WO1993005027A1 - Amine tertiaire triazolylee ou un sel de celle-ci - Google Patents

Amine tertiaire triazolylee ou un sel de celle-ci Download PDF

Info

Publication number: WO1993005027A1
Authority: WO; WIPO (PCT)
Prior art keywords: heterocyclic group; triazolylated; salt; tertiary amine; amine compound
Prior art date: 1991-09-02

Application number

PCT/JP1992/001089

Other languages

English (en)

French (fr)

Inventor

Minoru Okada

Eiji Kawaminami

Toru Yoden

Masafumi Kudo

Yasuo Isomura

Original Assignee

Yamanouchi Pharmaceutical Co., Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-02

Filing date

1992-08-27

Publication date

1993-03-18

1992-08-27 Priority to KR1019940700682A priority Critical patent/KR100204697B1/ko

1992-08-27 Priority to EP92918529A priority patent/EP0641785B1/en

1992-08-27 Priority to HU9400611A priority patent/HU220863B1/hu

1992-08-27 Priority to CA002116773A priority patent/CA2116773C/en

1992-08-27 Priority to AU24874/92A priority patent/AU665569B2/en

1992-08-27 Priority to UA94005459A priority patent/UA41295C2/uk

1992-08-27 Priority to DE69230225T priority patent/DE69230225T2/de

1992-08-27 Priority to RO94-00319A priority patent/RO114129B1/ro

1992-08-27 Priority to US08/199,180 priority patent/US5674886A/en

1992-08-27 Application filed by Yamanouchi Pharmaceutical Co., Ltd. filed Critical Yamanouchi Pharmaceutical Co., Ltd.

1993-03-18 Publication of WO1993005027A1 publication Critical patent/WO1993005027A1/ja

1994-02-28 Priority to NO940686A priority patent/NO305284B1/no

1994-02-28 Priority to BG98618A priority patent/BG61688B1/bg

1994-03-02 Priority to FI940988A priority patent/FI940988L/fi

Links

-1 tertiary amine compound Chemical class 0.000 title abstract 5
150000003839 salts Chemical class 0.000 title abstract 2
125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 2
125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000002619 bicyclic group Chemical group 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
102000014654 Aromatase Human genes 0.000 abstract 1
108010078554 Aromatase Proteins 0.000 abstract 1
206010006187 Breast cancer Diseases 0.000 abstract 1
208000026310 Breast neoplasm Diseases 0.000 abstract 1
201000009273 Endometriosis Diseases 0.000 abstract 1
206010051482 Prostatomegaly Diseases 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
208000030270 breast disease Diseases 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Cosmetics (AREA)
Treatments Of Macromolecular Shaped Articles (AREA)
Processes Of Treating Macromolecular Substances (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Medicinal Preparation (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)

PCT/JP1992/001089 1991-09-02 1992-08-27 Amine tertiaire triazolylee ou un sel de celle-ci WO1993005027A1 (fr)

Priority Applications (12)

Application Number	Priority Date	Filing Date	Title
RO94-00319A RO114129B1 (ro)	1991-09-02	1992-08-27	Derivaţi aminici terţiari substituiţi cu triazolil
HU9400611A HU220863B1 (en)	1991-09-02	1992-08-27	Triazolylated tertiary amines, process for producing them and pharmaceutical compositions containing them
CA002116773A CA2116773C (en)	1991-09-02	1992-08-27	Triazolylated tertiary amine compound or salt thereof
AU24874/92A AU665569B2 (en)	1991-09-02	1992-08-27	Triazolylated tertiary amine compound or salt thereof
UA94005459A UA41295C2 (uk)	1991-09-02	1992-08-27	Триазолілзаміщені третинні амінні сполуки або їх солі як інгібітор ароматази та фармацевтична композиція на їх основі
KR1019940700682A KR100204697B1 (ko)	1991-09-02	1992-08-27	트리아졸릴 치환된 3급 아민 화합물 또는 이의 염
EP92918529A EP0641785B1 (en)	1991-09-02	1992-08-27	Triazolylated tertiary amine compound or salt thereof
DE69230225T DE69230225T2 (de)	1991-09-02	1992-08-27	Triazolylierte tertiäre aminverbindungen oder ihre salze
US08/199,180 US5674886A (en)	1991-09-02	1992-08-27	Triazolylated teritiary amine compound or salt thereof
NO940686A NO305284B1 (no)	1991-09-02	1994-02-28	Triazolylerte, tertiµre aminoforbindelser eller salter derav og farmas°ytisk preparat inneholdende disse
BG98618A BG61688B1 (bg)	1991-09-02	1994-02-28	Триазолирани третични амини и техни соли
FI940988A FI940988L (fi)	1991-09-02	1994-03-02	Triatsolyloitu tertiäärinen amiiniyhdiste ja sen suola

