WO1992013491A1 - Materiel chirurgical ameliore avec enrobage en argent bacteriostatique et procede d'utilisation de ce materiel - Google Patents
Materiel chirurgical ameliore avec enrobage en argent bacteriostatique et procede d'utilisation de ce materiel Download PDFInfo
- Publication number
- WO1992013491A1 WO1992013491A1 PCT/US1992/000209 US9200209W WO9213491A1 WO 1992013491 A1 WO1992013491 A1 WO 1992013491A1 US 9200209 W US9200209 W US 9200209W WO 9213491 A1 WO9213491 A1 WO 9213491A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hardware
- silver
- surgical
- silver coating
- wound
- Prior art date
Links
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 title claims abstract description 33
- 229910052709 silver Inorganic materials 0.000 title claims abstract description 33
- 239000004332 silver Substances 0.000 title claims abstract description 33
- 239000011248 coating agent Substances 0.000 title claims abstract description 25
- 238000000576 coating method Methods 0.000 title claims abstract description 25
- 238000000034 method Methods 0.000 title claims abstract description 15
- 230000003385 bacteriostatic effect Effects 0.000 title claims abstract description 13
- 206010052428 Wound Diseases 0.000 claims abstract description 21
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 21
- 229910052751 metal Inorganic materials 0.000 claims abstract description 16
- 239000002184 metal Substances 0.000 claims abstract description 16
- 208000015181 infectious disease Diseases 0.000 claims abstract description 8
- 206010048038 Wound infection Diseases 0.000 claims abstract description 5
- 208000002847 Surgical Wound Diseases 0.000 claims abstract description 3
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 7
- 239000010936 titanium Substances 0.000 claims description 7
- 229910052719 titanium Inorganic materials 0.000 claims description 7
- 229910001220 stainless steel Inorganic materials 0.000 claims description 6
- 239000010935 stainless steel Substances 0.000 claims description 6
- 238000007747 plating Methods 0.000 claims description 5
- 150000003378 silver Chemical class 0.000 claims 3
- 229920001817 Agar Polymers 0.000 description 3
- 239000008272 agar Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 150000002739 metals Chemical class 0.000 description 3
- 241000589516 Pseudomonas Species 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 2
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 241000588722 Escherichia Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000023753 dehiscence Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000004070 electrodeposition Methods 0.000 description 1
- 210000003195 fascia Anatomy 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910001961 silver nitrate Inorganic materials 0.000 description 1
- BSWGGJHLVUUXTL-UHFFFAOYSA-N silver zinc Chemical compound [Zn].[Ag] BSWGGJHLVUUXTL-UHFFFAOYSA-N 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 108010050327 trypticase-soy broth Proteins 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/064—Surgical staples, i.e. penetrating the tissue
Definitions
- This invention relates to surgical hardware of the type used to close wounds, and to an improved method of closing wounds using such hardware.
- Various items of metal hardware have been developed to assist in closing wounds. At one time such hardware was made from solid silver. However, because of silver's high ductility and relatively low strength, silver hardware had to be made very coarse to have adequate mechanical properties. For many applications solid silver hardware was objectionably coarse. High strength metals such as stainless steel and titanium, permit more slender, clinically desirable hardware designs, and have for decades been the state of the art materials for surgical hardware.
- Wound infection is always a serious concern because of its system-wide effect and retardation of normal wound healing, but when surgical hardware is required and used there are additional potential complications from wound infection including dehiscence or splitting of the wound, leakage from the wound, and formation of adhesions. While conventional steel and titanium hardware can be sterilized, it does not appear to have significant bacteriostatic effect, and may actually promote infection compared with other materials. Nevertheless, because these high strength metals permit the manufacture of such small, high strength hardware, these metals are still widely used.
- the present invention provides an improved item of surgical hardware that provides the strength and compact size of a high strength metal such as stainless steel or titanium, and bacteriostatic properties to reduce the risk of wound infection.
- This hardware allows wounds to be neatly and effectively closed, and provides some bacteriostatic action that reduces the risk of many of the complications encountered in the use of surgical hardware.
- the invention relates to a staple, wire suture, clip, or other item of surgical hardware used in closing wounds.
- the surgical hardware constructed according to the principles of the present invention comprises an item of surgical hardware that is made from a high strength metal, for example stainless steel or titanium, and which has a silver coating.
- the silver coating may be either silver plating, or a coating of silver salt.
- the method of closing wounds comprises closing the wounds with surgical hardware made from a high strength metal and which has a silver coating.
