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WO1992007566A3 - Activite antifongique d'analogues de methylxanthine et leur utilisation dans la prevention de la nephrotoxicite medicamenteuse - Google Patents

Activite antifongique d'analogues de methylxanthine et leur utilisation dans la prevention de la nephrotoxicite medicamenteuse Download PDF

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Publication number
WO1992007566A3
WO1992007566A3 PCT/US1991/008086 US9108086W WO9207566A3 WO 1992007566 A3 WO1992007566 A3 WO 1992007566A3 US 9108086 W US9108086 W US 9108086W WO 9207566 A3 WO9207566 A3 WO 9207566A3
Authority
WO
WIPO (PCT)
Prior art keywords
analogs
methylxanthine
4coh
analogues
prevention
Prior art date
Application number
PCT/US1991/008086
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English (en)
Other versions
WO1992007566A2 (fr
Inventor
David R Luke
Gabriel Lopez-Berestein
Kiumars Vadiei
Lane J Brunner
Kishor Wasan
Kurt L Berens
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Publication of WO1992007566A2 publication Critical patent/WO1992007566A2/fr
Publication of WO1992007566A3 publication Critical patent/WO1992007566A3/fr

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne l'emploi de certains analogues de méthylxanthine hémorhéologique ayant la structure (I) dans laquelle R1 représente -(CH2)4COCH3, ou -(CH2)4COH(CH3)2 et R2 représente -(CH3), -H ou CH2OCH2CH3. On peut utiliser ces anlogues de nméthylxanthine dans le traitement d'infections fongiques générales, par exemple de la candidose. On peut administrer les analogues, de préférence par voie parentérale, au moins une fois et éventuellement selon un schéma posologique multiple afin de combattre efficacement les infections fongiques générales. La posologie thérapeutiquement efficace préférée pour ledit traitement consiste en l'administration de 1 mg à 100 mg par kg du poids de l'animal. L'analogue préféré dans ce traitement est obtenu lorsque R1 représente -(CH2)4COH(CH3)2 et R2 représente -H. De manière générale, on peut utiliser les analogues précités dans le traitement d'un animal afin d'inhiber le développement ou d'obtenir un soulagement de dysfonctionnements rénaux se manifestant par des réductions de flux sanguin rénal et de taux de filtration glomérulaire avec une résistance vasculaire accrue. Ce dysfonctionnement peut n'avoir aucun lien ou être en rapport avec la toxicité d'autres médicaments tels que la cyclosporine ou l'amphotéricine B.
PCT/US1991/008086 1990-11-01 1991-11-01 Activite antifongique d'analogues de methylxanthine et leur utilisation dans la prevention de la nephrotoxicite medicamenteuse WO1992007566A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60815890A 1990-11-01 1990-11-01
US608,158 1990-11-01

Publications (2)

Publication Number Publication Date
WO1992007566A2 WO1992007566A2 (fr) 1992-05-14
WO1992007566A3 true WO1992007566A3 (fr) 1992-10-15

Family

ID=24435308

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/008086 WO1992007566A2 (fr) 1990-11-01 1991-11-01 Activite antifongique d'analogues de methylxanthine et leur utilisation dans la prevention de la nephrotoxicite medicamenteuse

Country Status (2)

Country Link
AU (1) AU9084991A (fr)
WO (1) WO1992007566A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4430127A1 (de) * 1994-08-25 1996-03-14 Hoechst Ag Kombinationspräparat, enthaltend Cyclosporin A oder FK506 und ein Xanthinderivat
US5981536A (en) * 1996-07-31 1999-11-09 Hoechst Aktiengesellschaft Use of xanthine derivatives for the modulation of apoptosis
US5856330A (en) * 1996-07-31 1999-01-05 Hoechst Aktiengesellschaft Use of xanthine derivatives for the inhibition of dephosphorylation of cofilin
US6294350B1 (en) * 1997-06-05 2001-09-25 Dalhousie University Methods for treating fibroproliferative diseases
JP4486167B2 (ja) * 1998-02-27 2010-06-23 アスビオファーマ株式会社 薬剤性腎障害の予防または治療剤
SE0000234D0 (sv) * 2000-01-26 2000-01-26 Kjell Grankvist Antifungal drug composition and drug delivery system
US20090239886A1 (en) 2008-02-29 2009-09-24 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
US20110053961A1 (en) 2009-02-27 2011-03-03 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
MX2012002704A (es) 2009-09-02 2012-03-21 Concert Pharmaceuticals Inc Derivados de xantina sustituidos.
WO2012031138A2 (fr) 2010-09-01 2012-03-08 Concert Pharmaceuticals, Inc. Polymorphes de (s)-1-(4,4,6,6,6-pentadeutéro-5-hydroxyhexyl)-3-7-diméthyl-1h-purine-2,6(3h,7h)dione
US20140296263A1 (en) 2011-07-19 2014-10-02 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
WO2013155465A1 (fr) 2012-04-13 2013-10-17 Concert Pharmaceuticals, Inc. Dérivés de xanthine substituée
WO2013159006A1 (fr) 2012-04-20 2013-10-24 Concert Pharmaceuticals, Inc. Polymorphes de (s)-1-(4,4,6,6,6-pentadeutéro-5-hydroxyhexyl)-3,7-diméthyl-1h-purine-2,6(3h,7h)-dione

