WO1992005415A1 - Indicateur de temperature-temps - Google Patents
Indicateur de temperature-temps Download PDFInfo
- Publication number
- WO1992005415A1 WO1992005415A1 PCT/GB1991/001538 GB9101538W WO9205415A1 WO 1992005415 A1 WO1992005415 A1 WO 1992005415A1 GB 9101538 W GB9101538 W GB 9101538W WO 9205415 A1 WO9205415 A1 WO 9205415A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- substrate
- enzyme
- indicator according
- reaction
- label
- Prior art date
Links
- 239000000758 substrate Substances 0.000 claims abstract description 30
- 102000004190 Enzymes Human genes 0.000 claims abstract description 27
- 108090000790 Enzymes Proteins 0.000 claims abstract description 27
- 239000007795 chemical reaction product Substances 0.000 claims abstract description 9
- 238000006243 chemical reaction Methods 0.000 claims description 11
- 238000006911 enzymatic reaction Methods 0.000 claims description 8
- 239000000853 adhesive Substances 0.000 claims description 5
- 230000001070 adhesive effect Effects 0.000 claims description 5
- 238000007641 inkjet printing Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims description 2
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims description 2
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 claims 1
- 239000000047 product Substances 0.000 abstract description 12
- 230000000750 progressive effect Effects 0.000 abstract 1
- 235000013305 food Nutrition 0.000 description 6
- 238000004040 coloring Methods 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000007639 printing Methods 0.000 description 3
- BTJIUGUIPKRLHP-UHFFFAOYSA-N 4-nitrophenol Chemical compound OC1=CC=C([N+]([O-])=O)C=C1 BTJIUGUIPKRLHP-UHFFFAOYSA-N 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 235000013611 frozen food Nutrition 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000005022 packaging material Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- ZVKNWKGWWVXHCU-UHFFFAOYSA-N 4,4-dinitro-2-phenylcyclohexa-1,5-dien-1-ol Chemical compound C1C([N+]([O-])=O)([N+]([O-])=O)C=CC(O)=C1C1=CC=CC=C1 ZVKNWKGWWVXHCU-UHFFFAOYSA-N 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 238000003475 lamination Methods 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000001139 pH measurement Methods 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010408 sweeping Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
- G01K3/00—Thermometers giving results other than momentary value of temperature
- G01K3/02—Thermometers giving results other than momentary value of temperature giving means values; giving integrated values
- G01K3/04—Thermometers giving results other than momentary value of temperature giving means values; giving integrated values in respect of time
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
- C12Q2334/10—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases p-Nitrophenol derivatives
Definitions
- This invention concerns time temperature indication and relates to a time temperature indicator, more especially for chilled or frozen foods.
- the invention also relates to a label incorporating such an indicator, and a method of time temperature indication.
- a time temperature indicator is a device for indicating temperature conditions with respect to time. In the case of chilled or frozen food products, for example, it is important to be able to establish if a product has been subject to proper temperature conditions over a period of time, since this determines the shelf life of the product.
- One time temperature indicator is known from U.K. Specification No. 1366797.
- the principle of this indicator is an enzyme catalysed reaction. Enzyme catalysed reaction rates are affected by a number of parameters, but given a standard chemical environment, the major parameter is temperature. Enzymes have an optimum temperature range at which they operate, and below that range reaction rates are considerably slowed.
- the relationship between temperature and reaction rate may be plotted and enzymes selected for which the relationship of reaction rate to temperature over the temperature range of 4-20 C is linear. This is the expected temperature range for chilled food products. If however an enzyme system were selected where the relationship between temperature and reaction rate is non-linear, it is possible to make allowances for this within the system.
- the disadvantage of the indicating system known from the above specification is that the enzyme catalysed reaction produces a change in pH which then requires a second reaction to indicate the pH change which has occurred.
- a time temperature indicator is provided which is based on by an enzyme catalysed reaction in which the enzyme catalyses reaction of a substrate to produce directly a differently coloured reaction product.
- the invention provides a time temperature indicator, characterised by a substrate and an enzyme which catalyses reaction of the substrate to produce directly a reaction product of different colour to the substrate.
- the enzyme catalysed reaction is chosen such that it fulfils one of the following conditions:-
- the substrate is either colourless or possesses a pale colour, whilst the product of the reaction is strongly coloured.
