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WO1992005425A1 - Procede et moyen pour retirer un liquide d'une cuve - Google Patents

Procede et moyen pour retirer un liquide d'une cuve Download PDF

Info

Publication number
WO1992005425A1
WO1992005425A1 PCT/FI1991/000286 FI9100286W WO9205425A1 WO 1992005425 A1 WO1992005425 A1 WO 1992005425A1 FI 9100286 W FI9100286 W FI 9100286W WO 9205425 A1 WO9205425 A1 WO 9205425A1
Authority
WO
WIPO (PCT)
Prior art keywords
cuvette
transfer tube
liquid
matrix
guide
Prior art date
Application number
PCT/FI1991/000286
Other languages
English (en)
Inventor
Osmo Suovaniemi
Original Assignee
Biohit Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biohit Oy filed Critical Biohit Oy
Publication of WO1992005425A1 publication Critical patent/WO1992005425A1/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/11—Filling or emptying of cuvettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L13/00—Cleaning or rinsing apparatus
    • B01L13/02—Cleaning or rinsing apparatus for receptacle or instruments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates

Definitions

  • the present invention concerns a procedure as defined in the preamble to claim 1. Furthermore, the invention concerns a means as defined in the preamble to claim 8.
  • procedures_ and means are known for removing liquid from a cuvette, e.g. a liquid fill ⁇ ing, a washing and/or flushing liquid.
  • the cuvette com- prises a wall and a bottom. Determination of the liquid sample in the cuvette is made optically, through the liquid and the cuvette bottom.
  • a transfer tube may be used, first, to introduce the liquid in the cuvette, and to draw it out from the cuvette.
  • An operating means moves the transfer tube into the cuvette and out there ⁇ from.
  • Such procedures and means are also known in which for achieving maximum possible liquid removal capacity the end of the transfer tube is curved, as for instance in certain microtitre plate washing apparatus of prior art.
  • An elastic transfer tube tip e.g. Auto-ETA; Lab- systems Oy
  • a specially shaped, multiple-aperture transfer tube tip have also been used.
  • liquid quantity left in the cuvette may vary between emptyings and between cuvettes.
  • the object of the invention is to eliminate the drawbacks mentioned and the inaccuracies which they introduce in apparatus and methods.
  • the cuvette used for reaction vessel may for instance be a well of a so-called microtitre plate.
  • the procedure of the invention is character ⁇ ized by that which is stated in Claim 1.
  • the means of the invention is characterized by that which is stated in Claim 8.
  • the cuvette is inclined with reference to the horizon ⁇ tal plane at an angle, the end of the transfer tube is lowered into the inclined cuvette and/or the cuvette which is being tilted, in the corner between wall and bottom, where the liquid has accumulated, and the li ⁇ quid is drawn from the cuvette with the aid of the transfer tube.
  • the angle of inclination of the cuvette is from 10 to 70°, advan- tageously from 20 to 30°.
  • the cuvette matrix is a so-called microtitre plate.
  • the end of the transfer tube is curved and the transfer tube is lowered into the cuvette substantially at right angles against the plane of the bottom.
  • the trans ⁇ fer tube is lowered into the cuvette at an angle rela ⁇ tive to the central axis of the cuvette.
  • the washing and/or flushing liquid is introduced in the cuvette, and drawn off, by means of one and the same transfer tube.
  • the means compris- es a swivelling means for inclining the cuvette at an angle relative to the horizontal plane.
  • the swivelling means has been arranged to incline the cuvette at an angle of inclination which is from 10 to 70° , advan- tageously from 20 to 30°.
  • the swivelling means comprises a substantially stationary frame; a supporting member for supporting the cuvette or cuvette matrix, this supporting member being carried turnably relative to the frame into an inclined position from the horizontal plane; and a force means which has been disposed to incline said supporting member.
  • the swivelling means comprises a form which is by one edge pivotally attached to the frame to be turnable; a first guide on which the supporting member is carried movably relative to the form; a first transit means arranged to move the supporting member, and by its mediation the cuvette matrix, in the direction of the first guide; a second guide, attached to the form and which is substantially perpendicular against the first guide, and carried on which the first guide is arranged to be movable; a sec ⁇ ond transit means, arranged to move the first guide, and by its mediation the cuvette matrix, in the direc- tion of the second guide; and a carrying arm, attached to the form and on which the transfer tube has been disposed to be movable substantially at right angles against the plane of the cuvette bottom, whereby each individual cuvette of the cuvette matrix can be placed in register with the transfer tube for washing, flush ⁇ ing and/or emptying. It is equally possible that, in case the cuvettes form a cuvette matrix, there is a plurality
