+

WO1992005449A1 - Dispositif pour la mesure simultanee de differents parametres physiques et chimiques d'un liquide - Google Patents

Dispositif pour la mesure simultanee de differents parametres physiques et chimiques d'un liquide Download PDF

Info

Publication number
WO1992005449A1
WO1992005449A1 PCT/EP1991/001755 EP9101755W WO9205449A1 WO 1992005449 A1 WO1992005449 A1 WO 1992005449A1 EP 9101755 W EP9101755 W EP 9101755W WO 9205449 A1 WO9205449 A1 WO 9205449A1
Authority
WO
WIPO (PCT)
Prior art keywords
measuring
liquid
line
channel
unit
Prior art date
Application number
PCT/EP1991/001755
Other languages
German (de)
English (en)
Inventor
Joachim Hermann Lehner
Original Assignee
Joachim Hermann Lehner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Joachim Hermann Lehner filed Critical Joachim Hermann Lehner
Publication of WO1992005449A1 publication Critical patent/WO1992005449A1/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/492—Determining multiple analytes

Definitions

  • the invention relates to a device for the simultaneous determination of several physical and chemical parameters of inorganic, organic or biological solutions or liquids, from a technical or biological process for the required or periodic monitoring of the change over time of these parameters and to a measurement method to be carried out therewith .
  • Such parameters are e.g. the pH value, the electrical conductivity, temperature, pressure, concentrations of dissolved substances, etc.
  • the device is particularly suitable for determining the parameters of body fluids - in particular blood.
  • the measuring system is suitable for both in vitro and in vivo applications.
  • measuring liquid The determination of the physical and chemical parameters of solutions and liquids (hereinafter referred to as measuring liquid) can be carried out separately for each parameter using known measuring methods.
  • DE-A-22 12 801 describes a device for analyzing a liquid or gas sample and a flow cell therefor.
  • This device is characterized by a very complicated mechanism for introducing the measuring liquid from a sample container, in particular from an injection syringe, into the sample channel containing the measuring electrodes.
  • three electrodes are attached within the sample channel together with a single reference electrode, which allows the simultaneous measurement of three parameters, preferably the pH value PO and PCO value
  • Allow 2 2 of the measuring liquid The entire measuring process is divided into four sub-processes “sampling”, “measurement”, “rinsing” and “calibration” by means of various switching states of liquid connection, calibration and rinsing lines with respect to the actual measuring line.
  • US Pat. No. 3,88,640 describes an analysis device for determining at least two parameters, for example pH value, partial pressure of dissolved gases, concentration of inorganic ions, hemoglobin concentration or temperature of a measuring liquid.
  • the above-mentioned parameters are measured electrochemically by electrodes which are independent of one another and which are arranged within a flow channel.
  • the flow channel is both with internals for generating a turbulent flow as well as provided with a heat exchange device to enable efficient measurement and a good flushing of the flow channel with a small flow volume.
  • measuring liquid takes place from storage containers provided for this purpose and is controlled automatically.
  • the device is constructed from two modules, one module containing the electronic data processing and control unit, while the second module contains a sample flow unit with sample inlet valve 1, which is connected to two reagent containers via a connection line ⁇ le, which contains the measuring electrodes and with a second rotary valve, which communicates with a pump and via connecting lines with the container with a boundary fluid and the ejection container.
  • the second module is designed as a single article, with which several samples can be measured in succession, and encapsulates all the additional reagents required for the measurement.
  • the second module is replaced as a whole and disposed of.
  • US-A-3,763,422 describes a method and a device for the electrochemical analysis of a small amount of blood, which is transferred from a sample container into the measuring chamber of the analysis device, in which the pH is PCO and PO value
  • the device contains a measuring chamber, a pH electrode with a reference electrode, a PCO and PO electrode, a perestal ti seh ar-
  • a subset of the above Analysis devices are devices in which the measuring chambers are arranged in modules which can be combined with one another. This enables the device to be adapted to changing monitoring tasks.
  • an analysis device for simultaneously carrying out several tests on at least one liquid sample.
  • the analyzer consists of a plurality of measuring cells which can be connected in series, each measuring cell having an examination chamber with a measuring probe, an inlet and an outlet channel for the liquid sample to be examined in the examination chamber, the outlet channel of the one measuring cell with the inlet channel, which in the next measuring cell is connectable.
