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WO1994005360A1 - Dispositif de distribution de medicament - Google Patents

Dispositif de distribution de medicament Download PDF

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Publication number
WO1994005360A1
WO1994005360A1 PCT/GB1993/001894 GB9301894W WO9405360A1 WO 1994005360 A1 WO1994005360 A1 WO 1994005360A1 GB 9301894 W GB9301894 W GB 9301894W WO 9405360 A1 WO9405360 A1 WO 9405360A1
Authority
WO
WIPO (PCT)
Prior art keywords
reservoir
end portion
sectional area
medicament
metering
Prior art date
Application number
PCT/GB1993/001894
Other languages
English (en)
Inventor
Clive Graham Angel
Mark Alexander Harris
William Richard Treneman
Original Assignee
Norton Healthcare Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929218937A external-priority patent/GB9218937D0/en
Priority claimed from GB929225389A external-priority patent/GB9225389D0/en
Application filed by Norton Healthcare Limited filed Critical Norton Healthcare Limited
Priority to AU49763/93A priority Critical patent/AU4976393A/en
Publication of WO1994005360A1 publication Critical patent/WO1994005360A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Definitions

  • This invention relates to a dispensing device, and more specifically, to a device suitable for dispensing discrete amounts of a particulate material entrained in an air flow.
  • the invention is concerned with a dispensing device of the type where a metered dose is administered on inhalation by a patient.
  • Metered dose inhalers are well known in medicine for treatment, or alleviation of the effects of respiratory complaints, for example asthma. Many of these devices are for use with a pressurized aerosol dispensing container. However, inhalers for dispensing metered doses of drugs in dry powder form are also known.
  • US-2,587,215 describes devices having separate drug reservoirs and air mixing chambers in which metered doses of the drug are dispersed in an air stream which is inhaled by a patient.
  • the metering member is in the form of either a slide plate having a metering hole therein for receiving a drug dose, or a rotatable slide member having dose-receiving depressions in its upper surface.
  • EP-0,488,609 similarly describes a slide plate dose metering device.
  • EP-0,069,715 describes a device in which doses of drugs are transferred by a perforated membrane from a storage reservoir across an air conduit through which air inhaled by a patient is drawn.
  • EP-0,079,478; EP-0,166,294 and GB-2,165,159 describe devices in which a drug dose is transferred from a storage reservoir to a passage for air inhaled by a ' patient located immediately beneath the reservoir, in a recess formed in a rotatable metering member positioned between the reservoir and the air passage.
  • US-4,274,403 describes an inhaler having a jrotary metering member with a drug dose receiving aperture therethrough.
  • the metering member is slidable between positions in which the aperture is aligned with an outlet of a drug storage reservoir for loading a dose of drug into the aperture, and in which it is aligned with an inhalation nozzle.
  • the metering member also has a further passage communicating with the drug receiving aperture therein, the passage being open to the ambient atmosphere when the aperture is aligned with the inhalation nozzle to allow air to be drawn through the aperture and to entrain the drug therein for inhalation by a patient.
  • WO 92/00771 describes an inhaler having a rotary metering member with drug dose-receiving depressions in its periphery. A dose of drug is loaded in each depression when aligned with a drug storage reservoir. The metering member is rotated to bring a dose laden depression into communication with an air inhalation passage for inhalation of the drug dose by a patient.
  • WO 92/10229 in our name, describes an inhaler which utilizes a flow of compressed air to fluidize and load powdered medicament contained in a storage reservoir, into a dose metering chamber for inhalation by a patient. A controlled air bleed through the metering chamber is achieved to provide a full dose of drug in the metering chamber.
  • WO 92/09322 describes an inhaler having a rotatable metering drum for receiving powder doses and for delivering such doses to an inhalation mouthpiece.
  • the device has an air channel communicating with a metered dose in the metering drum for discharging the dose in an air flow inhaled through the mouthpiece.
  • GB-2,165,159 describes a dosing device which utilizes a storage chamber for a medicinal substance which is generally cylindrical and has a generally conical " discharge end.
  • GB-1,329,415 relates to a vending machine having storage bottles for powdered substances which reduce in cross- sectional area towards the discharge ends thereof.
  • the object of the invention is to provide improvements in dry powder medicament dispensing devices and component parts thereof to facilitate the operation thereof. It is also an object to improve the delivery of drug doses so as to achieve more consistency in the metered doses of the drug.
  • the invention provides a reservoir for receiving a supply of medicament in powder form, which reservoir has one end portion of a relatively large internal cross-sectional area through which powder can be loaded into the reservoir and an opposite end portion providing a discharge aperture of a relatively small cross-sectional area, wherein the internal cross-sectional area of the reservoir reduces progressively between said one end portion and said opposite end portion so that the relationship between cross-sectional area and the distance from said one end portion towards said opposite end portion, is generally linear.
