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WO1992017151A3 - Procede d'administration de medicaments par l'intermediaire de la modification des jonctions occlusives eptheliales par le facteur de necrose tumorale - Google Patents

Procede d'administration de medicaments par l'intermediaire de la modification des jonctions occlusives eptheliales par le facteur de necrose tumorale Download PDF

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Publication number
WO1992017151A3
WO1992017151A3 PCT/US1992/002312 US9202312W WO9217151A3 WO 1992017151 A3 WO1992017151 A3 WO 1992017151A3 US 9202312 W US9202312 W US 9202312W WO 9217151 A3 WO9217151 A3 WO 9217151A3
Authority
WO
WIPO (PCT)
Prior art keywords
necrosis factor
tumor necrosis
administering
pharmacologically
homeostatic
Prior art date
Application number
PCT/US1992/002312
Other languages
English (en)
Other versions
WO1992017151A2 (fr
Inventor
James M Mullin
Original Assignee
Lankenau Medical Research Cent
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lankenau Medical Research Cent filed Critical Lankenau Medical Research Cent
Publication of WO1992017151A2 publication Critical patent/WO1992017151A2/fr
Publication of WO1992017151A3 publication Critical patent/WO1992017151A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Procédé et système d'administration trans-épithéliale de substances pharmacologiquement actives à travers les barrières épithéliales mammifères. Ils comportent l'administration séquentielle à des cellules épithéliales prédéterminées comprises dans la barrière de cellules épithéliales mammifères, portant des récepteurs du facteur de nécrose tumorale et présentant entre elles une résistance homéostatique de jonction occlusive, d'une quantité suffisante d'une substance biologiquement active apte à entrer en réaction avec lesdits récepteurs du facteur de nécrose tumorale, pour réduire ladite résistance homéostatique de jonction occlusive et pour permettre ainsi le passage trans-épithélial desdites substances pharmacologiquement actives à travers lesdites barrières; puis l'administration exogène d'une substance pharmacologiquement active dans un vecteur pharmaceutiquement acceptable à une barrière épithéliale mammifère prédéterminée avant que ladite résistance de jonction occlusive ne retourne audit état homéostatique.
PCT/US1992/002312 1991-03-27 1992-03-20 Procede d'administration de medicaments par l'intermediaire de la modification des jonctions occlusives eptheliales par le facteur de necrose tumorale WO1992017151A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67575491A 1991-03-27 1991-03-27
US675,754 1991-03-27

Publications (2)

Publication Number Publication Date
WO1992017151A2 WO1992017151A2 (fr) 1992-10-15
WO1992017151A3 true WO1992017151A3 (fr) 1992-11-12

Family

ID=24711843

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/002312 WO1992017151A2 (fr) 1991-03-27 1992-03-20 Procede d'administration de medicaments par l'intermediaire de la modification des jonctions occlusives eptheliales par le facteur de necrose tumorale

Country Status (2)

Country Link
AU (1) AU1768692A (fr)
WO (1) WO1992017151A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4417865A1 (de) * 1994-05-20 1995-11-23 Behringwerke Ag Kombination von Tumornekrose-induzierenden Substanzen mit Substanzen, die durch Nekrosen aktiviert werden, zur selektiven Tumortherapie

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989004663A1 (fr) * 1987-11-18 1989-06-01 State Of Oregon Acting By And Through The State Bo Procede d'administration de matiere genetique a travers la barriere sanguine du cerveau

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989004663A1 (fr) * 1987-11-18 1989-06-01 State Of Oregon Acting By And Through The State Bo Procede d'administration de matiere genetique a travers la barriere sanguine du cerveau

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Cancer Research, vol. 50, no. 7, 1 April 1990, J.M. MULLIN et al.: "Effect of tumor necrosis factor on epithelial tight junctions and transepithelial permeability", pages 2172-2176, see the whole document *
FEBS Letters, vol. 221, no. 2, 14 September 1987, J.M. MULLIN et al.: "The phorbol ester, TPA, increases transepithelial epidermal growth factor flux", pages 359-364, see the whole document *
J. Cell. Biology, vol. 115 (3 part 2), 1991, A.D. MARMORSTEIN et al.: "Tumor necrosis factor but not interleukin-1 increases the permaebility of a renal epithelium (MDCK)", page 480A, see the whole document *
The Journal of Cell Biology, vol. 109, no. 4, October 1989, J.M. MULLIN et al.: "Tumor necrosis factor causes leakiness in epithelial tight junctions", see the whole document *

Also Published As

Publication number Publication date
AU1768692A (en) 1992-11-02
WO1992017151A2 (fr) 1992-10-15

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