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WO1993023061B1 - Therapeutic uses of pungent botanicals and their related compounds - Google Patents

Therapeutic uses of pungent botanicals and their related compounds

Info

Publication number
WO1993023061B1
WO1993023061B1 PCT/US1993/004763 US9304763W WO9323061B1 WO 1993023061 B1 WO1993023061 B1 WO 1993023061B1 US 9304763 W US9304763 W US 9304763W WO 9323061 B1 WO9323061 B1 WO 9323061B1
Authority
WO
WIPO (PCT)
Prior art keywords
analog
species
includes those
genus
amended
Prior art date
Application number
PCT/US1993/004763
Other languages
French (fr)
Other versions
WO1993023061A1 (en
Filing date
Publication date
Application filed filed Critical
Priority to GB9423318A priority Critical patent/GB2286120B/en
Priority to US08/338,489 priority patent/US6063381A/en
Priority to DE4392300T priority patent/DE4392300T1/en
Publication of WO1993023061A1 publication Critical patent/WO1993023061A1/en
Publication of WO1993023061B1 publication Critical patent/WO1993023061B1/en
Priority to US09/571,644 priority patent/US6593371B1/en
Priority to US10/620,794 priority patent/US20050058729A1/en

Links

Abstract

A new class of general antiinfective compounds extracted from pepper, ginger, and other plant species containing vanillyl (Fig. 3), and piperidine (Fig. 7) ring structures typical of the pungent principals found in pepper, and ginger. The role of these structures, their attached hydrocarbon groups, and other compounds found within the plant extract is demonstrated in the topical treatment of dermatophyte infections, tissue injuries, and abnormal proliferations of keratin.

