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WO1992019211A3 - Imidazobenzoquinones et composition contenant ces dernieres permettant de prevenir ou de traiter l'hypertension ou l'insuffisance cardiaque - Google Patents

Imidazobenzoquinones et composition contenant ces dernieres permettant de prevenir ou de traiter l'hypertension ou l'insuffisance cardiaque Download PDF

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Publication number
WO1992019211A3
WO1992019211A3 PCT/US1992/003440 US9203440W WO9219211A3 WO 1992019211 A3 WO1992019211 A3 WO 1992019211A3 US 9203440 W US9203440 W US 9203440W WO 9219211 A3 WO9219211 A3 WO 9219211A3
Authority
WO
WIPO (PCT)
Prior art keywords
heart failure
congestive heart
preventing
treating hypertension
imidazobenzoquinones
Prior art date
Application number
PCT/US1992/003440
Other languages
English (en)
Other versions
WO1992019211A2 (fr
Inventor
Keiko Koh
Noriie Itoh
Kazunori Ozawa
Hiroshi Kushida
William W Mcwhorter Jr
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP3346283A priority Critical patent/JPH05112533A/ja
Application filed by Upjohn Co filed Critical Upjohn Co
Priority to JP4510074A priority patent/JPH06507620A/ja
Priority to EP92910914A priority patent/EP0586466A1/fr
Priority to US08/122,445 priority patent/US5506361A/en
Priority to AU17848/92A priority patent/AU650342B2/en
Publication of WO1992019211A2 publication Critical patent/WO1992019211A2/fr
Publication of WO1992019211A3 publication Critical patent/WO1992019211A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Composés actifs au niveau pharmacologique qui sont très efficaces pour traiter l'hypertension ou l'insuffisance cardiaque, qui sont bien absorbées dans le corps et qui ont un effet durable. Cette invention concerne donc un composé représenté par la formule (I) ou un ester pharmacologiquement acceptable ou un de ses sels, et une composition pharmacologique permettant de prévenir ou de traiter l'hypertension ou l'insuffisance cardiaque, qui contient ledit composé en tant qu'ingrédient actif.
PCT/US1992/003440 1991-05-08 1992-04-30 Imidazobenzoquinones et composition contenant ces dernieres permettant de prevenir ou de traiter l'hypertension ou l'insuffisance cardiaque WO1992019211A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP3346283A JPH05112533A (ja) 1991-05-08 1991-12-27 イミダゾベンゾキノン類およびこれを有効成分とする高血圧・鬱血性心不全の予防・治療剤
JP4510074A JPH06507620A (ja) 1991-05-08 1992-04-30 イミダゾベンゾキノン類およびこれを有効成分とする高血圧・鬱血性心不全の予防・治療剤
EP92910914A EP0586466A1 (fr) 1991-05-08 1992-04-30 Imidazobenzoquinones et composition contenant ces dernieres permettant de prevenir ou de traiter l'hypertension ou l'insuffisance cardiaque
US08/122,445 US5506361A (en) 1991-05-08 1992-04-30 Imidazobenzoquinones and composition for preventing or treating hypertension or congestive heart failure containing the same
AU17848/92A AU650342B2 (en) 1991-05-08 1992-04-30 Imidazobenzoquinones and composition for preventing or treating hypertension or congestive heart failure containing the same

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP10263991 1991-05-08
JP3/102639 1991-05-08
JP14005791 1991-06-12
JP3/140057 1991-06-12
JP3/205879 1991-08-16
JP20587991 1991-08-16
JP3346283A JPH05112533A (ja) 1991-05-08 1991-12-27 イミダゾベンゾキノン類およびこれを有効成分とする高血圧・鬱血性心不全の予防・治療剤
JP3/346283 1991-12-27

Publications (2)

Publication Number Publication Date
WO1992019211A2 WO1992019211A2 (fr) 1992-11-12
WO1992019211A3 true WO1992019211A3 (fr) 1993-01-21

Family

ID=27469029

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/003440 WO1992019211A2 (fr) 1991-05-08 1992-04-30 Imidazobenzoquinones et composition contenant ces dernieres permettant de prevenir ou de traiter l'hypertension ou l'insuffisance cardiaque

Country Status (6)

