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WO1992015562A3 - Preparation d'alcanamide omega-substitue - Google Patents

Preparation d'alcanamide omega-substitue Download PDF

Info

Publication number
WO1992015562A3
WO1992015562A3 PCT/US1992/001507 US9201507W WO9215562A3 WO 1992015562 A3 WO1992015562 A3 WO 1992015562A3 US 9201507 W US9201507 W US 9201507W WO 9215562 A3 WO9215562 A3 WO 9215562A3
Authority
WO
WIPO (PCT)
Prior art keywords
omega
preparation
produce
alkanamide
substituted
Prior art date
Application number
PCT/US1992/001507
Other languages
English (en)
Other versions
WO1992015562A2 (fr
Inventor
Paul Richard Buckland
Original Assignee
Eastman Kodak Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eastman Kodak Co filed Critical Eastman Kodak Co
Publication of WO1992015562A2 publication Critical patent/WO1992015562A2/fr
Publication of WO1992015562A3 publication Critical patent/WO1992015562A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention se rapporte à un procédé de préparation d'oméga-arylthioalcanamides, en particulier d'oméga-imidazolylthioalcanamides, s'utilisant, par exemple, dans la préparation de certains agents de lutte contre l'hypercholestérolémie. Le procédé comprend trois étapes y compris une réaction d'addition entre une lactone et une amine, afin d'obtenir un oméga-hydroxyalcanamide; une réaction de condensation entre ledit oméga-hydroxyalcanamide et un halogénure d'acide ou un anhydride alcanesulfonique, afin d'obtenir un ester d'alcanesulfonate; la réaction dudit ester d'alcanesulfonate avec un sel de mercaptan aromatique, particulièrement un imidazole-2-thiol, afin d'obtenir les oméga-imidazolylthioalcanamides.
PCT/US1992/001507 1991-03-04 1992-03-03 Preparation d'alcanamide omega-substitue WO1992015562A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US663,525 1991-03-04
US07/663,525 US5212318A (en) 1991-03-04 1991-03-04 Preparation of omega-substituted alkanamide

Publications (2)

Publication Number Publication Date
WO1992015562A2 WO1992015562A2 (fr) 1992-09-17
WO1992015562A3 true WO1992015562A3 (fr) 1992-10-29

Family

ID=24662207

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/001507 WO1992015562A2 (fr) 1991-03-04 1992-03-03 Preparation d'alcanamide omega-substitue

Country Status (2)

Country Link
US (1) US5212318A (fr)
WO (1) WO1992015562A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8067402B2 (en) * 2005-12-12 2011-11-29 Allaccem, Inc. Methods and systems for coating an oral surface
US8222239B2 (en) * 2007-02-21 2012-07-17 Allaccem, Inc. Bridged polycyclic compound based compositions for the inhibition and amelioration of disease
US8188068B2 (en) * 2007-08-10 2012-05-29 Allaccem, Inc. Bridged polycyclic compound based compositions for coating oral surfaces in pets
US8153618B2 (en) * 2007-08-10 2012-04-10 Allaccem, Inc. Bridged polycyclic compound based compositions for topical applications for pets
US8153617B2 (en) * 2007-08-10 2012-04-10 Allaccem, Inc. Bridged polycyclic compound based compositions for coating oral surfaces in humans
US20090074833A1 (en) * 2007-08-17 2009-03-19 Whiteford Jeffery A Bridged polycyclic compound based compositions for controlling bone resorption

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0372445A1 (fr) * 1988-12-05 1990-06-13 The Du Pont Merck Pharmaceutical Company Imidazoles pour le traitement de l'athérosclérose
WO1991009030A1 (fr) * 1989-12-12 1991-06-27 Rhone-Poulenc Sante 4,5-diphenyle-imidazoles substituees en position 2
WO1991010662A1 (fr) * 1990-01-12 1991-07-25 Rhone-Poulenc Rorer S.A. 4,5-diphenyl-imidazoles substitues en position 2
WO1991013876A1 (fr) * 1990-03-16 1991-09-19 Rhone-Poulenc Rorer Limited Imidazoles
WO1991018885A1 (fr) * 1990-06-04 1991-12-12 The Du Pont Merck Pharmaceutical Company Imidazoles utilises dans le traitement de l'atherosclerose

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3271451A (en) * 1962-07-03 1966-09-06 Merck & Co Inc Process for preparing 5-(3-methylaminopropyl)-5h-dibenzo [a, d] cycloheptenes
US3536721A (en) * 1963-09-13 1970-10-27 Stauffer Chemical Co Substituted-sulfonyl glycolamide compositions
US3715363A (en) * 1971-07-20 1973-02-06 Zoecon Corp Certain 2-aliphatic-thiobenzothiazoles

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0372445A1 (fr) * 1988-12-05 1990-06-13 The Du Pont Merck Pharmaceutical Company Imidazoles pour le traitement de l'athérosclérose
WO1991009030A1 (fr) * 1989-12-12 1991-06-27 Rhone-Poulenc Sante 4,5-diphenyle-imidazoles substituees en position 2
WO1991010662A1 (fr) * 1990-01-12 1991-07-25 Rhone-Poulenc Rorer S.A. 4,5-diphenyl-imidazoles substitues en position 2
WO1991013876A1 (fr) * 1990-03-16 1991-09-19 Rhone-Poulenc Rorer Limited Imidazoles
WO1991018885A1 (fr) * 1990-06-04 1991-12-12 The Du Pont Merck Pharmaceutical Company Imidazoles utilises dans le traitement de l'atherosclerose

Also Published As

Publication number Publication date
WO1992015562A2 (fr) 1992-09-17
US5212318A (en) 1993-05-18

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