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WO1992007939A3 - Polypeptide possedant la specificite de liaison de l'antigene de differenciation 46kd hmfg - Google Patents

Polypeptide possedant la specificite de liaison de l'antigene de differenciation 46kd hmfg Download PDF

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Publication number
WO1992007939A3
WO1992007939A3 PCT/US1991/006656 US9106656W WO9207939A3 WO 1992007939 A3 WO1992007939 A3 WO 1992007939A3 US 9106656 W US9106656 W US 9106656W WO 9207939 A3 WO9207939 A3 WO 9207939A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptide
differentiation antigen
antigen binding
binding specificity
antibody
Prior art date
Application number
PCT/US1991/006656
Other languages
English (en)
Other versions
WO1992007939A2 (fr
Inventor
Roberto L Ceriani
Jerry Arthur Peterson
David James Larocca
Original Assignee
Muir John Cancer & Res
Ceriani Roberto Luis
Jerry Arthur Peterson
David James Larocca
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Muir John Cancer & Res, Ceriani Roberto Luis, Jerry Arthur Peterson, David James Larocca filed Critical Muir John Cancer & Res
Priority to JP4502207A priority Critical patent/JPH06510981A/ja
Publication of WO1992007939A2 publication Critical patent/WO1992007939A2/fr
Publication of WO1992007939A3 publication Critical patent/WO1992007939A3/fr
Priority to KR1019930701319A priority patent/KR930703442A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1051—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from breast, e.g. the antibody being herceptin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

On décrit un polypeptide qui possède l'activité de liaison d'anticorps de l'antigène de différenciation 46K dalton HMFG (globule gras de lait humain) et/ou une homologie avec au moins une des chaînes légères des facteurs de coagulation V et VIII; ledit polypeptide en tant que protéine de fusion avec un second polypeptide antigénique; un anticorps possédant une affinité pour le polypeptide de la présente invention ou un fragment fonctionnel dudit polypeptide; des méthodes in vivo ou in vitro de vaccination thérapeutique et de détection de la présence du polypeptide, de l'anticorps, de l'ADN et de l'ARN de la présente invention; des séquences d'ADN et d'ARN codant ledit polypeptide ou des fragments dudit polypeptide; des trousses d'essais immunologiques comprenant les anticorps et/ou les polypeptides susmentionnés.
PCT/US1991/006656 1990-11-01 1991-09-16 Polypeptide possedant la specificite de liaison de l'antigene de differenciation 46kd hmfg WO1992007939A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP4502207A JPH06510981A (ja) 1990-11-01 1991-09-16 ４６キロダルトンｈｍｆｇ分化抗原結合特異性と第５及び第８凝固因子軽鎖ホモロジーとを有するポリペプチド
KR1019930701319A KR930703442A (ko) 1991-09-16 1993-04-30 Kd hmfg 분화항원 결합특이성을 갖는 폴리펩티드

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US607,538 1990-11-01
US07/607,538 US5455031A (en) 1990-11-01 1990-11-01 Polypeptide with 46 Kdalton HMFG differentiation antigen binding specificity, composition, kit and diagnostic method

Publications (2)

Publication Number Publication Date
WO1992007939A2 WO1992007939A2 (fr) 1992-05-14
WO1992007939A3 true WO1992007939A3 (fr) 1992-10-15

Family

ID=24432717

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/006656 WO1992007939A2 (fr) 1990-11-01 1991-09-16 Polypeptide possedant la specificite de liaison de l'antigene de differenciation 46kd hmfg

Country Status (6)

