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WO1992005792A1 - Utilisation du produit de reaction entre un gaz et un liquide, procede et dispositif de production de celui-ci - Google Patents

Utilisation du produit de reaction entre un gaz et un liquide, procede et dispositif de production de celui-ci Download PDF

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Publication number
WO1992005792A1
WO1992005792A1 PCT/EP1990/001651 EP9001651W WO9205792A1 WO 1992005792 A1 WO1992005792 A1 WO 1992005792A1 EP 9001651 W EP9001651 W EP 9001651W WO 9205792 A1 WO9205792 A1 WO 9205792A1
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WO
WIPO (PCT)
Prior art keywords
liquid
gas
gas mixture
reaction product
vortex
Prior art date
Application number
PCT/EP1990/001651
Other languages
German (de)
English (en)
Inventor
Klaus L. Buchholz
Original Assignee
Buchholz Klaus L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Buchholz Klaus L filed Critical Buchholz Klaus L
Priority to PCT/EP1990/001651 priority Critical patent/WO1992005792A1/fr
Publication of WO1992005792A1 publication Critical patent/WO1992005792A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/40—Peroxides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/10—Mixing by creating a vortex flow, e.g. by tangential introduction of flow components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/10—Mixing by creating a vortex flow, e.g. by tangential introduction of flow components
    • B01F25/102—Mixing by creating a vortex flow, e.g. by tangential introduction of flow components wherein the vortex is created by two or more jets introduced tangentially in separate mixing chambers or consecutively in the same mixing chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F2025/91—Direction of flow or arrangement of feed and discharge openings
    • B01F2025/919—Direction of flow or arrangement of feed and discharge openings characterised by the disposition of the feed and discharge openings
    • B01F2025/9191—Direction of flow or arrangement of feed and discharge openings characterised by the disposition of the feed and discharge openings characterised by the arrangement of the feed openings for one or more flows, e.g. for the mainflow and the flow of an additional component

Definitions

  • the invention relates to the use of a reaction product of a gas and a liquid, the gas being present under normal conditions in an activated form and in an amount which is at least 30% above the normal conditions corresponding saturation amount for the solution of the gas in the liquid, and which contains at least water and oxygen; further a process for producing such a reaction product according to the preamble of claims 2 to 4; and a device for carrying out the method according to the preamble of claim 7 or claim 12.
  • reaction product in particular from gas and water
  • EP-AI-0314015 Such a reaction product, in particular from gas and water, is known from EP-AI-0314015. This document describes that this reaction product of oxygen and water has proven to be successful in the treatment of Candida albicans and congelatio cutis. When this reaction product was taken orally, a significant reduction in the - previously elevated - blood alcohol content was found. However, the uses described for therapeutic purposes are only a small part of a much broader field of application.
  • the reaction product of oxygen and water is suitable for the production of medicaments for the therapeutic and/or prophylactic treatment of a wide variety of pathological changes.
  • the water-oxygen mixture has proven to be particularly suitable for therapy or to support therapy, which is briefly outlined below:
  • the deteriorated ability to absorb and utilize oxygen with increasing age causes poorer glucose utilization, which can lead to adult-onset diabetes, among other things.
  • the learning ability and reaction time of older people is also reduced.
  • the use of the water-oxygen reaction product has proven to be successful in the early stages of adult-onset diabetes; in many cases it was possible to dispense with further medication with oral antidiabetics.
  • the therapeutically effective water-oxygen reaction product in which the oxygen becomes active beyond the reactivity achieved in dissolved form, remains stable for a long time without special measures, such as storage under increased pressure or reduced temperature. and the half-life is at least a month, mostly even a year.
  • the dissolution (solubility) of gases in water is proportional to the partial pressure of the gas above the solution.
  • gases in liquids these are generally introduced into the liquids.
  • the maximum amount of gas absorbed at a given temperature is the saturation concentration. It increases with sinking the temperature of the liquid.
  • the partial pressure of the gas above the liquid By increasing the partial pressure of the gas above the liquid, the liquid-gas mixture becomes supersaturated, but after the partial pressure has been reduced, the excess dissolved gas, which is then no longer soluble, is quickly released.
  • Various methods for introducing bubbles into liquids are known. From DE-3543002-C1, for example, a device for gassing liquids is known, with gas being introduced from a chamber into liquid via an elastic chamber wall which vibrates.
  • a helical flow can be maintained in a reaction vessel if the feedstock is introduced tangentially into the reaction space at one or more points.