Claims

AMENDED CLAIMS
[received by the International Bureau on 11 November 1993 (11.11.93); original claims 69-81 amended and renumbered as claims 69-80; claims 82-173 amended and renumbered as claims 81-170; new claims 171-184 added; other claims unchanged (14 pages)]
69. A method as in any one of claims 1 - 9, or 14 - 21 , wherein said carrier is a douche.
70. A method as in any one of claims 1 - 9, or 14 - 21, wherein said carrier is a suppository.
71. A method as in any one of claims 1 - 9, or 14 - 21, wherein said carrier is an injection.
72. The method of claim 71, wherein said injection is intravenous.
73. The method of claim 71, wherein said injection is in spinal fluid.
74. The method of claim 71, wherein said injection is in deep tissue.
75. A method as in any one of claims 1 - 9, or 14 - 21 , wherein said carrier is an article of clothing.
76. The method of claim 75, wherein said article of clothing is underwear.
77. The method of claim 75, wherein said article of clothing are socks.
78. The method of claim 75, wherein said article of clothing are shoes.
79. The method of claim 75, wherein said article of clothing are shoe liners.
80. A method as in any one of claims 1 - 9 , or 14 - 21, wherein said carrier is a rectal, or vaginal suppository. 86
81. A method of inducing eye, skin, or respiratory discomfort in humans and animals for the purpose of discouraging their occupation of a given area comprised of: applying to an atmosphere within the given area, a vapor containing an irritant compound that is obtainable from a water, an alcohol, or an other solvent extraction of a component of a plant species having a component that contains a suitable quantity of a vanillyl (Fig. 3) analog, or a piperidine (Fig. 7) analog that produces irritation, or a synthetic equivalent thereof distributed by means of a device particularly well suited for producing said vapor, in a therapeutically effective amount sufficient to induce discomfort to the humans, or animals, to discourage the occupation of the given area.
82. The method of claim 81, wherein said vapor contains alcohol.
83. The method of claim 82, wherein said alcohol is ethanol.
84. The method of claim 81, wherein said vapor contains acetone.
85. The method of claim 81, wherein said vapor contains chloroform.
86. The method of claim 81, wherein said vapor contains ether.
87. The method of claim 81, wherein said vapor contains water.
88. The method of claim 81, wherein said vapor contains about 40% water and 60% ethanol together. 87
89. A method for treating infectious diseases in plants comprised of: applying to an area of infection, a therapeutically suitable carrier containing an antiinfective compound that is obtainable from a water, an alcohol, or an other solvent extraction of a component of a solanacea family pepper plant species such as is available from a common commercial grade of oleoresin, or an other plant species having a component that also contains a suitable quantity of a vanillyl (Fig. 3) analog that is analogous to a pungent compound found in said pepper plant species, in a therapeutically effective amount not exceeding a concentration of said antiinfective compound, or an analog of said antiinfective compound not normally found occurring in said common commercial grade of an oleoresin prepared from said pepper plant components, or a common commercial grade of oleoresin likewise prepared from said other plant species, or a synthetic equivalent thereof sufficient to eliminate, or reduce in severity the infectious disease.
90. A method for treating infectious diseases in plants comprised of: applying to an area of infection, a therapeutically suitable carrier containing an antiinfective compound, that is a vanillyl (Fig. 3) analog that is analogous to a pungent compound found in a pepper plant species of the piperacea family, or a synthetic equivalent thereof in a therapeutically effective amount sufficient to eliminate, or reduce in severity the infectious disease.
91. A method for treating infectious diseases in plants comprised of: applying to an area of infection, a therapeutically suitable carrier containing an antiinfective compound, that is obtainable from a water, an alcohol, or an other solvent extraction of a component of a piperacea family 88
pepper plant species, or an other plant species having a component that also contains a suitable quantity of a piperidine (Fig. 3) analog that is analogous to a pungent compound found in said pepper plant species, or a synthetic equivalent thereof, in a therapeutically effective amount sufficient to eliminate, or reduce in severity the infectious disease.
92. A method for treating infectious diseases in plants comprised of: applying to an area of infection, a therapeutically suitable carrier containing an antiinfective compound, that is a piperidine (Fig. 4) analog that is analogous to a pungent compound found in a piperacea family pepper plant species, or a synthetic equivalent thereof in a therapeutically effective amount sufficient to eliminate, or reduce in severity the infectious disease.
93. A method as in any one of claims 89 - 93, wherein said diseases include fungal infections.
94. A method as in any one of claims 89 - 92, wherein said diseases include bacterial infections.
95. A method as in any one of claims 89 - 92, wherein said diseases include viral infections.