Country Link
US (1) US5455031A (fr)
EP (1) EP0555397A1 (fr)
JP (1) JPH06510981A (fr)
AU (1) AU9057091A (fr)
CA (1) CA2095330A1 (fr)
WO (1) WO1992007939A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972337A (en) * 1990-11-01 1999-10-26 Cancer Research Fund Of Contra Costa 46 kilodalton human milk fat globule (HMFG) antigen, fragments and fusion protein
US6939677B1 (en) * 1990-11-01 2005-09-06 Cancer Research Fund Of Contra Costa Antibody with 46 kdalton HMFG antigen binding specificity, immunoassay kit and diagnostic method
WO1994011508A2 (fr) * 1992-11-13 1994-05-26 Cancer Research Fund Of Contra Costa Polypeptides presentant une specificite par rapport aux neoplasies, kit et procedes diagnostiques, therapeutiques et de vaccination
IL125608A0 (en) * 1998-07-30 1999-03-12 Yeda Res & Dev Tumor associated antigen peptides and use of same as anti-tumor vaccines
EP1004664A1 (fr) * 1998-11-24 2000-05-31 Institut National De La Sante Et De La Recherche Medicale (Inserm) Compositions et procédés utilisant la lactadhérine ou des dérivés de celle-ci
US20040241179A1 (en) * 1999-11-23 2004-12-02 Graca Raposo Compositions and methods using lactadherin or variants thereof
AU2001229637A1 (en) * 2000-01-21 2001-07-31 Thomas Jefferson University Nipple aspirate fluid specific microarrays
CA2454756C (fr) 2001-08-17 2014-02-18 Anosys, Inc. Procedes et composes pour le ciblage de proteines vers des exosomes
AU2003237870A1 (en) * 2002-06-07 2003-12-22 The Brigham & Women's Hospital, Inc. Method and composition for inhibing or slowing blood coagulation
EP1615670A4 (fr) * 2003-04-01 2006-12-13 Intradigm Corp Cibles pour l'inhibition de la croissance tumorale
WO2005005954A2 (fr) * 2003-06-30 2005-01-20 The Brigham & Women's Hospital, Inc. Procede, composition et trousse pour la detection de phosphatidylserine sur des membranes cellulaires

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988009935A1 (fr) * 1987-06-12 1988-12-15 Bartos Patent Development & Holding Company Ltd. Procede d'examen oncologique d'admission et de therapie anti-cancereuse integres

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4348384A (en) * 1980-10-17 1982-09-07 Dainippon Pharmaceutical Co., Ltd. Pharmaceutical composition for oral administration containing coagulation factor VIII or IX
US4857635A (en) * 1983-03-31 1989-08-15 Scripps Clinic And Research Foundation Factor VIII coagulant polypeptides and monoclonal antibodies tof them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988009935A1 (fr) * 1987-06-12 1988-12-15 Bartos Patent Development & Holding Company Ltd. Procede d'examen oncologique d'admission et de therapie anti-cancereuse integres

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts, volume 113, part 3, 16 July 1990, (Columbus, Ohio, US) D. Larocca et al.: "Cloning and sequencing of a complementary DNA encoding a M, 70.000 human breast epithelial mucin-associated antigen", see page 174, abstract 225514x, & Cancer Res. 1990, 50(18), 5925-30 *
Chemical Abstracts, volume 115, 11 November 1991, (Columbus, Ohio, US) D. Larocca et al.: "A M, 46,000 human milk fat globule protein that is highly expressed in human breast tumors contains factor VIII-like domains", see page 722, abstract 204741v, & Cancer Res. 1991, 51(18), 4994-8 *
Hybridoma, volume 9, no. 3, June 1990 (New York, US) J.A. Peterson et al.: "Biochemical and histological characterization of antigens preferentially expressed on the surface and cytoplasm of breast carcinoma cells identified by monoclonal antibodies against the human milk fat globule", pages 221-235, see the whole article (cited in the application) *
Journal of the National Cancer Institute, volume 81, no. 20, 18 October 1989; M. Rothenberg et al.: "Oligodeoxynucleotides as anti-sense inhibitors of gene expression: therapeutic implications", pages 1539-1545, see the whole article *
Science, volume 242, 14 October 1988 (Lancaster, US) U. Landegren et al.: "DNA diagnostics - molecular techniques and automation", pages 229-237, see the whole article *
Trends in Biotechnology, volume 9, no. 1, January 1991, Elsevier Science Publishers Ltd. (Cambridge, GB) R. Sherwood: "Protein fusions: bioseparation and application", pages 1-3, see the whole article *

Also Published As

Publication number Publication date
WO1992007939A2 (fr) 1992-05-14
CA2095330A1 (fr) 1992-05-02
EP0555397A1 (fr) 1993-08-18
AU9057091A (en) 1992-05-26
US5455031A (en) 1995-10-03
JPH06510981A (ja) 1994-12-08

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