- the hardware of the present invention provides all of the advantages of being constructed from a high strength metal, including high strength and compact size, and the additional benefit of bacteriostatic action which helps to reduce the risk of complications resulting from the use of the hardware.
- the compact design permitted by the present invention ensures that the hardware has sufficient strength to hold the wound closed, and a sufficiently compact size that it does not unduly disturb the wound site or interfere with healing.
- the cost of manufacturing hardware according to the principles of the present invention is only marginally higher than the cost of manufacturing conventional hardware.
- the method of this invention provides a way to close wounds with reduced risk of infection and complications.
- FIGURE 1 is a perspective view of an internal (soft tissue) staple constructed according to the principles of this invention
- FIGURE 2 is a perspective view of a skin staple constructed according to the principles of this invention
- FIGURE 3 is a perspective view of a fascia staple constructed according to the principles of this invention
- FIGURE 4 is a. perspective view of a vascular staple constructed according to the principles of this invention
- FIGURE 5 is a perspective view of a vascular clip constructed according to the principles of this invention
- FIGURE 6 is a perspective view of a wire suture constructed according to the principles of this invention.
- FIGURE 7 is a cross-sectional view of the wire suture, taken along the plane of line 7-7 in Figure 6.
- Surgical staples constructed according to the principles of the present invention are indicated generally as 20, 22, 24, and 26 in Figures 1 - 4.
- a surgical clip constructed according to the principles of the present invention is indicated generally as 28 in Figure 5.
- a wire suture constructed according to the principles of the present invention is indicated generally as 30 in Figure 6.
- the staples 20 - 26, the clip 28, and the suture 30 are made from a high strength surgical metal such as a stainless steel or titanium.
- the staples 20 - 26, the clip 28, and the wire suture 30 have a silver coating. This is best shown in Figure 7 where the suture is shown as comprising high strength surgical metal 32 with a silver coating 34.
- the silver coating provides a bacteriostatic action that inhibits infection. Thus infection is less likely to propagate when the surgical hardware of the present invention is used, and thus there is a reduced risk from infection-related complications from the use of such hardware.
- the silver coating may be silver plating applied by a hot dip or electro-deposition process, or some other method.
- the coating may be a silver salt applied to the exterior of the item of hardware, for example silver nitrate, or silver-zinc allantoinate.
- the method of the present invention relates to an improved method of closing surgical wounds with reduced risk of infection.
- the method comprises the step of closing the wound with a staple, wire suture, clip or other item of surgical hardware made from a high strength metal that has a silver coating.
- the bacteriostatic effect of the hardware of this invention was tested by introducing a silver coated staple according to the principles of this invention, a stainless steel staple, and titanium staple into two difference agar media: Trypticase Soy Sheep Agar and Mueller Hinton Agar.
- Each of the staples was screened against staph aureus, Escherichia coli, Pseudomonas aeriginosa, and strep faecales.
- the plates were inoculated with a standard turbidity of a 0.5 McFarland standard.
- the staples were placed on top of the agar and the plates were incubated at 35°C for 24 hours.
- only the silver coated staple of the present invention showed any bacteriostatic action showing a zone of inhibition around the staple.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
Abstract