96. A method of disinfecting an inanimate object of living microorganisms comprised of: applying to the object, a therapeutically suitable carrier containing a disinfectant compound, obtainable from a water, an alcohol, or an other solvent extraction of a component of a solanacea, or piperacea family pepper plant species, or an other plant species having a component that also contains a suitable quantity of a vanillyl (Fig. 3) analog, or a piperidine (Fig. 7) analog that is analogous to a pungent compound found in said 89
pepper plant species, or a synthetic equivalent thereof, in a therapeutically effective amount sufficient to reduce the number of the microorganisms living on the object.
97. A method of killing insects comprised of: applying to the insect, a therapeutically suitable carrier containing an insecticidal compound that is obtainable from a water, an alcohol, or an other solvent extraction of a component of a solanacea family pepper plant species, or other plant species having a component that contains a suitable quantity of a vanillyl (Fig. 3) analog that is analogous to a pungent compound found in said pepper plant species, or a synthetic equivalent thereof, in a therapeutically effective amount sufficient to kill the insect.
98. The method of claim 97, wherein the insect destroys crops.
99. A method of killing crop destroying insects comprised of: applying to the insect, a therapeutically suitable carrier containing an insecticidal compound that is obtainable from a water, an alcohol, or an other solvent extraction of a component of a piperacea family pepper plant species, or an other plant species having a component that also contains a suitable quantity of a piperidine (Fig. 7) analog that is analogous to a pungent compound found in said pepper plant species, or an analogous synthetic equivalent thereof, in a therapeutically effective amount sufficient to kill the crop destroying insect.
100. A method of preserving crops from the destructive influences of microbes, or animals comprised of: applying to the crops, a therapeutically suitable carrier containing a repellent compound that is obtainable from a water, an alcohol, or an other solvent extraction of 90
a component of a plant species that contains a suitable quantity of a vanillyl (Fig. 3) analog, or a synthetic equivalent thereof, in a therapeutically effective amount sufficient to preserve the crops by repelling the microbes, or animals that cause the destruction.
101. A method of preserving crops from the destructive influences of microbes, or animals comprised of: administration to the crops, a therapeutically suitable carrier containing a repellent compound that is a vanillyl (Fig. 3) analog, in a therapeutically effective amount sufficient to preserve the crops by repelling the microbes, or animals that cause the destruction.
102. A method of preserving crops from the destructive influences of microbes, or animals comprised of: administration to the crops, a therapeutically suitable carrier containing a repellent compound that is obtainable from a water, an alcohol, or an other solvent extraction of a component of a plant species that contains a suitable quantity of a piperidine (Fig. 7) analog, or a synthetic equivalent thereof, in a therapeutically effective amount sufficient to preserve the crops by repelling the microbes, or animals that cause the destruction.
103. A method of preserving crops from the destructive influences of microbes, or animals comprised of: administration to the crops, a therapeutically suitable carrier containing a repellent compound that is a piperidine (Fig. 7) analog, in a therapeutically effective amount sufficient to preserve the crops by repelling the microbes, or animals that cause the destruction.
104. A method as in any one of claims 1 - 9, 14 - 21, 81, 89 - 92, 96, 97, or 99 - 103, wherein said carrier is liquid drops. 91
105. A method as in any one of claims 1 - 9, 14 - 21, 81, 89 - 92, 96, 97, or 99 - 103, wherein said carrier is a powder.
106. A method as in any one of claims 1 - 9, 14 - 21, 81, 89 - 92, 96, 97, or 99 - 103, wherein said carrier is an aerosol.
107. A method as in any one of claims 1 - 9 , 14 - 21, 81, 89 - 92, 96, 97, or 99 - 103, wherein said carrier' is water based.
108. A method as in any one of claims 1 - 9, 14 - 21, 81, 89 - 92, 96, 97, or 99 - 103, wherein said carrier is alcohol.
109. A method as in any one of claims 81, or 100 - 103, wherein said animal is a rodent.
110. A method as in any one of claims 81, or 100 - 103, wherein said animal is an insect.
111. A method as in any one of claims 81, or 100 - 103 wherein said animal is a bird.
112. A method as in any one of claims 1, 6, 14, 18, 81, 100, or 102, wherein said plant includes the pepper species.
113. The method of claim 112, wherein said pepper species includes those of the solanacea family.
114. The method of claim 113, wherein said solanacea family includes those of the genus capsicum.
115. The method of claim 114, wherein said capsicum genus includes those of the frutescens species. 92
116. The method of claim 114, wherein said capsicum genus includes those of the annuum species.
117. The method of claim 114, wherein said capsicum genus includes those of the baccatum species.
118. The method of claim 114, wherein said capsicum genus includes those of the longum species.
119. The method of claim 112, wherein said plant of the pepper species includes those of the piperacea family.
120. The method of claim 119, wherein said piperacea family includes those of the genus peperoma.
