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WO1993003754A1 - Preparation de proteines contenant les acides amines essentiels - Google Patents

Preparation de proteines contenant les acides amines essentiels Download PDF

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Publication number
WO1993003754A1
WO1993003754A1 PCT/DK1992/000249 DK9200249W WO9303754A1 WO 1993003754 A1 WO1993003754 A1 WO 1993003754A1 DK 9200249 W DK9200249 W DK 9200249W WO 9303754 A1 WO9303754 A1 WO 9303754A1
Authority
WO
WIPO (PCT)
Prior art keywords
protein composition
protein
nutrio
miprodan
pro
Prior art date
Application number
PCT/DK1992/000249
Other languages
English (en)
Inventor
Povl Willadsen
Henning Skjoldborg
Original Assignee
Lube A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lube A/S filed Critical Lube A/S
Publication of WO1993003754A1 publication Critical patent/WO1993003754A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/04—Animal proteins
    • A23J3/08—Dairy proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/14—Vegetable proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/168—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants

Definitions

  • the invention relates to a protein composition.
  • Proteins also named albumin
  • proteins have many functions in the human organism and control almost all body pro ⁇ Des. Proteins are sine qua non. They are a major constituent of all cells, organs and organ systems. They start reactions and control them.
  • the so-called enzymes, hormones and proteins constitute the structural basis for all tissue, connective tissue and muscular tissue, transporting essential substances in the body, e.g. oxygen, and creating the so-called antibodies, the pro ⁇ tective substances of the body.
  • the nine vital amino acids must be supplied in a certain amount and at a certain mutual ratio. If one of these sine qua non amino acids is only supplied in e.g. approx. 50% of the necessary quantity the utilization of the other amino acids will likewise be reduced to approx. 50%. The remainder is wasted and must be ex- creted in the kidney and in adverse conditions this may be detrimental to the kidneys. Consequently the correct composition of the supplied protein, a so-called high biological value is of the utmost importance. Cf. the article "Danish scientist finds new formula for the quality of protein" in the journal ⁇ konomaen No. 9-1976 publishing Inge Lise M ⁇ rup's research results concerning the biological value of proteins.
  • a protein deficiency can manifest itself in numer ⁇ ous manners. Some of the major symptoms are lassitude, myomalacia and a low resistance to infections.
  • Fig. 1 proves a higher rate of mortality when a protein deficiency is the issue.
  • Fig. 2 illustrates the relationship between the state of nutrition and sepsis upon surgical operations. An in ⁇ ferior state of nutrition thus results in an increased risk of sepsis.
  • Fig. 3 shows a table of deficiencies in protein and muscular tissue in various kinds and states of ailments.
  • Fig. 4 shows FAO's ideal aminogram and contents of various nutrients. As is illustrated all nutrients suffer from limitations when compared to the ideal that has been set.
  • the object of the present invention has been to provide a protein composition for human and veterinary uses containing the nine sine qua non proteins in a mutual relation as close to the uptimum as possible. This is achieved by a protein preparation according to the invention having the following composition:-
  • Nutrio P-PRO 2000 (brand name) or a similar sub ⁇ stance having a corresponding protein composition, Lacprodan-80 (brand name) or a similar substance having a corresponding protein composition and Miprodan 20-0 (brand name) or a similar substance having a correspond ⁇ ing protein composition
  • Nutrio P-PRO 2000 is pre ⁇ sent in a smaller quantity than each one individually of Lacprodan-80 and Miprodan 20-0, as the latter is present in the same or almost the same quantity preferably at the mutual ratio of 1:2:2:
  • Fig. 8 illustrates the composition of the nine sine qua non proteins for different mixture proportions of Nutrio, Lacprodan-80 and Miprodan 20-0.
  • the highest biological value is estab ⁇ lished at a mutual mixture proportion of 20/40/40.
  • the limiting amino acid is thyroxine.
  • the biological value is as high as 0.81, which in fact is exceptionally high.
  • Fig. 9 the analysis result with its associated amino acid composition of a tablet is stated and Fig. 10 is a table showing the calculated biological value of the nine sine qua non proteins.
  • Surgical patients, prolonged invalids (dialyses patients), cancer patients, old people, people in nurs- ing homes, athletes, emaciation, in other words in gen ⁇ eral people suffering from a protein deficiency can be mentioned as examples of fields of application.
  • a protein deficiency soon oc ⁇ curs, for which reason most people find it necessary to discontinue the diet.
  • This protein deficiency can be compensated for by using the present protein composi ⁇ tion.
  • those applications first mentioned are by far the most important ones.
  • a protein composition treatment before and after a surgical operation can reduce the subsequent complications from approx. 30% to approx. 10%, which obviously is of great importance for the patients, but also affects the economy of the hospi ⁇ tal sector positively.
  • Another aspect of the protein composition is its high content of glutamic acid which highly affects the intestinal function.
  • the tablet thus contains approx. 17.7% glutamic acid, cf. the analysis result.
  • the invention thus provides an exceptionally valu ⁇ able protein composition for human and veterinary uses based on accessible basic ingredients.
  • Methio- Methio- Methio- Tryp- Methio ⁇ nine nine nine tophane nine Trypto- lysine, iso-leucine phane iso-leucine tryptophane
  • NUTRIO P-PRO 2000 is a high functional protein isolate based on peas.
  • the product has a neutral flavour and colour which in combination with its excellent fat binding and good absorption capacities renders its application in a large number of nutrients possible.
  • Organoleptic A white to cream powder having neutral odour and flavour.
  • LACPRODAN-80 ( from Danmark Protein A/S)
  • LACPRODAN-80 is an undenatured whey protein concentrate (WPC) produced from whey by ultraf iltration and spray-drying.
  • MIPRODAN 20-0 Sodium Caseinate Fresh Curd is a spray-dried pure milk protein manufactured from fresh pasteurized skimmed milk by acid precipitation of the casein, neutralization and spray-drying.
  • MIPRODAN 20-0 Fresh Curd Sodium Caseinate is used as a protein source and functional ingredient in a wide range of food products. It has excellent emulsifying and water holding capacities which contribute to the stabilization of many formulations.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Botany (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Une composition de protéines contient les trois substances suivantes: a) Nutrio P-PRO 2000 (nom de marque) ou une substance similaire présentant une composition de protéines correspondante, b) Lacprodan-80 (nom de marque) ou une substance similaire présentant une composition de protéines correspondante et c) Miprodan 20-0 (nom de marque) ou une substance similaire présentant une composition de protéines correspondante. La quantité de Nutrio P-Pro 2000 est inférieure à celle de Lacprodan-80 et de Miprodan 20-0, ces dernières se trouvant en quantité égale ou presque, de préférence dans un mélange de proportions 20:40:40. La composition offre une valeur biologique exceptionnellement élevée et peut être conditionnée sous forme de tablettes par recours aux ingrédients courants pour leur production. La composition présente aussi une forte teneur en acide glutamique, ce qui favorise les fonctions intestinales.
PCT/DK1992/000249 1991-08-22 1992-08-24 Preparation de proteines contenant les acides amines essentiels WO1993003754A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK1495/91 1991-08-22
DK149591A DK149591A (da) 1991-08-22 1991-08-22 Proteinpraeparat

