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WO1993010785A1 - Procedes et compositions destines a traiter des infections a l'aide de (s)-lomefloxacine optiquement pure - Google Patents

Procedes et compositions destines a traiter des infections a l'aide de (s)-lomefloxacine optiquement pure Download PDF

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Publication number
WO1993010785A1
WO1993010785A1 PCT/US1992/010142 US9210142W WO9310785A1 WO 1993010785 A1 WO1993010785 A1 WO 1993010785A1 US 9210142 W US9210142 W US 9210142W WO 9310785 A1 WO9310785 A1 WO 9310785A1
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Prior art keywords
lomefloxacin
amount
composition according
pharmaceutically acceptable
adverse effects
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PCT/US1992/010142
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English (en)
Inventor
James W. Young
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Sepracor, Inc.
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Filing date
Publication date
Application filed by Sepracor, Inc. filed Critical Sepracor, Inc.
Priority to EP9292925403A priority Critical patent/EP0614364A4/fr
Priority to JP5510220A priority patent/JPH07503457A/ja
Publication of WO1993010785A1 publication Critical patent/WO1993010785A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Definitions

  • This invention relates to novel compositions of matter containing optically pure (S)-lomefloxacin.
  • These compositions possess potent activity in treating various infections while avoiding adverse effects associated with racemic lomefloxacin including but not limited to headache, stomach discomfort, gastrointestinal disorders, hypoglycemia, renal and hepatic dysfunction, allergic reactions and respiratory distress, and arthropathy, such as cartilage lesions and erosion and abnormalities in bone growth in immature patients.
  • these novel compositions of matter containing optically pure (S)-lomefloxacin are useful in treating infection in those patients with impaired renal function.
  • Stereochemical purity is of importance in the field of pharmaceuticals, where 12 of the 20 most prescribed drugs exhibit chirality.
  • a case in point is provided by the L-form of the jS-adrenergic blocking agent, propranolol, which is known to be 100 times more potent than the D-enantiomer.
  • optical purity is important since certain isomers may actually be deleterious rather than simply inert.
  • D-enantiomer of thalidomide was a safe and effective sedative when prescribed for the control of morning sickness during pregnancy, and that the corresponding L-enantiomer was a potent teratogen.
  • Lomefloxacin is described in United States Patent No. 4,528,287 and Japan Patent Publication No. 64979 (1985) .
  • Lomefloxacin is currently available commercially in Argentina, Japan, Mexico, and other countries in Asia and Eastern Europe, as the racemic mixture, i.e.. it is a 1:1 mixture of optical isomers. It is the optically pure, or substantially optically pure (S)-isomer of lomefloxacin, which is the subject of the present invention, hereinafter referred to as (S)-lomefloxacin.
  • Racemic lomefloxacin having the chemical name l-ethyl-6,8-difluoro-l,4-dihydro-7-(3-methyl-l- piperazinyl)-4-oxo-3-quinolinecarboxylic acid, belongs to the quinoline class of antibiotics.
  • the quinoline antibiotics in general, exhibit a broad spectrum of antibacterial action, demonstrating effectiveness against both Gram-positive and Gram-negative bacterial strains.
  • Quinoline antibiotics have been shown to be effective in treating infections of the respiratory, genito-urinary, and gastrointestinal tracts. They have also demonstrated utility in the treatment of patients with cystic fibrosis and pulmonary infections. Effectiveness has also been demonstrated in the treatment of intra-abdominal, bone and joint, skin, soft-tissue, pelvic, and eye, ear, nose, and throat infections.
  • the quinoline antibiotics derive their activity through inhibition of the bacterial enzyme, DNA gyrase, which is responsible for catalyzing the bacterial DNA supercoiling necessary to pack DNA filaments into bacterial cells. This inhibition causes irreversible chromosome damage leading to bacterial cell death.
  • DNA gyrase the bacterial enzyme responsible for catalyzing the bacterial DNA supercoiling necessary to pack DNA filaments into bacterial cells. This inhibition causes irreversible chromosome damage leading to bacterial cell death.
  • the selectivity of quinoline antibiotics for bacterial cells is the result of the supercoiling mechanism in eukariotic cells being mediated by a different set of enzymes not susceptible to quinoline inhibition. Quinoline antibiotics are also thought to interfere with proper bacterial cell membrane function, also contributing to cell death.
  • nalidixic acid The first quinoline antibiotic to be commercialized, nalidixic acid, was discovered following the observation that the structurally similar 6-chloro-lH-ethyl-4-oxoquinolone-3-carboxylic acid, a minor by-product of the commercial production of the antimalarial agent chloroquine, exhibited weak antibacterial action. Since the discovery of nalidixic acid, some 7,000 analogs belonging to approximately 16 different ring systems have been synthesized and tested for antibacterial action. From this data, a comprehensive structure/activity relationship has been elucidated.
