WO1993007250A1 - Novel skin and hand cleansing process and compositions - Google Patents
Novel skin and hand cleansing process and compositions Download PDFInfo
- Publication number
- WO1993007250A1 WO1993007250A1 PCT/AU1992/000539 AU9200539W WO9307250A1 WO 1993007250 A1 WO1993007250 A1 WO 1993007250A1 AU 9200539 W AU9200539 W AU 9200539W WO 9307250 A1 WO9307250 A1 WO 9307250A1
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- Prior art keywords
- skin
- water
- composition
- composition according
- alkanol
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 34
- 238000000034 method Methods 0.000 title claims abstract description 17
- 230000008569 process Effects 0.000 title description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 230000002421 anti-septic effect Effects 0.000 claims abstract description 7
- 239000004094 surface-active agent Substances 0.000 claims abstract description 7
- 230000003115 biocidal effect Effects 0.000 claims abstract description 6
- 239000003139 biocide Substances 0.000 claims abstract description 6
- 238000005406 washing Methods 0.000 claims abstract description 6
- 239000012141 concentrate Substances 0.000 claims abstract description 4
- 239000006260 foam Substances 0.000 claims abstract description 4
- 206010013786 Dry skin Diseases 0.000 claims abstract 3
- 230000037336 dry skin Effects 0.000 claims abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Natural products CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 7
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 7
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical group OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 4
- 229960003500 triclosan Drugs 0.000 claims description 4
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical group II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 claims description 3
- 229920000153 Povidone-iodine Polymers 0.000 claims description 3
- 238000004500 asepsis Methods 0.000 claims description 3
- 125000002091 cationic group Chemical group 0.000 claims description 3
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 claims description 3
- 229960003333 chlorhexidine gluconate Drugs 0.000 claims description 3
- ACGUYXCXAPNIKK-UHFFFAOYSA-N hexachlorophene Chemical compound OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(O)C(Cl)=CC(Cl)=C1Cl ACGUYXCXAPNIKK-UHFFFAOYSA-N 0.000 claims description 3
- 229960004068 hexachlorophene Drugs 0.000 claims description 3
- 229960001621 povidone-iodine Drugs 0.000 claims description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 239000003899 bactericide agent Substances 0.000 claims 4
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims 2
- 239000002280 amphoteric surfactant Substances 0.000 claims 2
- 125000000129 anionic group Chemical group 0.000 claims 2
- 210000004247 hand Anatomy 0.000 description 8
- 229920001817 Agar Polymers 0.000 description 4
- 239000008272 agar Substances 0.000 description 4
- 238000005201 scrubbing Methods 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- -1 aromatic alcohols Chemical class 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000003641 microbiacidal effect Effects 0.000 description 3
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 230000001476 alcoholic effect Effects 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 229960000686 benzalkonium chloride Drugs 0.000 description 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 2
- 230000018044 dehydration Effects 0.000 description 2
- 238000006297 dehydration reaction Methods 0.000 description 2
- 229960004592 isopropanol Drugs 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 description 1
- AZLWQVJVINEILY-UHFFFAOYSA-N 2-(2-dodecoxyethoxy)ethanol Chemical compound CCCCCCCCCCCCOCCOCCO AZLWQVJVINEILY-UHFFFAOYSA-N 0.000 description 1
- ZILVNHNSYBNLSZ-UHFFFAOYSA-N 2-(diaminomethylideneamino)guanidine Chemical compound NC(N)=NNC(N)=N ZILVNHNSYBNLSZ-UHFFFAOYSA-N 0.000 description 1
- YUAOWACIUDARDE-UHFFFAOYSA-N 2-(propylamino)tetradecanoic acid Chemical compound CCCCCCCCCCCCC(C(O)=O)NCCC YUAOWACIUDARDE-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- DPKCIHPXDVXZQH-UHFFFAOYSA-N C(C)OS(=O)(=O)OCCCCCCCCCCCC.C(O)CN Chemical class C(C)OS(=O)(=O)OCCCCCCCCCCCC.C(O)CN DPKCIHPXDVXZQH-UHFFFAOYSA-N 0.000 description 1
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- QWZLBLDNRUUYQI-UHFFFAOYSA-M Methylbenzethonium chloride Chemical compound [Cl-].CC1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 QWZLBLDNRUUYQI-UHFFFAOYSA-M 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 125000005037 alkyl phenyl group Chemical group 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
- LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical group OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 description 1
- KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 description 1
- 150000001767 cationic compounds Chemical class 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 239000013020 final formulation Substances 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 210000005224 forefinger Anatomy 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 229940100491 laureth-2 Drugs 0.000 description 1
- 229960002285 methylbenzethonium chloride Drugs 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000008149 soap solution Substances 0.000 description 1
- WQQPDTLGLVLNOH-UHFFFAOYSA-M sodium;4-hydroxy-4-oxo-3-sulfobutanoate Chemical class [Na+].OC(=O)CC(C([O-])=O)S(O)(=O)=O WQQPDTLGLVLNOH-UHFFFAOYSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2006—Monohydric alcohols
- C11D3/201—Monohydric alcohols linear
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
- C11D3/485—Halophors, e.g. iodophors
Definitions
- the present invention relates to a process for antiseptically cleaning the skin and hands and compositions therefor.
