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WO1993017651A3 - Antiviral nucleoside analogues, their production and use - Google Patents

Antiviral nucleoside analogues, their production and use Download PDF

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Publication number
WO1993017651A3
WO1993017651A3 PCT/DE1993/000213 DE9300213W WO9317651A3 WO 1993017651 A3 WO1993017651 A3 WO 1993017651A3 DE 9300213 W DE9300213 W DE 9300213W WO 9317651 A3 WO9317651 A3 WO 9317651A3
Authority
WO
WIPO (PCT)
Prior art keywords
production
nucleoside analogues
antiviral nucleoside
antiviral
disclosed
Prior art date
Application number
PCT/DE1993/000213
Other languages
German (de)
French (fr)
Other versions
WO1993017651A2 (en
Inventor
Eckart Matthes
Janta-Lipinski Martin Von
Original Assignee
Max Delbrueck Centrum
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Delbrueck Centrum filed Critical Max Delbrueck Centrum
Publication of WO1993017651A2 publication Critical patent/WO1993017651A2/en
Publication of WO1993017651A3 publication Critical patent/WO1993017651A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

New and known nucleoside analogues particularly effective against hepatitis B and HIV infections are disclosed, as well as their production and use.
PCT/DE1993/000213 1992-03-04 1993-03-03 Antiviral nucleoside analogues, their production and use WO1993017651A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19924207363 DE4207363A1 (en) 1992-03-04 1992-03-04 ANTIVIRAL NUCLEOSIDE ANALOGS, THEIR PRODUCTION AND THEIR PHARMACEUTICAL USE
DEP4207363.4 1992-03-04

Publications (2)

Publication Number Publication Date
WO1993017651A2 WO1993017651A2 (en) 1993-09-16
WO1993017651A3 true WO1993017651A3 (en) 1993-11-25

Family

ID=6453548

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1993/000213 WO1993017651A2 (en) 1992-03-04 1993-03-03 Antiviral nucleoside analogues, their production and use

Country Status (2)