- the substrate is strongly coloured, and the reaction product is pale or colourless.
- p-nitrophenol is normally colourless, but has a strong yellow colour under alkaline conditions.
- the enzyme is conveniently provided in association with the substrate at a range of concentrations, such that the rate of colour change varies only with time given a constant temperature.
- the principal advantage of the invention over the known indicator system, which uses lipase to degrade a lipid and then measures the resulting.pH change, is that it gives a direct reading, not affected by the variability and relative insensitivity of pH measurement.
- Another advantage inherent in the invention is that, provided a suitable enzyme and substrate system is selected, it is possible to have a fully food compatible system such that all reagents are natural food products and no food contamination problems exist.
- Still another advantage is that, given a suitable carrier system for the enzyme and substrate systems, they may be directly incorporated into a package and are therefore not removable for tampering purposes. They may, however, be produced in an adhesive label format if required.
- non-impact printing technology specifically ink jet printing
- ink jet printing to lay down the enzyme component in a label
- the label may have any format that is required, due to the flexibilty of the production process.
- the following physical formats of the label may be produced:
- a self adhesive paper label where the paper is impregnated with the enzyme substrate, and then the enzyme solution applied to the label using one of a variety of printing techniques to give a single layer label with the required graphics.
- the finished labels may then be stored frozen until applied to a food package.
- a paper label containing the enzyme substrate may be laminated on to the product package, during the production process, and then overprinted with the enzyme solution prior to the package entering a chill tunnel.
- the enzyme substrate may be directly incorporated into an ink formulation, such that it constitutes a label directly printed on to the packaging material.
- the enzyme solution may then be overprinted on to the substrate patch at a convenient later time, using a second ink formulation.
- This format has the specific advantage that it is integral"with the packaging material, and so cannot be removed from the food package, possibly to be tampered with. It is desirable to ensure that the labelling sets in a permeable and water proof fashion on curing.
- the graphics format of the label is also extremely adaptable because of the use of ink jet printing.
- Preferred formats are:
- a blush label Using grey scale printing technology and a carefully selected substrate which allows limited wicking, it is possible to produce a label such that colour change runs up the label with time. The colour therefore appears to "blush” up the label. Thus, the distance the colour front " has advanced up the label can be used to quantify how much of the total time/temperature history has been used.
- Another advantage of this format is that it can be utilised to run into the bar code on the package, thus interfering with scanning equipment, so that out of date articles will not pass through a check out scanner.
- a clock format This is a circular format where colour change develops like the sweeping action of a clock hand. This format can if desired be quantified to show the percentage of shelf life remaining.
- the invention provides a method of time temperature indication, characterised by use of an enzyme substrate to produce directly a reaction product of different colour to the substrate, and monitoring change of colour of the substrate with time.
- the illustrated embodiments each comprise a label impregnated with p-nitrophenol and carrying a layer of alkaline phosphatase laid down, eg by ink jet printing, in a pattern of varying concentration.
- Figures 1 to 3 show three examples of blush label, with enzyme concentration increasingly progressively from left to right.
- colouring progresses from left to right to indicate the days of shelf life remaining, assuming the product is stored at 4°C.
- the label of Figure 2 is used to indicate acceptance criteria for the product, at the stages of manufacture, distribution and offer for sale.
- Figure 3 shows a label marked to show the percentage of remaining shelf life, again as colouring progresses from left to right in accordance with time/temperature conditions of storage.
- a printed message appears at the end of shelf life, whilst in the label of Figure 5 a coloured window appears at the end of shelf-life.
- Figure 6 shows a label having a clock format, wherein enzyme concentration increases progressively around the clock and colouring progresses around the clock to indicate usable product life as a percentage of its full life.
- Colouring may commence, for example, approximately in the five o'clock position, for example, so that in the illustration, when this colouring has extended clockwise to beyond the seven o'clock position, nearly 25% of the product life has been used up, depending on the time for which the product has been stored since manufacture and the temperature conditions which have prevailed during that time period.