  • the aspect ratio of the reservoir is preferably in the range of substantially 2:1 to substantially 5:1.
  • the aspect ratio may be substantially 3:1.
  • An air permeable wall member may be provided at said one end portion of the reservoir to retain powdered medicament within the reservoir.
  • the cross-sectional area of said discharge aperture is preferably in the range of from substantially 0.2 mm 2 to substantially 13 mm 2 , e.g. in the range of from substantially 0.2 mm 2 to 3.5 mm 2 .
  • the invention also provides metering apparatus for dispensing a dose of medicament in powder form, comprising a reservoir structure including a reservoir for receiving a supply of medicament in powder form and a movable metering element having a metering cavity to receive a dose of medicament contained, in use, in the reservoir, wherein the cross-sectional area of a metering apparatus of the reservoir structure, which discharges into said metering cavity, is in the range of 0.2 mm 2 to 13 mm 2 .
  • the cross-sectional area of the discharge aperture may be in the range of from 0.2 mm 2 to 3.5 mm 2 .
  • the invention further provides a method of metering a dose of medicament in powder form, comprising applying a fluid pressure to a volume of such medicament in a reservoir which progressively decreases in internal cross-sectional area from one relatively large end portion thereof to an opposite end portion which provides a relatively small discharge aperture, so that the powder is discharged through said discharge aperture into a dose receiving cavity of a dose metering member at a velocity in the range of from substantially 5 m/s to substantially 35 m/s.
  • the invention further provides metering apparatus for dispensing a dose of medicament in powder form, comprising a reservoir for receiving a supply of medicament in powder form, which reservoir decreases in internal cross-sectional area from one relatively large end portion thereof to an opposite end portion which provides a relatively small discharge aperture, means for applying a fluid pressure to said one end portion of the reservoir, and a fluid permeable wall-member at said one end portion of the reservoir to retain powdered medicament within the reservoir.
  • Said fluid pressure applying means may be in the form of a fluid chamber which is expandable or contractible to alter in the internal volume thereof.
  • Figure l is a vertical section through a dry powder inhaler embodying the invention.
  • Figure 2 is an exploded view, on a reduced scale, of the inhaler of Figure l;
  • Figure 3 is a vertical cross-section through a hopper unit of the inhaler of Figs. 1 and 2.
  • Figure 4 illustrates a relationship"between the internal cross-sectional area and the vertical distance from the top of the hopper, in respect of a hopper in accordance with the present invention
  • Figures 5 and 6 are diagrammatic sectional details of the hopper and mouthpiece assembly of the inhaler illustrating the air flows therethrough;
  • Figures 7 and 8 are, respectively, a sectional side view and an end view of the mouthpiece assembly;
  • Figure 9 is a diagrammatic representation of a resilient cam track portion provided on a yoke assembly of the inhaler.
  • Figures 10A-10F are diagrammatic illustrations of different hopper cross-sections tested by the inventors.
  • the inhaler (10) comprises a hollow substantially cylindrical body (11) which is closed at its upper end by a cap portion (12) and has a hinged mouthpiece cover (13) which normally closes an aperture in a lower portion of the side wall of the cylindrical body (11) .
  • the body (11) comprises a lower case portion (14) on which the mouthpiece cover (13) is hingedly mounted, and an upper case closed portion (15) .
  • the general construction and operation of the inhaler is described in our British Patent Applications Nos. 9218937.2 and 9218978.6, the disclosures of which are incorporated herein by reference, and to which reference is directed for further details.
  • the hopper unit (16) for containing a supply of a drug in powdered form, is located within the body part (11) .
  • the hopper unit (16) is formed with a reservoir (20) for containing a supply of the powdered drug.
  • the upper end of the wall of the reservoir (20) is formed to seat a circular disc (23) which is air permeable.
  • a bellows (27) comprises a corrugated wall having a closed upper end and having at its lower end an integral sealing ring (28) for locating with t e upper end of the wall of the reservoir (20) in contact with the air filter disc (23).
  • a yoke member (31) is located on and in contact with the top of the bellows (27) .
  • a compression spring (37) is held in compression with the top case part (15) .
  • the yoke member (31) has a pair of downwardly depending elongate limbs (36) , the lower ends of which cooperate with cam portions (70,71) formed integrally with the cover (13) as described below.
  • the hopper assembly (16) is formed with a channel (45) open at either end for the passage of air therethrough.
  • the channel (45) is also downwardly open along the underside of the base plate portion (17) of the hopper unit.
  • a dose dispensing slide unit (44) comprises a slide member (46) having a dose receiving depression (47) formed in an upper surface thereof.