  • each measuring cell has two sample channels separated from the examination chamber and the inlet and outlet channels, one end of which protrudes from the measuring cell for the inflow or outflow of a sample and the other end of which can be connected to the inlet or outlet channel of a neighboring cell, that in addition to the series connection, all successive measuring cells can also be divided into two or more independent measuring sections.
  • DE-A-38 18 148 discloses an analysis device for examining body fluids with a loading device, a measuring section formed by a measuring chamber connected via a channel and a disposal device for removing the analyzed samples.
  • the measuring section is wholly or partly constructed from modules which can also be coupled directly to the loading device and the disposal device via a separate control block. In this way, an analysis device can be expanded simply and inexpensively in accordance with the analysis task at hand.
  • the analysis devices described so far work according to electrochemical measuring methods.
  • systems are also known in which an enzyme reaction, which can be carried out in the device in a reaction space provided for this purpose, is used to determine concentrations, especially of bio-chemical compounds.
  • the measurement can also be carried out again using selective electrodes or spectroscopically if indicators are additionally used.
  • DE-A-32 26 552 describes an electrochemical cell with two electrodes of identical construction, which are ion-selective for the same type of ion or can be gas-selective for the same type of gas, one of which is used as a measuring electrode and the other as a reference electrode is described.
  • the cell has two separate internal flow paths through which liquid substance can be passed, part of the substance to be measured being connected to a reaction chamber and the measuring electrode and part of the substance only being connected to the reference electrode stands.
  • a chemical reaction is carried out in the reaction chamber, the course of which can be followed on the basis of the potential difference between the measuring and reference electrodes.
  • US-A-4,680,270 relates to a method and apparatus for performing blood analysis in a flow system.
  • the blood sample is introduced into a switching valve and a first flow channel by a perestal pump via a sampler without being diluted. A tube of a certain volume is thereby filled within the switching valve.
  • the switching valve is actuated, a reaction solution containing enzymes being passed into the tube of a certain volume within the switching valve.
  • a reaction solution containing enzymes being passed into the tube of a certain volume within the switching valve.
  • the blood located there is diluted and expelled into a second flow tube.
  • the diluted sample is mixed into a reactor in which the enzyme reaction takes place
  • US-A-4.013, 413 relates to a device and a method for the automatic analysis of up to 150 samples per hour with high precision.
  • the analysis device contains a sample flow system which is independent of a reactant flow system, the two systems being connected to one another via a valve.
  • a sampler takes a large number of samples separated by air, rinsing liquids and again.
  • the connection valve selects the sample portion from this stream, mixes solvent and transfers the sample solvent into a mixer within the reactant flow system. As a result, the sample is mixed with reactant.
  • the mixture and then entering a reactor is then cooled and analyzed using a colorimeter or fluorimeter.
  • EP-A-127 958 describes a sensor electrode which can be inserted directly into a body tissue with the aid of a cannula in order to measure parameters of a body fluid there.
  • B. to measure blood or with which a liquid sample taken from the body can be measured.
  • the sensor electrode must therefore have very small dimensions and consists of a region in which an enzyme is specific for the size to be measured, e.g. Glucose content together with a compound transfers the charge to the electrode when the enzyme is catalytically active and applied to a substrate.
  • a second area which is located in the immediate vicinity of the first area, acts as a counter electrode. With this electrode, however, only a single measurement value can be recorded.
  • DE-A-39 10 086 describes a valve system for automatic analyzers which has a multiplicity of electromagnetic clamping valves.
  • a large number of electromagnets, which are arranged in a magnetic table, Net are on locking bolts which are attached in a cover, whereby intermediate elastic hoses are clamped off.
  • These hoses, which are inserted in a specific arrangement according to the functions of the automatic analyzer, are located in a hose cassette between the magnetic table and the cover part. To change the hose, only the hose cassette has to be replaced.
  • Venti 1 systems are known which, in addition to the flow control, also make it possible to meter the measuring fluid and to mix it with an inert fluid.
  • valve system in an automatically operated device for the dilution of measuring fluids.
  • the valve system consists of three elements, which have bores in different positions and which are arranged to be displaceable relative to one another. Fluid channels are opened or closed according to the relative position of the valves 1 to one another.
  • a slide valve 1 for a gas chromatographic measuring arrangement is known, the valve slide of which has such passage channels that in a first working position the flow path of the analysis gas leads through a line of a certain length inside the valve slide, which is thereby filled with the analysis gas.