  • Racemic lomefloxacin exhibits a broad spectrum of antibacterial action, demonstrating effectiveness against both gram-positive and gram- negative bacterial strains. Lomefloxacin has shown to be more effective against Gram-negative bacteria. In particular, lomefloxacin has shown excellent bacteriocidal activity against strains of
  • Lomefloxacin has an average elimination half-life of approximately 8 hours with peak plasma concentrations occurring at approximately 1 hour after oral dosing in humans. Its long half-life and dose proportionality have lead to introduction of lomefloxacin as the first, once-daily 4-quinoline antibiotic.
  • lomefloxacin does not interfere with the metabolism of theophylline.
  • co-administration of ranitidine with lomefloxacin has no effect on lomefloxacin's pharmacokinetics.
  • co- administration of sucralfate with lomefloxacin presumably through aluminum complexation, does reduce the absorption of the antibiotic.
  • lomefloxacin exhibits reduced renal clearance, with a consequential prolongation of the half-life by up to 24 hours. Antibacterial levels of lomefloxacin are therefore maintained in patients with reduced renal function for up to five days.
  • the (S)-isomer of ofloxacin has been reported to be twice as potent a bactericide as the racemate against a variety of gram- positive and gram-negative pathogens.
  • the racemic mixture of lomefloxacin is presently used primarily as an antibiotic agent for treatment of infection of the upper respiratory and urinary tract.
  • Viral infections of the respiratory tract are acute illnesses with local and systemic manifestations.
  • Coryza (common cold) , pharyngitis, laryngitis (including croup) , and tracheobronchitis are common respiratory syndromes. See, for example, Merck Manual 5th Ed., p.
  • Bacterial infections of the lower urinary tract are very common. The majority of urinary tract infections are caused by gram- negative bacteria. Organisms gaining access to the urethra may colonize on the periurethral glands and produce acute and chronic infection. This condition is termed urethritis. Infections of the prostate gland give rise to the condition prostatitis. Enteric, gram-negative organisms are the most common cause of prostate infection. Merck Manual 5th Ed., p. 1610, Merck, Sharpe & Dohme Research Laboratories (1987) .
  • racemic lomefloxacin has also been used in treating enteritis, sexually transmitted diseases, obstetric and gynecological infections, surgical infections, skin, soft tissue and joint infections, otorhinolaryngologic infections and ophthalmological infections.
  • lomefloxacin and quinoline antibiotics have several advantages, they also have disadvantages, namely, adverse effects.
  • the adverse effects of quinoline antibiotics in general include arthropathy, headache, stomach discomfort, gastrointestinal disorders, hypoglycemia, renal and hepatic dysfunction, allergic reactions and respiratory distress, and central nervous system effects including convulsions, increased intracranial pressure, and toxic psychoses.
  • the adverse effects of lomefloxacin in particular, include but are not limited to headache, stomach discomfort, gastrointestinal disorders, and arthropathy, such as cartilage lesions and erosion and abnormalities in bone growth in immature patients.
  • it would be particularly desirable to find a compound with the advantages of the racemic mixture of lomefloxacin which would not have the aforementioned disadvantages.
  • optically pure (S)-isomer of lomefloxacin is effective in treating infection in a human. Further, it has also been discovered that the optically pure (S)-isomer of lomefloxacin is effective in treating infection in a human while avoiding adverse effects associated with the administration of racemic lomefloxacin, including but not limited to headache, stomach discomfort, gastrointestinal disorders, hypoglycemia, renal and hepatic dysfunction, allergic reactions and respiratory distress, and arthropathy, such as cartilage lesions and erosion and abnormalities in bone growth in immature patients.
  • the present invention also includes methods for treating the above-described conditions in a human while avoiding the adverse effects that are associated with the racemic mixture of lomefloxacin, by administering the optically pure (S)-isomer of lomefloxacin to said human.
  • the present invention is a method of treating infection in a human which comprises administering to the human, an amout of (S)-lomefloxacin, or a pharmaceutically acceptable thereof, substantially free of its (R)-stereoisomer, said amount being sufficient to alleviate infection.
  • the present invention encompasses a method of treating infection in a human while avoiding the concomitant liability of adverse effects associated with the administration of racemic lomefloxacin, which comprises administering to said human, an amount of (S)-lomefloxacin, or a pharmaceutically acceptable salt thereof, substantially free of its (R)- stereoisomer, said amount being sufficient to alleviate infection, but insufficient to cause said adverse effects associated with administration of racemic lomefloxacin.
