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WO1992011367A3 - Recepteurs lipidiques de micro-organismes et adhesines correspondantes, sequences d'adn codant des adhesines et utilisation desdites adhesines - Google Patents

Recepteurs lipidiques de micro-organismes et adhesines correspondantes, sequences d'adn codant des adhesines et utilisation desdites adhesines Download PDF

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Publication number
WO1992011367A3
WO1992011367A3 PCT/US1991/009810 US9109810W WO9211367A3 WO 1992011367 A3 WO1992011367 A3 WO 1992011367A3 US 9109810 W US9109810 W US 9109810W WO 9211367 A3 WO9211367 A3 WO 9211367A3
Authority
WO
WIPO (PCT)
Prior art keywords
adhesins
microorganisms
dna sequences
sequences encoding
receptors
Prior art date
Application number
PCT/US1991/009810
Other languages
English (en)
Other versions
WO1992011367A2 (fr
Inventor
Howard C Krivan
Bo Nilsson
Clifford A Lingwood
Original Assignee
Microcarb Inc
Hsc Res Dev Lp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microcarb Inc, Hsc Res Dev Lp filed Critical Microcarb Inc
Priority to JP4502887A priority Critical patent/JPH06504670A/ja
Publication of WO1992011367A2 publication Critical patent/WO1992011367A2/fr
Publication of WO1992011367A3 publication Critical patent/WO1992011367A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/295—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Chlamydiales (O)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention décrit des molécules lipidiques de cellules hôtes (''récepteurs'') permettant la liaison de micro-organismes. On fabrique des compositions pharmaceutiques à partir desdits récepteurs, en combinaison avec un agent porteur ou diluant acceptables pharmaceutiquement. L'invention se rapporte également à des protéines microbiennes (''adhésines''), induisant la liaison des micro-organismes aux cellules hôtes, ainsi qu'à des séquences d'ADN codant les protéines d'adhésine. On fabrique des vaccins à partir d'une protéine d'adhésine en combinaison avec un agent porteur ou un diluant acceptables pharmaceutiquement.
PCT/US1991/009810 1990-12-21 1991-12-20 Recepteurs lipidiques de micro-organismes et adhesines correspondantes, sequences d'adn codant des adhesines et utilisation desdites adhesines WO1992011367A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4502887A JPH06504670A (ja) 1990-12-21 1991-12-20 微生物に関する脂質レセプター及び対応の付着因子、付着因子をコードするｄｎａ配列、並びにそれらの利用方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63237190A 1990-12-21 1990-12-21
US632,371 1990-12-21

Publications (2)

Publication Number Publication Date
WO1992011367A2 WO1992011367A2 (fr) 1992-07-09
WO1992011367A3 true WO1992011367A3 (fr) 1992-10-15

Family

ID=24535261

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/009810 WO1992011367A2 (fr) 1990-12-21 1991-12-20 Recepteurs lipidiques de micro-organismes et adhesines correspondantes, sequences d'adn codant des adhesines et utilisation desdites adhesines

Country Status (4)

Country Link
EP (1) EP0563240A1 (fr)
JP (1) JPH06504670A (fr)
CA (1) CA2098733A1 (fr)
WO (1) WO1992011367A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506139A (en) * 1994-07-21 1996-04-09 Connaught Laboratories Limited Analog of haemophilus Hin47 with reduced protease activity
US5939297A (en) * 1994-07-21 1999-08-17 Connaught Laboratories Limited Analog of haemophilus HIN47 with reduced protease activity
US5981503A (en) * 1994-06-07 1999-11-09 Connaught Laboratories Limited Analog of Haemophilus Hin47 with reduced protease activity
US6147057A (en) * 1994-07-21 2000-11-14 Connaught Laboratories Limited Analog of Haemophilus Hin47 with reduced protease activity
BR9506272B8 (pt) * 1994-07-21 2014-08-05 Connaught Lab PROTEÍNA MUTANTE ISOLADA E PURIFICADA Hin47 DE Haemophilus influenzae, MOLÉCULA QUIMÉRICA, MOLÉCULA DE ÁCIDO NUCLÉICO, PLASMÍDEO RECOMBINANTE, CÉLULA E. coli TRANSFORMADA, COMPOSIÇÃO IMUNOGÊNICA, PROCESSO PARA DETERMINAR A PRESENÇA DE ANTICORPOS, ESPECIFICAMENTE REATIVOS COM A PROTEÍNA Hin47 NUMA AMOSTRA, PROCESSO PARA DETERMINAR A PRESENÇA DE PROTEÍNA Hin47 NUMA AMOSTRA E KIT DE DIAGNÓSTICO PARA DETERMINAR A PRESENÇA DE ANTICORPOS NUMA AMOSTRA ESPECIFICAMENTE REATIVA COM A PROTEÍNA Hin47.
CN1186516A (zh) * 1995-06-07 1998-07-01 阿斯特拉公司 与幽门螺杆菌相关的诊断和治疗用的核酸和氨基酸序列
AUPR512401A0 (en) * 2001-05-18 2001-06-14 Queensland University Of Technology Adherent entities and uses therefor

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985005037A1 (fr) * 1984-05-02 1985-11-21 Syn-Tek Ab Antigenes d'adhesine, anticorps et fragment d'adn codant l'antigene, procedes et moyen de diagnostic et d'immunisation, etc.
EP0293079A2 (fr) * 1987-04-24 1988-11-30 368800 Alberta Ltd Vaccin contre chlamydia

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985005037A1 (fr) * 1984-05-02 1985-11-21 Syn-Tek Ab Antigenes d'adhesine, anticorps et fragment d'adn codant l'antigene, procedes et moyen de diagnostic et d'immunisation, etc.
EP0293079A2 (fr) * 1987-04-24 1988-11-30 368800 Alberta Ltd Vaccin contre chlamydia

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Infection and Immunity, volume 55, no. 2, February 1987, Washington DC, US; G. Hinson et al.: "Adherence to human colonocytes of an Escherichia coli strain isolated from severe infantile enteritis: molecular and ultrastructural studies of a fibrillar adhesin", pages 393-402, see the whole article *
Infection and Immunity, volume 58, no. 4, April 1990, Washington, DC, US Hua Sue et al.: "Chlamydia trachomatis host cell interactions: role of the chlamydial major outer membrane protein as an adhesin", pages 1017-1025, see the wole article *
Journal of Bacteriology, volume 169, no. 11, November 1987, Baltimore, MD, US, R. Kaul et al.: "Cloning, expression and primary structure of a chlamydia trachomatis binding protein", pages 5152-5156, see the abstract and figure 3 *

Also Published As

Publication number Publication date
EP0563240A1 (fr) 1993-10-06
WO1992011367A2 (fr) 1992-07-09
JPH06504670A (ja) 1994-06-02
CA2098733A1 (fr) 1992-06-22

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