  • the slide plate is maintained in contact with the underside of the base plate (17) of the hopper unit for sliding movement between a first position in which the dose receiving depression (47) is located beneath the outlet orifice (21) of the drug reservoir (20) and a second position in which the depression (47) containing the dose of drug is placed in a primary air mixing chamber provided by the channel (45) in the hopper unit base plate (17) .
  • the slide (46) is in the form of a narrow plate with the depression (47) formed in its upper surface.
  • a pair of spaced transverse walls (48,49) project upwardly and are received in a slot in the hopper base plate (17) .
  • the slide (46) also has a laterally projecting peg (50) .
  • the slide (46) is spring biassed to its second position in which its depression (47) is placed in the primary mixing chamber (45), by a leaf spring (51), one end of the spring being located in the slot defined between the walls (48,49) of the slide and the other end of the leaf spring being fixed to an outer side wall portion of the reservoir (20).
  • the slide member (46) is mounted on.a slide carrier (53) which has in its upper surface a channel (54) in which the slide member (46) is slidably mounted and in its lower surface a recess (55) for receiving a biassing spring (56) .
  • the slide mounting (53) has an upwardly projecting narrow flange (57) which defines with a lower portion of the side wall of the reservoir (20) an inlet air passage to the primary mixing chamber (45) .
  • the contact between the slide member (46) and the base plate (17) and a leg portion (40) of the hopper unit is such that pressurized air can bleed therebetween without permitting the passage of the powdered drug therebetween. This is a feature of the method of loading a dose of drug into the metering depression (47) in the slide plate.
  • a further element of the device is an integral mouthpiece and cyclone unit (60) .
  • the mouthpiece section (61) communicates with a secondary air and powder mixing chamber (62).
  • the mixing chamber (62) comprises a cyclone having four equi-angularly spaced tangential air inlets (63) arranged in an annulus around the mixing chamber.
  • the uppermost tangential inlet passage (63) communicates with the primary mixing chamber (45) whilst the remaining three tangential inlets allow air to be drawn therethrough into the cyclone on inhalation through the mouthpiece (61) .
  • the mouthpiece cover (13) is hingedly mounted to the bottom wall of the lower case part (14) . Opposite sides of the mouthpiece at its hinged parts, are formed with respective cam formations (70 and 71) . At one side of the cover, a circular cam (70) is formed in association with the cover hinge (72) for cooperation with the lower end of one of the downwardly extending limbs (36) of the yoke member (31) . As the cover opens, the cam moves to a position to allow the yoke to drop in order to cause actuation of the drug dispensing mechanism as described below.
  • the cam (71) cooperates with a resilient pivotally • mounted trigger mechanism (74) which cooperates with the other limb (36) of the yoke member (31) .
  • the trigger (74) which is pivotally mounted on the lower casing part (14) comprises three radially extending portions, a first relatively thick portion (75) against which the end of the corresponding yoke limb (36) locates, a second narrower portion (77) for engaging with the cam (71) and a third narrower and more flexible portion (78) which resiliently abuts against the side wall of the lower case part (14) for resetting the trigger.
  • the yoke In the closed position of the cover, the yoke is maintained in its upper position by engagement with the first trigger projection (75) , the trigger being maintained in this position by engagement of the second trigger portion (77) with an abutment surface (78) on the cam (71) .
  • the cam (71) As the cover is opened, the cam (71) is rotated anti-clockwise until a second abutment surface (79) thereof engages the trigger portion (77) sufficiently to release the trigger portion (75) , with a snap action, from its engagement supporting the yoke limb (36) which is thereby allowed to drop under the action of biassing spring (37) acting on the yoke.
  • the third trigger portion (78) is then resiliently deformed against the side wall of the lower case so that when the cover is closed again and the yoke is lifted to its upper position by rotation of the cam (70) , the trigger is resiliently reset to its original position in engagement with the lower end of the corresponding yoke limb (36) .
  • one of the yoke limbs (36) is formed with a laterally projecting, resiliently mounted cam portion (80) having a .three dimensional, generally triangular cam track (81) provided thereon ( Figure 9) .
  • the peg (50) formed on the side of the slide member (46) engages in the cam track (81) .
  • the slide (46) is held in its initial position against the action of biassing spring (51) , when the yoke member is in its upper position with the mouthpiece cover (13) in its closed position, with the peg (50) at the lower end of the vertical portion of the cam track (81) .
  • the cam After a drug dispensing operation and when the cover (13) is again moved towards its closed position so that the yoke is lifted, the cam then moves upwardly in relation to the peg (50) so that the peg (50) then moves along the slanted portion (81C) of the cam track (81) to bring the slide (46) back towards its initial position against the action of its biassing spring (51) .
