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WO1994000489A3 - Peptides derives de la somatostatine et marques de maniere radioactive pour imagerie et utilisations therapeutiques - Google Patents

Peptides derives de la somatostatine et marques de maniere radioactive pour imagerie et utilisations therapeutiques Download PDF

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Publication number
WO1994000489A3
WO1994000489A3 PCT/US1993/006029 US9306029W WO9400489A3 WO 1994000489 A3 WO1994000489 A3 WO 1994000489A3 US 9306029 W US9306029 W US 9306029W WO 9400489 A3 WO9400489 A3 WO 9400489A3
Authority
WO
WIPO (PCT)
Prior art keywords
labeled
peptides
somatostantin
radioactively
imaging
Prior art date
Application number
PCT/US1993/006029
Other languages
English (en)
Other versions
WO1994000489A2 (fr
Inventor
Richard T Dean
John Lister-James
Original Assignee
Diatech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diatech Inc filed Critical Diatech Inc
Priority to US08/347,397 priority Critical patent/US5871711A/en
Priority to JP6502568A priority patent/JPH08503924A/ja
Priority to DE69330521T priority patent/DE69330521T2/de
Priority to DK93918129T priority patent/DK0649434T3/da
Priority to AT93918129T priority patent/ATE203754T1/de
Priority to CA002138647A priority patent/CA2138647C/fr
Priority to AU47688/93A priority patent/AU690071B2/en
Priority to EP93918129A priority patent/EP0649434B1/fr
Publication of WO1994000489A2 publication Critical patent/WO1994000489A2/fr
Publication of WO1994000489A3 publication Critical patent/WO1994000489A3/fr
Priority to SG1996004666A priority patent/SG48977A1/en
Priority to AU70990/94A priority patent/AU701083B2/en
Priority to EP00122241A priority patent/EP1092726B1/fr
Priority to ES94920076T priority patent/ES2158897T3/es
Priority to AT94920076T priority patent/ATE199089T1/de
Priority to DE69434832T priority patent/DE69434832D1/de
Priority to DK94920076T priority patent/DK0720621T3/da
Priority to EP00122242A priority patent/EP1099707A3/fr
Priority to AT00122241T priority patent/ATE337338T1/de
Priority to PCT/US1994/006274 priority patent/WO1995000553A1/fr
Priority to EP94920076A priority patent/EP0720621B1/fr
Priority to DE69426673T priority patent/DE69426673T2/de
Priority to ZA944498A priority patent/ZA944498B/xx
Priority to AU77481/98A priority patent/AU7748198A/en
Priority to AU18288/01A priority patent/AU776961B2/en
Priority to GR20010400678T priority patent/GR3035830T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des peptides et réactifs thérapeutiques, des réactifs et peptides radiodiagnostiques, ainsi que des procédés de production d'agents radiodiagnostiques marqués. En particulier, l'invention concerne des dérivés peptidiques et des analogues de la somatostatine, ainsi que des modes de réalisation de tels peptides marqués avec le technetium-99m (Tc-99m), ainsi que des procédés et des kits de production, radiomarquage et utilisation de tels peptides pour visionner des sites dans le corps d'un mammifère. L'invention concerne également des dérivés de peptides et des analogues de somatostatine marqués avec le rhénium-186 (186Re) et le rhénium-188 (188Re), ainsi que des procédés et kits de production, radiomarquage et utilisation thérapeutique de tels peptides dans un corps d'un mammifère.
PCT/US1993/006029 1992-01-14 1993-06-23 Peptides derives de la somatostatine et marques de maniere radioactive pour imagerie et utilisations therapeutiques WO1994000489A2 (fr)

Priority Applications (24)

