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WO1994008571A3 - Emplatre pour administration percutanee d'ingredients volatils, chimiquement basiques, pharmaceutiquement actifs, et son procede de preparation - Google Patents

Emplatre pour administration percutanee d'ingredients volatils, chimiquement basiques, pharmaceutiquement actifs, et son procede de preparation Download PDF

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Publication number
WO1994008571A3
WO1994008571A3 PCT/EP1993/002899 EP9302899W WO9408571A3 WO 1994008571 A3 WO1994008571 A3 WO 1994008571A3 EP 9302899 W EP9302899 W EP 9302899W WO 9408571 A3 WO9408571 A3 WO 9408571A3
Authority
WO
WIPO (PCT)
Prior art keywords
plaster
matrix
volatile
producing
transdermal administration
Prior art date
Application number
PCT/EP1993/002899
Other languages
German (de)
English (en)
Other versions
WO1994008571A2 (fr
Inventor
Karin Wolter
Walter Mueller
Guenter Simon
Christa Nalbach
Rainer Hoffmann
Original Assignee
Lts Lohmann Therapie-Systeme Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA002146645A priority Critical patent/CA2146645C/fr
Priority to HU9501125A priority patent/HU221594B/hu
Priority to EP94900072A priority patent/EP0665745B1/fr
Priority to DE59308413T priority patent/DE59308413D1/de
Priority to DK94900072T priority patent/DK0665745T3/da
Priority to SK515-95A priority patent/SK51595A3/sk
Priority to JP50965794A priority patent/JP3731016B2/ja
Priority to PL93308292A priority patent/PL173552B1/pl
Application filed by Lts Lohmann Therapie-Systeme Gmbh & Co. Kg filed Critical Lts Lohmann Therapie-Systeme Gmbh & Co. Kg
Priority to KR1019950701535A priority patent/KR100261913B1/ko
Priority to AU54627/94A priority patent/AU674902B2/en
Publication of WO1994008571A2 publication Critical patent/WO1994008571A2/fr
Publication of WO1994008571A3 publication Critical patent/WO1994008571A3/fr
Priority to FI951887A priority patent/FI112325B/fi
Priority to NO19951523A priority patent/NO311404B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

L'invention concerne un emplâtre pour administration percutanée d'ingrédients volatils, chimiquement basiques, pharmaceutiquement actifs, qui contient un système à éléments multiples comprenant: (a) une matrice dans laquelle la substance volatile mentionnée ci-dessus ou un de ses sels physiologiquement acceptable est réparti(e) comme principe actif, la matrice contenant une substance adhésive, (b) un élément d'une composition adhésive qui - si (a) contient un sel - contient des groupes basiques qui libèrent la base libre de leur sel, (c) une couche de base imperméable aux ingrédients diffusibles de (a) et de (b) et, (d) une pellicule à enlever, imperméable aux ingrédients diffusibles de (a) et de (b). La matrice (a) ou au moins une partie de (b), selon que c'est la matrice ou une partie de (b) qui est en contact avec la pellicule à enlever (d), a une adhésivité suffisante pour que l'emplâtre adhère à la peau. Chaque partie de (b) placée entre la matrice (a) et la pellicule à enlever (d) est perméable au principe actif, de préférence du déprényle et/ou un de ses sels. L'invention concerne en outre un procédé de préparation d'un emplâtre de ce type.
PCT/EP1993/002899 1992-10-22 1993-10-20 Emplatre pour administration percutanee d'ingredients volatils, chimiquement basiques, pharmaceutiquement actifs, et son procede de preparation WO1994008571A2 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
JP50965794A JP3731016B2 (ja) 1992-10-22 1993-10-20 化学的に塩基性の揮発性医療用活性物質の経皮的投与のためのプラスタおよびその製造方法
EP94900072A EP0665745B1 (fr) 1992-10-22 1993-10-20 Emplatre pour administration percutanee d'ingredients volatils, chimiquement basiques, pharmaceutiquement actifs, et son procede de preparation
DE59308413T DE59308413D1 (de) 1992-10-22 1993-10-20 Pflaster zur transdermalen verabreichung von flüchtigen, pharmazeutisch wirksamen, chemisch basischen inhaltsstoffen und verfahren zu seiner herstellung
DK94900072T DK0665745T3 (da) 1992-10-22 1993-10-20 Plaster til transdermal administrering af flygtige, farmaceutisk aktive, kemisk basiske indholdsstoffer samt fremgangsmåde
SK515-95A SK51595A3 (en) 1992-10-22 1993-10-20 Plaster for the transdermal administration of volatile, pharmaceutically active, chemically alkaline active ingredients, and processs for producing the same
CA002146645A CA2146645C (fr) 1992-10-22 1993-10-20 Emplatre pour l'administration transdermique d'ingredients alcalins volatils, possedant des proprietes pharmaceutiques; methode de preparation
AU54627/94A AU674902B2 (en) 1992-10-22 1993-10-20 Plaster for the transdermal administration of volatile, pharmaceutically active, chemically alkaline ingredients, and processs for producing the same
PL93308292A PL173552B1 (pl) 1992-10-22 1993-10-20 Plaster do podawania przez skórę lotnych substancji biologicznie czynnych, farmaceutycznie aktywnych, o charakterze zasadowym i sposób wytwarzania plastra do podawania przez skórę lotnych substancji biologicznie czynnych, farmaceutycznie aktywnych o charakterze zasadowym
KR1019950701535A KR100261913B1 (ko) 1992-10-22 1993-10-20 휘발성이고, 약제학적으로 활성이고 화학적으로 알칼리성인 성분의 경피 투여를 위해 사용되는 플라스터, 및 이것의 제조 방법
HU9501125A HU221594B (hu) 1992-10-22 1993-10-20 Tapasz illó, gyógyászatilag hatásos, bázisos anyagok bőrön keresztül történő bevitelére, valamint eljárás ennek előállítására
FI951887A FI112325B (fi) 1992-10-22 1995-04-20 Menetelmä laastarin valmistamiseksi, jolla voidaan ihon läpi antaa haihtuvia, farmaseuttisesti vaikuttavia, kemiallisesti emäksisiä aineosia
NO19951523A NO311404B1 (no) 1992-10-22 1995-04-21 Plaster for transdermal administrering av flyktige, farmasöytisk aktive, kjemisk basiske bestanddeler, samtfremgangsmåte for fremstilling av plasteret

