.J.) under the trade name of MS-2.
  • This mixture of surfactants includes PEG-80, sorbitanlaurate, sodium trideceth sulphate, PEG-1 50 distearate, cocamidopropylhydroxy sultaine, lauroamphocarboxy glycinate, and sodium laureth-13 carboxylate.
  • the compositions also include sodium chloride, an emollient and surfactant agent of PEG-15 tallow polyamine, a micro biological preservative which may be Quaternium-1 5, or benzyl alcohol, and optionally, a chelating agent such as sodium EDTA.
  • Quaternium-1 5 is well known for its microbiological preservative property and has been used as an ingredient in skin care compositions.
  • N-(3-chloroallyl) hexamminium chloride a quaternary ammonium salt marketed by Dow Chemical Company under the trade name of Dowacil ® 200.
  • the lid scrub composition not containing androsterone is disclosed in U.S.P.N. 4,904,698 which is incorporated hereby by reference.
  • the applications of the lid scrub composition are greatly enhanced by the addition of a pheromone of androsterone at either 0.3% (w/v) or 0.6% (w/v).
  • Eye lid cleaning is normally regarded as a tedious and unpleasant task for someone to rid of Blepharitis problem since washing the eye lids would inevitably involve touching or rubbing against the eye balls.
  • the patient feels good every time the eye lids are cleaned by the novel lid scrub composition. The good feeling can last for a period of time during which the patient feels relaxed and satisfied.
  • This novel invention of adding pheromone to lid scrub compositions therefore greatly ease the burden on the patient and turning an unpleasant task into a pleasant one.
  • compositions disclosed in Examples 1 through 6 are merely given as illustrative examples, any suitable pheromone can be added to any other eye care product. It is worth noting that since androsterone has limited solubility in water, it may be desirable to add a suspending agent or dispersant into the aqueous solution to facilitate the dispersion of androsterone in the eye care or lens care product. Androsterone may also be ground to very small particle size to achieve better dispersion in water.
  • the present invention may also include applications in nose spray or spray useful in dental applications.
  • Pheromone may be added to a nose spray or a spray or solution used in dental applications to make the patient feel good.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Eyeglasses (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)

Abstract

L'invention se rapporte à des produits ophtalmologiques tels que des lentilles de contact, des solutions pour lentilles de contact et des compositions ophtalmologiques qui contiennent un additif de phéromone, de sorte que l'utilisateur ayant recours à ces produits éprouve une sensation de confort, de bien-être et de satisfaction lorsque ces produits sont placés sur l'÷il.
PCT/US1994/002575 1993-03-12 1994-03-10 Produits ophtalmologiques contenant un additif de pheromone et son procede d'utilisation WO1994020598A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP6520297A JPH08507884A (ja) 1993-03-12 1994-03-10 フェロモン添加剤を含有するアイケア用品およびその使用方法
EP94911527A EP0688357A1 (fr) 1993-03-12 1994-03-10 Produits ophtalmologiques contenant un additif de pheromone et son procede d'utilisation
AU64012/94A AU6401294A (en) 1993-03-12 1994-03-10 Eye care products containing a pheromone additive and method of using the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3115393A 1993-03-12 1993-03-12
US08/031,153 1993-03-12

Publications (1)

Publication Number Publication Date
WO1994020598A1 true WO1994020598A1 (fr) 1994-09-15

Family

ID=21857904

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/002575 WO1994020598A1 (fr) 1993-03-12 1994-03-10 Produits ophtalmologiques contenant un additif de pheromone et son procede d'utilisation

Country Status (5)

Country Link
EP (1) EP0688357A1 (fr)
JP (1) JPH08507884A (fr)
AU (1) AU6401294A (fr)
CA (1) CA2157934A1 (fr)
WO (1) WO1994020598A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000060038A1 (fr) * 1999-04-02 2000-10-12 Laboratoire Medidom S.A. Solution ophtalmique a viscosite amelioree ayant une action detergente sur des lentilles de contact
AU726674B2 (en) * 1998-04-20 2000-11-16 Illinois Tool Works Inc. Fastener driving tool for trim applications
WO2008144494A1 (fr) * 2007-05-18 2008-11-27 Alcon Research, Ltd. Compositions de phospholipide pour entretien de lentille de contact et préservation de compositions pharmaceutiques
WO2012103186A3 (fr) * 2011-01-26 2012-09-20 Allergan, Inc. Composition androgène pour le traitement d'une affection ophtalmique

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993020823A1 (fr) * 1992-04-21 1993-10-28 The Schepens Eye Research Institute, Inc. Traitement oculaire a l'androgene pour soigner le syndrome de sjögren

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993020823A1 (fr) * 1992-04-21 1993-10-28 The Schepens Eye Research Institute, Inc. Traitement oculaire a l'androgene pour soigner le syndrome de sjögren

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU726674B2 (en) * 1998-04-20 2000-11-16 Illinois Tool Works Inc. Fastener driving tool for trim applications
US6528465B1 (en) 1999-04-02 2003-03-04 Laboratoire Medidom S.A. Viscosity enhanced ophthalmic solution, having a detergent action on contact lenses
WO2000060038A1 (fr) * 1999-04-02 2000-10-12 Laboratoire Medidom S.A. Solution ophtalmique a viscosite amelioree ayant une action detergente sur des lentilles de contact
AU2008254858B2 (en) * 2007-05-18 2013-06-20 Alcon Research, Ltd. Phospholipid compositions for contact lens care and preservation of pharmaceutical compositions
WO2008144494A1 (fr) * 2007-05-18 2008-11-27 Alcon Research, Ltd. Compositions de phospholipide pour entretien de lentille de contact et préservation de compositions pharmaceutiques
US9119772B2 (en) 2011-01-26 2015-09-01 Allergan, Inc. Androgen composition for treating an opthalmic condition
WO2012103186A3 (fr) * 2011-01-26 2012-09-20 Allergan, Inc. Composition androgène pour le traitement d'une affection ophtalmique
RU2599036C2 (ru) * 2011-01-26 2016-10-10 Аллерган, Инк. Андрогенная композиция для лечения офтальмологического заболевания
US9504646B2 (en) 2011-01-26 2016-11-29 Allergan, Inc. Androgen composition for treating an opthalmic condition
AU2012209184B2 (en) * 2011-01-26 2017-06-15 Allergan, Inc. Androgen composition for treating an opthalmic condition
US9937188B2 (en) 2011-01-26 2018-04-10 Allergan, Inc. Non-irritating testosterone emulsions
US10780098B2 (en) 2011-01-26 2020-09-22 Allergan, Inc. Non-irritating testosterone emulsions
US10905696B2 (en) 2011-01-26 2021-02-02 Allergan, Inc. Androgen composition for treating an ophthalmic condition

Also Published As

Publication number Publication date
AU6401294A (en) 1994-09-26
EP0688357A1 (fr) 1995-12-27
JPH08507884A (ja) 1996-08-20
CA2157934A1 (fr) 1994-09-15

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