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WO1994008989A1 - Composes n-arylheteroarylalkyle 1-cycloalkyle-imidazole-2-one pour le traitement des maladies circulatoires - Google Patents

Composes n-arylheteroarylalkyle 1-cycloalkyle-imidazole-2-one pour le traitement des maladies circulatoires Download PDF

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Publication number
WO1994008989A1
WO1994008989A1 PCT/US1993/005601 US9305601W WO9408989A1 WO 1994008989 A1 WO1994008989 A1 WO 1994008989A1 US 9305601 W US9305601 W US 9305601W WO 9408989 A1 WO9408989 A1 WO 9408989A1
Authority
WO
WIPO (PCT)
Prior art keywords
methyl
butyl
phenyl
pyridinyl
dihydro
Prior art date
Application number
PCT/US1993/005601
Other languages
English (en)
Inventor
David B. Reitz
Robert E. Manning
Original Assignee
G.D. Searle & Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by G.D. Searle & Co. filed Critical G.D. Searle & Co.
Priority to AU45336/93A priority Critical patent/AU4533693A/en
Priority to EP93915307A priority patent/EP0664803A1/fr
Priority to JP6509961A priority patent/JPH08502285A/ja
Publication of WO1994008989A1 publication Critical patent/WO1994008989A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un groupe de composés N-arylhétéroarylalkyle 1-cycloalkyle-imidazole-2-one, utilisés dans le traitement des maladies circulatoires telles que l'hypertension et les défauts cardiaques congestifs, est décrit. Les composés ayant un intérêt particulier sont les antagonistes de l'angiotensine II selon la formule (A), dans laquelle A est sélectionné parmi: (a), (b), (c), (d), (e) et (f), dans lesquelles chaque R1, R2 et R3 est indépendamment sélectionné dans les composés hydrides, alkyle, alkoxy, halo, hydroxy, carboxyle, alkoxy carbonyle, formyle et acétyle; dans lesquelles R7 représente un hydrido; dans lesquelles R8 représente un alkyle; dans lesquelles R9 représente un groupe acide sélectionné parmi COOH et (g) ou une forme stéréo-isomère ou tautomère de ces composés ou un sel pharmaceutiquement acceptable de ces composés.
PCT/US1993/005601 1992-10-13 1993-06-16 Composes n-arylheteroarylalkyle 1-cycloalkyle-imidazole-2-one pour le traitement des maladies circulatoires WO1994008989A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU45336/93A AU4533693A (en) 1992-10-13 1993-06-16 N-arylheteroarylalkyl 1-cycloalkyl-imidazol-2-one compounds for treatment of circulatory disorders
EP93915307A EP0664803A1 (fr) 1992-10-13 1993-06-16 Composes n-arylheteroarylalkyle 1-cycloalkyle-imidazole-2-one pour le traitement des maladies circulatoires
JP6509961A JPH08502285A (ja) 1992-10-13 1993-06-16 循環系障害処置用ｎ−アリールヘテロアリールアルキル１−シクロアルキル−イミダゾール−２−オン化合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95957592A 1992-10-13 1992-10-13
US07/959,575 1992-10-13

Publications (1)

Publication Number Publication Date
WO1994008989A1 true WO1994008989A1 (fr) 1994-04-28

Family

ID=25502163

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/005601 WO1994008989A1 (fr) 1992-10-13 1993-06-16 Composes n-arylheteroarylalkyle 1-cycloalkyle-imidazole-2-one pour le traitement des maladies circulatoires

Country Status (5)

Country Link
EP (1) EP0664803A1 (fr)
JP (1) JPH08502285A (fr)
AU (1) AU4533693A (fr)
CA (1) CA2143192A1 (fr)
WO (1) WO1994008989A1 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992007834A1 (fr) * 1990-10-31 1992-05-14 G.D. Searle & Co. Composes d'imidazol-2-one substituee par n, utilises dans le traitements de troubles circulatoires
EP0508393A1 (fr) * 1991-04-05 1992-10-14 G.D. Searle & Co. Composés de N-arylhétéroarylalkyl imidazol-2-one dans le traitement de troubles circulatoires

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992007834A1 (fr) * 1990-10-31 1992-05-14 G.D. Searle & Co. Composes d'imidazol-2-one substituee par n, utilises dans le traitements de troubles circulatoires
EP0508393A1 (fr) * 1991-04-05 1992-10-14 G.D. Searle & Co. Composés de N-arylhétéroarylalkyl imidazol-2-one dans le traitement de troubles circulatoires

Also Published As

Publication number Publication date
JPH08502285A (ja) 1996-03-12
CA2143192A1 (fr) 1994-04-28
EP0664803A1 (fr) 1995-08-02
AU4533693A (en) 1994-05-09

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