  • the present invention also encompasses an antibiotic composition for treating infection in a human which comprises, an amount of (S)-lomefloxacin or a pharmaceutically acceptable salt thereof, substantially free of its (R)-stereoisomer, said amount being sufficient to alleviate said infection but insufficient to cause adverse effects associated with lomefloxacin.
  • the available racemic mixture of lomefloxacin i.e.. a 1:1 mixture of the two enantiomers
  • lomefloxacin possesses antibiotic activity, and provides therapy and a reduction of symptoms in a variety of conditions and disorders related to bacterial infection; however, this racemic mixture, while offering the expectation of efficacy, causes adverse effects.
  • Utilizing the substantially optically pure (S)-isomer of lomefloxacin results in clearer dose-related definitions of efficacy, diminished adverse effects, and accordingly, an improved therapeutic index. It is therefore, more desirable to use the (S)-isomer of lomefloxacin.
  • abnormalities includes, but is not limited to headache, stomach discomfort, gastrointestinal disorders, hypoglycemia, renal and hepatic dysfunction, allergic reactions and respiratory distress, and arthropathy, such as cartilage lesions and erosion and abnormalities in bone growth in immature patients.
  • substantially free of its (R)- stereoisomer as used herein means that the composition contains a greater proportion of the (S)- isomer of lomefloxacin in relation to the (R)-isomer of lomefloxacin.
  • the term "substantially free of its (R)-isomer” as used herein means that the composition contains at least 90% by weight of (S)-lomefloxacin, and 10% by weight or less of (R)-lomefloxacin. These percentages are based on the total amount of lomefloxacin present in the composition. In the most preferred embodiment the term "substantially free of the (R)-stereoisomer” means that the composition contains at least 99% by weight (S)-lomefloxacin, and 1% or less of (R)- lomefloxacin.
  • the term "substantially free of its (R)-stereoisomer” as used herein means that the composition contains 100% by weight of (S)-lomefloxacin.
  • the terms “substantially optically pure (S)-isomer of lomefloxacin” and “optically pure (S)-isomer of lomefloxacin” are also encompassed by the above- described amounts.
  • amount sufficient to alleviate infection means an amount which eliminates or inhibits the growth of foreign microorganisms that are harmful to the normal functioning of the host organism, particularly humans.
  • the chemical synthesis of the racemic mixture of lomefloxacin can be performed by the method described in United States Patent No. 4,528,287.
  • X C1 or F
  • the preparation of the type 2. compounds has previously been described in Japanese Patent Publication No. 141286/1978, Japanese Patent Publication No. 47658/1980 and Japanese Patent Publication No. 30964/1981.
  • the (S)-isomer of lomefloxacin may be obtained by resolution of the mixture of enantiomers of lomefloxacin using conventional means such as an optically active resolving acid; see, for example "Stereochemistry of Carbon Compounds," by D.L. Eliel (McGraw Hill 1962) and Lochmuller, C.H. et al. , J. Chromatogr. 113: (3) 283-302 (1975).
  • (S)- Lomefloxacin can be prepared from the racemate through the diastereomeric crystallization scheme shown below:
  • Racemic lomefloxacin is treated with an optically pure base (an a ine is shown above) to give a pair of diastereo eric salts.
  • the difference in solubility between the two diastereomers allows one to be selectively crystallized from the solvent while the other remains in solution. Crystals of the single diastereomer are then separated from the other diastereomer by filtration. Once separated, the diastereomers can be converted back to the original enantiomers by treatment with acid.
  • the magnitude of a prophylactic or therapeutic dose of (S)-lomefloxacin in the acute or chronic management of disease will vary with the severity of the condition to be treated and the route of administration.
  • the dose, and perhaps the dose frequency will also vary according to the age, body weight, and response of the individual patient.
  • the total daily dose ranges, for the conditions described herein is from about 100 mg to about 400 mg. However, the dosage may be as high as about 800 mg.
  • a daily dose range should be between about 100 mg to about 200 mg.
  • the therapy should be initiated at a lower dose, perhaps about 100 mg to about 200 mg and increased up to about 400 mg or higher depending on the patient's global response.
  • method of treating infection includes but is not limited to infections such as urinary tract infection, upper respiratory tract infection, sexually transmitted infection, ophthalmological infection, gastrointestinal infections such as those caused by H. pylori and any other infections which may arise in cells or tissues of a human and which require treatment with antibiotics.
  • any suitable route of administration may be employed for providing the patient with an effective dosage of (S)-lomefloxacin.