L'invention se rapporte à une agrafe, un fil de suture, une attache ou autre article de matériel chirurgical, qui peut être utilisé pour fermer une plaie et qui est fabriqué à partir d'un métal très résistant de façon à présenter un profil extra-plat pour réduire au minimum les gênes occasionnées à la plaie, et qui possède un enrobage en argent bactériostatique destiné à réduire les risques d'infection de la plaie par le matériel. L'invention décrit également un procédé qui permet de fermer des plaies chirurgicales en réduisant les risques d'infection et qui consiste à fermer la plaie au moyen d'une agrafe, d'un fil de suture, d'une attache ou d'un autre article de matériel chirurgical fabriqué à partir d'un métal très résistant recouvert d'un enrobage d'argent.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65335391A | 1991-02-06 | 1991-02-06 | |
| US653,353 | 1991-02-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1992013491A1 true WO1992013491A1 (fr) | 1992-08-20 |
Family
ID=24620504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1992/000209 WO1992013491A1 (fr) | 1991-02-06 | 1992-01-08 | Materiel chirurgical ameliore avec enrobage en argent bacteriostatique et procede d'utilisation de ce materiel |
Country Status (2)
| Country | Link |
|---|---|
| EP (1) | EP0570452A1 (fr) |
| WO (1) | WO1992013491A1 (fr) |
Cited By (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001080920A2 (fr) | 2000-04-17 | 2001-11-01 | Nucryst Pharmaceuticals Corp. | Matieres antimicrobiennes bioabsorbables |
| KR20020057446A (ko) * | 2001-01-04 | 2002-07-11 | 안정오 | 금이나 은 함유 수술실 |
| EP1449816A1 (fr) | 2003-02-20 | 2004-08-25 | Gemtron Corporation | Verre antimicrobien et produits vitreux et procédé de leur préparation |
| US6861570B1 (en) | 1997-09-22 | 2005-03-01 | A. Bart Flick | Multilayer conductive appliance having wound healing and analgesic properties |
| US6939568B2 (en) | 2001-04-23 | 2005-09-06 | Nucryst Pharmaceuticals Corp. | Treatment of inflammatory skin conditions |
| US6989157B2 (en) | 2000-07-27 | 2006-01-24 | Nucryst Pharmaceuticals Corp. | Dry powders of metal-containing compounds |
| US7001617B2 (en) | 2001-04-23 | 2006-02-21 | Nueryst Pharmaceuticals Corp. | Method of induction of apoptosis and inhibition of matrix metalloproteinases using antimicrobial metals |
| US7005556B1 (en) | 1995-09-05 | 2006-02-28 | Argentum Medical | Multilayer wound dressing |
| WO2006021155A1 (fr) * | 2004-08-25 | 2006-03-02 | Xiaoyan Ren | Fil recouvert de nanoparticules d’argent |
| US7008647B2 (en) | 2001-04-23 | 2006-03-07 | Nucryst Pharmaceuticals Corp. | Treatment of acne |
| US7078060B2 (en) | 2000-07-27 | 2006-07-18 | Nucryst Pharmaceuticals Corp. | Solutions and aerosols of metal-containing compounds |
| US7137968B1 (en) | 2000-03-13 | 2006-11-21 | Nucryst Pharmaceuticals Corp. | Transcutaneous medical device dressings and method of use |
| US7201925B2 (en) | 2002-04-23 | 2007-04-10 | Nueryst Pharmaceuticals Corp. | Treatment of ungual and subungual diseases |
| US7214847B1 (en) | 1997-09-22 | 2007-05-08 | Argentum Medical, L.L.C. | Multilayer conductive appliance having wound healing and analgesic properties |
| US7230153B2 (en) | 1997-09-22 | 2007-06-12 | Argentum International, Llc | Multilayer conductive appliance having wound healing and analgesic properties |
| US7255881B2 (en) | 2000-07-27 | 2007-08-14 | Nucryst Pharmaceuticals Corp. | Metal-containing materials |
| US7385101B2 (en) | 2001-12-20 | 2008-06-10 | Noble Fiber Technologies, Llc | Antibiotic textile materials suitable for wound dressings and wound dressings incorporating the same |
| US7427416B2 (en) | 2000-07-27 | 2008-09-23 | Nucryst Pharmaceuticals Corp. | Methods of treating conditions using metal-containing materials |
| US7470437B2 (en) | 2000-07-27 | 2008-12-30 | Nucryst Pharmaceuticals Corp. | Methods of treating conditions with a metal-containing material |
| US8097017B2 (en) | 2004-10-18 | 2012-01-17 | Tyco Healthcare Group Lp | Surgical fasteners coated with wound treatment materials |
| US20130302427A1 (en) * | 2012-05-11 | 2013-11-14 | Dentsply International Inc. | Medical device having a surface comprising nanoparticles |