  • the operation of the device is generally as follows.
  • the cover (13) is open sufficiently to release the trigger (47)
  • the yoke (31) is moved downwardly under the action of its biassing spring (36) .
  • This causes the bellows (27) to be compressed which results in air being forced through the supply of powdered drug (90) located in the reservoir (20) .
  • the air flow fluidizes the powdered drug and entrains the drug so as to fill the metering depression (47) in the slide (46) .
  • This filling operation is effected by providing an air bleed between the slide (46) and the engaging portions of the hopper unit (16) to maintain an air flow through the dose receiving depression (47) thereby effectively filling that depression with powdered drug.
  • the slide is moved to its second position under the action of spring (51) whereby the dose laden depression (47) is brought into the primary mixing chamber (45) .
  • spring (51) On inhalation at the mouthpiece (61) , air is drawn through the primary mixing chamber (45) causing turbulence around the drug laden depression (47) in the slide (46) which draws the dose of drug into the air stream in the primary mixing chamber (45) .
  • Continued inhalation draws the air and powdered drug mixture through the upper tangential air inlet (63) into the second cyclone mixing chamber (62) as well as drawing further swirling air flows through the other three tangential air inlets (63) of the cyclone.
  • the thoroughly mixed air and powdered drug is then inhaled by the patient.
  • the mouthpiece cover (13) is closed thereby lifting the yoke (35) and causing the slide (46) to be moved back to its initial position as the peg (50) thereof is moved along the slanted portion (81C) of the cam track of cam (81) as described above.
  • the device is then ready for another drug dispensing operation.
  • Suitable drugs or drug blends which may be used in an inhaler described above may include salbuta ol, beclomethasome dipropionate, budesonide and sodium cromoglycate.
  • the internal shape of the reservoir (20) is important in order to achieve reliable metering. To achieve this, it is necessary to maintain the bulk properties of the drug in the reservoir during the dispensing of, for example, 200 doses.
  • the shape of a reservoir according to the invention avoids the common problems of coring (when the bulk powder movement produces a hole from top to bottom allowing air to pass without powder movement) and bridging where the powder will not pass through a narrower part of the hopper causing horizontal voids in the bulk.
  • the aperture cross-sectional area is therefore in the range of about 0.2 mm 2 to about 3.14 mm 2 (or say about 3.5 mm 2 ).
  • the hopper exit diameter needs to be optimised for different blends, e.g. Salbutamol 1.0 mm diameter, Sodium Cromoglycate 1.5 mm diameter.
  • An optimum practical range for the hopper exit is 0.5 mm to 4.0 mm diameter or equivalent cross-sectional area, namely about 0.2 mm 2 to about 13 mm 2 .
  • the powder dispensing outlet cross-sectional area may be reduced to the above stated range at a point downstream of the hopper where the powder is dispensed into the volumetric metering cavity.
  • the optimum internal shape of the hopper is a cross-section which reduces progressively from a large diameter top portion to a small exit aperture, in accordance with a relationship between the internal cross-sectional area of the hopper and the vertical height thereof, which is close to a linear relationship as illustrated in Fig. 4.
  • the inventors tested various shapes for the cross-section of the hopper, as illustrated in Figures 10A-10F.
  • the inventors also tested a hopper in accordance with the above-mentioned relationship and found, unexpectedly, that it achieved a better performance, in particular, in reducing the tendency of "coring” and “bridging” as described above, so as to deliver consistently a full dose of powder under an air fluidisation dose delivery system as described above.
  • the whole hopper shape at its outlet end portion is a smoothly tapering nozzle which has been found to give a beneficial fluid behaviour of the hopper for use with a pneumatic fluidizing effect as utilized in the present inhaler device.
  • the hopper aspect ratio (as defined by height over large diameter) is most preferably around 3:1. Generally it has been found that hoppers having aspect ratios of less than 2:1 or greater than 5:1 do generally not work without coring or bridging occurring.
  • the filter system used to divide the hopper from the air pumping system is also most advantageous to the device. Without the filter the bulk powder is free to move around a system of around twice its nominal volume which results in the requirement for a gross overfill to achieve the nominal dose output. This also leads to reliability problems towards the end of the product life as inversion of the device allows a by now small amount of powder to migrate away from the dosing nozzle with the result of no dose being dispensed.
  • Experiments with different mesh sizes for the filter from a nominal 15 ⁇ m hole size to HO ⁇ have been made. These represent the outer useful envelopes for powders with a nominal particle diameter of 30-60 ⁇ m.
  • the effective mesh range would increase correspondingly.
  • the filter then represents a serious pressure drop to the driving air system and, at around say 2 ⁇ m nominal hole size, it is difficult to achieve the high exit velocity required to achieve effective metering.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