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- General Physics & Mathematics (AREA)
- Measuring Temperature Or Quantity Of Heat (AREA)
Abstract
Indicateur de température-temps, servant à indiquer notamment la durée de vie d'un produit, dans lequel une étiquette, directement incorporée dans ou appliquée à un emballage, porte un substrat qui est catalysé par une enzyme appliquée en un concentration progressive pour obtenir directement un produit de réaction de couleurs différentes, et dont le développement progresse le long ou autour de l'étiquette en fonction des conditions de temps et de température.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909020364A GB9020364D0 (en) | 1990-09-18 | 1990-09-18 | Time temperature indicator |
GB9020364.7 | 1990-09-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1992005415A1 true WO1992005415A1 (fr) | 1992-04-02 |
Family
ID=10682381
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1991/001538 WO1992005415A1 (fr) | 1990-09-18 | 1991-09-10 | Indicateur de temperature-temps |
Country Status (2)
Country | Link |
---|---|
GB (1) | GB9020364D0 (fr) |
WO (1) | WO1992005415A1 (fr) |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2714474A1 (fr) * | 1993-12-23 | 1995-06-30 | Marconi Gec Ltd | Procédé, composition et combinaison de marquage enzymatique, et trousse de test et substance marquée correspondantes. |
WO2001025472A1 (fr) * | 1999-10-05 | 2001-04-12 | Bioett Ab | Biocapteur et son utilisation indiquant l'etat d'un produit |
WO2006015961A3 (fr) * | 2004-08-11 | 2006-06-01 | Ciba Sc Holding Ag | Indicateur de température dans le temps à base d’enzyme |
GB2435632A (en) * | 2006-03-03 | 2007-09-05 | Canon Europa Nv | Manufacturing an environmentally sensitive label |
US7287001B1 (en) * | 1995-07-31 | 2007-10-23 | Ipms, Inc. | Electronic product information display system |
US7294379B2 (en) | 2002-03-07 | 2007-11-13 | Avery Dennison Corporation | Color changing device for time indicating label and methods of making and using the same |
DE102007056915A1 (de) * | 2007-11-27 | 2009-05-28 | Bizerba Gmbh & Co. Kg | Drucker und Verfahren zur Warenkennzeichnung |
WO2009040547A3 (fr) * | 2007-09-26 | 2009-09-11 | Intray Limited | Dispositif d'indicateur de temps |
EP2333505A1 (fr) * | 2009-12-08 | 2011-06-15 | Basf Se | Composition et procédé de surveillance de la température de produits réfrigérés et congelés |
CN102175677A (zh) * | 2011-01-20 | 2011-09-07 | 江南大学 | 基于脂肪酶反应扩散的时间温度指示器的制备方法和应用 |
CN102495052A (zh) * | 2011-12-02 | 2012-06-13 | 江南大学 | 糖化酶型时间-温度指示器 |
WO2013050846A2 (fr) | 2011-10-04 | 2013-04-11 | Sanko Tekstil Isletmeleri Sanayi Ve Ticaret A.S. | Étiquette intelligente indiquant une température et procédé associé |
US9367851B2 (en) | 2009-09-17 | 2016-06-14 | Information Planning & Management Service, Inc. | System and method for managing compliance with retail display regulations across a plurality of jurisdictions |
WO2017103206A1 (fr) * | 2015-12-17 | 2017-06-22 | Keep-It Technologies As | Système indicateur de temps-température imprimable |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0132830A2 (fr) * | 1983-07-25 | 1985-02-13 | EASTMAN KODAK COMPANY (a New Jersey corporation) | Elément analytique sec pour l'essai de phosphatase alcaline |
EP0310014A2 (fr) * | 1987-09-30 | 1989-04-05 | BEHRINGWERKE Aktiengesellschaft | Substrat chromogène |
US4826762A (en) * | 1987-10-23 | 1989-05-02 | Massachusetts Industry Of Technology | Enzymatic temperature change indicator |
-
1990
- 1990-09-18 GB GB909020364A patent/GB9020364D0/en active Pending
-
1991
- 1991-09-10 WO PCT/GB1991/001538 patent/WO1992005415A1/fr active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0132830A2 (fr) * | 1983-07-25 | 1985-02-13 | EASTMAN KODAK COMPANY (a New Jersey corporation) | Elément analytique sec pour l'essai de phosphatase alcaline |