  • oral, rectal, parenteral, transdermal, subcutaneous. intramuscular, and the like may be employed as appropriate.
  • Dosage forms include tablets, coated tablets, troches, dispersions, suspensions, solutions, caplets, capsules, patches, and the like.
  • the pharmaceutical compositions of the present invention comprise (S)-lomefloxacin as active ingredient, or a pharmaceutically acceptable salt thereof, and may also contain a pharmaceutically acceptable carrier, and optionally, other therapeutic ingredients.
  • (S)-lomefloxacin hydrochloride is a pharmaceutically acceptable salt of (S)-lomefloxacin.
  • the most preferred pharmaceutically acceptable salt of (S)-lomefloxacin is the monohydrochloride salt.
  • salts refers to salts prepared from pharmaceutically acceptable non-toxic acids or bases including inorganic acids and bases and organic acids and bases. Since the compound of the present invention is both basic and acidic, salts may be prepared from pharmaceutically acceptable non-toxic acids or bases including inorganic and organic acids or inorganic and organic bases. Such salts may contain any of the following anions: acetate, benzensulfonate, benzoate, camphorsulfonate, citrate, fumarate, gluconate, hydrobromide, hydrochloride, lactate, maleate, mandelate, mucate, nitrate, pamoate, phosphate, succinate, sulfate, tartrate and the like.
  • Such salts may also contain the following cations: aluminum, calcium, lithium, magnesium, potassium, sodium, zinc, benzathine, chloroprocaine, choline, diethanolamine, ethylenediamine, meglumine, and procaine.
  • compositions include compositions suitable for oral, rectal and parenteral (including subcutaneous, intramuscular, and intravenous) administration, although the most suitable route in any given case will depend on the nature and severity of the condition being treated.
  • the most preferred route of the present invention is the oral route.
  • the compositions may be conveniently presented in unit dosage form, and prepared by any of the methods well known in the art of pharmacy.
  • a suitable dosage range for use is e.g., from about 100 mg to about 400 mg total daily dose, given as a once daily administration in the morning or in divided doses if required.
  • a dose of 400 mg is given as a once daily administration.
  • a dose range of between about 100 mg to about 200 mg is given as a once daily administration or in divided doses if required.
  • Patients may be upward titrated from below to within this dose range to a satisfactory control of symptoms.
  • (S)-lomefloxacin can be combined as the active ingredient in intimate admixture with a pharmaceutical carrier according to conventional pharmaceutical compounding techniques.
  • the carrier may take a wide variety of forms depending on the form of the preparation desired for administration, e.g., oral or parenteral (including intravenous injections or infusions) .
  • oral or parenteral including intravenous injections or infusions
  • any of the usual pharmaceutical media may be employed.
  • Usual pharmaceutical media includes, for example, water, glycols, oils, alcohols, flavoring agents, preservatives, coloring agents, and the like in the case of oral liquid preparations (such as for example, suspensions, solutions, and elixirs) ; aerosols; or carriers such as starches, sugars, microcrystalline cellulose, diluents, granulating agents, lubricants, binders, disintegrating agents and the like, in the case of oral solid preparations (such as for example, powders, capsules, and tablets) with the oral solid preparations being preferred over the oral liquid preparations.
  • oral liquid preparations such as for example, suspensions, solutions, and elixirs
  • aerosols or carriers such as starches, sugars, microcrystalline cellulose, diluents, granulating agents, lubricants, binders, disintegrating agents and the like
  • oral solid preparations such as for example, powders, capsules, and tablets
  • the most preferred oral solid preparation is tablets.
  • tablets and capsules represent the most advantageous oral dosage unit form, in which case solid pharmaceutical carriers are employed. If desired, tablets may be coated by standard aqueous or nonaqueous techniques.
  • the parenteral dosage form can consist of a sterile solution of the active ingredient, either in its free or salt form, in physiological buffer or sterile water.
  • the compounds of the present invention may also be administered by controlled release means and/or delivery devices such as those described in U.S. Patent Nos. : 3,845,770; 3,916,899; 3,536,809; 3,598,123; 3,630,200; 4,008,719; 4,687,660 and 4,769,207, the disclosures of which are hereby incorporated by reference.
  • compositions of the present invention suitable for oral administration may be presented as discrete units such as capsules, cachets, or tablets, or aerosols sprays, each containing a predetermined amount of the active ingredient, as a powder or granules, or as a solution or a suspension in an aqueous liquid, a non-aqueous liquid, an oil-in- water emulsion, or a water-in oil liquid emulsion.
  • Such compositions may be prepared by any of the methods of pharmacy, but all methods include the step of bringing into association the active ingredient with the carrier which constitutes one or more necessary ingredients.