  • the advantage gained with the invention is that the cuvette can be emptied of liquid substantially completely in practice.
  • FIG. 1 presents, in elevational view and part- ly sectioned, an embodiment of the means of the inven ⁇ tion, and
  • Fig. 2 presents the means of Fig. I, at a cer ⁇ tain stage in the procedure of the invention.
  • Fig. 1 is depicted a means for removing liquid, e.g. a liquid sample or a washing and/or flush ⁇ ing liquid, from a cuvette 1.
  • a cuvette 1 There is a plurality of cuvettes 1, side by side, and in aggregate they consti ⁇ tute a cuvette matrix 6.
  • Each cuvette 1 is cup-like and comprises a wall 2 and a bottom 3.
  • the means comprises a transfer tube 4, by which washing and flushing liquid can be introduced, as well as removed from the cuvette.
  • the means further comprises an operating means 7, by which the transfer tube 4 is moved into and out from the cuvette.
  • the means includes a swivelling means 8 by which the cuvette matrix 6 can be inclined relative to the horizontal plane to be positioned at a suitable angle ⁇ .
  • the swivelling means 8 is disposed to tilt the cuvette matrix 1 to an angle of inclination which is advantageously 20 to 30°.
  • the cuvette matrix 6, a so-called microtitre plate in this instance, is carried by a supporting mem- ber 10.
  • the supporting member 10 is a thermocassette in this instance.
  • the swivelling means 8 comprises a form 12, pivotally attached on its edge with a pivot axle 18 to the frame 9, to be swivellable.
  • the means comprises a first guide 13, on which the thermocassette 10 is carried to be movable relative to the form 12.
  • a first transit means 14 is disposed to move the thermocassette 10, and by its mediation the microtitre plate 6, in the direction of the first guide.
  • a second guide 15 which is perpendicular against the first guide 13 and perpendicular against the plane of the drawing, and on which the firs guide 14 is arranged to be movable.
  • a second transit means 16 moves the first guide 13, and by its mediation the microtitre plate 6, in the direction of the second guide 15.
  • the transit means 14 and 16 may include, for instance, an electrically operated motion screw/motion nut drive.
  • a carrier arm 17 is affixed to the form 12, and the transfer tube 4 is carried movably on the carrier arm 17, substantially at right angles against the plane of the bottom 3 of the cuvette 1.
  • Fig. 2 illustrates the way in which, according to the procedure, the microtitre plate 6, mounted on the supporting member 10 of the form 12 of the swiv ⁇ elling means 8, is inclined by means of a force means 11 relative to the horizontal plane at a given angle , which is advantageously between 20 and 30 c .
  • the force means 11 acts on one edge of the form 12, and the opposite edge of the form is pivotally attached to the frame 9.
  • the force means 11 may be any appropriate kind of force means known in the art, and it may be operated with pressurized fluid or electro-mechanic, such as e.g. an electrically operated motion screw/motion nut assembly.
  • the curved tip end 19 of the transfer tube 4 is lowered with the aid of the operating means 7 into the inclined and/or tilting cuvette, to go into the lowermost corner 5 between the wall 2 and the bottom 3, i.e., to that part of the interior volume of the cuvette 1 where the liquid has collected. Subsequently, a vacuum is produced in the transfer tube 4, and the liquid is drawn out from the cuvette 1 with the aid and mediation of the transfer tube 4. Since the cuvette 1 should be inclined expressly at the time when the liquid present therein is exhausted, the tip 19 of the transfer tube 4 may be lowered into the cuvette 1, and removal suction commenced, already before the most favourable inclination has been reached, for instance while the cuvette is still in the horizontal position of Fig. 1, or during the tilting motion.
  • microtitre plate 6 can be moved, with the aid of the transit means 14 and 16 and of the guides 13 and 15, in two dimensions in a plane which is perpen ⁇ dicular against the plane of drawing in Fig. 2, whereby each individual cuvette 1 can be placed in register with the transfer tube 4 for washing, flushing and/or emptying.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