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP3/248268		1991-09-02
JP24826891		1991-09-02
JP3/344011		1991-12-02
JP34401191		1991-12-02

Publications (1)

Publication Number	Publication Date
WO1993005027A1 true WO1993005027A1 (fr)	1993-03-18

Family

ID=26538684

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PCT/JP1992/001089 WO1993005027A1 (fr)	1991-09-02	1992-08-27	Amine tertiaire triazolylee ou un sel de celle-ci

Country Status (20)

Country	Link
US (1)	US5674886A (ja)
EP (1)	EP0641785B1 (ja)
KR (1)	KR100204697B1 (ja)
CN (1)	CN1035817C (ja)
AT (1)	ATE186052T1 (ja)
AU (1)	AU665569B2 (ja)
BG (1)	BG61688B1 (ja)
CA (1)	CA2116773C (ja)
DE (1)	DE69230225T2 (ja)
ES (1)	ES2139605T3 (ja)
FI (1)	FI940988L (ja)
HU (1)	HU220863B1 (ja)
MX (1)	MX9204996A (ja)
NO (1)	NO305284B1 (ja)
PT (1)	PT100821B (ja)
RO (1)	RO114129B1 (ja)
RU (1)	RU2124010C1 (ja)
TW (1)	TW225526B (ja)
UA (1)	UA41295C2 (ja)
WO (1)	WO1993005027A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2005514374A (ja) *	2001-11-21	2005-05-19	ステリックスリミテッド	アロマターゼインヒビターとしてのスルファメート基を含む１，２，４−トリアゾール誘導体
WO2011002096A1 (ja) *	2009-07-03	2011-01-06	独立行政法人理化学研究所	Ｐｅｔ用標識化合物

Families Citing this family (15)

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Publication number	Priority date	Publication date	Assignee	Title
US5770616A (en)	1995-06-07	1998-06-23	The Procter & Gamble Company	Pharmaceutical composition for inhibiting the growth of cancers
RU2131422C1 (ru) *	1997-05-21	1999-06-10	Иван Антонович Мазур	Бромид 1-пентил-4-(п-метоксибензилиденамино)-1,2,4-триазолия, проявляющий спазмолитическую активность
US6420400B1 (en)	2000-04-07	2002-07-16	Kinetek Pharmaceuticals, Inc.	Antiproliferative 1,2,3-thiadiazole compounds
US7022702B2 (en) *	2000-04-07	2006-04-04	Qlt Inc.	Antiproliferative 1,2,3-thiadiazole compounds
PL363316A1 (en) *	2000-12-22	2004-11-15	Ortho Mc Neil Pharmaceutical, Inc.	Substituted triazole diamine derivatives as kinase inhibitors
GB0120147D0 (en) *	2001-08-17	2001-10-10	Metris Therapeutics Ltd	Treatment method
MXPA04004802A (es) *	2001-11-21	2004-08-11	Sterix Ltd	Derivados del 1,2,4-triazol que contienen un grupo sulfamato como inhibidores de aromatasa.
EP1431292A1 (en) *	2002-12-16	2004-06-23	Laboratoire Theramex	1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors
JP2004196795A (ja) *	2002-12-16	2004-07-15	Wyeth	外部寄生虫駆除剤としてのｎ−フェニル−３−シクロプロピルピラゾール−４−カルボニトリル
EP1544195A1 (en) *	2003-12-15	2005-06-22	Laboratoire Theramex	1-N-phenyl-amino- 1H-imidazole derivatives and pharmaceutical compositions containing them
NZ548399A (en) *	2003-12-15	2011-01-28	Theramex	1-N-phenyl-amino-1H-imidazole derivatives and pharmaceutical compositions containing them
AU2011226950B9 (en) *	2003-12-15	2013-04-11	Laboratoire Theramex	1-N-phenyl-amino-1H-imidazole derivatives and pharmaceutical compositions containing them
GB0411562D0 (en) *	2004-05-24	2004-06-23	Sterix Ltd	Compound
GB0914767D0 (en)	2009-08-24	2009-09-30	Sterix Ltd	Compound
CN113387894B (zh) *	2021-06-22	2023-02-24	首都医科大学脑重大疾病研究中心(北京脑重大疾病研究院)	1-n-苯乙腈基氨基-三氮唑和嘧啶衍生物及其制备方法和应用