- antiseptic skin and hand cleansing is effected by treating the hands with an anti-microbial agent dissolved in an alcohol such as ethyl or isopropylalcohol or a mixture thereof at high concentrations, usually 70% v/v, or by scrubbing the hands or skin for 5 minutes with an antibacterial aqueous soap solution.
- an anti-microbial agent dissolved in an alcohol such as ethyl or isopropylalcohol or a mixture thereof at high concentrations, usually 70% v/v, or by scrubbing the hands or skin for 5 minutes with an antibacterial aqueous soap solution.
- an antiseptic cleansing composition comprising an alkanol and an aqueous concentrate of a surfactant.
- a method for cleansing skin comprising applying the composition of this invention onto the skin in a sufficient amount and for a sufficient period of time in order to achieve asepsis.
- Suitable alkanols are the lower alkanols such as methanol, ethanol, n-propanol or isopropanol. Alkanols might be single or mixtures thereof and should not be less than
- aromatic alcohols such as benzyl alcohol, phenoxyethyl or - propyl alcohol might be added to a maximum of 5 % calculated on the total volume of the final formulation.
- the cationic compound may be a quaternary ammonium compound or a bis or di-bis-biguanidine:
- the composition may also contain a microbiocidal compound which may be any commonly used for disinfection.
- the microbiocide may be a cationic microbiocide, an iodophor, a bacteriostat or a phenol or derivative thereof.
- Suitable quaternary ammonium compounds are benzalkonium chloride, benzethonium chloride, methylbenzethonium chloride, hexadecylpyridinium chloride, alkylisoquinolinium bromide or hexadecyltrimethylammonium bromide. Most preferably the quaternary ammonium compound is benzalkonium chloride.
- a preferred biguanidine is chlorhexidine gluconate.
- a preferred iodophor is povidone iodine.
- a preferred bacteriostat is hexachlorophene or triclosan.
- a preferred phenol is 2-hydroxy diphenyl.
- Surfactants should preferably be mild to the skin such as the sodium sulfosuccinates, monoethanolamine lauryl ethoxy sulfonates or amphoterics such as dodecyl propylamino acetic acid.
- the nonionic surfactant may be the ethoxy-derivative of either a fatty alkanol or alkyl phenyl. The alkanol may be present up to 80 parts by volume.
- the time of application is from a minimum of about 30 to a maximum until most or all of the alkanol has evaporated, but preferably about 90 seconds.
- compositions of this invention may be used to disinfect the skin.
- Advantageously foaming agents can be included in the compositions such as the alkyl mono or diethanolamine of oleyl-, coco-, lauryl- or undecylenic acid or thickening agent such as carbopol or hydroxyethyl cellulose.
- This novel preparation provides a new process of complete hand and skin disinfection by reducing scrubbing time considerably from the standard time of 5 minutes by 2 to 3 minutes without dermatological damage to the skin on repeated applications. This method is particularly applicable to human handwashing.
- Example 1 The hand wash of Example 1 was evenly applied for 60 seconds on dry hands to 5 cover all parts and a little water added with a routine washing movement of the hands. A copious foam developed similar to washing with soaps. After 30 seconds the hands were
- compositions of the present invention will find wide use in medical, veterinary, and food processing industries.