121. The method of claim 119, wherein said piperacea family includes those of the genus piper.
122. The method of claim 121, wherein said piper genus includes those of the nigrum species.
123. The method of claim 121, wherein said piper genus includes those of the retrofractum species.
124. The method of claim 121, wherein said piper genus includes those of the longum species.
125. A method as in any one of claims 1, 6, 14, 18, 81, 89, 96, 97, or 100, wherein said plant species that contains a vanillyl analog include those of the Zingiberacea family.
126. The method of claim 125, wherein the Zingiberaceae species includes those of the genus Zingiber.
127. The method of claim 126, wherein the Zingiber genus includes those of the species officinale. 128. The method of claim 125, wherein the Zingiberaceae species includes those of the genus Elettaria.
129. The method of claim 128, wherein the Elettaria genus includes those of the cardamomum species.
130. The method of claim 125, wherein the Zingiberaceae species includes those of the genus Curcuma.
131. The method of claim 130, wherein the Curcuma genus include those of the longa species.
132. The method of claim 125, wherein the Zingiberaceae species includes Aframonum elegueta.
133. A method as in any one of claims 1, 6, 14, 18, 81, 89, 96, 97, or 100, wherein said plant species that contains a vanillyl analog includes those of the genus Euphorbia.
134. The method of claim 133, wherein said Euphorbia genus includes those of the resinifera species.
135. The method of claim 133, wherein said Euphorbia genus includes those of the pulcherrima species.
136 .A method as in any one of claims 1, 6, 14, 18, 81, 89, 96, 97, or 100, wherein said plant species that contains a vanillyl analog includes Eugenia aromatica.
137. A method as in any one of claims 1 - 9 , 14 - 21, 81, 89 - 92, 96, 97, or 99 - 103, wherein said compound is pungent.
138. A method as in any one of claims 1 - 9, 14 - 21, 81, 89 - 92, 96, 97, or 99 - 103, wherein said compound has been hydrolysed. 94
139. A method as in any one of claims 1, 3, 6, 8, 14, 16, 18, 20, 81, 89, 91, 92, 96, 97, 99, 100, or 102, wherein said component includes the fruit.
140. A method as in any one of claims 1, 3, 6, 8, 14, 16, 18, 20, 81, 89, 91, 92, 96, 97, 99, 100, or 102, wherein said component includes the seeds.
141. A method as in any one of claims 1, 3, 6, 8, 14, 16, 18, 20, 81, 89, 91, 92, 96, 97, 99, 100, or 102, wherein said component includes the leaves or stems.
142. A method as in any one of claims 1, 3, 6, 8, 14, 16, 18, 20, 81, 89, 91, 92, 96, 97, 99, 100, or 102, wherein said component includes the roots, or rhizomes.
143. A method as in any one of claims 1, 2, 6, 7, 14, 15, 18, 19, 81, 89, 96, 97, 100, or 101, wherein said analog of vanillyl is a gingerol (Fig. 11) analog.
144. The method of claim 143, wherein said gingerol analog is a gingerol hydrolyte.
145. The method of claim 143, wherein said gingerol analog is a shogaol (Fig. 11 ) analog.
146. The method of claim 143, wherein said gingerol analog is a paradol (Fig. 11) analog.
147. The method of claim 143, wherein said gingerol analog is a zingerone (Fig. 11 ) analog.
148. A method as in any one of claims 1 , 2, 6, 1 , 14, 15, 18, 19, 81, 89, 96, 97, 100, or 101 , wherein said analog of vanillyl is a curcumin (Fig. 10) analog.
149. A method as in any one of claims 1, 2, 6, 7, 14, 95
15, 18, 19, 81, 89, 96, 97, 100, or 101, wherein said analog of vanillyl is a eugenol (Fig. 9) analog.
150. A method as in any one of claims 1, 2, 6, 7, 14, 15, 18, 19, 81, 89, 96, 97, 100, or 101, wherein said analog of vanillyl is a vanillylamide (Fig. 5).
151. The method of claim 150, wherein said vanillylamide is a capsaicinoid (Fig. 6) analog.
152. The method of claim 151, wherein said capsaicinoid analog is an analog of capsaicin (Fig. 6).
153. The method of claim 151, wherein said capsaicinoid analog is an analog of dihydrocapsaicin (Fig. 6).
154. The method of claim 151, wherein said capsaicinoid analog is an analog of norcapsaicin (Fig. 6).
155. The method of claim 151, wherein said capsaicinoid analog is an analog of nordihydrocapsaicin (Fig. 6).
156. The method of claim 151, wherein said capsaicinoid analog is an analog of homocapsaicin (Fig. 6).
157. The method of claim 151, wherein said capsaicinoid analog is an analog of homodihydrocapsaicin (Fig. 6).
158. The method of claim 151, wherein said capsaicinoid analog is an analog of N-vanillyl-nonamide (Fig. 6).
159. The method of claim 151, wherein said capsaicinoid analog is an analog of nonanoic acid vanillylamide (Fig. 6).
160. The method of claim 151, wherein said capsaicinoid analog is an analog of decanoic acid vanillylamide (Fig. 96
6 ) .
161. A method as in any one of claims 1, 2, 6, 7, 14, 15, 18, 19, 81, 89, 96, 97, 100, or 101, wherein said analog of vanillyl is a resiniferatoxin (Fig. 12) analog.
162. The method of claim 161, wherein said analog of resiniferatoxin is a tinyatoxin (Fig. 13) analog.
163. The method of claim 152, wherein said capsaicin analog is an analog of a capsaicin (Fig. 6) hydrolyte.
164. The method of claim 163, wherein said analog of a capsaicin hydrolyte is methoxyhydroxybenzylamine (Fig. 4).
165. The method of claim 163, wherein said analog of a capsaicin (Fig. 6) hydrolyte is isodecylenic acid.
166. A method as in any one of claims 3, 4, 8, 9, 16, 17, 20, 21, 81, 91, 92, 99, or 103, wherein said analog of piperidine is a piperine (Fig. 8) analog.