  • Such devices are also known under the designation cyclone or centrifugal separator; they serve to separate solid substances from gases or from liquids.
  • DE-C-967943 uses this flow phenomenon for intensive mixing of the reactants when carrying out endothermic chemical reactions.
  • a similar device is known as the Hilsch tube, in which, when gases are blown in, a vortex that is cold on the inside and warm on the outside is created around the axis of the tube. None of these methods are suitable for introducing gas into liquid in a form and quantity desired for the use according to the invention.
  • a method is described in EP-A1-0314015 in which a gas is "bound" in the water, namely beyond the saturation value under the corresponding standard conditions.
  • the gas is introduced into the water via a vortex thread.
  • a container is provided, hereinafter referred to as perturbator * , which is connected via hose lines to a reaction chamber, hereinafter referred to as converter, in a closed circuit, with a liquid-conveying pump being provided in this circuit.
  • the method according to the invention uses the known, vortex-generating mode of operation of a cyclone, combined with additional method steps containing a smooth flow path and, as a result of an uninterrupted, extended, preferably repeated, cycle, the effect is increased to a greater extent, as in the characterizing features of Anspru ⁇ ches 2 or claims 3 or 4 described.
  • Advantageous developments of the method are described in the features of claims 5 and 6.
  • the reaction chamber or the converter of EP-A1-0314015 is only very conditionally suitable for ensuring a uniform, rotating flow movement due to the described shape.
  • the channels leading into the interior of the converter allow an approximately tangential inflow direction.
  • the channels should on the one hand also be guided at an angle towards the closed apex of the converter interior and on the other hand have their outlet openings on the inside still if possible below the largest diameter of the converter interior (seen in relation to the direction of flow) .
  • the special measures consist in the introduction of a gas into a liquid in a multi-part device consisting of vor ⁇ preferably three, partly cyclone-like devices, which are referred to as perturbator 1, spinner 2 and converter 3, with this sub-mixing continuously in the circuit over several Hours, preferably at least 36 hours is operated (Fig.1).
  • Perturbator 1, spinner 2 and converter 3 are connected by means of hose lines 6 to form a closed circuit.
  • the perturbator 1 consists of an approximately pear-shaped container 7 with a volume of 20 liters, for example. Its three-dimensional form can be imagined composed of a hollow spherical cap with a diameter of approx. If this three-dimensional form also proves to be particularly suitable for the course of the process, then good process results are achieved, especially with a different but always funnel-shaped design of the rotary body (e.g. dashed).
  • the pipe extension 21 is preferably inserted obliquely into the wall of the perturbator 1, in such a way that its axis 36 points obliquely from bottom to top by about 15° to the equatorial plane BB of the perturbator 1—preferably below it opening out - is inclined and with: it encloses an angle of about 45° with the plane passing through the axis of rotation 24 and the center point 30 of the tube attachment.
  • the container 7 is filled with a liquid up to a level 9, via a filling opening 10 with an internal diameter of about 30 mm, which sits gas-tight on the upper side of the container 7 and can be shut off in the operating state (see also FIG. 4).
  • a gas inlet 12 which can be shut off by means of a valve 8 and has a clear width of 8 mm, as well as a connection 13 for measuring devices (not shown).
  • a gas space 14 into which gas, for example pure oxygen, was introduced via the gas inlet 12 .
  • the perturbator 1 is connected to the spinner 2 via a hose line 6b, any intermediate units 4 and a hose line 6c which is designed as a cyclone-like mixing device for the liquid-gas mixture. It serves as an auxiliary unit between the perturbator 1 and the converter 3 and is located in front of the pump 5.
  • the spatial shape of the spinner 2 corresponds to a hollow egg, which extends downwards in a funnel shape and opens out via an outflow opening 18 into the hose line 6d to the pump 5 .
  • the feeding hose line 6c opens into the spinner 2 via a pipe part 16, the axis 37 of which opens obliquely from bottom to top at an angle of about 10° to the equatorial plane FF of the spinner 2, if necessary above this, and at an angle of approximately 45° to a plane determined by the axis of symmetry 17 of the spinner 2 and the center point of the inlet opening 31 .
  • the spinner 2 At its equatorial plane FF, the spinner 2 has a diameter which is at least twice the diameter of the supply hose line 6c.
  • the outflow opening 18 of the spinner 2 is connected via a hose line 6d m * t to a preferably magnetically coupled pump 5, which has a minimum output of preferably 25 liters/min for the 20-liter perturbator system.
