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WO1993010742A3 - Chemical compounds, their preparation and use - Google Patents

Chemical compounds, their preparation and use Download PDF

Info

Publication number
WO1993010742A3
WO1993010742A3 PCT/DK1992/000348 DK9200348W WO9310742A3 WO 1993010742 A3 WO1993010742 A3 WO 1993010742A3 DK 9200348 W DK9200348 W DK 9200348W WO 9310742 A3 WO9310742 A3 WO 9310742A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
compounds
chemical compounds
cns
preparing
Prior art date
Application number
PCT/DK1992/000348
Other languages
French (fr)
Other versions
WO1993010742A2 (en
Inventor
John Bondo Hansen
Lone Jeppesen
Frederick Christian Groenvald
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK71092A external-priority patent/DK71092D0/en
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Priority to AU30817/92A priority Critical patent/AU672182B2/en
Priority to EP92924586A priority patent/EP0679085A1/en
Priority to JP5509722A priority patent/JPH07502268A/en
Publication of WO1993010742A2 publication Critical patent/WO1993010742A2/en
Publication of WO1993010742A3 publication Critical patent/WO1993010742A3/en
Priority to NO941965A priority patent/NO300684B1/en
Priority to FI942468A priority patent/FI942468A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

The present invention relates to therapeutically active piperidine derivatives (I), a method of preparing the same and to pharmaceutical compositions comprising the compounds. The compounds are useful in the treatment of indications related to the CNS-system, cardiovascular system or to gastrointestinal disorders, wherein A represents a straight or branched saturated hydrocarbon chain containing from 2 to 6 carbon atoms, R1 is (II).
PCT/DK1992/000348 1991-11-27 1992-11-25 Chemical compounds, their preparation and use WO1993010742A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU30817/92A AU672182B2 (en) 1991-11-27 1992-11-25 Piperidine derivatives and their use in treating psychosis
EP92924586A EP0679085A1 (en) 1991-11-27 1992-11-25 Chemical compounds, their preparation and use
JP5509722A JPH07502268A (en) 1991-11-27 1992-11-25 Chemical compounds, their preparation and use
NO941965A NO300684B1 (en) 1991-11-27 1994-05-26 Piperidine Compounds, Pharmaceutical Preparations Containing Them, and Use of the Compounds for the Preparation of a Medication for the Treatment of Psychosis
FI942468A FI942468A0 (en) 1991-11-27 1994-05-26 Chemical compounds, their preparation and use

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK9100354 1991-11-27
DKPCT/DK91/00354 1991-11-27
DK0710/92 1992-05-27
DK71092A DK71092D0 (en) 1992-05-27 1992-05-27 CHEMICAL COMPOUNDS, THEIR PREPARATION AND USE

Publications (2)

Publication Number Publication Date
WO1993010742A2 WO1993010742A2 (en) 1993-06-10
WO1993010742A3 true WO1993010742A3 (en) 1993-07-22

Family

ID=26064501

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK1992/000348 WO1993010742A2 (en) 1991-11-27 1992-11-25 Chemical compounds, their preparation and use

Country Status (4)

Country Link
JP (1) JPH07502268A (en)
AU (1) AU672182B2 (en)
NZ (1) NZ245260A (en)
WO (1) WO1993010742A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK60593D0 (en) * 1993-05-26 1993-05-26 Novo Nordisk As CHEMICAL COMPOUNDS, THEIR PREPARATION AND USE
US5482950A (en) * 1993-10-15 1996-01-09 Eli Lilly And Company Methods for lowering serum cholesterol
US5476862A (en) * 1993-12-21 1995-12-19 Eli Lilly And Company Methods of increasing thrombomodulin expression
US5461064A (en) * 1993-12-21 1995-10-24 Eli Lilly And Company Methods of inhibiting atrophy of the skin and vagina
US5441966A (en) * 1993-12-21 1995-08-15 Eli Lilly And Company Methods of inhibiting Turner's syndrome
US5708009A (en) * 1993-12-21 1998-01-13 Eli Lilly And Company Methods of inhibiting myeloperoxidase activity
US6562862B1 (en) 1994-10-20 2003-05-13 Eli Lilly And Company Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y
GB9500580D0 (en) * 1995-01-12 1995-03-01 Merck Sharp & Dohme Therapeutic agents
US5998401A (en) * 1995-02-28 1999-12-07 Eli Lilly And Company Naphthyl compounds, intermediates, compositions, and methods
US5510357A (en) * 1995-02-28 1996-04-23 Eli Lilly And Company Benzothiophene compounds as anti-estrogenic agents
US5856340A (en) * 1995-02-28 1999-01-05 Eli Lilly And Company Method of treating estrogen dependent cancers
US5856339A (en) * 1995-02-28 1999-01-05 Eli Lilly And Company Benzothiophene compounds, intermediates, compositions, and methods
US5919800A (en) * 1995-02-28 1999-07-06 Eli Lilly And Company Benzothiophene compounds, intermediates, compositions, and methods
US5998441A (en) * 1995-02-28 1999-12-07 Eli Lilly And Company Benzothiophene compounds, intermediates, compositions, and methods
US5977093A (en) * 1995-02-28 1999-11-02 Eli Lilly And Company Benzothiophene compounds, intermediates, compositions, and methods
FR2821356A1 (en) 2001-02-23 2002-08-30 Cerep NOVEL ARYLCARBAMATE AND ARYLUREES DERIVATIVES, PREPARATIONS AND USES

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0368388A2 (en) * 1988-11-07 1990-05-16 Janssen Pharmaceutica N.V. 3-Piperidinyl-1,2-benzisoxazoles
EP0377528A1 (en) * 1989-01-05 1990-07-11 Lipha, Lyonnaise Industrielle Pharmaceutique Piperidines, process for their preparation and pharmaceutical compounds containing them
EP0402644A1 (en) * 1989-05-19 1990-12-19 Hoechst-Roussel Pharmaceuticals Incorporated N-(aryloxyalkyl)heteroarylpiperidines and -heteroarylpiperazines,a process for their preparation and their use as medicaments
EP0428437A1 (en) * 1989-11-07 1991-05-22 Adir Et Compagnie 1,2-Benzisoxazole derivatives, process for their preparation and pharmaceutical compositions containing them

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0368388A2 (en) * 1988-11-07 1990-05-16 Janssen Pharmaceutica N.V. 3-Piperidinyl-1,2-benzisoxazoles
EP0377528A1 (en) * 1989-01-05 1990-07-11 Lipha, Lyonnaise Industrielle Pharmaceutique Piperidines, process for their preparation and pharmaceutical compounds containing them
EP0402644A1 (en) * 1989-05-19 1990-12-19 Hoechst-Roussel Pharmaceuticals Incorporated N-(aryloxyalkyl)heteroarylpiperidines and -heteroarylpiperazines,a process for their preparation and their use as medicaments
EP0428437A1 (en) * 1989-11-07 1991-05-22 Adir Et Compagnie 1,2-Benzisoxazole derivatives, process for their preparation and pharmaceutical compositions containing them

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. Med. Chem., Volume 29, 1986, JOSEPH P. YEVICH et al., "Synthesis and Biological Evaluation of 1-(1,2-Benzisothiazol-3-yl)- and (1,2-Benzisoxazol-3-yl)piperazine Derivatives as Potential Antipsychotic Agents", see page 359. *

Also Published As

Publication number Publication date
AU3081792A (en) 1993-06-28
AU672182B2 (en) 1996-09-26
NZ245260A (en) 1995-06-27
JPH07502268A (en) 1995-03-09
WO1993010742A2 (en) 1993-06-10

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