  • the compositions are prepared by uniformly and intimately admixing the active ingredient with liquid carriers or finely divided solid carriers or both, and then, if necessary, shaping the product into the desired presentation.
  • a tablet may be prepared by compression or molding, optionally, with one or more accessory ingredients.
  • Compressed tablets may be prepared by compressing in a suitable machine the active ingredient in a free-flowing form such as powder or granules, optionally mixed with a binder, lubricant, inert diluent, surface active or dispersing agent.
  • Molded tablets may be made by molding in a suitable machine, a mixture of the powdered compound moistened with an inert liquid diluent.
  • each tablet contains from about 100 mg to about 200 mg of the active ingredient, and each cachet or capsule contains from about 100 mg to about 200 mg of the active ingredient, (S)-lomefloxacin.
  • the tablet, cachet or capsule contains either one of two dosages, about 100 mg or about 200 mg of the active ingredient.
  • the invention is further defined by reference to the following examples describing in detail, the preparation of the compound, and the compositions of the present invention. It will be apparent to those skilled in the art, that many modifications, both to materials, and methods, may be practiced without departing from the purpose and interest of this invention. 4 . EXAMPLES
  • the active ingredient, (S)-lomefloxacin, lactose, and corn starch are blended until uniform.
  • the magnesium stearate is then blended into the resulting powder.
  • the resulting mixture is encapsulated into suitably sized two-piece hard gelatin capsules.
  • the active ingredient is sieved through a suitable sieve and blended with lactose, starch, and pregelatinized maize starch. Suitable volumes of purified water are added and the powders are granulated. After drying, the granules are screened and blended with the magnesium stearate. The granules are then compressed into tablets using punches.
  • Tablets of other strengths may be prepared by altering the ratio of active ingredient to lactose or the compression weight and using punches to suit.
  • Intravenous infusion solutions of (S)- lomefloxacin may also be prepared with Sodium Chloride Injection USP 0.9% or Dextrose Injection USP 5%.
  • Cultures of various gram-negative and gram- positive bacteria, including obligate anaerobes, are grown in various standard media suited to the particular microorganism of interest. [See, for example, Sato, K. et al.. Antimicrob . Agent ⁇ and Chemotherapy, 22(4): 548-553 (1982).] Isolates are grown overnight at 37°C and adjusted to the density of a 0.5 McFarland standard (i.e., about 10 8 cFu/mL) , and then diluted to 10" 2 .
  • a 0.5 McFarland standard i.e., about 10 8 cFu/mL
  • One loopful of cells (5 ⁇ L) of each diluted culture (approximately 1000 cells) is then inoculated onto 10-mL drug-containing agar layers in Petri dishes using a multi-point inoculator. Following inoculation, agar plates are incubated for 18 hours at 37°C in air with the exception of the obligate anaerobes, which are incubated in an atmosphere containing 10% C0 2 .
  • the MIC is defined as the lowest concentration of (S)-lomefloxacin that completely prevents the visible growth of the inoculum on the surface of the (S)-lomefloxacin-containing medium.
  • Testing for quinolone-induced arthropathy can be accomplished by administering the quinolone at a suitable dose, on a once-daily basis, to 3-4 month old, skeletally immature Beagle dogs, for 1, 2, 5, or 7 days.
  • a placebo is given to a second group of Beagle dogs to act as a control.
  • a scoring technique that includes lesion size and histologic features is used to determine the progression of the lesions.
  • Hepatic microsomes are prepared from human liver. Tissue is thawed and then homogenized in 0.15 M KC1 in a Polytron homogenizer. The homogenate is centrifuged and the pellet is resuspended and homogenized in 0.15 M KC1. Aliquots are frozen and stored at -70°C.
  • Human lymphocytes are aseptically isolated from fresh, heparinized human blood. Blood is diluted with Eagle's minimal essential medium and layered on Ficoll-Paque. The samples are centrifuged, and lymphocytes are then removed from the aqueous-Ficoll interface and suspended in medium (15 Mm 4-(2- hydroxyethyl)-1-piperazine ethane sulfonic acid [HEPES], pH 7.4). The cells are then centrifuged, washed once in the HEPES medium, and resuspended. Incubation Conditions and Cvtotoxic Assay
  • Cytotoxicity is assessed by the conversion of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) to a purple formazan.
  • MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide
  • the conversion of MTT to dye is done in multiwell plates. After preparation, hepatic microsomes or lymphocytes are incubated alone or with the test compound in a concentration range from 1 to 400 ⁇ M at 37°C in a humidified incubator. After incubation, the microsomes/cells are washed with 5% albumin in HEPES- buffered medium and resuspended. The microsomes/cells are then incubated at 37°C in a humidified incubator.