167. A method as in any one of claims 3, 4, 8, 9, 16, 17, 20, 21, 81, 91, 92, 99, or 103, wherein said analog of piperidine is a chavicine (Fig. 8) analog.
168. The method according to claim 167, wherein said analog of chavicine is chavicic acid.
169. The method according to claim 167, wherein said analog of chavicine is piperic acid.
170. A method as in any one of claims 3, 4, 8, 9, 16, 17, 20, 21, 81, 91, 92, 99, or 103, wherein said analog of piperidine is a piperettine (Fig. 8) analog. 97
171. A method as in any one of claims 3, 4, 8, 9, 16, 17, 20, 21, 81, 91, 92, 99, or 103, wherein said analog of piperidine is a piperolein A (Fig. 8) analog.
172. A method as in any one of claims 3, 4, 8, 9, 16, 17, 20, 21, 81, 91, 92, 99, or 103, wherein said analog of piperidine is a piperettine (Fig. 8) analog.
173. A method as in any one of claims 3, 4, 8, 9, 16, 17, 20, 21, 81, 91, 92, 99, or 103, wherein said analog of piperidine is a piperettine (Fig. 8) analog.
174. A method as in any one of claims 3, 4, 8, 9, 16, 17, 20, 21, 81, 91, 92, 99, or 103, wherein said analog of piperidine is a piperettine (Fig. 8) analog.
175. A method as in any one of claims 89, or 96, wherein said solanacea family pepper plant species includes those of the genus capsicum.
176. The method of claim 175, wherein said capsicum genus includes those of the frutescens species.
177. The method of claim 175, wherein said capsicum genus includes those of the annuum species.
178. The method of claim 175, wherein said capsicum genus includes those of the baccatum species.
179. The method of claim 175, wherein said capsicum genus includes those of the longum species.
180. A method as in any one of claims 90 - 92, or 99, wherein said piperacea family includes those of the genus peperoma.
181. A method as in any one of claims 90 - 92, or 99, 98
wherein said piperacea family includes those of the genus piper.
182. The method of claim 181, wherein said piper genus includes those of the nigrum species.
183. The method of claim 181, wherein said piper genus includes those of the retrofractum species.
184. The method of claim 181, wherein said piper genus includes those of the longum species.
STATEMENT UNDER ARTICLE 19
Differences Between Claim Sheets as Filed, and as Amended
Sheet Claim Number Claim Number Number as filed as amended
2 - 73 69 - 81 69 80
74 82 87 81 - 88
2 - 75 88 - 94 89 - 91
2 - 76 95 - 102 92 96
2 - 77 103 108 97 - 100
2 - 78 109 - 116 101 - 104
2 - 79 117 - 128 105 - 115
2 - 80 129 - 139 116 - 127
81 140 - 149 128 - 138
2 - 82 150 - 160 139 - 149
2 - 83 161 - 171 150 - 160
2 - 84 172 - 173 161 - 170
2 - 85 171 - 181
2 - 86 182 - 184 Explanation of Amendments to the Claims as Filed
Claim Number Claim Number Description of Amendment as filed as amended
1 - 70 1 - 70 (70) claims are unchanged,
76 - 85 71 - 80 replaced (10) claims for renumeration only.
86 - 89 81 replaced (4) claims, Amended preamble.
87 - 89 cancelled (3) claims. Subject matter incorporated into amended claim 81 as above.
90 - 96 82 - 88 replaced (7) claims for renumeration only.
100 89 replaced (1) claim. Amended to include oleoresin source limitation.
101 - 103 90 - 92 replaced (3) claims, Amended to include pungent compound limitation.
104 - 106 93 - 95 replaced (3) claims for renumeration.
107 - 110 96 replaced (4) claims, Amended to include limitation of pepper species, and pungent compound.
- 110 cancelled (3) claims. Subject matter incorporated into amended claim 96 as above.
97 - 99 added (3) new claims that direct same compounds toward use as an insecticide as originally disclosed (see pages 2 - 61 & 62) but not claimed.
100 - 103 added (4) new claims that direct same compounds toward use as crop preservative as originally disclosed (see pages 2 - 61 & 62) but not claimed.
- 75 104 - 108 replaced (5) claims. Amended to include dependency on appropriate new claims.
- 99 109 - 111 replaced (5) claims. Amended to include dependency on appropriate new claims.
- 123 112 - 124 replaced (13) claims, Amended to include dependency on appropriate new claims.
124 - 173 125 - 174 replaced (50) claims. Amended to include dependency on appropriate new claims.
113 - 117 175 - 179 division of (5) claims. Amended to include dependency on appropriate new claims.
119 - 123 180 - 184 division of (5) claims. Amended to include dependency on appropriate new claims.
Impact of the Above Amendment A of the Claims on the Description, and Drawings of the International Application
No appreciable impact, as the subject matter, and terminology used in the above new, and amended claims is derived from the original disclosure of the international application as filed.
PCT/US1993/004763 1992-05-21 1993-05-19 Therapeutic uses of pungent botanicals and their related compounds WO1993023061A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GB9423318A GB2286120B (en) 1992-05-21 1993-05-19 Therapeutic pepper extracts and related compounds
US08/338,489 US6063381A (en) 1993-05-19 1993-05-19 Therapeutic uses of pungent botanicals and their related compounds
DE4392300T DE4392300T1 (en) 1992-05-21 1993-05-19 Therapeutic Uses of Biting Plants and their Related Compositions
US09/571,644 US6593371B1 (en) 1993-05-19 2000-05-15 Treatment for wart and related disorders
US10/620,794 US20050058729A1 (en) 1993-05-19 2003-07-15 Treatment for bacterial infections and related disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88664092A 1992-05-21 1992-05-21
US07/886,640 1992-05-21

