+

WO1992008465A3 - 2-decarboxyle-2-aminoalkyle-prostagladines comme agents hypotensifs oculaires - Google Patents

2-decarboxyle-2-aminoalkyle-prostagladines comme agents hypotensifs oculaires Download PDF

Info

Publication number
WO1992008465A3
WO1992008465A3 PCT/US1991/007982 US9107982W WO9208465A3 WO 1992008465 A3 WO1992008465 A3 WO 1992008465A3 US 9107982 W US9107982 W US 9107982W WO 9208465 A3 WO9208465 A3 WO 9208465A3
Authority
WO
WIPO (PCT)
Prior art keywords
decarboxyl
aminoalkyl
prostaglandins
ocular hypotensives
hypotensives
Prior art date
Application number
PCT/US1991/007982
Other languages
English (en)
Other versions
WO1992008465A2 (fr
Inventor
Ming Fai Chan
David Frederick Woodward
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Priority to CA002095430A priority Critical patent/CA2095430A1/fr
Priority to JP50084392A priority patent/JP3488456B2/ja
Priority to BR919107071A priority patent/BR9107071A/pt
Priority to AU90414/91A priority patent/AU656752B2/en
Priority to EP92900219A priority patent/EP0556296B1/fr
Priority to DE69127755T priority patent/DE69127755T2/de
Publication of WO1992008465A2 publication Critical patent/WO1992008465A2/fr
Publication of WO1992008465A3 publication Critical patent/WO1992008465A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Geophysics And Detection Of Objects (AREA)
  • Feedback Control In General (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention se rapporte à des dérivés 2-décarboxyle-2-aminoalkyle de prostaglandines naturelles et synthétiques, des dérivés N-substitués, des promédicaments d'ester et des homologues de tels composés qui sont des agents hypotensifs oculaires puissants, et qui conviennent particulièrement au traitement du glaucome.
PCT/US1991/007982 1990-11-09 1991-10-30 2-decarboxyle-2-aminoalkyle-prostagladines comme agents hypotensifs oculaires WO1992008465A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002095430A CA2095430A1 (fr) 1990-11-09 1991-10-30 2-decarboxyl-2-aminoalkylprostaglandines, agents oculaires hypotensifs
JP50084392A JP3488456B2 (ja) 1990-11-09 1991-10-30 眼圧降下剤としての２−デカルボキシル−２−アミノアルキル−プロスタグランジン
BR919107071A BR9107071A (pt) 1990-11-09 1991-10-30 2-decarboxil-2-aminoalquil-prostag landinas como hipotensivos oculares
AU90414/91A AU656752B2 (en) 1990-11-09 1991-10-30 2-decarboxyl-2-aminomethyl PGF2alpha derivatives as ocular hypotensives
EP92900219A EP0556296B1 (fr) 1990-11-09 1991-10-30 2-decarboxyle-2-aminoalkyle-prostagladines comme agents hypotensifs oculaires
DE69127755T DE69127755T2 (de) 1990-11-09 1991-10-30 Okulare hypotensive 2-dekarboxyl-2-aminoalkyl-prostaglandine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/611,029 US5270049A (en) 1990-11-09 1990-11-09 2-decarboxyl-2-aminoalkyl-prostaglandins as ocular hypotensives
US611,029 1990-11-09

Publications (2)

Publication Number Publication Date
WO1992008465A2 WO1992008465A2 (fr) 1992-05-29
WO1992008465A3 true WO1992008465A3 (fr) 1992-10-15

Family

ID=24447325

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/007982 WO1992008465A2 (fr) 1990-11-09 1991-10-30 2-decarboxyle-2-aminoalkyle-prostagladines comme agents hypotensifs oculaires

Country Status (15)

Country Link
US (1) US5270049A (fr)
EP (1) EP0556296B1 (fr)
JP (1) JP3488456B2 (fr)
AT (1) ATE158506T1 (fr)
AU (1) AU656752B2 (fr)
BR (1) BR9107071A (fr)
CA (1) CA2095430A1 (fr)
DE (1) DE69127755T2 (fr)
ES (1) ES2107522T3 (fr)
HU (1) HUT70500A (fr)
IE (1) IE913906A1 (fr)
IL (1) IL99975A (fr)
NZ (1) NZ240502A (fr)
WO (1) WO1992008465A2 (fr)
ZA (1) ZA918869B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9522153B2 (en) 2009-12-22 2016-12-20 Allergan, Inc. Compositions and methods for lowering intraocular pressure

