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WO1992009694A3 - CLONING OF UDP-N-ACETYLGLUCOSAMINE:α-3-D-MANNOSIDE β-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE I - Google Patents

CLONING OF UDP-N-ACETYLGLUCOSAMINE:α-3-D-MANNOSIDE β-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE I Download PDF

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Publication number
WO1992009694A3
WO1992009694A3 PCT/CA1991/000417 CA9100417W WO9209694A3 WO 1992009694 A3 WO1992009694 A3 WO 1992009694A3 CA 9100417 W CA9100417 W CA 9100417W WO 9209694 A3 WO9209694 A3 WO 9209694A3
Authority
WO
WIPO (PCT)
Prior art keywords
mannoside
acetylglucosaminyltransferase
acetylglucosamine
udp
cloning
Prior art date
Application number
PCT/CA1991/000417
Other languages
French (fr)
Other versions
WO1992009694A2 (en
Inventor
Harry Schachter
Mohan Sarkar
Original Assignee
Hsc Res Dev Lp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hsc Res Dev Lp filed Critical Hsc Res Dev Lp
Publication of WO1992009694A2 publication Critical patent/WO1992009694A2/en
Publication of WO1992009694A3 publication Critical patent/WO1992009694A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The genes encoding rabbit and human GnT I have been cloned.
PCT/CA1991/000417 1990-11-30 1991-11-29 CLONING OF UDP-N-ACETYLGLUCOSAMINE:α-3-D-MANNOSIDE β-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE I WO1992009694A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62009890A 1990-11-30 1990-11-30
US620,098 1990-11-30

Publications (2)

Publication Number Publication Date
WO1992009694A2 WO1992009694A2 (en) 1992-06-11
WO1992009694A3 true WO1992009694A3 (en) 1996-10-10

Family

ID=24484567

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1991/000417 WO1992009694A2 (en) 1990-11-30 1991-11-29 CLONING OF UDP-N-ACETYLGLUCOSAMINE:α-3-D-MANNOSIDE β-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE I

Country Status (2)

Country Link
AU (1) AU8941191A (en)
WO (1) WO1992009694A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874271A (en) * 1992-08-21 1999-02-23 Takara Shuzo Co., Ltd. Human glycosyltransferase gene, compounds and method for inhibiting cancerous metastasis
JP2789283B2 (en) * 1992-08-21 1998-08-20 寳酒造株式会社 Human glycosyltransferase gene
JP3979678B2 (en) * 1992-08-24 2007-09-19 サントリー株式会社 Novel glycosyltransferase, gene encoding the same, and method for producing the enzyme
US5834251A (en) * 1994-12-30 1998-11-10 Alko Group Ltd. Methods of modifying carbohydrate moieties
DE19754622A1 (en) * 1997-12-09 1999-06-10 Antje Von Dr Schaewen Plant GntI sequences and the use thereof for obtaining plants with reduced or missing N-acetylglucosaminyltransferase I (GnTI) activity
US7252933B2 (en) * 2002-06-26 2007-08-07 Flanders Interuniversity Institute For Biotechnology Protein glycosylation modification in methylotrophic yeast
US7332299B2 (en) 2003-02-20 2008-02-19 Glycofi, Inc. Endomannosidases in the modification of glycoproteins in eukaryotes
US7507573B2 (en) 2003-11-14 2009-03-24 Vib, Vzw Modification of protein glycosylation in methylotrophic yeast
WO2011149999A2 (en) 2010-05-27 2011-12-01 Merck Sharp & Dohme Corp. Method for preparing antibodies having improved properties
WO2012162277A1 (en) 2011-05-25 2012-11-29 Merck Sharp & Dohme Corp. METHOD FOR PREPARING Fc-CONTAINING POLYPEPTIDES HAVING IMPROVED PROPERTIES

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
Biochem. Soc. Trans., vol. 19, no. 3, August 1991, Biochemical Society, (London, GB), H. SCHACHTER et al.: "Molecular cloning of human and rabbit UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I", pages 645-648, see page 646, left-hand column, line 1 - page 648, right-hand column, line 23 *
Glycoconjugate Journal, vol. 7, no. 5, 10 October 1990, (Lund, SE), E. HULL et al.: "Isolation of 13 and 15 kilobase human genomic DNA clones containing the gene for UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I", page 468, abstract no. 85, see the whole document *
Glycoconjugate Journal, vol. 7, no. 5, 10 October 1990, (Lund, SE), M. SARKAR et al.: "Rabbit liver UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I: characteriazation of a 2,5 kilobase cDNA clone", page 380, abstract no. 4, see the whole document *
J. Biol. Chem., vol. 256, no. 2, 25 January 1981, Am. Soc. Biol. Chem., Inc., (US), C.L. OPPENHEIMER et al.: "Purification and characterization of a rabbit liver alpha1 3 mannoside beta1 2 N-acetylglucosaminyltransferase", pages 799-804, see page 801, left-hand column, line 8 - right-hand column, line 8 (cited in the application) *
J. Biol. Chem., vol. 263, no. 17, 15 June 1988, Am. Soc. Biol. Chem., Inc., (US), Y. NISHIKAWA et al.: "Control of glycoprotein synthesis. Purification and characterization of rabbit liver UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I", pages 8270-8281, see table I; abstract; page 8270, right-hand column, lines 25-29 (cited in the application) *
J. Biol. Chem., vol. 265, no. 2, 15 January 1990, Am. Soc. Biol. Chem., Inc., (US), F. YAMAMOTO et al.: "Cloning and characterization of DNA complementary to human UDP-Ga1NAc: Fucalpha1 2Ga1 alpha1 3Ga1NAc transferase (histo-blood group A transferase) mRNA", pages 1146-1151, see materials and methods (cited in the application) *
Proc. Natl. Acad. Sci. USA, vol. 88, no. 1, January 1991, Natl. Acad. Sci., (Washington, DC, US), M. SAKKAR et al.: "Molecular cloning and expression of cDNA encoding the enzyme that controls conversion of high-mannose to hybrid and complex N-glycans: UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I", pages 234-238, see figure 4; page 236, left-hand column, line 26 - page 237, right-hand column, line 6 *

Also Published As

Publication number Publication date
WO1992009694A2 (en) 1992-06-11
AU8941191A (en) 1992-06-25

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