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Environmental Sciences (AREA)
- Plant Pathology (AREA)
- Zoology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Abstract
The present invention provides an antiseptic cleansing composition comprising an alkanol and an aqueous concentrate of a surfactant. The compositions may also comprise a biocide. The present invention further provides a method for cleansing skin comprising applying the composition of this invention onto the skin allowing the alkanol in the composition on the skin to evaporate whereby the skin is substantially dry, applying a small amount of water to the substantially dry skin, washing the skin under foam generation and finally rinsing the skin.
Description
Novel Skin And Hand Cleansing Process And Compositions
Technical Field
The present invention relates to a process for antiseptically cleaning the skin and hands and compositions therefor. Background Art
It has been common practice worldwide that preoperative hand cleansing has been carried out in either of the two following ways.
In one instance antiseptic skin and hand cleansing is effected by treating the hands with an anti-microbial agent dissolved in an alcohol such as ethyl or isopropylalcohol or a mixture thereof at high concentrations, usually 70% v/v, or by scrubbing the hands or skin for 5 minutes with an antibacterial aqueous soap solution.
Although the use of antiseptic alcoholic solutions achieves complete disinfection of the hands and skin, repeated application can cause, due to dehydration, reddening with irritation and in some cases breaking of the skin. In the other instance hand scrubbing procedures with aqueous germicidal soaps over the prescribed 5 minute period can cause considerable, but not complete reduction of the bacterial flora on the skin and although dehydration of the skin is largely reduced in comparison to antiseptic alcoholic preparations, repeated prolonged scrubbing can produce similar deterioration of the skin. Disclosure Of The Invention
According to one broad form of the present invention there is provided an antiseptic cleansing composition comprising an alkanol and an aqueous concentrate of a surfactant.
According to another broad form of this invention there is provided a method for cleansing skin comprising applying the composition of this invention onto the skin in a sufficient amount and for a sufficient period of time in order to achieve asepsis.
Suitable alkanols are the lower alkanols such as methanol, ethanol, n-propanol or isopropanol. Alkanols might be single or mixtures thereof and should not be less than
40% and not more than 80% and generally not more than 60% of the total volume. Further aromatic alcohols such as benzyl alcohol, phenoxyethyl or - propyl alcohol might be added to a maximum of 5 % calculated on the total volume of the final formulation.
The cationic compound may be a quaternary ammonium compound or a bis or di-bis-biguanidine:
The composition may also contain a microbiocidal compound which may be any commonly used for disinfection. For example, the microbiocide may be a cationic microbiocide, an iodophor, a bacteriostat or a phenol or derivative thereof.
Suitable quaternary ammonium compounds are benzalkonium chloride, benzethonium chloride, methylbenzethonium chloride, hexadecylpyridinium chloride,
alkylisoquinolinium bromide or hexadecyltrimethylammonium bromide. Most preferably the quaternary ammonium compound is benzalkonium chloride. A preferred biguanidine is chlorhexidine gluconate. A preferred iodophor is povidone iodine. A preferred bacteriostat is hexachlorophene or triclosan.
A preferred phenol is 2-hydroxy diphenyl.
Surfactants should preferably be mild to the skin such as the sodium sulfosuccinates, monoethanolamine lauryl ethoxy sulfonates or amphoterics such as dodecyl propylamino acetic acid. Where a catiomc biocide is used, the nonionic surfactant may be the ethoxy-derivative of either a fatty alkanol or alkyl phenyl. The alkanol may be present up to 80 parts by volume.
______ I
The time of application is from a minimum of about 30 to a maximum until most or all of the alkanol has evaporated, but preferably about 90 seconds.
Furthermore on application of a small amount of water excellent sudsing cleansing is obtained on normal handwashing movements, for 15 to 30 seconds. The hands are then rinsed under running water and dried.
The compositions of this invention may be used to disinfect the skin. Advantageously foaming agents can be included in the compositions such as the alkyl mono or diethanolamine of oleyl-, coco-, lauryl- or undecylenic acid or thickening agent such as carbopol or hydroxyethyl cellulose.
The benefit of this novel preparation is that it provides a new process of complete hand and skin disinfection by reducing scrubbing time considerably from the standard time of 5 minutes by 2 to 3 minutes without dermatological damage to the skin on repeated applications. This method is particularly applicable to human handwashing.
Best And Other Modes For Carrying Out The Invention The present invention will now be described with reference to the following examples which should not be construed as limiting on the scope thereof.