Application Number Priority Date Filing Date Title
US08/347,397 US5871711A (en) 1992-06-23 1993-06-23 Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
JP6502568A JPH08503924A (ja) 1992-06-23 1993-06-23 造影および治療用途の放射性標識ソマトスタチン誘導ペプチド
DE69330521T DE69330521T2 (de) 1992-06-23 1993-06-23 Radioaktiv-markierte peptidderivate des somatostatin zur bildformenden und therapeutischen verwendung
DK93918129T DK0649434T3 (da) 1992-06-23 1993-06-23 Radioaktivt mærkede somatostatin-afledte peptider til billeddannende og terapeutiske anvendelser
AT93918129T ATE203754T1 (de) 1992-06-23 1993-06-23 Radioaktiv-markierte peptidderivate des somatostatin zur bildformenden und therapeutischen verwendung
CA002138647A CA2138647C (fr) 1992-06-23 1993-06-23 Peptides derives de la somatostatine, marques d'une substance radioactive, pour utilisation en imagerie et a des fins therapeutiques
AU47688/93A AU690071B2 (en) 1992-06-23 1993-06-23 Radioactively-labeled somatostantin-derived peptides for imaging and therapeutic uses
EP93918129A EP0649434B1 (fr) 1992-06-23 1993-06-23 Peptides derives de la somatostatine et marques de maniere radioactive pour imagerie et utilisations therapeutiques
EP94920076A EP0720621B1 (fr) 1993-06-23 1994-06-03 Peptides radiomarques derives de la somatostatine et utilises dans des procedes d'imagerie et therapeutiques
DE69426673T DE69426673T2 (de) 1993-06-23 1994-06-03 Radiomarkierte somatostatin derivate zur abbildung und zur therapeutischen verwendung
EP00122242A EP1099707A3 (fr) 1993-06-23 1994-06-03 Peptides derives de la somatostatine et marques de maniere radioactive pour imagerie et utilisations therapeutiques
SG1996004666A SG48977A1 (en) 1993-06-23 1994-06-03 Radiolabeled peptides
EP00122241A EP1092726B1 (fr) 1993-06-23 1994-06-03 Peptides dérivés de la somatostatine et marqués de manière radioactive pour imagerie et utilisations thérapeutiques
ES94920076T ES2158897T3 (es) 1993-06-23 1994-06-03 Peptidos radiomarcados derivados de somatostatina y utilizados en procedimientos de formacion de imagenes y terapeuticos.
AT94920076T ATE199089T1 (de) 1993-06-23 1994-06-03 Radiomarkierte somatostatin derivate zur abbildung und zur therapeutischen verwendung
DE69434832T DE69434832D1 (de) 1993-06-23 1994-06-03 Radioaktiv-markierte Peptidderivate des Somatostatins zur bildformenden und therapeutischen Verwendung
DK94920076T DK0720621T3 (da) 1992-01-14 1994-06-03 Radiomærkede somatostation-afledte peptider til billeddannende og terapeutiske anvendelser
AU70990/94A AU701083B2 (en) 1993-06-23 1994-06-03 Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
AT00122241T ATE337338T1 (de) 1993-06-23 1994-06-03 Radioaktiv-markierte peptidderivate des somatostatins zur bildformenden und therapeutischen verwendung
PCT/US1994/006274 WO1995000553A1 (fr) 1993-06-23 1994-06-03 Peptides radiomarques derives de la somatostatine et utilises dans des procedes d'imagerie et therapeutiques
ZA944498A ZA944498B (en) 1993-06-23 1994-06-23 Radiolabeled peptides
AU77481/98A AU7748198A (en) 1992-06-23 1998-07-23 Radioactively-labeled somatostantin-derived peptides for imaging and therapeutic uses
AU18288/01A AU776961B2 (en) 1992-06-23 2001-02-05 Radioactively-labeled somatostantin-derived peptides for imaging and therapeutic uses
GR20010400678T GR3035830T3 (en) 1993-06-23 2001-05-07 Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/902,935 US5716596A (en) 1992-06-23 1992-06-23 Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US902,935 1992-06-23

Publications (2)

Publication Number Publication Date
WO1994000489A2 WO1994000489A2 (fr) 1994-01-06
WO1994000489A3 true WO1994000489A3 (fr) 1994-03-31

Family

ID=25416650

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/006029 WO1994000489A2 (fr) 1992-01-14 1993-06-23 Peptides derives de la somatostatine et marques de maniere radioactive pour imagerie et utilisations therapeutiques

Country Status (10)

Country Link
US (5) US5716596A (fr)
EP (2) EP1094074A3 (fr)
JP (1) JPH08503924A (fr)
AT (1) ATE203754T1 (fr)
AU (1) AU690071B2 (fr)
CA (1) CA2138647C (fr)
DE (1) DE69330521T2 (fr)
DK (1) DK0649434T3 (fr)
ES (1) ES2164667T3 (fr)
WO (1) WO1994000489A2 (fr)

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CA2138647C (fr) 2002-11-12
DK0649434T3 (da) 2001-11-12
US5814298A (en) 1998-09-29
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AU4768893A (en) 1994-01-24
US5833942A (en) 1998-11-10
EP0649434B1 (fr) 2001-08-01
US5820845A (en) 1998-10-13
ATE203754T1 (de) 2001-08-15
DE69330521D1 (de) 2001-09-06
ES2164667T3 (es) 2002-03-01
US5716596A (en) 1998-02-10
US5843401A (en) 1998-12-01
EP0649434A1 (fr) 1995-04-26
DE69330521T2 (de) 2002-05-16
AU690071B2 (en) 1998-04-23
WO1994000489A2 (fr) 1994-01-06
EP1094074A2 (fr) 2001-04-25
JPH08503924A (ja) 1996-04-30

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