  • a flow path of the carrier gas from the gas source through the gas chromatographic column to the measuring detector is formed.
  • EP-A-0 136 550 proposes a metering mixing device for liquid media with fixed and a movable element. In order to take up and separate a volumized sample amount and to feed and mix this sample amount with a volumized dilution, the elements are provided with corresponding flow and metering openings arranged in relation to one another.
  • Object of the present invention is, therefore, "to provide a device which makes it possible, as needed or continuously dene physical and chemical parameters 29ie ⁇ at regular intervals of a measurement liquid to be monitored from a technical or process bio ⁇ logical o ⁇ -line without Interruption of the process and with direct connection to the process to be monitored on a small sample volume in parallel to one another or in quick succession to be determined and, after suitable processing and evaluation, displayed on a display device and saved for later analysis.
  • a device for simultaneous on-line measurement of various physical and chemical parameters of a measuring liquid without interrupting the process with a direct connection to the process to be examined, comprising a measuring head which has a switching unit with three liquids supply lines for the measuring liquid, for calibration solutions and for rinsing solutions, a measuring unit with a measuring chamber, a liquid connection line between the switching unit and measuring chamber and a liquid outlet, the switching unit being provided with a.
  • Suitable switching elements enable five switching states, namely "readiness”, “sampling”, “measurement”, “flushing” and “calibration”, a liquid delivery device, an electrical supply unit for the micro sensors, a measured value recording and Processing unit, a control and evaluation unit, a display unit and a storage unit for storing the measured values, the measuring head in sandwich form being constructed from three plates, one plate forming the switching unit, of which the second plate forming the measuring unit through a thin partition plate that the liquid connection line contains, is separated, the measuring chamber contains more than one and up to 15 micro sensors and additionally has a micro pressure sensor separated from the micro sensors, which is connected to the switching unit via its own liquid connection line, in the "measurement” state the same switching element setting as in the "ready” state is present, in the “ready” state the rinsing line is connected to the measuring line, while the flow in the flow lines is blocked, and the pressure measuring probe is connected directly via the connecting line is connected to the measuring line and the measuring line can be brought into direct connection with the system to be examined
  • the measuring liquids to be monitored are preferably body fluids, e.g. Blood, urine and ha ofi 1 occurred.
  • m robiological and genetic engineering methods such as e.g. enzyme-controlled reactions are monitored.
  • This device for the simultaneous measurement of various physical and chemical parameters of a measuring liquid is additionally characterized in that the switching unit and measuring unit are made of transparent plastic, such as e.g. Polymethyl ethacrylate, are built and the partition plate is colored opaque, the measuring head in sandwich form is made up of 3 plastic plates, which are placed on top of each other a plastic cuboid with the outer dimensions of about 2.5 - 4.0 cm x 3.0 - 5.0 cm x 0.8 - 2.0 cm edge length result.
  • transparent plastic such as e.g. Polymethyl ethacrylate
  • the inventive idea is advantageously further developed by a device in which the calibration line and flushing line are connected to storage vessels for the calibration solutions and flushing solutions, the storage vessels can be operated without pressure or pressurized and the liquid delivery device is a piston pump or a peristaltic pump.
  • the measuring unit and measuring chamber can select a combination of the microsensors of the following parameters, pressure, Na -,
  • the lower cuboid plastic plate with the two main surfaces and the jacket surface, consisting of the two transverse surfaces and the two longitudinal surfaces, forms the switching unit and (a) has the measuring line and on the opposite transverse surface, calibration line and flushing line along the transverse direction offset from one another into the switching unit,
  • liquid channels are machined, which emanate from the liquid supply lines and lie in the plane of the plate.