  • a hose line 6e the cross section of which is approximately 10 to 15 mm smaller than the cross section of all other hose lines, which are dimensioned at 20 mm, to the lower inlet 19 of the converter 3.
  • the "heart" of the converter consists of a preferably egg-shaped hollow body 25 (length approx. 7 cm, diameter approx. 3.5 cm), in whose wall in a plane parallel to the equatorial plane DD of the hollow body 25 several obliquely channels 11 running below open tangentially.
  • the axes of the channels 11 are inclined by preferably 45° relative to the equatorial plane D-D and relative to the axis of symmetry of the hollow body 25 . If the opening ends of the channels 11 in the interior of the hollow body 25 lie below the equatorial plane D-D, an optimal, cyclone-like functioning of the hollow body 25 is guaranteed.
  • This egg-shaped hollow body 25 is introduced into an outer hollow body 39 and connected to it firmly and seamlessly, in such a way that the egg-shaped hollow body 25 is held above the channels 11 in the shape of a ring.
  • This holder 27, which encloses the upper part of the egg-shaped hollow body 25, has a channel-like opening in its center, and thus also in the apex of the egg-shaped hollow body 25.
  • Fig. 1 which consists of a Pertur ⁇ bator 1, a spinner 2 and a converter 3, represents a variant of carrying out the method. If the process is carried out using only one perturbator 1 and one converter 3, as described for example in EP-A1-0314015, the process time is lengthened.
  • one (or more) perturbator(s) 1 can also be provided.
  • the position of the individual devices in relation to one another and in space is not necessarily fixed.
  • the axes 17 and 38 of spinner 2 and converter 3 can be inclined or even horizontal, so that the designation used in the description of "above” and “below” for various parts of the device is only relative with reference to the drawing understand.
  • the perturbator 1, as a liquid-receiving apparatus, must of course be positioned vertically, preferably in such a way that no other part of the device comes to lie above the level determined by the filling height 9 for the liquid.
  • the entire system In the operating state, the entire system, with the exception of the gas space 14, is filled with liquid, in particular water.
  • liquid is conveyed in the direction of the arrows 22, with the tangential inflow of water into the container 7 creating a vortex.
  • the surface of the water In the container 7, the surface of the water is changed from its resting position 9 to the funnel position 23 shown in dashed lines, with oxygen au; the gas space 14 is sucked into the liquid in the form of bubbles and conveyed further in the system according to the arrows 22, or is sucked and pressed.
  • converter 3 which contains cavities 25 and 40 - 1 0 -
  • liquid-gas mixture flows according to the arrows 22, via the channels 11 tangentially into the hollow body 25, a liquid-gas coat rotating on the inner wall is formed there, which reverses at the lower end of the hollow body 25 with increasing rotational speed and whirls along the axis 38 in the form of a rapidly rotating vortex thread against the outlet nozzle 28, where it breaks off into the smallest liquid-gas mixed droplets and, with suitable dimensioning, and a vortex system is formed behind the nozzle edge.
  • the expanded upper hollow body 40 into which the liquid mixture is injected acts as a diffuser.
  • the parts of the liquid-gas mixture should have a maximum diameter of approx. 0.01 ⁇ m here, with suitable dimensioning of all components and a suitably selected pump capacity
  • the gas bubbles are distributed more and more finely as a result of the treatment in the various apparatuses.
  • the resulting mixture is drawn off via an outlet valve 33 arranged in the hose line 6b, for example.
  • the process runs for several hours, preferably at least 36 hours, during which the gas obviously attaches itself to the liquid molecules, or imprints a stable, activated structure on the liquid over a long period of time.
  • the spatial forms of the perturbator 1 described in FIGS. 1 and 2a are possible variants.
  • the one shown in FIG. 2b is characterized by particularly good results.
  • the three-dimensional form composed of two half-hyperboloids, which have the axis of symmetry 24" as the axis of rotation. These hyperboloids are connected to one another without any kinks by a flat, barrel-like center piece.
  • This spatial form variant like that in Fig. 2a shown three-dimensional shape, the advantageous property of assigning an ever smaller diameter to the vortex produced during the process, and thus increasing the rotational speed of the vortex funnel.
  • the container 7 of the perturbator 1 is also possible, which is designed to correspond to an inverted, wide bottle with an approximately funnel-shaped neck.