L'invention concerne un réservoir (20) destiné à recevoir un médicament en poudre dont une extrémité présente une section interne relativement importante par laquelle on peut charger la poudre dans le réservoir, et dont l'extrémité opposée constitue une ouverture de décharge (21) de section relativement faible, la superficie de la section du réservoir se réduisant progressivement entre ladite première extrémité et ladite extrémité opposée de façon que la relation entre la superficie de la section et la distance entre ladite première extrémité et ladite extrémité opposée soit généralement linéaire.
PCT/GB1993/001894 1992-09-08 1993-09-07 Dispositif de distribution de medicament WO1994005360A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU49763/93A AU4976393A (en) 1992-09-08 1993-09-07 Medicament dispensing device

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9218937.2 1992-09-08
GB929218937A GB9218937D0 (en) 1992-09-08 1992-09-08 Medicament dispensing device
GB9225389.7 1992-12-04
GB929225389A GB9225389D0 (en) 1992-09-08 1992-12-04 Medicament dispensing device

Publications (1)

Publication Number Publication Date
WO1994005360A1 true WO1994005360A1 (fr) 1994-03-17

Family

ID=26301571

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1993/001894 WO1994005360A1 (fr) 1992-09-08 1993-09-07 Dispositif de distribution de medicament

Country Status (4)

Country Link
CN (1) CN1084082A (fr)
AU (1) AU4976393A (fr)
IL (1) IL106930A0 (fr)
WO (1) WO1994005360A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998011929A1 (fr) * 1996-09-20 1998-03-26 Tebro Distributeur de poudre avec chambre de dosage basculante
WO2001000262A1 (fr) * 1999-06-23 2001-01-04 Cambridge Consultants Limited Inhalateurs
GB2365778A (en) * 2000-06-23 2002-02-27 Norton Healthcare Ltd Inhaler dose metering system
WO2002089883A1 (fr) 2001-05-10 2002-11-14 Innovata Biomed Limited Dispositif de distribution pour une substance fluide
WO2005034833A2 (fr) 2003-10-02 2005-04-21 Ivax Corporation Appareil d'inhalation de poudre seche
GB2461752A (en) * 2008-07-14 2010-01-20 Neo Inhalation Products Ltd Metered dose inhaler with vortex device
CN115003248A (zh) * 2020-01-27 2022-09-02 阿普塔尔法国简易股份公司 粉末产品分配装置
US11975141B2 (en) 2018-12-18 2024-05-07 Koninklijke Philips N.V. Breath actuated inhalers