Publications (1)

Publication Number Publication Date
WO1993003754A1 true WO1993003754A1 (fr) 1993-03-04

Family

ID=8105436

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK1992/000249 WO1993003754A1 (fr) 1991-08-22 1992-08-24 Preparation de proteines contenant les acides amines essentiels

Country Status (3)

Country Link
AU (1) AU2492492A (fr)
DK (1) DK149591A (fr)
WO (1) WO1993003754A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8815797B2 (en) 2008-03-12 2014-08-26 N.V. Nutricia High protein liquid enteral nutritional composition
US8999423B2 (en) 2007-12-05 2015-04-07 N. V. Nutricia High energy liquid enteral nutritional composition

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2066644A (en) * 1979-12-21 1981-07-15 Rhone Poulenc Ind Food products based on protein fibres, and process and equipment for their manufacture
EP0374390A1 (fr) * 1988-12-23 1990-06-27 Immunotech Research Corporation Ltd. Composition de protéines de petit lait, procédé de production et application de la composition de protéines de petit-lait

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2066644A (en) * 1979-12-21 1981-07-15 Rhone Poulenc Ind Food products based on protein fibres, and process and equipment for their manufacture
EP0374390A1 (fr) * 1988-12-23 1990-06-27 Immunotech Research Corporation Ltd. Composition de protéines de petit lait, procédé de production et application de la composition de protéines de petit-lait

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DIALOG INFORMATION SERVICES, File 351, WPIL Dialog Accession No. 009089297, ASAFOV V.A. et al.: "Mfr. of Dried Protein Material for Use in Dairy Foodstuffs, etc. - by Condensing Whey or Permeate, Adding Protein Material and Dispersing"; & WO,A,92 09207, 11-06-92, 9226. *
DIALOG INFORMATION SERVICES, File 51, FSTA, Dialog Accession No. 00394145, MADSEN J: "Rea Protein in Low Fat Spread"; & RESEARCH DISCLOSURE, 1989, No. 299, p. 179-180. *
PATENT ABSTRACTS OF JAPAN, Vol. 8, No. 15, C-206; & JP,A,58 180 429, 21-10-1983. *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8999423B2 (en) 2007-12-05 2015-04-07 N. V. Nutricia High energy liquid enteral nutritional composition
US9345256B2 (en) 2007-12-05 2016-05-24 N.V. Nutricia High energy liquid enteral nutritional composition
US8815797B2 (en) 2008-03-12 2014-08-26 N.V. Nutricia High protein liquid enteral nutritional composition
US9420816B2 (en) 2008-03-12 2016-08-23 N.V. Nutricia High protein liquid enteral nutritional composition

Also Published As

Publication number Publication date
DK149591A (da) 1993-03-19
AU2492492A (en) 1993-03-16
DK149591D0 (da) 1991-08-22

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