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5288754A (en) * 1992-02-04 1994-02-22 Allergan, Inc. Polar C-1 esters of prostaglandins
US5688819A (en) * 1992-09-21 1997-11-18 Allergan Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5352708A (en) * 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5834498A (en) * 1992-09-21 1998-11-10 Allergan Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US5972991A (en) 1992-09-21 1999-10-26 Allergan Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US5328933A (en) * 1992-10-28 1994-07-12 Allergan, Inc. Cyclopentane heptenylnitro and heptanylnitro-2-aliphatic or aryl aliphatic derivatives and homologues
US6124353A (en) * 1992-11-12 2000-09-26 Allergan Sales, Inc. Method of treating ocular hypertension with 8-epi prostaglandins
US5545665A (en) * 1993-12-28 1996-08-13 Allergan Cyclopentane(ene) heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents
US5698733A (en) * 1994-09-30 1997-12-16 Alcon Laboratories, Inc. Use of 9-deoxy prostaglandin derivatives to treat glaucoma
AU7672096A (en) 1995-06-07 1998-06-03 Alcon Laboratories, Inc. Conformationally rigid aryl- or heteroaryl prostaglandins for use in glaucoma therapy
US6066671A (en) 1997-12-19 2000-05-23 Alcon Laboratories, Inc. Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides
US6646001B2 (en) 1997-12-19 2003-11-11 Alcon Manufacturing, Ltd. Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension
US6096783A (en) * 1998-12-15 2000-08-01 Alcon Laboratories, Inc. Cyclobutane prostaglandin analogues as ocular hypotensive agents
US6211226B1 (en) 1998-12-17 2001-04-03 Alcon Laboratories, Inc. 11-Aza prostaglandins for the treatment of glaucoma and ocular hypertension
US6160013A (en) * 1998-12-17 2000-12-12 Alcon Laboratories, Inc. 14-aza prostaglandins for the treatment of glaucoma and ocular hypertension
US20090148527A1 (en) * 2007-12-07 2009-06-11 Robinson Michael R Intraocular formulation
US7851504B2 (en) 2005-03-16 2010-12-14 Allergan, Inc. Enhanced bimatoprost ophthalmic solution
US9241918B2 (en) 2005-03-16 2016-01-26 Allergan, Inc. Enhanced bimatoprost ophthalmic solution

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2336924A1 (fr) * 1975-12-29 1977-07-29 Upjohn Co Analogues de prostaglandines et leur preparation
EP0242580A2 (fr) * 1986-03-13 1987-10-28 The Trustees Of Columbia University In The City Of New York Utilisation des prostaglandines A,B et C, et leurs dérivés pour le traitement de l'hypertension oculaire et du glaucome
EP0253094A2 (fr) * 1986-05-16 1988-01-20 Research Development Corporation of Japan Utilisation des substances prostaglandine D2-actives pour le traitement de l'hypertension oculaire et du glaucome
WO1991019490A1 (fr) * 1990-06-14 1991-12-26 Allergan, Inc. Alcools de pgf 1 et leur emploi en tant qu'hypotenseurs oculaires

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599353A (en) * 1982-05-03 1986-07-08 The Trustees Of Columbia University In The City Of New York Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma
US4883819A (en) * 1986-07-31 1989-11-28 The Trustees Of Columbia University In The City Of New York Use of A, B and C prostaglandins and derivatives thereof to treat ocular hypertension and glaucoma
US4952581A (en) * 1987-04-03 1990-08-28 The Trustees Of Columbia University In The City Of New York Use of a prostaglandin in combination with an adrenergic blocking agent for reduction of intraocular pressure
EP0308135B1 (fr) * 1987-09-18 1992-11-19 R-Tech Ueno Ltd. Agents hypotenseurs ophtalmologiques
US4927846A (en) * 1988-11-23 1990-05-22 Allergan, Inc. Intraocular pressure reducing 1,11-lactone prostaglandins
US4994274A (en) * 1989-07-27 1991-02-19 Allergan, Inc. Intraocular pressure reducing 11,15-diacyl prostaglandins and method of using
US5011856A (en) * 1990-03-12 1991-04-30 Allergan, Inc. Use of prostaglandin F3 α as an ocular hypotensive agent

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2336924A1 (fr) * 1975-12-29 1977-07-29 Upjohn Co Analogues de prostaglandines et leur preparation
EP0242580A2 (fr) * 1986-03-13 1987-10-28 The Trustees Of Columbia University In The City Of New York Utilisation des prostaglandines A,B et C, et leurs dérivés pour le traitement de l'hypertension oculaire et du glaucome
EP0253094A2 (fr) * 1986-05-16 1988-01-20 Research Development Corporation of Japan Utilisation des substances prostaglandine D2-actives pour le traitement de l'hypertension oculaire et du glaucome
WO1991019490A1 (fr) * 1990-06-14 1991-12-26 Allergan, Inc. Alcools de pgf 1 et leur emploi en tant qu'hypotenseurs oculaires