Country Link
DE (1) DE4207363A1 (en)
WO (1) WO1993017651A2 (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9109001B2 (en) 2012-05-22 2015-08-18 Idenix Pharmaceuticals, Inc. 3′,5′-cyclic phosphoramidate prodrugs for HCV infection
US9187515B2 (en) 2013-04-01 2015-11-17 Idenix Pharmaceuticals Llc 2′,4′-fluoro nucleosides for the treatment of HCV
US9192621B2 (en) 2012-09-27 2015-11-24 Idenix Pharmaceuticals Llc Esters and malonates of SATE prodrugs
US9211300B2 (en) 2012-12-19 2015-12-15 Idenix Pharmaceuticals Llc 4′-fluoro nucleosides for the treatment of HCV
US9243025B2 (en) 2011-03-31 2016-01-26 Idenix Pharmaceuticals, Llc Compounds and pharmaceutical compositions for the treatment of viral infections
US9296778B2 (en) 2012-05-22 2016-03-29 Idenix Pharmaceuticals, Inc. 3′,5′-cyclic phosphate prodrugs for HCV infection
US9309275B2 (en) 2013-03-04 2016-04-12 Idenix Pharmaceuticals Llc 3′-deoxy nucleosides for the treatment of HCV
US9403863B2 (en) 2011-09-12 2016-08-02 Idenix Pharmaceuticals Llc Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections
US10005779B2 (en) 2013-06-05 2018-06-26 Idenix Pharmaceuticals Llc 1′,4′-thio nucleosides for the treatment of HCV
US10202411B2 (en) 2014-04-16 2019-02-12 Idenix Pharmaceuticals Llc 3′-substituted methyl or alkynyl nucleosides nucleotides for the treatment of HCV
US10231986B2 (en) 2013-03-13 2019-03-19 Idenix Pharmaceuticals Llc Amino acid phosphoramidate pronucleotides of 2′-cyano, azido and amino nucleosides for the treatment of HCV
US10238680B2 (en) 2013-08-01 2019-03-26 Idenix Pharmaceuticals Llc D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995022330A1 (en) * 1994-02-17 1995-08-24 Commonwealth Scientific And Industrial Research Organisation Antiviral agents
NZ536570A (en) 2000-05-26 2006-08-31 Idenix Cayman Ltd Methods and compositions for treating flaviviruses and pestiviruses
GB0114286D0 (en) 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
PL377342A1 (en) 2002-11-15 2006-01-23 Idenix (Cayman) Limited 2'-branched nucleosides and flaviviridae mutation
CN100351264C (en) * 2002-11-19 2007-11-28 霍夫曼-拉罗奇有限公司 Antiviral nucleoside derivatives
TWI332507B (en) * 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
CA2904692A1 (en) * 2005-09-26 2007-04-05 Gilead Pharmasset Llc Modified 4'-nucleosides as antiviral agents
US20080261913A1 (en) 2006-12-28 2008-10-23 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of liver disorders
CA2843221A1 (en) * 2011-07-29 2013-02-07 Michael John Booth Methods for detection of nucleotide modification
BR112014029115A8 (en) 2012-05-22 2018-04-03 Idenix Pharmaceuticals Inc COMPOUND, PHARMACEUTICAL COMPOSITION, AND, USE OF A COMPOUND OR COMPOSITION
BR112014029185B1 (en) 2012-05-25 2020-07-21 Janssen Sciences Ireland Uc uracil spirooxethane nucleosides, their use, pharmaceutical composition and product comprising them
CN104936970A (en) 2012-10-08 2015-09-23 埃迪尼克斯医药公司 2'-chloronucleoside analogues for HCV infection
US9339541B2 (en) 2013-03-04 2016-05-17 Merck Sharp & Dohme Corp. Thiophosphate nucleosides for the treatment of HCV
CN104193801A (en) * 2014-08-12 2014-12-10 苏州维泰生物技术有限公司 Guanine peptide nucleic acid monomer and synthetic method thereof
BR112020018209A2 (en) * 2018-03-07 2020-12-29 Emory University PHARMACEUTICAL COMPOSITIONS, PRESSURIZED CONTAINER, AND, METHODS FOR TREATING OR PREVENTING A VIRAL INFECTION AND TO TREAT OR PREVENT A HUMAN CORONAVIRUS, CORONAVIRUS SARS, CORONAVIRUS MERS, ENCEPHALITIS ECLINIS, EQUAL ENVIRONMENTAL EQUALINE CHICUNGUNHA, ROSS RIVER VIRUS, RSV, INFLUENZA A VIRUS, INFLUENZA B VIRUS, TACARIBE VIRUS, PICHINDE VIRUS, JUNIN VIRUS, LASSA FEVER VIRUS, LYMPHOCYTROUS VIRUS, TYRUS, VIRUS, VIRUS, VIRUS, RER MAPORAL, HEARTLAND VIRUS, AND SEVERE FEVER THROMBOCYTOPENIA SYNDROME VIRUS, POLIOVIRUS, COXSACKIE VIRUS, NOROVIRUS OR ENTEROVIRUS INFECTION IN A PATIENT

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0277599A2 (en) * 1987-01-30 1988-08-10 Asahi Glass Company Ltd. Fluorine containing cyclopentane derivatives and processes for their production
EP0322384A1 (en) * 1987-11-03 1989-06-28 Medivir Aktiebolag Nucleosides for use in therapy
EP0375183A1 (en) * 1988-12-05 1990-06-27 Schering Corporation Antiviral dimers and trimers
WO1991019727A1 (en) * 1990-06-19 1991-12-26 Sloan-Kettering Institute For Cancer Research 5'-hydrogenphosphonates and 5'-methylphosphonates of sugar modified nucleosides, compositions and uses thereof
EP0464642A1 (en) * 1990-07-02 1992-01-08 Hoechst Aktiengesellschaft Pyrimidine derivatives, their preparation and use as well as medicaments containing them
EP0302760B1 (en) * 1987-08-07 1992-07-29 The Governors of the University of Alberta Antiviral therapy for hepatitis b using 2',3'-dideoxynucleosides

