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WO1993000313A3 - Sigma receptor ligands and the use thereof - Google Patents

Sigma receptor ligands and the use thereof Download PDF

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Publication number
WO1993000313A3
WO1993000313A3 PCT/US1992/005330 US9205330W WO9300313A3 WO 1993000313 A3 WO1993000313 A3 WO 1993000313A3 US 9205330 W US9205330 W US 9205330W WO 9300313 A3 WO9300313 A3 WO 9300313A3
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WO
WIPO (PCT)
Prior art keywords
sigma receptor
receptor ligands
treatment
certain
sigma
Prior art date
Application number
PCT/US1992/005330
Other languages
French (fr)
Other versions
WO1993000313A2 (en
Inventor
Richard A Glennon
Original Assignee
Univ Virginia Commonwealth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from US07/894,771 external-priority patent/US6057371A/en
Application filed by Univ Virginia Commonwealth filed Critical Univ Virginia Commonwealth
Priority to AU22945/92A priority Critical patent/AU676993B2/en
Priority to JP5501248A priority patent/JPH06509069A/en
Priority to EP92914789A priority patent/EP0591426A4/en
Publication of WO1993000313A2 publication Critical patent/WO1993000313A2/en
Publication of WO1993000313A3 publication Critical patent/WO1993000313A3/en

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    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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Abstract

The invention relates to methods for the treatment of central nervous system disorders, gastrointestinal disorders, drug abuse, angina, migraine, hypertension and depression by administering a pharmaceutical composition comprising an effective amount of certain sigma receptor ligands to a patient in need of such treatment. The invention further relates to novel sigma receptor ligands having high binding to the sigma receptor and pharmaceutical compositions thereof. Unexpectedly, certain of the sigma receptor ligands of the present invention have selectivity for the sigma receptor over the DA, PCP and 5-HT1A receptors.
PCT/US1992/005330 1991-06-27 1992-06-26 Sigma receptor ligands and the use thereof WO1993000313A2 (en)

Priority Applications (3)

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AU22945/92A AU676993B2 (en) 1991-06-27 1992-06-26 Sigma receptor ligands and the use thereof
JP5501248A JPH06509069A (en) 1991-06-27 1992-06-26 Sigma receptor ligands and their uses
EP92914789A EP0591426A4 (en) 1991-06-27 1992-06-26 Sigma receptor ligands and the use thereof

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US72017391A 1991-06-27 1991-06-27
US720,173 1991-06-27
US07/894,771 US6057371A (en) 1989-12-28 1992-06-10 Sigma receptor ligands and the use thereof
US894,771 1992-06-10

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WO1993000313A2 WO1993000313A2 (en) 1993-01-07
WO1993000313A3 true WO1993000313A3 (en) 1993-03-04

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JP (1) JPH06509069A (en)
AU (1) AU676993B2 (en)
CA (1) CA2111957A1 (en)
IE (1) IE922112A1 (en)
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AU2294592A (en) 1993-01-25
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IE922112A1 (en) 1992-12-30
WO1993000313A2 (en) 1993-01-07
PT100639A (en) 1993-09-30
JPH06509069A (en) 1994-10-13

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