| US8636191B2 (en) | 2003-05-09 | 2014-01-28 | Covidien Lp | Anastomotic staple with capillary which expels a bonding agent upon deformation |
| RU2517121C2 (ru) * | 2012-08-21 | 2014-05-27 | Государственное научное учреждение Институт экспериментальной ветеринарии Сибири и Дальнего Востока Российской академии сельскохозяйственных наук (ГНУ ИЭВСиДВ Россельхозакадемии) | Способ повышения качества хирургической нити |
| RU2770277C1 (ru) * | 2021-08-23 | 2022-04-15 | Федеральное государственное бюджетное учреждение науки Южный научный центр Российской академии наук (ЮНЦ РАН) | Способ повышения количества и антибактериальной активности наночастиц серебра на шовном материале из шелка |
| WO2023009082A1 (fr) * | 2021-07-30 | 2023-02-02 | Dogan Oezcan | Agrafes cutanées chirurgicales avec revêtement d'ions argent |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1981002668A1 (fr) * | 1980-03-27 | 1981-10-01 | Nat Res Dev | Implants orthopediques |
| EP0046715A2 (fr) * | 1980-08-25 | 1982-03-03 | United States Surgical Corporation | Agrafes chirurgicales |
| CH654738A5 (en) * | 1985-02-26 | 1986-03-14 | Ines Blaettler | Surgical implants and repair plates |
| EP0206024A2 (fr) * | 1985-06-07 | 1986-12-30 | Becton, Dickinson and Company | Surfaces antimicrobiennes et inhibition de la croissance des micro-organismes sur ces surfaces |
| EP0255248A2 (fr) * | 1986-07-24 | 1988-02-03 | Minnesota Mining And Manufacturing Company | Pansement microbicide pour blessure |
| EP0328421A2 (fr) * | 1988-02-11 | 1989-08-16 | The Trustees Of Columbia University In The City Of New York | Compositions résistant aux infections, dispositifs et surfaces médicaux et méthode pour leur préparation et leur utilisation |
| EP0406014A1 (fr) * | 1989-06-30 | 1991-01-02 | Ethicon, Inc. | Agrafe chirurgicale pour améliorer la qualité de son image |
-
1992
- 1992-01-08 WO PCT/US1992/000209 patent/WO1992013491A1/fr not_active Application Discontinuation
- 1992-01-08 EP EP19920904466 patent/EP0570452A1/fr not_active Withdrawn
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1981002668A1 (fr) * | 1980-03-27 | 1981-10-01 | Nat Res Dev | Implants orthopediques |
| EP0046715A2 (fr) * | 1980-08-25 | 1982-03-03 | United States Surgical Corporation | Agrafes chirurgicales |
| CH654738A5 (en) * | 1985-02-26 | 1986-03-14 | Ines Blaettler | Surgical implants and repair plates |
| EP0206024A2 (fr) * | 1985-06-07 | 1986-12-30 | Becton, Dickinson and Company | Surfaces antimicrobiennes et inhibition de la croissance des micro-organismes sur ces surfaces |
| EP0255248A2 (fr) * | 1986-07-24 | 1988-02-03 | Minnesota Mining And Manufacturing Company | Pansement microbicide pour blessure |
| EP0328421A2 (fr) * | 1988-02-11 | 1989-08-16 | The Trustees Of Columbia University In The City Of New York | Compositions résistant aux infections, dispositifs et surfaces médicaux et méthode pour leur préparation et leur utilisation |
| EP0406014A1 (fr) * | 1989-06-30 | 1991-01-02 | Ethicon, Inc. | Agrafe chirurgicale pour améliorer la qualité de son image |
Cited By (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7005556B1 (en) | 1995-09-05 | 2006-02-28 | Argentum Medical | Multilayer wound dressing |
| US6861570B1 (en) | 1997-09-22 | 2005-03-01 | A. Bart Flick | Multilayer conductive appliance having wound healing and analgesic properties |
| US7291762B2 (en) | 1997-09-22 | 2007-11-06 | Argentum International, Llc | Multilayer conductive appliance having wound healing and analgesic properties |
| US7230153B2 (en) | 1997-09-22 | 2007-06-12 | Argentum International, Llc | Multilayer conductive appliance having wound healing and analgesic properties |
| US7214847B1 (en) | 1997-09-22 | 2007-05-08 | Argentum Medical, L.L.C. | Multilayer conductive appliance having wound healing and analgesic properties |
| US7137968B1 (en) | 2000-03-13 | 2006-11-21 | Nucryst Pharmaceuticals Corp. | Transcutaneous medical device dressings and method of use |
| WO2001080920A2 (fr) | 2000-04-17 | 2001-11-01 | Nucryst Pharmaceuticals Corp. | Matieres antimicrobiennes bioabsorbables |