Citations (6)

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Publication number	Priority date	Publication date	Assignee	Title
US4602025A (en) *	1984-06-18	1986-07-22	Eli Lilly And Company	Aromatase inhibitors
US4609666A (en) *	1984-06-18	1986-09-02	Eli Lilly And Company	Aromatase inhibiting derivatives of α,α-bis(4-halophenyl)methyltetrazoles and triazoles
EP0236940A2 (en)	1986-03-07	1987-09-16	Ciba-Geigy Ag	Alpha-heterocycle substituted tolunitriles
JPS63145270A (ja) *	1986-12-03	1988-06-17	サンド・アクチエンゲゼルシャフト	アゾール誘導体
EP0293978A2 (en)	1987-06-01	1988-12-07	Janssen Pharmaceutica N.V.	(1H-azol-1-ylmethyl)substituted benzotriazole derivatives
US5041458A (en)	1987-03-20	1991-08-20	E. I. Du Pont De Nemours And Company	Fungicidal aminotriazoles and aminoimidazoles

Family Cites Families (6)

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Publication number	Priority date	Publication date	Assignee	Title
FR2488891A1 (fr) *	1980-08-22	1982-02-26	Roussel Uclaf	Nouveaux derives du 4h-1,2,4-triazole, leur procede de preparation et leur application comme medicament
DE3410700A1 (de) *	1984-03-23	1985-09-26	Basf Ag, 6700 Ludwigshafen	2,4,5-triphenyl-v-triazole und deren verwendung
US4661508A (en) *	1984-06-18	1987-04-28	Eli Lilly And Company	Aromatase inhibiting α,α-diphenyl-4(5)imidazole-methanes or -ethanes
AU1543488A (en) *	1987-03-20	1988-10-10	E.I. Du Pont De Nemours And Company	Fungicidal aminotriazoles and aminoimidazoles
US4806554A (en) *	1988-01-11	1989-02-21	Hoechst-Roussel Pharmaceuticals, Inc.	Pyrazol and indazolpyridinamines
GR900100380A (el) *	1989-05-20	1991-10-10	Fisons Plc	Μέ?οδος παρασκευής αντι-φλεγμονωδών παραγώγων αμινοφενόλης.