Country Link
EP (1) EP0586466A1 (fr)
JP (2) JPH05112533A (fr)
AU (1) AU650342B2 (fr)
CA (1) CA2106968A1 (fr)
MX (1) MX9202132A (fr)
WO (1) WO1992019211A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7368469B2 (en) 1999-08-30 2008-05-06 Sanofi-Aventis Deutschland Gmbh Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0132001B1 (ko) * 1994-05-21 1998-04-17 강박광 신규한 치환된 이미다졸 유도체
FR2742155B1 (fr) * 1995-12-12 1998-02-13 Innothera Lab Sa Utilisation de derives heteroaromatiques et tricycliques du 1,4-dihydro-1,4-dioxonaphtalene, nouveaux composes obtenus et leur application en therapeutique
FR2742154B1 (fr) * 1995-12-12 1998-02-13 Innothera Lab Sa Utilisation de derives de tetracycles mono ou dicetoniques, nouveaux composes obtenus et leur application en therapeutique
FR2742153B1 (fr) * 1995-12-12 1998-02-13 Innothera Lab Sa Utilisation de derives tricycliques du 1,4-dihydro-1,4- dioxo-1h-naphtalene, nouveaux composes obtenus et leur application en therapeutique
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
CA2426674A1 (fr) * 2000-10-25 2002-05-02 Takeda Chemical Industries, Ltd. Agents pour prevenir ou traiter l'hypertension portale
WO2008096820A1 (fr) * 2007-02-07 2008-08-14 Kyowa Hakko Kirin Co., Ltd. Dérivé diphényle
DK2170930T3 (da) 2007-06-04 2012-11-05 Synergy Pharmaceuticals Inc Agonister af guanylatcyclase, anvendelige til behandlingen af gastrointestinale sygdomme, inflammation, cancer og andre sygdomme
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2522968T3 (es) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
EP3241839B1 (fr) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonistes de guanylate cyclase utiles pour le traitement de troubles gastro-intestinaux, inflammatoires, cancéreux et autres
ES2449396T3 (es) * 2008-07-22 2014-03-19 Trustees Of Dartmouth College Cianoenonas monocíclicas y métodos de uso de las mismas
CA2797719C (fr) 2010-04-30 2019-11-26 Dana-Farber Cancer Institute, Inc. Inhibiteurs de petites molecules de l'activite de l'enzyme de deubiquination usp1
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
CA2905438A1 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase et leurs utilisations
KR102272746B1 (ko) 2013-06-05 2021-07-08 보슈 헬스 아일랜드 리미티드 구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법
US9725425B1 (en) 2014-02-25 2017-08-08 Dana-Farber Cancer Institute, Inc. Compounds and methods for treating cancer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0209707A2 (fr) * 1985-06-21 1987-01-28 Dr. Karl Thomae GmbH Aryl-2-imidazoles, compositions pharmaceutiques contenant ces composés et procédé pour leur préparation
EP0400835A1 (fr) * 1989-05-15 1990-12-05 Merck & Co. Inc. Benzimidazoles substitués comme antagoniste d'angiotensine II
EP0400974A2 (fr) * 1989-05-30 1990-12-05 Merck & Co. Inc. Antagonistes d'angiotensine II du type imidazo condensé à un hétérocycle à 6 chaînons substitués
EP0426021A1 (fr) * 1989-10-31 1991-05-08 Fujisawa Pharmaceutical Co., Ltd. Dérivés condensés d'imidazole et procédés de leur préparation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0209707A2 (fr) * 1985-06-21 1987-01-28 Dr. Karl Thomae GmbH Aryl-2-imidazoles, compositions pharmaceutiques contenant ces composés et procédé pour leur préparation
EP0400835A1 (fr) * 1989-05-15 1990-12-05 Merck & Co. Inc. Benzimidazoles substitués comme antagoniste d'angiotensine II
EP0400974A2 (fr) * 1989-05-30 1990-12-05 Merck & Co. Inc. Antagonistes d'angiotensine II du type imidazo condensé à un hétérocycle à 6 chaînons substitués
EP0426021A1 (fr) * 1989-10-31 1991-05-08 Fujisawa Pharmaceutical Co., Ltd. Dérivés condensés d'imidazole et procédés de leur préparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7368469B2 (en) 1999-08-30 2008-05-06 Sanofi-Aventis Deutschland Gmbh Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events

Also Published As

Publication number Publication date
WO1992019211A2 (fr) 1992-11-12
EP0586466A1 (fr) 1994-03-16
JPH06507620A (ja) 1994-09-01
MX9202132A (es) 1993-04-01
AU1784892A (en) 1992-12-21
CA2106968A1 (fr) 1992-11-09
AU650342B2 (en) 1994-06-16
JPH05112533A (ja) 1993-05-07

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