  • the upper part 7" or 7b is cylindrical, spherical cap, cone-shell or hyperboloid-shaped, the lower part 7' or 7a is cone-shell or hyperboloid-shaped, the corresponding ver ⁇ binding central part 35 is designed in the shape of a barrel or cylinder, then in all these cases it proves to be additionally beneficial to the process if the height h of the lower container part 7' or 7a is as large as possible compared to the radius r of the perturbator container 7 is selected (FIG. 2b)
  • the vortex thread 26, which is important for the process, is then longer and therefore more effective.
  • the method was described using a perturbator 1 with a capacity of about 20 liters. Larger and also smaller embodiments are conceivable, with smaller dimensions (for example for a perturbator 1 holding approximately 5 l) for the converter 3 a variant corresponding to FIG. 3 proving to be advantageous.
  • the channels 11' are not in the wall of the egg-shaped hollow body 25', the wall thickness of which would be too thin for that.
  • the ring-shaped holder 27' is extended downwards in the manner of a ring, so that the channels 11' lie in this ring part. Access to the ducts 11' occurs here via guide ducts 32 which are mounted in the holder 27'.
  • FIG. 4 shows a compact arrangement of the components spinner 2, perturbator 1, converter 3, pump 5 and coil 4 within an equipment cabinet 41, which at the same time assumes the function of the cooling unit.
  • This arrangement which can be designed, for example, as a 20 1, 10 1 or 5 1 system, based on the fluid content, could prove itself when used in doctor's surgeries, therapy centers, sanatoriums, etc.
  • the combination of components shown in FIG. 4 is only one possible example; all other possibilities described above and also below are conceivable.
  • the liquid is filled in via a filling opening 10 which can be closed here with a standard ground cone 43 which has a cock which is closed at the end of the gassing.
  • the filling level 9 for the liquid can be checked via a filling level indicator 42 .
  • a viewing window can simply be provided in the equipment cabinet 41; however, the display is also possible via tubes that communicate with one another, with the connection to the perturbator 1 or the filling vessel being cut off after the filling level 9 has been reached.
  • a gas reservoir 46 is filled from a gas bottle 45 and feeds the system with gas via the gas inlet opening.
  • a plug-in contact 47 is provided for connecting the portable compact device to the mains power supply.
  • the perturbator 1 is fastened in, for example, a ring-shaped holder 43, and the spinner 2 and converter 3 are arranged around the perturbator 1.
  • a manometer 52 should be connected to the connection 13 provided for this purpose, in order to be able to determine any leaks that may occur in the system or functional defects.
  • 5a to 5c show schematic arrangement variants for carrying out the method according to the invention, in which neither a perturbator 1 nor a converter 3 is required. Since this latter component in particular has a relatively complicated structure, its replacement be preferred by simpler and thus cheaper to produce components.
  • the perturbator 1 other devices can be used by means of which gas can be introduced into liquid in a manner known per se. The effectiveness of the gas intake is increased by passing through several spinners 2, through one or more coils 4 and by continuously running through and repeating the same cycle.
  • 5a, b and c show the very wide freedom in the number and choice of components that can be used (for the sake of clarity, cooling units are not shown).
  • a gas introduction device in the form of a vibrator 49 is provided, with gas being introduced into the liquid in a known manner from a gas space via a vibrating membrane provided with fine holes.
  • This arrangement is provided in place of the perturbator. This introduction of gas should take place throughout the process.
  • the liquid-gas mixture flows again and again through the mixing container of the vibrator and there is always the possibility of introducing additional gas into the gas-liquid mixture.
  • a suction device 50 is provided for the gas from a gas reservoir 46a, the mode of operation of which corresponds to the principle of a water jet pump.
  • the device of FIG. 5c contains an atomizer 51, which brings liquid in a very finely nebulized form into the container filled with gas, which is provided instead of the perturbator.
  • the liquid-gas mixture runs through the circuit in the manner described above, but in addition to increasing the effectiveness it can be atomized several times via the atomizing device, which is in the form of a nozzle or a centrifugal atomizer can be formed, are nebulized into the gas atmosphere.
  • a variant of this consists in atomizing the liquid in an atomizer 51 and feeding it gas in a pulsating manner via a pressure wave generator 53 .
  • a fundamentally different way of running the process consists in introducing gas under increased pressure and/or reduced temperature into a liquid, i.e. dissolving it therein, and dissolving this gas-liquid mixture in, for example, one shown in FIG to c or to subject it to a corresponding cycle, the pressure being reduced and/or the temperature being increased step by step, until normal pressure or normal temperature is reached.