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92118036A EP0593807A1 (fr) 1992-10-22 1992-10-22 Pansement transdermique pour l'administration de principes actifs pharmaceutiques volatiles alcalins et procédé pour sa préparation
GB92118036.0 1992-10-22

Publications (2)

Publication Number Publication Date
WO1994008571A2 WO1994008571A2 (fr) 1994-04-28
WO1994008571A3 true WO1994008571A3 (fr) 1994-05-26

Family

ID=8210159

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1993/002899 WO1994008571A2 (fr) 1992-10-22 1993-10-20 Emplatre pour administration percutanee d'ingredients volatils, chimiquement basiques, pharmaceutiquement actifs, et son procede de preparation

Country Status (24)

Country Link
EP (2) EP0593807A1 (fr)
JP (1) JP3731016B2 (fr)
KR (1) KR100261913B1 (fr)
AT (1) ATE165001T1 (fr)
AU (1) AU674902B2 (fr)
CA (1) CA2146645C (fr)
CZ (1) CZ290122B6 (fr)
DE (1) DE59308413D1 (fr)
DK (1) DK0665745T3 (fr)
ES (1) ES2116572T3 (fr)
FI (1) FI112325B (fr)
HR (1) HRP931308A2 (fr)
HU (1) HU221594B (fr)
IL (1) IL107360A (fr)
MY (1) MY109783A (fr)
NO (1) NO311404B1 (fr)
NZ (1) NZ257829A (fr)
PH (1) PH30790A (fr)
PL (1) PL173552B1 (fr)
SI (1) SI9300559A (fr)
SK (1) SK51595A3 (fr)
WO (1) WO1994008571A2 (fr)
YU (1) YU48350B (fr)
ZA (1) ZA937807B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4433191A1 (de) * 1994-09-17 1996-03-21 Lohmann Therapie Syst Lts Selbstklebendes Pflaster zur Abgabe von Wirkstoff an die Umgebung eines Trägers
US6033682A (en) 1995-01-13 2000-03-07 Somerset Pharmaceuticals, Inc. S(+) desmethylselegiline and its use in therapeutic methods and pharmaceutical compositions
US6299901B1 (en) 1995-01-13 2001-10-09 Somerset Pharmaceuticals, Inc. Methods and pharmaceutical compositions employing desmethylselegiline
US6319954B1 (en) 1995-01-13 2001-11-20 Somerset Pharmaceuticals, Inc. S-(+)-desmethylselegiline and its use in the therapeutic methods and pharmaceutical compositions
US6348208B1 (en) 1995-01-13 2002-02-19 Somerset Pharmaceuticals, Inc. Methods and pharmaceutical compositions employing desmethylselegiline
US6316022B1 (en) 1995-06-07 2001-11-13 Noven Pharmaceuticals, Inc. Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures
WO1996040085A2 (fr) * 1995-06-07 1996-12-19 Noven Pharmaceuticals, Inc. Compositions transdermiques contenant des medicaments de faible poids moleculaire liquides a temperature ambiante
AU6821196A (en) * 1995-08-14 1997-03-12 Janssen Pharmaceutica N.V. Transdermal administration of vorozole
DE19533772C1 (de) * 1995-09-12 1998-01-02 Hexal Ag Tacrin/Selegilin-Pflaster
US7150881B2 (en) * 1997-06-26 2006-12-19 Mylan Technologies, Inc. Adhesive mixture for transdermal delivery of highly plasticizing drugs
DE19733981A1 (de) * 1997-08-06 1999-02-11 Lohmann Therapie Syst Lts Transdermales Therapeutisches System (TTS) zur Abgabe von Wirkstoff durch die Haut an einen Organismus und Verfahren zur Applikation auf der Haut
WO1999022678A1 (fr) * 1997-11-04 1999-05-14 Clear Sport Ltd. Ameliorations concernant des dispositifs adhesifs tels que des bandes, des timbres, des bandes adhesives et similaires prevus pour etre appliques au corps de l'homme
ATE222101T1 (de) 1998-03-16 2002-08-15 Somerset Pharmaceuticals Inc Verwendung von selegilin oder desmethylselegilin zur behandlung von wunden, verbrennungen und hautschäden