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Abstract

Procédés et compositions utilisant l'isomère (S) optiquement pur de loméfloxacine. Ce composé est un médicament puissant destiné à traiter des infections et d'autres maladies nécessitant des antibiotiques, tout en évitant les inconvénients concomitants dus aux effets néfastes qui sont associés au mélange racémique de loméfloxacine.
PCT/US1992/010142 1991-11-27 1992-11-25 Procedes et compositions destines a traiter des infections a l'aide de (s)-lomefloxacine optiquement pure WO1993010785A1 (fr)

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Application Number Priority Date Filing Date Title
EP9292925403A EP0614364A4 (fr) 1991-11-27 1992-11-25 Procedes et compositions destines a traiter des infections a l'aide de (s)-lomefloxacine optiquement pure.
JP5510220A JPH07503457A (ja) 1991-11-27 1992-11-25 光学的に純粋な（ｓ）−ロメフロキサシンを用いた感染症治療の方法と組成物

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US79924391A 1991-11-27 1991-11-27
US799,243 1991-11-27

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Cited By (1)

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WO1996038147A1 (fr) * 1995-05-31 1996-12-05 Sepracor Inc. Procedes et compositions servant au traitement d'infections au moyen de (s)-lomefloxacine optiquement pure

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AU553415B2 (en) * 1983-09-19 1986-07-17 Abbott Japan Co., Ltd. 6-fluoro-1-4-dihydro-4-oxo-7-substituted piperazinyl- quinoline-3-carboxylic acids
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6075024A (en) * 1991-11-27 2000-06-13 Sepracor Inc. Methods for treating infection using optically pure (S)-lomefloxacin
US6337339B2 (en) 1991-11-27 2002-01-08 Sepracor Inc. Methods and compositions for treating infection using optically pure (S)-lomefloxacin
US6534508B2 (en) 1991-11-27 2003-03-18 Sepracor Inc. Methods and compositions for treating infection using optically pure (S)-lomefloxacin
WO1996038147A1 (fr) * 1995-05-31 1996-12-05 Sepracor Inc. Procedes et compositions servant au traitement d'infections au moyen de (s)-lomefloxacine optiquement pure
AU723788B2 (en) * 1995-05-31 2000-09-07 Sepracor, Inc. Methods and compositions for treating infection using optically pure (S)-lomefloxacin

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AU1515197A (en) 1997-05-22
CA2124443A1 (fr) 1993-06-10
JPH07503457A (ja) 1995-04-13
EP0614364A1 (fr) 1994-09-14
AU3147493A (en) 1993-06-28
EP0614364A4 (fr) 1994-10-19

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