  • a pressure vessel would have to be provided, which regulates the pressure in the vessel and thus also in the circuit via compensating valves;
  • the entire circuit should advantageously run in a thermostat-controlled environment (housing).
  • a doctor suffering from advanced thymus carcinoma and being treated with radiotherapy took the oxygen-water reaction product orally. She believed that the usual hangover from radiation, which led to great exhaustion after the radiation, did not occur if she took about 1 dl of the reaction product before the radiation .
  • Dry cornea (keratitis sicca) often occurs in contact lens wearers. Rinsing the cornea with the oxygen-water reaction product or dripping in the reaction product was found to be extremely soothing by 5 test persons. In addition, a large amount of experience material is included volunteer test persons who treated their "tired eyes" with the oxygen-water reaction product (eye bath, instillation with a pipette, spraying with a soft nozzle). The subjective impression of relief was significantly represented.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Inorganic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un produit de réaction entre un gaz et un liquide, le gaz étant présent dans des conditions normales sous une forme activée et dans une quantité qui dépasse d'au moins 30% le niveau de saturation, dans des conditions normales, pour la dissolution du gaz dans le liquide, et qui contient au moins de l'eau et de l'oxygène, est utilisé pour produire un médicament utile pour le traitement thérapeutique et/ou prophylactique de l'herpes zoster, de la gangrène, de la stomatite, des maladies des yeux, du diabète de la maturité, des lésions torpides, des kératites, de la radiotoxémie ou pour le traitement d'accompagnement lors de l'irradiation avec des rayonnements faiblement ionisants. On peut le produire par pompage du liquide ou du mélange de liquide et de gaz dans un circuit fermé et (a) par aspiration du gaz sous forme de bulles minuscules par un tourbillon en entonnoir et par un filet tourbillonnaire formés dans le liquide, de préférence oscillants autour de leur axe de tourbillonnement, et/ou (b) par projection du liquide ou du mélange à travers un ajutage dans l'atmosphère gazeuse et/ou (c) par formation d'un filet tourbillonnaire de mélange de liquide et de gaz à haute énergie de rotation dans l'atmosphère gazeuse. Au moins une des étapes suivantes est en outre mise en ÷uvre : (d) une répétition unique ou multiple d'au moins une des étapes du procédé décrites sous (a), (b) et (c) ; (e) l'écoulement, au moins une fois, à travers un tube hélicoïde ; (f) l'introduction tangentielle, au moins une fois, du mélange de liquide et de gaz dans un mélangeur de type à cyclone rempli du mélange de liquide et de gaz ; (g) l'introduction, au moins une fois, de bulles de gaz dans le liquide (ou le traitement du mélange de liquide et de gaz) au moyen d'un vibrateur et/ou d'un générateur d'ondes de pression.
PCT/EP1990/001651 1990-10-02 1990-10-02 Utilisation du produit de reaction entre un gaz et un liquide, procede et dispositif de production de celui-ci WO1992005792A1 (fr)

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Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999056861A1 (fr) * 1998-04-30 1999-11-11 Hans Wiederkehr Dispositif permettant d'introduire du gaz dans des liquides
CN102413817A (zh) * 2009-04-27 2012-04-11 利发利希奥公司 治疗胰岛素抗性和糖尿病的组合物和方法
US8962700B2 (en) 2006-10-25 2015-02-24 Revalesio Corporation Electrokinetically-altered fluids comprising charge-stabilized gas-containing nanostructures
US8980325B2 (en) 2008-05-01 2015-03-17 Revalesio Corporation Compositions and methods for treating digestive disorders
US9011922B2 (en) 2009-04-27 2015-04-21 Revalesio Corporation Compositions and methods for treating insulin resistance and diabetes mellitus
US9034195B2 (en) 1997-10-24 2015-05-19 Revalesio Corporation Diffuser/emulsifier for aquaculture applications
US9198929B2 (en) 2010-05-07 2015-12-01 Revalesio Corporation Compositions and methods for enhancing physiological performance and recovery time