DE19814083C2 (de) * 1998-03-30 2002-02-07 Lohmann Therapie Syst Lts Verfahren zur Herstellung von transdermalen therapeutischen Systemen unter Verwendung von basischen Alkalimetallsalzen zur Umwandlung von Wirkstoffsalzen in die freien Basen
DE19814257A1 (de) * 1998-03-31 1999-10-07 Asta Medica Ag Brauseformulierungen
DE19826592A1 (de) 1998-06-15 1999-12-16 Lohmann Therapie Syst Lts Verfahren zur Herstellung eines aus einzelnen Schichten bestehenden Laminats
DE19950066A1 (de) * 1999-10-16 2001-04-26 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit einem Gehalt an Tulobuterol-hydrochlorid zur Verabreichung des Bronchodilatators Tulobuterol über die Haut
CA2463987C (fr) 2001-11-05 2011-03-08 Seth Lederman Compositions et methodes permettant d'augmenter l'observance therapeutique au moyen d'inhibiteurs de l'aldehyde deshydrogenase et traitement de l'alcoolisme
WO2009009649A1 (fr) * 2007-07-10 2009-01-15 Agile Therapeutics, Inc. Dispositif d'administration dermique avec un joint in situ
US20100087768A1 (en) 2008-10-02 2010-04-08 Forlano Paula Transdermal drug delivery system for liquid active ingredient
MX2012012069A (es) 2010-04-30 2012-11-22 Teikoku Pharma Usa Inc Composiciones transdermicas de propinilaminoindan.
US9119799B2 (en) 2011-03-24 2015-09-01 Teikoku Pharma Usa, Inc. Transdermal compositions comprising an active agent layer and an active agent conversion layer
WO2014070622A1 (fr) 2012-11-02 2014-05-08 Teikoku Pharma Usa, Inc. Compositions transdermiques de propynylaminoindane

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3797494A (en) * 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
WO1989009051A1 (fr) * 1988-03-29 1989-10-05 Sandoz Ag Deprenyle pour administration transdermique systemique

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3797494A (en) * 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
WO1989009051A1 (fr) * 1988-03-29 1989-10-05 Sandoz Ag Deprenyle pour administration transdermique systemique

Also Published As

Publication number Publication date
ES2116572T3 (es) 1998-07-16
SK51595A3 (en) 1997-03-05
CZ290122B6 (cs) 2002-06-12
NO951523D0 (no) 1995-04-21
HU9501125D0 (en) 1995-06-28
CZ102295A3 (en) 1995-11-15
KR100261913B1 (ko) 2000-08-01
EP0665745B1 (fr) 1998-04-15
EP0665745A1 (fr) 1995-08-09
ATE165001T1 (de) 1998-05-15
WO1994008571A2 (fr) 1994-04-28
JP3731016B2 (ja) 2006-01-05
HRP931308A2 (en) 1994-12-31
NO311404B1 (no) 2001-11-26
ZA937807B (en) 1994-05-16
IL107360A (en) 1998-06-15
HU221594B (hu) 2002-11-28
FI112325B (fi) 2003-11-28
IL107360A0 (en) 1994-01-25
HUT71684A (en) 1996-01-29
PL173552B1 (pl) 1998-03-31
YU48350B (sh) 1998-07-10
NO951523L (no) 1995-04-21
AU5462794A (en) 1994-05-09
FI951887A0 (fi) 1995-04-20
KR950703939A (ko) 1995-11-17
PL308292A1 (en) 1995-07-24
AU674902B2 (en) 1997-01-16
CA2146645C (fr) 2004-06-29
CA2146645A1 (fr) 1994-04-28
DK0665745T3 (da) 1999-02-08
YU67293A (sh) 1996-02-19
MY109783A (en) 1997-06-30
EP0593807A1 (fr) 1994-04-27
PH30790A (en) 1997-10-17
FI951887A7 (fi) 1995-04-20
SI9300559A (en) 1994-06-30
NZ257829A (en) 1996-11-26
DE59308413D1 (de) 1998-05-20
JPH08502279A (ja) 1996-03-12

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