1992
- 1992-08-27 HU HU9400611A patent/HU220863B1/hu not_active IP Right Cessation
- 1992-08-27 ES ES92918529T patent/ES2139605T3/es not_active Expired - Lifetime
- 1992-08-27 RO RO94-00319A patent/RO114129B1/ro unknown
- 1992-08-27 KR KR1019940700682A patent/KR100204697B1/ko not_active Expired - Fee Related
- 1992-08-27 CA CA002116773A patent/CA2116773C/en not_active Expired - Fee Related
- 1992-08-27 EP EP92918529A patent/EP0641785B1/en not_active Expired - Lifetime
- 1992-08-27 DE DE69230225T patent/DE69230225T2/de not_active Expired - Fee Related
- 1992-08-27 UA UA94005459A patent/UA41295C2/uk unknown
- 1992-08-27 AT AT92918529T patent/ATE186052T1/de not_active IP Right Cessation
- 1992-08-27 RU RU94016190/04A patent/RU2124010C1/ru not_active IP Right Cessation
- 1992-08-27 AU AU24874/92A patent/AU665569B2/en not_active Ceased
- 1992-08-27 TW TW081106759A patent/TW225526B/zh active
- 1992-08-27 US US08/199,180 patent/US5674886A/en not_active Expired - Fee Related
- 1992-08-27 WO PCT/JP1992/001089 patent/WO1993005027A1/ja active IP Right Grant
- 1992-08-28 PT PT100821A patent/PT100821B/pt not_active IP Right Cessation
- 1992-08-31 MX MX9204996A patent/MX9204996A/es unknown
- 1992-09-02 CN CN92110016A patent/CN1035817C/zh not_active Expired - Fee Related
1994
- 1994-02-28 NO NO940686A patent/NO305284B1/no unknown
- 1994-02-28 BG BG98618A patent/BG61688B1/bg unknown
- 1994-03-02 FI FI940988A patent/FI940988L/fi unknown

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4602025A (en) *	1984-06-18	1986-07-22	Eli Lilly And Company	Aromatase inhibitors
US4609666A (en) *	1984-06-18	1986-09-02	Eli Lilly And Company	Aromatase inhibiting derivatives of α,α-bis(4-halophenyl)methyltetrazoles and triazoles
EP0236940A2 (en)	1986-03-07	1987-09-16	Ciba-Geigy Ag	Alpha-heterocycle substituted tolunitriles
JPS63145270A (ja) *	1986-12-03	1988-06-17	サンド・アクチエンゲゼルシャフト	アゾール誘導体
US5041458A (en)	1987-03-20	1991-08-20	E. I. Du Pont De Nemours And Company	Fungicidal aminotriazoles and aminoimidazoles
EP0293978A2 (en)	1987-06-01	1988-12-07	Janssen Pharmaceutica N.V.	(1H-azol-1-ylmethyl)substituted benzotriazole derivatives

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Title
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CLINICAL ENDOCRINOLOQY, vol. 32, 1990, pages 623
ENDOCRINOL. JAPAN, vol. 37, no. 5, 1990, pages 719
ENDOCRINOLOQY, vol. 114, no. 2, 1984, pages 486
ENDOCRINOLOQY, vol. 126, no. 6, 1990, pages 3263
J. BIOL. CHEM., vol. 249, 1974, pages 5364
J. STEROID BIOCHEM. MOLEC. BIOL., vol. 37, no. 3, 1990, pages 335
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STEROIDS, vol. 50, 1987, pages 1
THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 244, no. 2, 1988

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2005514374A (ja) *	2001-11-21	2005-05-19	ステリックスリミテッド	アロマターゼインヒビターとしてのスルファメート基を含む１，２，４−トリアゾール誘導体
US7745472B2 (en)	2001-11-21	2010-06-29	Sterix Limited	Compound
JP4771660B2 (ja) *	2001-11-21	2011-09-14	ステリックスリミテッド	アロマターゼインヒビターとしてのスルファメート基を含む１，２，４−トリアゾール誘導体
WO2011002096A1 (ja) *	2009-07-03	2011-01-06	独立行政法人理化学研究所	Ｐｅｔ用標識化合物
JP5777163B2 (ja) *	2009-07-03	2015-09-09	国立研究開発法人理化学研究所	Ｐｅｔ用標識化合物