  • the calibration duct starts from the calibration duct parallel to the longitudinal surface and ends at a distance from the duct piece in the guide groove
  • the slide arranged in the guide groove has a through bore extending transversely to its direction of displacement and a U-shaped liquid channel, the two legs of which point in the direction of the transverse surface and whose distance corresponds exactly to the distance between the two liquid channels and so that in the basic position A of the slide, the through hole connects the two liquid channels and and in slide position B the U-shaped liquid channel connects the channel to the channel,
  • the flushing channel starting from the flushing line is divided into two parallel channels, which run along the longitudinal axis run in the direction of the transverse surface and there open into the first legs of two nested u-shaped channel pieces, the second legs of which lie between the channels and the previously described channel,
  • the guide groove is arranged so that it intersects the channel and the first and second legs and the u-shaped channel pieces, so that the u-shaped channel pieces on one side of the guide groove and another u-shaped channel piece on the come to rest on the other side of the guide groove
  • the slide located in the guide groove 3 has transversely to the displacement direction through holes and two U-shaped channel pieces, these liquid channels being arranged so that in the basic position A of the slide the holes Channel pieces with and with, the bore connecting the channel pieces and the u-shaped channel pieces connecting the liquid channels, and in position B of the slide the bore connecting the two channel pieces with each other, while all other connections are broken
  • the slide furthermore has a blind bore, which, coming from the direction of the first main surface of the switching unit, is introduced into the slide and in the basic position A of the slide connects the U-shaped channel piece to the connecting line
  • the slide located in the guide groove has a through hole running transverse to the direction of displacement which connects the channel pieces in the basic position A of
  • the slides can be adjusted electronically, electromagnetically or by manual push buttons.
  • the device according to the invention is additionally characterized in that the middle plastic plate of the measuring head is designed as a thin separating plate between the lower and the upper plate and has two through holes which form the liquid connection lines and are arranged in such a way that the connecting line connects the blind hole the switching unit connects to the measuring chamber in the measuring unit and the connecting line in the basic position A of the slide connects the material bore of the slide to the micro pressure sensor, whereby (a) the upper plastic plate forms the measuring unit which forms the measuring chamber and a separate micro pressure sensor contains,
  • the measuring chamber has up to 15 micro sensors for different parameters and (d) the measuring chamber can be emptied via the liquid outlet.
  • the measuring chamber in the measuring unit is constructed in the form of a channel, the micro sensors are arranged along the measuring channel and the measuring channel is designed in a meandering manner to increase the number of micro sensors.
  • the device according to the invention enables a measuring method for the simultaneous measurement of various physical and chemical parameters of a measuring liquid with the device according to claims 1-14, characterized in that the measuring of a liquid from a process "on-line", Without interrupting the process and with a direct connection to the process to be monitored, the control unit switches from the "ready” state to the "sampling", “measuring” states one after the other while continuously measuring the pressure after triggering a measuring cycle. "Flush”, “Calibration” and again "Readiness” offset, whereby
  • the measuring line is connected to the liquid connection line, and by means of the sampling unit the single to multiple of the measuring volume V of the measuring chamber of measuring liquid is conveyed through the measuring chamber and this is thereby filled with fresh measuring liquid, the Any liquid in the measuring chamber before the measuring cycle and excess measuring liquid are disposed of via the line, (b) in the "measurement” state, all slides are in the starting position, the parameters are measured and, at the same time, the flushing line, as in the state "Ready” is connected to the measuring line, by opening the valve flushing solution through the switch unit into the measuring line and thus the measuring liquid is removed from the channels of the switching unit and rinsing liquid, together with residues of the measuring liquid, is pressed into the system which contains the measuring liquid.
  • the switching states can be switched on manually.
  • Blood can be used as the measuring liquid. Any combination of blood pressure, Na -,
  • the measuring method is further characterized in that a physiological saline solution, a Ringer's solution or a Ringer's lactate solution is used as the rinsing solution, a sodium bicarbonate buffer containing glucose being used as the calibration solution.
  • the constructive design according to the invention makes it possible to maintain constant contact with the system to be monitored, for example a patient, while at the same time ensuring that no liquid can get back into the system from the device. In the known devices, this was ensured by the separate sampling and avoidance of a continuous connection between the measuring device and the liquid system to be monitored. For the first time, the invention creates the possibility of a permanent connection of the measuring device to the liquid system to be monitored.
  • the device contains a measuring head with a switching unit and a measuring unit with a measuring chamber and up to 15 Mi microsensors.
  • the micro sensors are supplied by an electrical supply unit with the electrical voltages required for their operation.
  • the measuring signals go via appropriate measuring cables to an electronic measured value acquisition and processing unit, which amplifies the measured values and transmits them in digital form to a digital control unit, from which a further evaluation and evaluation of the measurements is carried out becomes.
  • the control unit displays the measurement results on a display unit and stores them in a storage unit for later analysis.
  • the measuring device can for example contain micro sensors for the following parameters: Pressure, Na “ -, K ⁇ -, Ca " concentration, pH value, HCO " concentration, glucose concentration, lactate concentration,
  • the micro pressure sensor is arranged separately from the other sensors and is connected to the switching unit via its own liquid line.
