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WO1992011370A3 - Von proteinen des hepatitis c-virus abgeleitete polypeptide und deren verwendung - Google Patents

Von proteinen des hepatitis c-virus abgeleitete polypeptide und deren verwendung Download PDF

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Publication number
WO1992011370A3
WO1992011370A3 PCT/DE1991/001020 DE9101020W WO9211370A3 WO 1992011370 A3 WO1992011370 A3 WO 1992011370A3 DE 9101020 W DE9101020 W DE 9101020W WO 9211370 A3 WO9211370 A3 WO 9211370A3
Authority
WO
WIPO (PCT)
Prior art keywords
hepatitis
virus
polypeptides
proteins
polypeptides derived
Prior art date
Application number
PCT/DE1991/001020
Other languages
English (en)
French (fr)
Other versions
WO1992011370A2 (de
Inventor
Klaus Fuchs
Manfred Motz
Michael Roggendorf
Erwin Soutschek
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6421107&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1992011370(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Priority to US08/078,271 priority Critical patent/US6136527A/en
Priority to EP92902118A priority patent/EP0564532B1/de
Priority to DE59109261T priority patent/DE59109261D1/de
Priority to AT92902118T priority patent/ATE270333T1/de
Priority to JP4502438A priority patent/JP2598596B2/ja
Publication of WO1992011370A2 publication Critical patent/WO1992011370A2/de
Publication of WO1992011370A3 publication Critical patent/WO1992011370A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Die Klonierung und Sequenzierung von verschiedenen Polypeptiden aus dem Genom eines Hepatitis-C-Virus wird offenbart. Die Polypeptide werden als Nicht-Fusionsproteine in guter Ausbeute hergestellt. Das von dem Strukturprotein (Core) abstammende Polypeptide ist unter physiologischen Bedingungen löslich. Da die Polypeptide keine Fremdproteinanteile aufweisen, werden sie bevorzugt bei Testkits und als Impfstoff eingesetzt.
PCT/DE1991/001020 1990-12-21 1991-12-20 Von proteinen des hepatitis c-virus abgeleitete polypeptide und deren verwendung WO1992011370A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US08/078,271 US6136527A (en) 1990-12-21 1991-12-20 Polypeptides derived from proteins of the hepatitis C virus, test kits containing these polypeptides and vaccines against infections of hepatitis C viruses
EP92902118A EP0564532B1 (de) 1990-12-21 1991-12-20 Von proteinen des hepatitis c-virus abgeleitete polypeptide und deren verwendung
DE59109261T DE59109261D1 (de) 1990-12-21 1991-12-20 Von proteinen des hepatitis c-virus abgeleitete polypeptide und deren verwendung
AT92902118T ATE270333T1 (de) 1990-12-21 1991-12-20 Von proteinen des hepatitis c-virus abgeleitete polypeptide und deren verwendung
JP4502438A JP2598596B2 (ja) 1990-12-21 1991-12-20 Ｃ型肝炎ウイルスの蛋白質に由来するポリペプチド、該ポリペプチドを含有するテストキットおよびｃ型肝炎ウイルス感染予防ワクチン

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4041304A DE4041304A1 (de) 1990-12-21 1990-12-21 Von strukturproteinen des hepatitis c-virus abgeleitete polypeptide, testkits, die diese polypeptide enthalten und impfstoffe gegen infektionen von hepatitis c-viren
DEP4041304.7 1990-12-21

Publications (2)

Publication Number Publication Date
WO1992011370A2 WO1992011370A2 (de) 1992-07-09
WO1992011370A3 true WO1992011370A3 (de) 1992-10-29

Family

ID=6421107

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1991/001020 WO1992011370A2 (de) 1990-12-21 1991-12-20 Von proteinen des hepatitis c-virus abgeleitete polypeptide und deren verwendung

Country Status (7)

