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WO1994014967A3 - Sous-unite d'une capsule proteique cs31a modifiee par au moins un peptide heterologue, capsule proteique cs31a comportant une telle sous-unite et micro-organismes dont la membrane externe porte de telles sous-unites; procedes d'obtention et utilisation de ceux-ci - Google Patents

Sous-unite d'une capsule proteique cs31a modifiee par au moins un peptide heterologue, capsule proteique cs31a comportant une telle sous-unite et micro-organismes dont la membrane externe porte de telles sous-unites; procedes d'obtention et utilisation de ceux-ci Download PDF

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Publication number
WO1994014967A3
WO1994014967A3 PCT/FR1993/001281 FR9301281W WO9414967A3 WO 1994014967 A3 WO1994014967 A3 WO 1994014967A3 FR 9301281 W FR9301281 W FR 9301281W WO 9414967 A3 WO9414967 A3 WO 9414967A3
Authority
WO
WIPO (PCT)
Prior art keywords
cs31a
subunit
protein capsule
preparing
protein
Prior art date
Application number
PCT/FR1993/001281
Other languages
English (en)
Other versions
WO1994014967A2 (fr
Inventor
Jean-Pierre Girardeau
Christine Martin
Marie-Claire Mechin
Vartanian Maurice Der
Francois Bousquet
Original Assignee
Agronomique Inst Nat Rech
Girardeau Jean Pierre
Christine Martin
Mechin Marie Claire
Vartanian Maurice
Francois Bousquet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agronomique Inst Nat Rech, Girardeau Jean Pierre, Christine Martin, Mechin Marie Claire, Vartanian Maurice, Francois Bousquet filed Critical Agronomique Inst Nat Rech
Priority to AU68087/94A priority Critical patent/AU6808794A/en
Priority to EP94903914A priority patent/EP0684996A1/fr
Priority to US08/491,954 priority patent/US6096321A/en
Publication of WO1994014967A2 publication Critical patent/WO1994014967A2/fr
Publication of WO1994014967A3 publication Critical patent/WO1994014967A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12311—Rotavirus, e.g. rotavirus A
    • C12N2720/12322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32611—Poliovirus
    • C12N2770/32622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention concerne la sous-unité de la capsule protéique CS31A dont la séquence en acides aminés est modifiée par au moins un peptide hétérologue, ainsi que la capsule protéique CS31A comportant une telle sous-unité et les micro-organismes qui portent une capsule protéique CS31A dont la séquence en acides aminés de la sous-unité est modifiée par au moins un peptide hétérologue. L'invention concerne aussi les procédés d'obtention de telles sous-unités, des capsules protéiques CS31A les comportant et des micro-organismes qui portent ces capsules protéiques CS31A, ainsi que l'utilisation de ceux-ci pour la préparation de vaccins, la production de peptides et la préparation de tests immunologiques.
PCT/FR1993/001281 1992-12-22 1993-12-21 Sous-unite d'une capsule proteique cs31a modifiee par au moins un peptide heterologue, capsule proteique cs31a comportant une telle sous-unite et micro-organismes dont la membrane externe porte de telles sous-unites; procedes d'obtention et utilisation de ceux-ci WO1994014967A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU68087/94A AU6808794A (en) 1992-12-22 1993-12-21 cs31a protein capsule subunit modified by at least one heterologous peptide, cs31a protein capsule comprising said subunit, micro-organisms having such subunits on their outer membrane, and methods for preparing and using same
EP94903914A EP0684996A1 (fr) 1992-12-22 1993-12-21 Sous-unite d'une capsule proteique cs31a modifiee par au moins un peptide heterologue, capsule proteique cs31a comportant une telle sous-unite et micro-organismes dont la membrane externe porte de telles sous-unites; procedes d'obtention et utilisation de ceux-ci
US08/491,954 US6096321A (en) 1992-12-22 1993-12-21 ClpG subunit of CS31A protein capsule containing heterologous peptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9215464A FR2699538B1 (fr) 1992-12-22 1992-12-22 Sous-unité d'une capsule protéique CS31A modifiée par au moins un peptide hétérologue, capsule protéique CS31A et microorganismes portant ces sous-unités; procédés d'obtention et utilisation de ceux-ci.
FR92/15464 1992-12-22

Publications (2)