EP2097107B1 (fr) * 2006-10-25 2016-05-04 Revalesio Corporation Traitement thérapeutique des yeux à l'aide d'une solution enrichie en oxygène
US9492404B2 (en) 2010-08-12 2016-11-15 Revalesio Corporation Compositions and methods for treatment of taupathy
US9512398B2 (en) 2006-10-25 2016-12-06 Revalesio Corporation Ionic aqueous solutions comprising charge-stabilized oxygen-containing nanobubbles
US9523090B2 (en) 2007-10-25 2016-12-20 Revalesio Corporation Compositions and methods for treating inflammation
US9745567B2 (en) 2008-04-28 2017-08-29 Revalesio Corporation Compositions and methods for treating multiple sclerosis
US10125359B2 (en) 2007-10-25 2018-11-13 Revalesio Corporation Compositions and methods for treating inflammation

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DE967943C (de) * 1951-12-31 1958-01-02 Johannes Wotschke Dr Ing Verfahren und Vorrichtung zur Durchfuehrung chemischer und/oder physikalischer Vorgaenge bei hohen Temperaturen
EP0254413A2 (fr) * 1986-06-13 1988-01-27 Yoshiaki Matsuo Eau contenant des ions d'argent et ses applications
EP0263443A2 (fr) * 1986-10-08 1988-04-13 Zugol AG Procédé et dispositif pour produire une émulsion eau-en-huile
EP0279379A1 (fr) * 1987-02-20 1988-08-24 Air Products And Chemicals, Inc. Administration interstitielle d'emulsions de composés perfluorés pour la reoxygénation de cellules cancéreuses hypoxiques
EP0314015A1 (fr) * 1987-10-23 1989-05-03 Tecno-Bio Co., Ltd. Procédé pour introduire et pour lier du gaz dans de l'eau, appareil pour exécuter le procédé et eau obtenue par ce procédé
EP0379765A1 (fr) * 1989-01-27 1990-08-01 Varix Ag Méthode et composition pour promouvoir la santé de la peau

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE967943C (de) * 1951-12-31 1958-01-02 Johannes Wotschke Dr Ing Verfahren und Vorrichtung zur Durchfuehrung chemischer und/oder physikalischer Vorgaenge bei hohen Temperaturen
EP0254413A2 (fr) * 1986-06-13 1988-01-27 Yoshiaki Matsuo Eau contenant des ions d'argent et ses applications
EP0263443A2 (fr) * 1986-10-08 1988-04-13 Zugol AG Procédé et dispositif pour produire une émulsion eau-en-huile
EP0279379A1 (fr) * 1987-02-20 1988-08-24 Air Products And Chemicals, Inc. Administration interstitielle d'emulsions de composés perfluorés pour la reoxygénation de cellules cancéreuses hypoxiques
EP0314015A1 (fr) * 1987-10-23 1989-05-03 Tecno-Bio Co., Ltd. Procédé pour introduire et pour lier du gaz dans de l'eau, appareil pour exécuter le procédé et eau obtenue par ce procédé
EP0379765A1 (fr) * 1989-01-27 1990-08-01 Varix Ag Méthode et composition pour promouvoir la santé de la peau

Cited By (19)

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US9034195B2 (en) 1997-10-24 2015-05-19 Revalesio Corporation Diffuser/emulsifier for aquaculture applications
WO1999056861A1 (fr) * 1998-04-30 1999-11-11 Hans Wiederkehr Dispositif permettant d'introduire du gaz dans des liquides
US8962700B2 (en) 2006-10-25 2015-02-24 Revalesio Corporation Electrokinetically-altered fluids comprising charge-stabilized gas-containing nanostructures
US9512398B2 (en) 2006-10-25 2016-12-06 Revalesio Corporation Ionic aqueous solutions comprising charge-stabilized oxygen-containing nanobubbles
US9511333B2 (en) 2006-10-25 2016-12-06 Revalesio Corporation Ionic aqueous solutions comprising charge-stabilized oxygen-containing nanobubbles
US9402803B2 (en) 2006-10-25 2016-08-02 Revalesio Corporation Methods of wound care and treatment
US9004743B2 (en) 2006-10-25 2015-04-14 Revalesio Corporation Mixing device for creating an output mixture by mixing a first material and a second material
EP2097107B1 (fr) * 2006-10-25 2016-05-04 Revalesio Corporation Traitement thérapeutique des yeux à l'aide d'une solution enrichie en oxygène
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CN102413817A (zh) * 2009-04-27 2012-04-11 利发利希奥公司 治疗胰岛素抗性和糖尿病的组合物和方法
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EP2424507A4 (fr) * 2009-04-27 2012-10-24 Revalesio Corp Compositions et procédés pour le traitement de la résistance à l'insuline et du diabète
CN102413817B (zh) * 2009-04-27 2014-12-17 利发利希奥公司 治疗胰岛素抗性和糖尿病的组合物和方法
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