Country Link
US (1) US6136527A (de)
EP (1) EP0564532B1 (de)
JP (2) JP2598596B2 (de)
AT (1) ATE270333T1 (de)
DE (2) DE4041304A1 (de)
ES (1) ES2222453T3 (de)
WO (1) WO1992011370A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1249684B (it) * 1991-07-19 1995-03-09 Sorin Biomedica Spa Epitopi della proteina env del virus dell'epatite c.
US6153378A (en) * 1992-10-16 2000-11-28 Bionova Corporation Diagnosis of, and vaccination against, a positive stranded RNA virus using an isolated, unprocessed polypeptide encoded by a substantially complete genome of such virus
JP2778886B2 (ja) * 1992-10-16 1998-07-23 エバーニュー バイオテック インコーポレイティド Ｃ型肝炎ウィルスのコア抗原タンパク質及びそれを用いての診断方法及びキット
US5514539A (en) * 1993-06-29 1996-05-07 The United States Of America As Represented By The Department Of Health And Human Services Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
DE4428705A1 (de) 1994-08-12 1996-02-15 Boehringer Mannheim Gmbh Rekombinantes Antigen aus der NS3-Region des Hepatitis C Virus
GB9513261D0 (en) * 1995-06-29 1995-09-06 Smithkline Beecham Biolog Vaccines
AU2003295427A1 (en) * 2002-11-08 2004-06-03 The Administrators Of The Tulane Educational Fund Flaviviris fusion inhibitors
WO2008046923A2 (en) * 2006-10-20 2008-04-24 Innogenetics N.V. Methodology for analysis of sequence variations within the hcv ns3/4a genomic region

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0388232A1 (de) * 1989-03-17 1990-09-19 Chiron Corporation NANBV-Diagnostika und Vakzine
EP0450931A1 (de) * 1990-04-04 1991-10-09 Chiron Corporation Kombinationen Hepatitis-C-Virus(HCV)-Antigene zur Anwendung in Immunoassays für Anti-HCV-Antikörper
EP0464287A1 (de) * 1990-06-25 1992-01-08 The Research Foundation for Microbial Diseases of Osaka University Non-A, Non-B Hepatitis Virus genomisches DNS und Antigenpolypeptide
EP0468657A2 (de) * 1990-07-09 1992-01-29 Tonen Corporation Non-A, non-B Hepatitis-spezifisches Antigen und seine Verwendung zur Hepatitis-Diagnose

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5350671A (en) * 1987-11-18 1994-09-27 Chiron Corporation HCV immunoassays employing C domain antigens

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0388232A1 (de) * 1989-03-17 1990-09-19 Chiron Corporation NANBV-Diagnostika und Vakzine
EP0450931A1 (de) * 1990-04-04 1991-10-09 Chiron Corporation Kombinationen Hepatitis-C-Virus(HCV)-Antigene zur Anwendung in Immunoassays für Anti-HCV-Antikörper
EP0464287A1 (de) * 1990-06-25 1992-01-08 The Research Foundation for Microbial Diseases of Osaka University Non-A, Non-B Hepatitis Virus genomisches DNS und Antigenpolypeptide
EP0468657A2 (de) * 1990-07-09 1992-01-29 Tonen Corporation Non-A, non-B Hepatitis-spezifisches Antigen und seine Verwendung zur Hepatitis-Diagnose

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Japanese Journal of Experimental Medicine, Band 60, Nr. 4, 1990 (Tokyo, JP) H. Okamoto et al.: "Enzyme-linked immunosorbent assay for antibodies against the capsid protein of hepatitis C virus with a synthetic oligopeptide", Seiten 223-233, siehe Seiten 223-233 *
Nucleic Acids Research, Band 18, Nr. 15, August 1990, Oxford University Press (Oxford, GB) K. Takeuchi et al.: "Nucleotide sequence of core and envelope genes of the hepatitis C virus genome derived directly from human healthy carriers", Seite 4626 *
Peptide Chemistry 1990, Proceedings of the 28th Symposium on Peptide Chemistry, Osaka, 25-27 Oktober 1990, E. Munekata et al.: "Epitope-mapping of hepatitis C virus constituting protein", Seiten 211-214, siehe Seiten 211-214 *

Also Published As

Publication number Publication date
ATE270333T1 (de) 2004-07-15
US6136527A (en) 2000-10-24
ES2222453T3 (es) 2005-02-01
EP0564532B1 (de) 2004-06-30
JP2598596B2 (ja) 1997-04-09
EP0564532A1 (de) 1993-10-13
DE4041304A1 (de) 1992-06-25
DE59109261D1 (de) 2004-08-05
JPH06502542A (ja) 1994-03-24
WO1992011370A2 (de) 1992-07-09
JPH08275781A (ja) 1996-10-22

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