EP0310014A2 (fr) * | 1987-09-30 | 1989-04-05 | BEHRINGWERKE Aktiengesellschaft | Substrat chromogène |
US4826762A (en) * | 1987-10-23 | 1989-05-02 | Massachusetts Industry Of Technology | Enzymatic temperature change indicator |
Cited By (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2714474A1 (fr) * | 1993-12-23 | 1995-06-30 | Marconi Gec Ltd | Procédé, composition et combinaison de marquage enzymatique, et trousse de test et substance marquée correspondantes. |
US8910864B2 (en) | 1995-07-31 | 2014-12-16 | Information Planning & Management Service, Inc. | Electronic product information display system |
US7287001B1 (en) * | 1995-07-31 | 2007-10-23 | Ipms, Inc. | Electronic product information display system |
RU2266333C2 (ru) * | 1999-10-05 | 2005-12-20 | Биоэтт Аб | Биологический сенсор для индикации изменения состояния продукта, метка и способ индикации изменения состояния продуктов |
WO2001025472A1 (fr) * | 1999-10-05 | 2001-04-12 | Bioett Ab | Biocapteur et son utilisation indiquant l'etat d'un produit |
US6642016B1 (en) | 1999-10-05 | 2003-11-04 | Bioett Ab | Biosensor and its use to indicate the status of a product |
US7294379B2 (en) | 2002-03-07 | 2007-11-13 | Avery Dennison Corporation | Color changing device for time indicating label and methods of making and using the same |
US7736866B2 (en) | 2004-08-11 | 2010-06-15 | Ciba Corporation | Enzyme-based time temperature indicator |
WO2006015961A3 (fr) * | 2004-08-11 | 2006-06-01 | Ciba Sc Holding Ag | Indicateur de température dans le temps à base d’enzyme |
GB2435632A (en) * | 2006-03-03 | 2007-09-05 | Canon Europa Nv | Manufacturing an environmentally sensitive label |
WO2009040547A3 (fr) * | 2007-09-26 | 2009-09-11 | Intray Limited | Dispositif d'indicateur de temps |
US8104949B2 (en) | 2007-09-26 | 2012-01-31 | Intray Limited | Time indicator device |
DE102007056915A1 (de) * | 2007-11-27 | 2009-05-28 | Bizerba Gmbh & Co. Kg | Drucker und Verfahren zur Warenkennzeichnung |
US9367851B2 (en) | 2009-09-17 | 2016-06-14 | Information Planning & Management Service, Inc. | System and method for managing compliance with retail display regulations across a plurality of jurisdictions |
US11715115B2 (en) | 2009-09-17 | 2023-08-01 | Information Planning & Management Service Inc. | System and method for managing compliance with retail display regulations across a plurality of jurisdictions |
US10699279B2 (en) | 2009-09-17 | 2020-06-30 | Information Planning And Management Service Inc. | System and method for managing compliance with retail display regulations across a plurality of jurisdictions |
EP2333505A1 (fr) * | 2009-12-08 | 2011-06-15 | Basf Se | Composition et procédé de surveillance de la température de produits réfrigérés et congelés |
WO2011070491A1 (fr) * | 2009-12-08 | 2011-06-16 | Basf Se | Composition et procédé permettant de contrôler la température de produits réfrigérés et congelés |
CN102175677A (zh) * | 2011-01-20 | 2011-09-07 | 江南大学 | 基于脂肪酶反应扩散的时间温度指示器的制备方法和应用 |
US8695528B2 (en) | 2011-10-04 | 2014-04-15 | Sanko Tekstil Isletmeleri Sanayi Ve Ticaret A.S. | Intelligent temperature indicator label and method |
WO2013050846A2 (fr) | 2011-10-04 | 2013-04-11 | Sanko Tekstil Isletmeleri Sanayi Ve Ticaret A.S. | Étiquette intelligente indiquant une température et procédé associé |
CN102495052A (zh) * | 2011-12-02 | 2012-06-13 | 江南大学 | 糖化酶型时间-温度指示器 |
WO2017103206A1 (fr) * | 2015-12-17 | 2017-06-22 | Keep-It Technologies As | Système indicateur de temps-température imprimable |
US10859546B2 (en) | 2015-12-17 | 2020-12-08 | Keep-It Technologies As | Printable time-temperature indicator system |
Also Published As
Publication number | Publication date |
---|---|
GB9020364D0 (en) | 1990-10-31 |
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