Example 1 Hand Wash
Ethanol 70.0 ml
Triclosan 1.5 g
Laureth 2 5.0 g
Cocodiethanolamine 4.0 g Hydroxypropylcellulose 1.0 g
Water to final volume 100.0 ml
Example 2 Demonstration Of Effectiveness Of The Present Composition
The hand wash of Example 1 was evenly applied for 60 seconds on dry hands to 5 cover all parts and a little water added with a routine washing movement of the hands. A copious foam developed similar to washing with soaps. After 30 seconds the hands were
/ ^ rinsed well under running tap water and dried with a paper towel.
Two forefingers were then placed for 30 seconds on an unseeded agar plate, then on an agar plate seeded with Escherichia coli and again on unseeded agar. 10 None of the plates after incubation of 48 hours showed any growth. This demonstrated that not only complete disinfection after the novel washing process of one and a half minutes was achieved but also residual antibacterial properties on the skin by inhibiting growth of the seeded agar with E. coli after being in contact with it. Using the same conditions a glove juice test gave a log reduction between 1.5 to 2.0. 15
20
25
30
35
40
During the whole mixing process care has to be taken to ensure that the pH is always below 6.0 and is to be finally adjusted to 4.5 with either citric acid or triethanolamine.
Industrial Applicability It should be clear that the compositions of the present invention will find wide use in medical, veterinary, and food processing industries.
The foregoing describes only some embodiments of the present invention and modifications obvious to those skilled in the art can be made thereto without departing from the scope of the invention.
Claims
1. An antiseptic cleansing composition comprising an alkanol and an aqueous concentrate of a surfactant.
2. The composition of claim 1 further comprising a biocide.
5 3. The composition according to claim 1 or claim 2 where the alkanol is a rκ water-soluble aliphatic alcohol of not less than 40% and not more than 80% of the total volume.
4. The composition according to any one of claims 1 to 3 wherein the alkanol is selected from the group consisting of ethyl and n-propyl alcohol. 10
5. The composition according to any one of claims 1 to 4 wherein the surfactant is selected from the group consisting of an anionic, non-ionic and an amphoteric surfactant.
6. The composition according to any one of claims 1 to 5 wherein the biocide is selected from the group consisting of a water-soluble cationic bacteriocide, an iodophor,
15 or and a water-insoluble bacteriostat.
7. The composition according to claim 6 wherein the water-soluble bacteriocide is chlorhexidine gluconate, the iodophor is povidone iodine, and the water- insoluble bacteriostat is triclosan or hexachlorophene.
8. A method for cleansing skin comprising applying the composition of claim 20 1 onto the skin in a sufficient amount and for a sufficient period of time in order to achieve asepsis.
9. The method of claim 8 wherein the period of time is between 30 and 90 seconds.
10. The method according to claim 8 or claim 9 further comprising allowing 25 the alkanol in the composition on the skin to evaporate whereby the skin is substantially dry, applying a small amount of water to the substantially dry skin, washing the skin under foam generation and finally rinsing the skin.
11. The method of claim 10 wherein the skin is rinsed with water.
AMENDED CLAIMS
[received by the Intemationai Bureau on 18 February 1993 (18.02.93) , original claim 4 amended ; other claims unchanged (1 page)] Claims:
1. An antiseptic cleansing composition comprising an allkanol and an aqueous concentrate of a surfactant.
2. The composition of claim 1 further comprising a biocide. 3. The composition according to claim 1 or claim 2 where the alkanol is a water- soluble aliphatic alcohol of not less than 40% and not more than 80% of the total volume.
4. The composition according to any one off claims 1 to 3 wherein the alkanol is selected from the group consisting of ethanol, n-propanol and isopropanol.
5. The composition according to any one of claims 1 to 4 wherein the surfactant is selected from the group consisting of an anionic, non-ionic and an amphoteric surfactant.
6. The composition according to any one of claims 1 to 5 wherein the biocide is selected from the group consisting of a water-soluble cationic bacteriocide, an iodophor, or and a water-insoluble bacteriostat. 7. The composition according to claim 6 wherein the water-soluble bacteriocide is chlorhexidine gluconate, the iodophor is povidone iodine, and the water-insoluble bacteriostat is triclosan or hexachlorophene.