  • the structural design of a suitable micro pressure sensor working on the basis of a capacitive measuring principle is known from DE-A-40 04 179.
  • the sensor described therein essentially contains a pressure sensor cavity which is arranged between a semiconductor substrate and a polycrystalline layer.
  • This semiconductor layer is made of membrane above the pressure sensor cavity, which is provided with doping and forms an electrode of the measuring capacitor.
  • a region of the semiconductor substrate which is electrically insulated from the substrate acts as the counter electrode.
  • This insulation is achieved either by doping the semiconductor region opposite to the substrate in order to produce a pn junction, or by a buried insulation layer between the semiconductor region and the substrate.
  • the polycrystalline semiconductor layer is electrically separated from the semiconductor region below the pressure sensor cavity by an insulator layer. If there is a change in pressure, the distance between the membrane-like semiconductor layer and the counterelectrode changes and thus the capacitance of the measuring capacitor.
  • the arrangement of the other micro sensors in the measuring unit is arbitrary as long as it is ensured that the reference electrodes are placed at the end of the measuring chain, since the micro sensors used make no or only insignificant changes to the measuring medium.
  • the micro sensors are preferably arranged in the flow direction of the measuring media in the order Na -, K -,
  • the micro sensors for the parameters mentioned are not all connected in series, but rather are grouped together in parallel channels in the measuring unit.
  • the first channel contains in
  • the reference electrode in the second channel are the PO, pH, PCO sensors and the reference electrodes in the second channel.
  • a third channel contains the sensors for the other parameters in the order glucose, lacatate, hemoglobin.
  • a fourth channel can also be provided for optional sensors.
  • the control unit also takes over the triggering and monitoring of the entire measuring sequence, which can be carried out automatically and continuously due to the direct connection of the measuring device to the system to be examined.
  • the measurement data is therefore determined periodically in predetermined time intervals.
  • the measurements can also be carried out manually using the single-step method.
  • the device according to the invention preferably includes a digital electronic control unit, embodiments are also possible in which the measuring sequence is carried out manually and the measured values are displayed, for example, with analog instruments.
  • the individual sensors are queried when they have each reached their stable O-Li ni enpotenti al.
  • the measuring head of the device enables the removal of a small sample volume of the measuring liquid from the technical or biological process to be monitored, the measurement of the parameters, the rinsing of the measuring head with a rinsing solution and the calibration of the measuring probes with a calibration solution.
  • the switching unit of the measuring head has three liquid inlets, one for the measuring liquid for sampling, one for the rinsing solution and one for the calibration solution.
  • the liquids pass from the switching unit via a liquid connection line into the measuring chamber with up to 15 microsensors for the parameters specified above and from there via a liquid drain into the waste.
  • a liquid delivery device is located in the processing unit to promote the flow of liquids.
  • This is preferably a piston or peristaltic pump with a suitable delivery volume, which enables it to deliver constant volumes of liquid on request from the control unit.
  • an additional valve in the processing line is necessary to limit the flow rates.
  • the liquid delivery device can also be realized by a combination of a check valve and a suction syringe.
  • the liquid lines and liquid channels in the measuring head can have round rectangular or square cross-sections, depending on the manufacturing process used, drilling, milling, etc.
  • the three cross-sectional shapes can also be present in one measuring head at the same time.
  • the cross-sectional dimensions are preferably in the range between 0.5 to 1.5 mm and are advantageously 0.8 mm.
  • a measuring cycle preferably has the following phases, namely "readiness”, possibly “calibration”, “sampling”, “measurement”, “rinsing” and “calibration”. Corresponding switching states of the switching unit are assigned to these measuring phases. It is the task of the switching unit to connect the three liquid inlets to one another and to the liquid connection line to the measuring chamber in accordance with the respective measuring phase.
  • the structural design of the switching unit ensures that the three liquids can only enter the measuring chamber one after the other and never at the same time.
  • the construction ensures that the generally very specific calibration solutions never get into the measuring line and can thus interfere with the technical or biological process to be monitored.
  • the calibration and rinsing solution are located in separate storage containers which are connected to the switching unit via the liquid lines mentioned.
  • An additional valve is attached between the reservoir for the flushing solution and the switching unit, which can be seen either by hand or with the help of electropneumatics, or can be operated by the control unit using electromagnetic actuators.