| US7470437B2 (en) | 2000-07-27 | 2008-12-30 | Nucryst Pharmaceuticals Corp. | Methods of treating conditions with a metal-containing material |
| US7427416B2 (en) | 2000-07-27 | 2008-09-23 | Nucryst Pharmaceuticals Corp. | Methods of treating conditions using metal-containing materials |
| US7255881B2 (en) | 2000-07-27 | 2007-08-14 | Nucryst Pharmaceuticals Corp. | Metal-containing materials |
| US6989157B2 (en) | 2000-07-27 | 2006-01-24 | Nucryst Pharmaceuticals Corp. | Dry powders of metal-containing compounds |
| US7078060B2 (en) | 2000-07-27 | 2006-07-18 | Nucryst Pharmaceuticals Corp. | Solutions and aerosols of metal-containing compounds |
| KR20020057446A (ko) * | 2001-01-04 | 2002-07-11 | 안정오 | 금이나 은 함유 수술실 |
| US7001617B2 (en) | 2001-04-23 | 2006-02-21 | Nueryst Pharmaceuticals Corp. | Method of induction of apoptosis and inhibition of matrix metalloproteinases using antimicrobial metals |
| US7008647B2 (en) | 2001-04-23 | 2006-03-07 | Nucryst Pharmaceuticals Corp. | Treatment of acne |
| US7087249B2 (en) | 2001-04-23 | 2006-08-08 | Nucryst Pharmaceuticals Corp. | Treatment of mucosal membranes |
| US6989156B2 (en) | 2001-04-23 | 2006-01-24 | Nucryst Pharmaceuticals Corp. | Therapeutic treatments using the direct application of antimicrobial metal compositions |
| US6939568B2 (en) | 2001-04-23 | 2005-09-06 | Nucryst Pharmaceuticals Corp. | Treatment of inflammatory skin conditions |
| US7385101B2 (en) | 2001-12-20 | 2008-06-10 | Noble Fiber Technologies, Llc | Antibiotic textile materials suitable for wound dressings and wound dressings incorporating the same |
| US7201925B2 (en) | 2002-04-23 | 2007-04-10 | Nueryst Pharmaceuticals Corp. | Treatment of ungual and subungual diseases |
| EP1449816A1 (fr) | 2003-02-20 | 2004-08-25 | Gemtron Corporation | Verre antimicrobien et produits vitreux et procédé de leur préparation |
| US6921546B2 (en) | 2003-02-20 | 2005-07-26 | Gemtron Corporation | Antimicrobial glass and glass-like products and method of preparing same |
| US9301762B2 (en) | 2003-05-09 | 2016-04-05 | Covidien Lp | Anastomotic staple with capillary which expels a bonding agent upon deformation |
| US8636191B2 (en) | 2003-05-09 | 2014-01-28 | Covidien Lp | Anastomotic staple with capillary which expels a bonding agent upon deformation |
| US10092289B2 (en) | 2003-05-09 | 2018-10-09 | Covidien Lp | Anastomotic staple with capillary which expels a bonding agent upon deformation |
| US10736627B2 (en) | 2003-05-09 | 2020-08-11 | Covidien Lp | Anastomotic staple with capillary which expels a bonding agent upon deformation |
| WO2006021155A1 (fr) * | 2004-08-25 | 2006-03-02 | Xiaoyan Ren | Fil recouvert de nanoparticules d’argent |
| US8097017B2 (en) | 2004-10-18 | 2012-01-17 | Tyco Healthcare Group Lp | Surgical fasteners coated with wound treatment materials |
| US8435263B2 (en) | 2004-10-18 | 2013-05-07 | Covidien Lp | Surgical fasteners coated with wound treatment materials |
| US8758404B2 (en) | 2004-10-18 | 2014-06-24 | Covidien Lp | Surgical fasteners coated with wound treatment materials |
| US20130302427A1 (en) * | 2012-05-11 | 2013-11-14 | Dentsply International Inc. | Medical device having a surface comprising nanoparticles |
| US9889237B2 (en) * | 2012-05-11 | 2018-02-13 | Dentsply Sirona Inc. | Medical device having a surface comprising nanoparticles |
| RU2517121C2 (ru) * | 2012-08-21 | 2014-05-27 | Государственное научное учреждение Институт экспериментальной ветеринарии Сибири и Дальнего Востока Российской академии сельскохозяйственных наук (ГНУ ИЭВСиДВ Россельхозакадемии) | Способ повышения качества хирургической нити |
| WO2023009082A1 (fr) * | 2021-07-30 | 2023-02-02 | Dogan Oezcan | Agrafes cutanées chirurgicales avec revêtement d'ions argent |
| RU2770277C1 (ru) * | 2021-08-23 | 2022-04-15 | Федеральное государственное бюджетное учреждение науки Южный научный центр Российской академии наук (ЮНЦ РАН) | Способ повышения количества и антибактериальной активности наночастиц серебра на шовном материале из шелка |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0570452A1 (fr) | 1993-11-24 |
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