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/571,644 Continuation-In-Part US6593371B1 (en) 1993-05-19 2000-05-15 Treatment for wart and related disorders

Publications (2)

Publication Number Publication Date
WO1993023061A1 WO1993023061A1 (en) 1993-11-25
WO1993023061B1 true WO1993023061B1 (en) 1994-01-06

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AU (1) AU4382693A (en)
CA (1) CA2136174A1 (en)
DE (1) DE4392300T1 (en)
GB (1) GB2286120B (en)
WO (1) WO1993023061A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925376C1 (en) * 1994-01-10 2001-03-20 Madalene C Y Heng Method for treating psoriasis using selected phosphorylase kinase inhibitor and additional compounds
PT1014927E (en) * 1997-01-09 2003-11-28 Lmd USE OF SHOGAOIS AND GINGERIALS FOR THE PREPARATION OF DEODORIZING COMPOSITIONS
FR2758087B1 (en) * 1997-01-09 1999-02-26 Daniel Jean USE OF GINGEROLS FOR THE PREPARATION OF DEODORANT AND ANTISEPTIC COMPOSITIONS AND COMPOSITIONS CONTAINING THEM
GB9710636D0 (en) * 1997-05-23 1997-07-16 Bauer Eran N Novel mixture
GB9711962D0 (en) * 1997-06-10 1997-08-06 Reckitt & Colmann Prod Ltd Therapeutically active compositions
EP1112745A1 (en) * 2000-01-03 2001-07-04 Irma Maestri Homeopathic composition
WO2001089571A2 (en) * 2000-05-19 2001-11-29 Sabinsa Corporation Method of increased bioavailability of nutrients and pharmaceutical preparations with tetrahydropiperine and its analogues and derivatives
TWI290469B (en) * 2000-07-12 2007-12-01 Medical & Pharm Ind Tech & Dev Method for manufacturing product with component capable of efficiently preventing inflammation and platelets agglutination form ginger and medical composition with the efficient component
ITMI20071136A1 (en) * 2007-06-04 2008-12-05 Velleja Res Srl TOPIC FORMULATIONS FOR THE PREVENTION AND TREATMENT OF THE INFLAMMATORY AND / OR INFECTIOUS STATES OF THE GENITAL AREA
DE102008009752A1 (en) 2007-10-09 2009-04-16 Jens Tannert Beverage for improving the state of health, contains chili pepper juice and grape fruit juice that are mixed to the beverage without alcohol
GB2455585B (en) * 2008-01-16 2010-07-28 Ali Reza Rezai-Fard Capsicum seeds for the treatment of eczema and dermatitis
US20100105644A1 (en) * 2008-10-27 2010-04-29 The Regents Of The University Of Michigan Botanical composition for enhanced skin repair and uses thereof
FR2950884B1 (en) 2009-10-01 2011-11-11 Oreal USE OF VANILLIN DERIVATIVES AS A PRESERVATIVE, METHOD OF PRESERVATION, COMPOUNDS AND COMPOSITION

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