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
STN File Server, Karlsruhe DE, & File CA, Chemical Abstracts, vol. 95, no. 3, abstract no. 18743r, (Columbus, Ohio, US), T.M. FITZPATRICK et al.: "Prostaglandin analogs that antagonize the vascular responses to particular prostaglandins", & NATO ADV. STUDY INST. SER., SER. A, A36(PROSTAGLANDIN SYST.: ENDOPEROXIDES, PROSTACYCLIN, THROMBOXANES) 1981, 283-9, see whole abstract (cited in the application) *
STN File Server, Karlsruhe DE, & File CA, Chemical abstracts, vol. 96, no. 23, abstract no. 194093h, (Columbus, Ohio, US), R.B. STINGER et al.: "Selective antagonism of prostaglandin F2.alpha.-mediated vascular responses by N-dimethylamino substitution of prostaglandin F2.alpha.", & J. PHARMACOL. EXP. THER., 1982, 220(3), 521-5, see whole abstract *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9522153B2 (en) 2009-12-22 2016-12-20 Allergan, Inc. Compositions and methods for lowering intraocular pressure

Also Published As

Publication number Publication date
ATE158506T1 (de) 1997-10-15
ZA918869B (en) 1992-07-29
ES2107522T3 (es) 1997-12-01
EP0556296B1 (fr) 1997-09-24
CA2095430A1 (fr) 1992-05-10
NZ240502A (en) 1995-07-26
IL99975A (en) 1996-05-14
BR9107071A (pt) 1993-09-21
WO1992008465A2 (fr) 1992-05-29
AU9041491A (en) 1992-06-11
HU9301327D0 (en) 1993-09-28
EP0556296A1 (fr) 1993-08-25
DE69127755D1 (de) 1997-10-30
AU656752B2 (en) 1995-02-16
IL99975A0 (en) 1992-08-18
IE913906A1 (en) 1992-05-20
DE69127755T2 (de) 1998-04-30
US5270049A (en) 1993-12-14
JP3488456B2 (ja) 2004-01-19
JPH06501482A (ja) 1994-02-17
HUT70500A (en) 1995-10-30

Similar Documents

Publication Publication Date Title
WO1992008465A3 (fr) 2-decarboxyle-2-aminoalkyle-prostagladines comme agents hypotensifs oculaires
HU912272D0 (en) Process for the production of 2,6-dialkyl-4- silil-phenol derivatives
IE780864L (en) Polyene compounds
AU8581991A (en) Mercaptoacetylamide derivatives as inhibitors of enkephalinase and ACE, and processes for their production
CA2135751A1 (fr) Derives de 4-mercaptoacetylamino-[2] benzazepinone(3) et leur utilisation comme inhibiteurs de l'enkephalinase
AU633754B2 (en) Composition for eye drops
AU647163B2 (en) Naphthyl-alkylamino-pyrimidine derivatives as pesticides
CA2141563A1 (fr) Nouveaux derives tricycliques de indane-2-mercaptoacetylamise subsitues en position 2 utilises comme inhibiteurs de l'encephalinase
AU7728691A (en) Use of substituted beta-hydroxyethylamines as potent inhibitors of the exoenzymes of fungi
MY104979A (en) [ 5(6)(ih-azole-1-ylmethyl) benzimidazole] carbamates.
AU575342B2 (en) Gamma - butyrolactone derivatives
HUT57197A (en) Process for producing iminothiazoline derivatives and their intermediates, as well as herbicidal compositions comprising iminothiazoline derivatives as active ingredient
ES2079872T3 (es) Derivados hipotensores oculares de la 2-descarboxil-2-aciltioalquilprostaglandina.
EP1008345A4 (fr) Agents anti-allergiques
WO1991001125A3 (fr) Composes a activite de peroxydase du glutathione et leur utilisation
WO1992010473A3 (fr) Prostaglandines a base de 2-decarboxyl-2-alcoxyalkyle utilisees comme hypotenseurs oculaires
WO1992010193A3 (fr) Derives d'homo-prostaglandines utilises comme hypotenseurs oculaires
AU621996B2 (en) 2,5,6,7-tetranor-4,8-inter-m-phenylene pgi2 derivatives
IE873119L (en) 12-halogenated forskolin derivatives, intermediates and a¹process for the preparation thereof and their use as¹medicaments
ZA907996B (en) Antimetastatically acting agents
EP0770614A3 (fr) Dérivé de pyrrolo(4,3,2-de)quinoline
AU1516892A (en) Novel 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors
ZA931062B (en) Compositions for the treatment of glaucoma.
WO1996018406A3 (fr) Formulations ophtalmiques de glycosides substitues

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU BB BG BR CA FI HU JP KP KR LK MC MG MW NO PL RO SD SU

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE BF BJ CF CG CH CI CM DE DK ES FR GA GB GN GR IT LU ML MR NL SE SN TD TG

AK Designated states

Kind code of ref document: A3

Designated state(s): AU BB BG BR CA FI HU JP KP KR LK MC MG MW NO PL RO SD SU

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE BF BJ CF CG CH CI CM DE DK ES FR GA GB GN GR IT LU ML MR NL SE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 1992900219

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2095430

Country of ref document: CA

WWP Wipo information: published in national office

Ref document number: 1992900219

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 1992900219

Country of ref document: EP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载