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201900006368A1 (it) * 2019-04-26 2020-10-26 Hsd Holding Smart Device S R L Inalatore di sostanze medicinali

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0424790A2 (fr) * 1989-10-27 1991-05-02 Miat S.P.A. Inhalateur à dosages multiples pour des médicamments sous forme de poudre
US5113855A (en) * 1990-02-14 1992-05-19 Newhouse Michael T Powder inhaler
WO1992009322A1 (fr) * 1990-11-29 1992-06-11 Boehringer Ingelheim Kg Dispositif d'inhalation
WO1992010229A1 (fr) * 1990-12-15 1992-06-25 Norton Healthcare Limited Dispositif distributeur de medicament en poudre

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0424790A2 (fr) * 1989-10-27 1991-05-02 Miat S.P.A. Inhalateur à dosages multiples pour des médicamments sous forme de poudre
US5113855A (en) * 1990-02-14 1992-05-19 Newhouse Michael T Powder inhaler
WO1992009322A1 (fr) * 1990-11-29 1992-06-11 Boehringer Ingelheim Kg Dispositif d'inhalation
WO1992010229A1 (fr) * 1990-12-15 1992-06-25 Norton Healthcare Limited Dispositif distributeur de medicament en poudre

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998011929A1 (fr) * 1996-09-20 1998-03-26 Tebro Distributeur de poudre avec chambre de dosage basculante
FR2753791A1 (fr) * 1996-09-20 1998-03-27 Tebro Distributeur de poudre avec chambre de dosage basculante
WO2001000262A1 (fr) * 1999-06-23 2001-01-04 Cambridge Consultants Limited Inhalateurs
US7246617B1 (en) 1999-06-23 2007-07-24 Vectura Delivery Devices Limited Inhalers
WO2002000281A3 (fr) * 2000-06-23 2003-01-03 Ivax Corp Inhalateur de medicaments
US7540282B2 (en) 2000-06-23 2009-06-02 Norton Healthcare Ltd Reservoir pressure system for medicament inhaler
US6718972B2 (en) 2000-06-23 2004-04-13 Ivax Corporation Dose metering system for medicament inhaler
AU2001270113B2 (en) * 2000-06-23 2004-08-12 Norton Healthcare, Ltd. Medicament inhaler
GB2365778B (en) * 2000-06-23 2004-10-13 Norton Healthcare Ltd Dose metering system for medicament inhaler
GB2365778A (en) * 2000-06-23 2002-02-27 Norton Healthcare Ltd Inhaler dose metering system
US8006690B2 (en) 2000-06-23 2011-08-30 Norton Healthcare Ltd Reservoir pressure system for medicament inhaler
WO2002089883A1 (fr) 2001-05-10 2002-11-14 Innovata Biomed Limited Dispositif de distribution pour une substance fluide
US8651103B2 (en) 2003-10-02 2014-02-18 Norton Healthcare Ltd. Dry powder inhalation apparatus
EP1667627A4 (fr) * 2003-10-02 2010-04-28 Norton Healthcare Ltd Appareil d'inhalation de poudre seche
JP2007521844A (ja) * 2003-10-02 2007-08-09 ノートン　ヘルスケアー　リミテッド 乾燥粉体吸入装置
WO2005034833A2 (fr) 2003-10-02 2005-04-21 Ivax Corporation Appareil d'inhalation de poudre seche
US9463288B2 (en) 2003-10-02 2016-10-11 Norton Healthcare Ltd. Dry powder inhalation apparatus
US10765820B2 (en) 2003-10-02 2020-09-08 Norton Healthcare Ltd. Dry powder inhalation apparatus
GB2461752A (en) * 2008-07-14 2010-01-20 Neo Inhalation Products Ltd Metered dose inhaler with vortex device
GB2461752B (en) * 2008-07-14 2013-04-17 Neo Inhalation Products Ltd Metered dose inhaler
US11975141B2 (en) 2018-12-18 2024-05-07 Koninklijke Philips N.V. Breath actuated inhalers
CN115003248A (zh) * 2020-01-27 2022-09-02 阿普塔尔法国简易股份公司 粉末产品分配装置

Also Published As

Publication number Publication date
IL106930A0 (en) 1993-12-28
AU4976393A (en) 1994-03-29
CN1084082A (zh) 1994-03-23

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