Also Published As

Publication number	Publication date
US5674886A (en)	1997-10-07
EP0641785A1 (en)	1995-03-08
KR100204697B1 (ko)	1999-06-15
CA2116773C (en)	2002-12-10
UA41295C2 (uk)	2001-09-17
CN1035817C (zh)	1997-09-10
NO940686L (ja)	1994-04-29
ES2139605T3 (es)	2000-02-16
RU2124010C1 (ru)	1998-12-27
BG98618A (bg)	1995-03-31
AU665569B2 (en)	1996-01-11
BG61688B1 (bg)	1998-03-31
HU220863B1 (en)	2002-06-29
DE69230225T2 (de)	2000-05-31
NO940686D0 (no)	1994-02-28
AU2487492A (en)	1993-04-05
PT100821A (pt)	1993-11-30
PT100821B (pt)	1999-07-30
CA2116773A1 (en)	1993-03-18
ATE186052T1 (de)	1999-11-15
FI940988A0 (fi)	1994-03-02
RO114129B1 (ro)	1999-01-29
TW225526B (ja)	1994-06-21
CN1069974A (zh)	1993-03-17
FI940988L (fi)	1994-04-05
DE69230225D1 (de)	1999-12-02
EP0641785B1 (en)	1999-10-27
HUT67249A (en)	1995-03-28
NO305284B1 (no)	1999-05-03
MX9204996A (es)	1993-08-01
EP0641785A4 (en)	1994-06-16
HU9400611D0 (en)	1994-09-28

Legal Events

Date	Code	Title	Description
1993-03-18	AK	Designated states	Kind code of ref document: A1 Designated state(s): AU BB BG BR CA CS FI HU JP KR LK MG MN MW NO PL RO RU SD US
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1993-05-13	DFPE	Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
1993-05-13	EX32	Extension under rule 32 effected after completion of technical preparation for international publication
1993-10-28	EX32	Extension under rule 32 effected after completion of technical preparation for international publication
1993-10-28	LE32	Later election for international application filed prior to expiration of 19th month from priority date or according to rule 32.2 (b)
1993-11-11	LE32	Later election for international application filed prior to expiration of 19th month from priority date or according to rule 32.2 (b)
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Publication	Publication Date	Title
WO1993005027A1 (fr)	1993-03-18	Amine tertiaire triazolylee ou un sel de celle-ci
HU9202931D0 (en)	1992-11-30	Iso- and heterocyclic compounds anellated with imidazole ring as well as method for producing them
HUT64327A (en)	1993-12-28	Process for production azolic compounds and pharmaceutical preparations containing these compounds
FI913640A0 (fi)	1991-07-30	Foerfarande foer framstaellning av nitriler.
RU94016190A (ru)	1995-12-10	Триазолилзамещенные третичные аминные соединения и их соли, способ их получения и содержащие их ингибитор ароматазы и фармацевтический состав
IE40243L (en)	1975-04-05	Imidazolyl derivatives
MY103241A (en)	1993-05-29	Imidazole and 1,2,4 triazole derivatives
EP0247760A3 (en)	1989-05-31	Benzoheterocyclic fungicides
MX9707697A (es)	1997-12-31	Agente antimicotico de triazol.
GB1237509A (en)	1971-06-30	0-trityl-1,2,4-triazoles
JPS643104A (en)	1989-01-06	Substituted nitroalkene
EP0820989A4 (en)	1998-05-06	IMIDAZOLE DERIVATIVES AND MEDICINAL COMPOSITION BASED ON SAID DERIVATIVES
DE3070234D1 (en)	1985-03-28	Process for the preparation of 1h-azole derivatives
GB1519580A (en)	1978-08-02	Aminomethylazole derivatives and their use as fungicides and plant-growth rugalators
AU1446892A (en)	1992-11-02	Novel oxa- or azasteroid derivative
EP0617961A4 (en)	1995-03-29	INHIBITOR OF EOSINOPHILIN INFILTRATION.
WO1997020825A1 (fr)	1997-06-12	Derives de triazine et sels de ces derives
ES2021476B3 (es)	1991-11-01	Azolilmetilciclopropano y su aplicacion como medio protector de plantas
JPS57106666A (en)	1982-07-02	N-substituted imidazoles
DK0699190T3 (da)	1998-11-09	Fremstilling af 3-mercapto-5-amino (1H)-1,2,4-triazol
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