Publication Number Publication Date
WO1994014967A2 WO1994014967A2 (fr) 1994-07-07
WO1994014967A3 true WO1994014967A3 (fr) 1994-09-29

Family

ID=9436901

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1993/001281 WO1994014967A2 (fr) 1992-12-22 1993-12-21 Sous-unite d'une capsule proteique cs31a modifiee par au moins un peptide heterologue, capsule proteique cs31a comportant une telle sous-unite et micro-organismes dont la membrane externe porte de telles sous-unites; procedes d'obtention et utilisation de ceux-ci

Country Status (5)

Country Link
US (1) US6096321A (fr)
EP (1) EP0684996A1 (fr)
AU (1) AU6808794A (fr)
FR (1) FR2699538B1 (fr)
WO (1) WO1994014967A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516637A (en) * 1994-06-10 1996-05-14 Dade International Inc. Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
FR2805994A1 (fr) * 2000-03-10 2001-09-14 Agronomique Inst Nat Rech Methode de detection de la guanylyl cyclase-c et son utilisation pour le diagnostic des tumeurs colorectales metastatiques
AU3054502A (en) 2000-10-23 2002-05-06 Gen Probe Inc Compositions and methods for detecting human immunodeficiency virus 2 (hiv-2)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0264150A1 (fr) * 1986-10-13 1988-04-20 Solvay Microorganismes comportant des pili comme protéines porteuses, pili isolés à partir de ces microorganismes, procédé d'excrétion de peptides ou de protéines à l'aide de ces pili et utilisation de ceux-ci
EP0385610A1 (fr) * 1989-02-14 1990-09-05 The Wellcome Foundation Limited Conjugés

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0264150A1 (fr) * 1986-10-13 1988-04-20 Solvay Microorganismes comportant des pili comme protéines porteuses, pili isolés à partir de ces microorganismes, procédé d'excrétion de peptides ou de protéines à l'aide de ces pili et utilisation de ceux-ci
EP0385610A1 (fr) * 1989-02-14 1990-09-05 The Wellcome Foundation Limited Conjugés

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
B. DELMAS ET AL.: "Four major antigenic sites of the coronavirus transmissible gastroenteritis virus are located on the amino-terminal half of spike glycoprotein S", J. GEN. VIROL., vol. 71, no. 6, June 1990 (1990-06-01), SOC. GEN. MICROBIOL. COLCH., LONDON, UK;, pages 1313 - 1323 *
E. KOHLI ET AL.: "Localization of group specific epitopes on the major capsid protein of group A rotavirus", J. GENERAL VIROLOGY, vol. 73, no. 4, April 1992 (1992-04-01), READINGS, BERKS,GB;, pages 907 - 914 *
G. POZZI ET AL.: "Delivery and expression of a heterologous antigen on the surface of Streptococci", INFECTION AND IMMUNITY, vol. 60, no. 5, May 1992 (1992-05-01), AM. SOC. MICROBIOL., BALTIMORE, US;, pages 1902 - 1907 *
J.P. GIRARDEAU ET AL.: "CS31A, a new K88-related fimbrial antigen on bovine enterotoxigenic and septicemic Escherichia coli strains", INFECTION AND IMMUNITY, vol. 56, no. 8, August 1988 (1988-08-01), AM. SOC. MICROBIOL.,US;, pages 2180 - 2188 *
M. AGTERBERG ET AL.: "Outer membrane PhoE protein of Escherichia coli as a carrier for foreign antigenic determinants: immunogenicity of epitopes of foot-and-mouth disease virus", VACCINE, vol. 8, no. 1, February 1990 (1990-02-01), BUTTERWORTH AND CO.,LONDON,GB;, pages 85 - 91 *
M.J. KORTH ET AL.: "Functional expression of heterologous fimbrial subunits mediated by the F41, K88, and CS31A determinants of Escherichia coli", INFECTION AND IMMUNITY, vol. 60, no. 6, June 1992 (1992-06-01), AM. SOC. MICROBIOL.,US;, pages 2500 - 2505 *

Also Published As

Publication number Publication date
FR2699538A1 (fr) 1994-06-24
FR2699538B1 (fr) 1995-02-03
AU6808794A (en) 1994-07-19
US6096321A (en) 2000-08-01
EP0684996A1 (fr) 1995-12-06
WO1994014967A2 (fr) 1994-07-07

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