Procédé et moyen pour retirer un liquide, par exemple un échantillon liquide, ou un liquide de lavage et/ou de rin¢age, d'une cuve (1) comprenant une paroi (2) et un fond(3). Selon ce procédé, le liquide est aspiré de la cuve à l'aide d'un tube de transfert (4) faisant partie du moyen, ledit tube de transfert (4) étant déplacé par un moyen de commande (7) vers ou depuis l'intérieur de la cuve (1) à un angle (α), par rapport à l'horizontale. Selon le procédé, on incline la cuve (1) à un angle (α) par rapport à l'horizontale, on introduit l'extrémité du tube de transfert (4) à l'intérieur de la cuve inclinée, dans la partie formant un coin (5) entre la paroi (2) et le fond (3), là où le liquide s'est déposé, et on aspire le liquide de la cuve à l'aide du tube de transfert.
PCT/FI1991/000286 1990-09-20 1991-09-20 Procede et moyen pour retirer un liquide d'une cuve WO1992005425A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI904639 1990-09-20
FI904639A FI904639L (fi) 1990-09-20 1990-09-20 Foerfarande och anordning foer avlaegsnande av vaetska fraon kyvett.

Publications (1)

Publication Number Publication Date
WO1992005425A1 true WO1992005425A1 (fr) 1992-04-02

Family

ID=8531093

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FI1991/000286 WO1992005425A1 (fr) 1990-09-20 1991-09-20 Procede et moyen pour retirer un liquide d'une cuve

Country Status (2)

Country Link
FI (1) FI904639L (fr)
WO (1) WO1992005425A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1093756A3 (fr) * 1999-10-18 2002-03-20 Matsushita Electric Industrial Co., Ltd. Cellule échantillon et dispositif de mesure de la concentration d'une solution et procèdé d'analyse d'urine utilisant ce dispositif.
CN112424603A (zh) * 2018-07-13 2021-02-26 迈恩医疗解决方案有限公司 用于执行非均相免疫测定的方法和设备
WO2025003087A1 (fr) * 2023-06-26 2025-01-02 Radiometer Medical Aps Appareil de mesure d'une quantité d'analyte dans un échantillon biologique

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3501242A (en) * 1967-11-06 1970-03-17 Perkin Elmer Corp Pivoting sample cell holder
US4566203A (en) * 1981-09-28 1986-01-28 Miles Laboratories, Inc. Apparatus and method useful for removing liquid from the outer surface of cylindrical pipette tube or the like
WO1989004955A1 (fr) * 1987-11-20 1989-06-01 Technicon Instruments Corporation Procede et appareil pour echantillonnage par tubes combines ferme et ouvert
WO1990011831A1 (fr) * 1987-11-17 1990-10-18 Prolic S.A. Dispositif de nettoyage pour cuvettes
AT392363B (de) * 1987-07-06 1991-03-25 Avl Verbrennungskraft Messtech Eingabevorrichtung zum einbringen fluessiger oder gasfoermiger medien

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3501242A (en) * 1967-11-06 1970-03-17 Perkin Elmer Corp Pivoting sample cell holder
US4566203A (en) * 1981-09-28 1986-01-28 Miles Laboratories, Inc. Apparatus and method useful for removing liquid from the outer surface of cylindrical pipette tube or the like
AT392363B (de) * 1987-07-06 1991-03-25 Avl Verbrennungskraft Messtech Eingabevorrichtung zum einbringen fluessiger oder gasfoermiger medien
WO1990011831A1 (fr) * 1987-11-17 1990-10-18 Prolic S.A. Dispositif de nettoyage pour cuvettes
WO1989004955A1 (fr) * 1987-11-20 1989-06-01 Technicon Instruments Corporation Procede et appareil pour echantillonnage par tubes combines ferme et ouvert

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1093756A3 (fr) * 1999-10-18 2002-03-20 Matsushita Electric Industrial Co., Ltd. Cellule échantillon et dispositif de mesure de la concentration d'une solution et procèdé d'analyse d'urine utilisant ce dispositif.
CN112424603A (zh) * 2018-07-13 2021-02-26 迈恩医疗解决方案有限公司 用于执行非均相免疫测定的方法和设备
WO2025003087A1 (fr) * 2023-06-26 2025-01-02 Radiometer Medical Aps Appareil de mesure d'une quantité d'analyte dans un échantillon biologique

Also Published As

Publication number Publication date
FI904639L (fi) 1992-03-21
FI904639A0 (fi) 1990-09-20

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