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WO1993013739A3 - Retroreverse pyrrole-amidino oligopeptide anticancer agent analogues, preparation of same, and pharmaceutical compositions containing such analogues - Google Patents

Retroreverse pyrrole-amidino oligopeptide anticancer agent analogues, preparation of same, and pharmaceutical compositions containing such analogues Download PDF

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Publication number
WO1993013739A3
WO1993013739A3 PCT/EP1993/000002 EP9300002W WO9313739A3 WO 1993013739 A3 WO1993013739 A3 WO 1993013739A3 EP 9300002 W EP9300002 W EP 9300002W WO 9313739 A3 WO9313739 A3 WO 9313739A3
Authority
WO
WIPO (PCT)
Prior art keywords
analogues
retroreverse
amidino
oligopeptide
pyrrole
Prior art date
Application number
PCT/EP1993/000002
Other languages
French (fr)
Other versions
WO1993013739A2 (en
Inventor
Federico Arcamone
Paolo Lombardi
Fabio Animati
Original Assignee
Menarini Farma Ind
Bristol Myers Squibb Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Farma Ind, Bristol Myers Squibb Spa filed Critical Menarini Farma Ind
Priority to EP93902141A priority Critical patent/EP0623023A1/en
Publication of WO1993013739A2 publication Critical patent/WO1993013739A2/en
Publication of WO1993013739A3 publication Critical patent/WO1993013739A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A description is given of compounds as per general formula (I), and of pharmaceutically acceptable salts thereof, active as anticancer and antivirus agents.
PCT/EP1993/000002 1992-01-10 1993-01-04 Retroreverse pyrrole-amidino oligopeptide anticancer agent analogues, preparation of same, and pharmaceutical compositions containing such analogues WO1993013739A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP93902141A EP0623023A1 (en) 1992-01-10 1993-01-04 Retroreverse pyrrole-amidino oligopeptide anticancer agent analogues, preparation of same, and pharmaceutical compositions containing such analogues

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI92A000021 1992-01-10
ITMI920021A IT1262921B (en) 1992-01-10 1992-01-10 ANALOGUE AGENTS ANALOGUES OF PYROL-AMIDINE OLIGOPEPTIDES BACK TO PREPARATION PROCESSES AND PHARMACEUTICAL PRODUCTS CONTAINING THEM

Publications (2)

Publication Number Publication Date
WO1993013739A2 WO1993013739A2 (en) 1993-07-22
WO1993013739A3 true WO1993013739A3 (en) 1993-11-25

Family

ID=11361495

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1993/000002 WO1993013739A2 (en) 1992-01-10 1993-01-04 Retroreverse pyrrole-amidino oligopeptide anticancer agent analogues, preparation of same, and pharmaceutical compositions containing such analogues

Country Status (4)

Country Link
EP (1) EP0623023A1 (en)
AU (1) AU3347893A (en)
IT (1) IT1262921B (en)
WO (1) WO1993013739A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1271456B (en) * 1993-03-01 1997-05-28 Menarini Farma Ind PYROL-AMIDINE COMPOUNDS, AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, PREPARATION PROCESSES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
IT1263089B (en) * 1993-04-26 1996-07-24 Menarini Farma Ind PYROL-AMIDINE COMPOUNDS, PREPARATION PROCESSES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
US5821258A (en) * 1994-12-27 1998-10-13 Mitsui Chemicals, Inc. Phenylbenzimidazole derivatives
US5808087A (en) * 1995-11-29 1998-09-15 Mitsui Chemicals, Inc. Sulfonium salts of pyrrolylbenzimidazoles
GB9623522D0 (en) * 1996-11-11 1997-01-08 Pharmacia & Upjohn Spa Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents
WO2001002359A1 (en) * 1999-07-01 2001-01-11 Ajinomoto Co., Inc. Heterocyclic compounds and medicinal use thereof
CA2403537A1 (en) 2000-03-16 2001-10-11 Genesoft, Inc. Charged compounds comprising a nucleic acid binding moiety and uses therefor
US7078536B2 (en) 2001-03-14 2006-07-18 Genesoft Pharmaceuticals, Inc. Charged compounds comprising a nucleic acid binding moiety and uses therefor
US7122626B2 (en) 2001-04-26 2006-10-17 Genesoft Pharmceuticals, Inc. Halogen-substitued thienyl compounds
AU2002312370A1 (en) 2001-06-13 2002-12-23 Roland W. Burli Antipathogenic benzamide compounds
CA2494139A1 (en) 2002-08-02 2004-02-12 Genesoft Pharmaceuticals, Inc. Biaryl compounds having anti-infective activity
AU2003285958A1 (en) 2002-10-25 2004-05-25 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
AU2003297822A1 (en) 2002-12-10 2004-06-30 Oscient Pharmaceuticals Corporation Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR4158M (en) * 1963-07-26 1966-05-16
DE3623880A1 (en) * 1985-07-16 1987-01-29 Erba Farmitalia POLY-4-AMINOPYRROL-2-CARBOXAMIDO DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
DE3623853A1 (en) * 1985-07-16 1987-01-29 Erba Farmitalia DISTAMYCINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
EP0246868A1 (en) * 1986-05-20 1987-11-25 FARMITALIA CARLO ERBA S.r.l. Site specific alkylating agents
EP0388948A1 (en) * 1989-03-23 1990-09-26 FARMITALIA CARLO ERBA S.r.l. Acryloyl substituted pyrrole derivatives

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR4158M (en) * 1963-07-26 1966-05-16
DE3623880A1 (en) * 1985-07-16 1987-01-29 Erba Farmitalia POLY-4-AMINOPYRROL-2-CARBOXAMIDO DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
DE3623853A1 (en) * 1985-07-16 1987-01-29 Erba Farmitalia DISTAMYCINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
EP0246868A1 (en) * 1986-05-20 1987-11-25 FARMITALIA CARLO ERBA S.r.l. Site specific alkylating agents
EP0388948A1 (en) * 1989-03-23 1990-09-26 FARMITALIA CARLO ERBA S.r.l. Acryloyl substituted pyrrole derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Dialog Information Services, file 155, Medline, Dialog accession no. 07972172, Medline accession no.92110172, Pezzoni G. et al: "Biological profile of FCE 24517, a novel benzoyl mustard analogue of distamycin A", Br J Cancer Dec 1991, 64 (6) p1047-50 *

Also Published As

Publication number Publication date
IT1262921B (en) 1996-07-22
WO1993013739A2 (en) 1993-07-22
AU3347893A (en) 1993-08-03
EP0623023A1 (en) 1994-11-09
ITMI920021A0 (en) 1992-01-10
ITMI920021A1 (en) 1993-07-10

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