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0344586A2 (fr) * 1988-05-27 1989-12-06 Taiho Pharmaceutical Co., Ltd. Médicament contenant un inhibiteur TNF
EP0414175A2 (fr) * 1989-08-22 1991-02-27 Hoechst Aktiengesellschaft Utilisation de derivés du xanthine afin de réduire la néphrotoxicité

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0344586A2 (fr) * 1988-05-27 1989-12-06 Taiho Pharmaceutical Co., Ltd. Médicament contenant un inhibiteur TNF
EP0414175A2 (fr) * 1989-08-22 1991-02-27 Hoechst Aktiengesellschaft Utilisation de derivés du xanthine afin de réduire la néphrotoxicité

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
Antimicrobial Agents and Chemotherapy, vol. 34, no. 2, February 1990, American Society for Microbiology, K.M. WASAN et al.: "Pentoxifylline in amphotericin B toxicity rat model", pages 241-244, see the whole article *
Chemical Abstracts, vol. 92, no. 19, 12 May 1980, (Columbus, Ohio, US), A.J. KOSTAKIS et al.: "The effect of pentoxifylline on rejection of rat cardiac allografts", see page 46, abstract no. 157772a, & IRCS MED. SCI.: LIBR. COMPEND. 1980, 81(1), 15, see the entire document *
Chemical Abstracts, vol. 96, no. 13, 29 March 1982, (Columbus, Ohio, US), V.L. KIRPATOVSKII et al.: "Pharmacological protection of the kidneys from ischemic injury. Mechanism for the realization of antiischemic protection of donor kidneys with preparations from various pharmacological groups", see page 91, abstract no. 97660h, & VESTN. AKAD. MED. NAUK. SSSR 1982, (1), 73-8, see the entire document *
Chemical Abstracts, vol. 96, no. 17, 26 April 1982, (Columbus, Ohio, US), A.J. KOSTAKIS et al.: "Prolongation of cardiac and renal allograft survival by pentoxifylline in rats", see page 55, abstract no. 135560k, & IRCS MED. SCI.: LIBR. COMPEND. 1982, 10(1), 77-8, see the entire document *
Chemical Abstracts, vol. 98, no. 1, 3 January 1983, (Columbus, Ohio, US), V.L. KIRPATOVSKII et al.: "Pharmacological protection of the kidneys from ischemic damage. Efficacy of antiischemic protection of the kidneys in simulated terminal state of the donors", see page 32, abstract no. 304a, & VESTN. AKAD. MED. NAUK. SSSR 1982, (9), 89-92, see the entire document *
Clinical Pharmcology & Therapeutics, vol. 47, no. 2, February 1990, K.L. BERENS et al.: "Effect of pentoxifylline (PTX) on dose-dependent cisplatin (C) nephrotoxicity", page 201, see the whole article *
Comprehensive Therapy, vol. 15, no. 5, 1989, G.P. STELLIN et al.: "Current and potential therapeutic effects of pentoxifylline", pages 11-13, see page 13 *
J. Infect. Dis., vol. 162, no. 1, July 1990, The University of Chicago, D.R. LUKE et al.: "Enhancement of the treatment of experimental candidiasis with vascular decongestants", pages 211-214, see the whole article *
Renal Failure, vol. 11, nos. 2,3, 1989, Marcel Dekker, Inc., L.J. BRUNNER et al.: "Prevention of cyclosporine-induced nephrotoxicity with pentoxitylline", pages 97-104, see the whole article *

Also Published As

Publication number Publication date
AU9084991A (en) 1992-05-26
WO1992007566A2 (fr) 1992-05-14

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