8. A method for cleansing skin comprising applying the composition of claim 1 onto the skin in a sufficient amount and for a sufficient period of time in order to achieve asepsis.
9. The method of claim 8 wherein the period of time is between 30 and 90 seconds.
10. The method according to claim 8 or claim 9 further comprising allowing the alkanol in the composition on the skin to evaporate whereby the skin is substantially dry, applying a small amount of water to the substantially dry skin, washing the skin under foam generation and finally rinsing the skin.
11. The method of claim 10 wherein the skin is rinsed with water.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPK879891 | 1991-10-09 | ||
| AUPK8798 | 1991-10-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1993007250A1 true WO1993007250A1 (en) | 1993-04-15 |
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ID=3775737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/AU1992/000539 WO1993007250A1 (en) | 1991-10-09 | 1992-10-09 | Novel skin and hand cleansing process and compositions |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO1993007250A1 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP0689767A3 (en) * | 1994-06-27 | 1996-03-27 | Becton Dickinson Co | Skin disinfecting formulations |
| WO1997035475A1 (en) * | 1996-03-27 | 1997-10-02 | Antiseptica Chemisch-Pharmazeutische Produkte Gmbh | Hand disinfectant |
| US5700842A (en) * | 1995-11-01 | 1997-12-23 | Kimberly-Clark Worldwide, Inc. | Methods of incorporating a hydrophobic substance into an aqueous solution |
| WO1998001110A1 (en) * | 1996-07-10 | 1998-01-15 | Calgon Vestal, Inc. | Triclosan skin wash with enhanced efficacy |
| WO1997046218A3 (en) * | 1996-06-04 | 1998-03-12 | Ciba Sc Holding Ag | Concentrated liquid formulations comprising a microbicidally active ingredient |
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| US5888524A (en) * | 1995-11-01 | 1999-03-30 | Kimberly-Clark Worldwide, Inc. | Antimicrobial compositions and wet wipes including the same |
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| WO2001064034A1 (en) * | 1999-05-19 | 2001-09-07 | Stack, Kevin | Antimicrobial sanitizing lotion with skin protection properties |
| US6531434B1 (en) * | 1997-05-20 | 2003-03-11 | Novapharm Research (Australia) Pty. | Alkylpolyglucosides containing disinfectant compositions active against pseudomonas microorganism |
| US6579516B1 (en) | 1995-06-13 | 2003-06-17 | Zahra Mansouri | Methods of delivering materials into the skin, and compositions used therein |
| WO2004101725A1 (en) * | 2003-05-15 | 2004-11-25 | Greenbridge Environmental Control Limited | Anti-viral cleaning composition |
| WO2004101726A3 (en) * | 2003-05-15 | 2005-03-17 | Greenbridge Environmental Cont | Anti-viral and anti-bacterial cleaning composition |
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| AU2005209647B2 (en) * | 1999-12-13 | 2008-10-02 | Ethicon, Inc. | Deep penetrating antimicrobial compositions |
| US7566740B2 (en) * | 1998-10-06 | 2009-07-28 | Bml Pharmaceuticals, Inc. | Method of treating mucositis |
| WO2012119644A1 (en) * | 2011-03-08 | 2012-09-13 | Sca Hygiene Products Ab | Low alcohol antimicrobial cleansing composition |
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| US7566740B2 (en) * | 1998-10-06 | 2009-07-28 | Bml Pharmaceuticals, Inc. | Method of treating mucositis |
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| EP1044686A1 (en) * | 1999-04-12 | 2000-10-18 | Laboratoires Gilbert SA | Alcoholic coloured chlorhexidine solution and its manufacturing process |
| FR2791890A1 (en) * | 1999-04-12 | 2000-10-13 | Gilbert Lab | COLORED ALCOHOLIC CHLORHEXIDINE SOLUTION AND MANUFACTURING METHOD THEREOF |
| WO2001064034A1 (en) * | 1999-05-19 | 2001-09-07 | Stack, Kevin | Antimicrobial sanitizing lotion with skin protection properties |
| AU2005209647B2 (en) * | 1999-12-13 | 2008-10-02 | Ethicon, Inc. | Deep penetrating antimicrobial compositions |
| WO2001041567A1 (en) * | 1999-12-13 | 2001-06-14 | Ethicon, Inc. | Deep penetrating antimicrobial compositions |
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