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0277599A2 (en) * 1987-01-30 1988-08-10 Asahi Glass Company Ltd. Fluorine containing cyclopentane derivatives and processes for their production
EP0302760B1 (en) * 1987-08-07 1992-07-29 The Governors of the University of Alberta Antiviral therapy for hepatitis b using 2',3'-dideoxynucleosides
EP0322384A1 (en) * 1987-11-03 1989-06-28 Medivir Aktiebolag Nucleosides for use in therapy
EP0375183A1 (en) * 1988-12-05 1990-06-27 Schering Corporation Antiviral dimers and trimers
WO1991019727A1 (en) * 1990-06-19 1991-12-26 Sloan-Kettering Institute For Cancer Research 5'-hydrogenphosphonates and 5'-methylphosphonates of sugar modified nucleosides, compositions and uses thereof
EP0464642A1 (en) * 1990-07-02 1992-01-08 Hoechst Aktiengesellschaft Pyrimidine derivatives, their preparation and use as well as medicaments containing them

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF ORGANIC CHEMISTRY. Bd. 41, Nr. 18, 3. September 1976, EASTON US Seiten 3010 - 3017 G.R.OWEN ET AL. '4'-Substituted Nucleosides. 3.Synthesis of Some 4'-Fluorouridine Derivatives.' *
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. Bd. 98, Nr. 11, 26. Mai 1976, GASTON, PA US Seiten 3346 - 3357 I.D.JENKINS ET AL. '4'-Substituted Nucleosides. 2. Synthesis of the Nucleoside Antibiotic Nucleocidin.' *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9243025B2 (en) 2011-03-31 2016-01-26 Idenix Pharmaceuticals, Llc Compounds and pharmaceutical compositions for the treatment of viral infections
US9403863B2 (en) 2011-09-12 2016-08-02 Idenix Pharmaceuticals Llc Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections
US9109001B2 (en) 2012-05-22 2015-08-18 Idenix Pharmaceuticals, Inc. 3′,5′-cyclic phosphoramidate prodrugs for HCV infection
US9296778B2 (en) 2012-05-22 2016-03-29 Idenix Pharmaceuticals, Inc. 3′,5′-cyclic phosphate prodrugs for HCV infection
US9192621B2 (en) 2012-09-27 2015-11-24 Idenix Pharmaceuticals Llc Esters and malonates of SATE prodrugs
US9211300B2 (en) 2012-12-19 2015-12-15 Idenix Pharmaceuticals Llc 4′-fluoro nucleosides for the treatment of HCV
US9309275B2 (en) 2013-03-04 2016-04-12 Idenix Pharmaceuticals Llc 3′-deoxy nucleosides for the treatment of HCV
US10231986B2 (en) 2013-03-13 2019-03-19 Idenix Pharmaceuticals Llc Amino acid phosphoramidate pronucleotides of 2′-cyano, azido and amino nucleosides for the treatment of HCV
US9187515B2 (en) 2013-04-01 2015-11-17 Idenix Pharmaceuticals Llc 2′,4′-fluoro nucleosides for the treatment of HCV
US10005779B2 (en) 2013-06-05 2018-06-26 Idenix Pharmaceuticals Llc 1′,4′-thio nucleosides for the treatment of HCV
US10238680B2 (en) 2013-08-01 2019-03-26 Idenix Pharmaceuticals Llc D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease
US10202411B2 (en) 2014-04-16 2019-02-12 Idenix Pharmaceuticals Llc 3′-substituted methyl or alkynyl nucleosides nucleotides for the treatment of HCV

Also Published As

Publication number Publication date
WO1993017651A2 (en) 1993-09-16
DE4207363A1 (en) 1993-09-09

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