  • the liquids in the storage containers are preferably subjected to a slight positive pressure.
  • the measuring chamber In the "standby" state, the measuring chamber is disconnected from all three liquid supply lines. 'The liquid line for the rinse solution is connected with the measuring line, a flow of the rinse solution in the measuring line is prevented, however, storage container through the closed valve between Vor ⁇ and switching unit.
  • the measuring line is connected to the liquid connecting line to the measuring chamber and a predetermined
  • the volume of the measuring liquid is conveyed through the measuring chamber, the liquid located in the measuring chamber before the measuring cycle and excess measuring liquid passing through the line into the waste.
  • This delivery volume should be as small as possible in order to influence the process to be monitored as little as possible.
  • the delivery volume must be large enough to ensure adequate rinsing of the measuring chamber with the measuring liquid and to ensure that only measuring liquid is in the measuring chamber during the measurement.
  • the conveying volume of the conveying device is one to many times the volume of the measuring chamber, preferably one to five times the measuring chamber volume.
  • the measuring line is immediately connected to the rinsing line again, as in the "standby" state.
  • the measuring liquid is now backwashed with the aid of the flushing solution by opening the valve between the storage container and the switching unit from the switching unit back into the measuring line.
  • the rinsing liquid is system-compatible and is pressed into the system containing the measuring liquid together with remnants of the measuring liquid, bypassing the measuring chamber. The duration of the rinsing process is freely selectable and, if necessary, can be completely omitted.
  • the measurements in the measuring chamber are carried out on the stationary measuring liquid. To shorten the measuring process, it is desirable to have the various measurements run as parallel as possible to one another. However, it is provided that measurements which change the measuring liquid itself and could thus lead to incorrect measurements of certain parameters are carried out at different times from these first measurements.
  • the measurement time for all parameters is typically up to 30 seconds.
  • the "flushing" measurement phase is switched on.
  • the rinsing solution is now connected to the liquid connection line to the measuring chamber and, by opening the rinsing valve and actuating the liquid-conveying device, a sufficient amount of rinsing solution is pumped through the measuring chamber so that the measuring liquid is safe is removed from it.
  • the “calibration” phase follows the "flushing" measurement phase.
  • the switching unit connects the calibration solution to the connecting line to the measuring chamber and the delivery unit conveys a predetermined volume of this calibration solution through the measuring chamber.
  • the delivered olumen of the calibration solution must be large enough again to rinse the measuring chamber sufficiently with calibration solution.
  • the switching unit then switches back to the "ready” state. After the micro sensors have been calibrated, the measuring device is ready for the next measuring cycle, the measuring solution displacing the remaining calibration solution from the measuring chamber when the sample is taken.
  • the pressure measurement requires special treatment.
  • the pressure of the measuring liquid can only be measured if the mini pressure sensor is directly connected to the system to be monitored. This means that the pressure of the measuring liquid must be transferred directly to the microsensor.
  • the measuring line of the device is connected directly to the blood circulation via a cannula.
  • the Mi pressure sensor is sensitive to contamination from the measuring liquid.
  • the pressure should therefore be measured using the flushing solution as the transmission medium.
  • the pressure measurement should take place as close as possible to the measuring line before the actual measuring chamber, in order to avoid falsification of the pressure curves by reflections of the pressure waves.
  • the pressure measuring probe is connected directly to the measuring line via a second connecting line between the switching unit and measuring unit in the "ready" switching state (same state as “measuring”).
  • a suitable constructive design of the switching unit ensures that the pressure measuring probe cannot come into contact with the measuring liquid when switching from “sampling” to “measurement” (same switching state as when “ready”). Since the measuring line is directly connected to the system to be monitored, a continuous pressure measurement is possible during the switching states “measurement and" readiness ".
  • the device according to the invention is designed as a disposable article with a service life of up to one week, but at least 48 hours.
  • the problem additionally arises that deposits can occur on the sensors which falsify the measurement results.
  • heparinized rinsing and calibration solutions are used to prevent or at least limit the formation of deposits on thin microsensors.
  • the measuring unit is provided with a silicone membrane through which a cleaning solution for detaching deposits from the sensors, such as e.g. hydrochloric pepsin solution, can be injected in the "calibration" state instead of the calibration solution.
  • Figure 1 Schematic structure of the measuring device
  • Figure 2 Structure of the measuring head from the example
  • F gur 3 switching unit according to theticiansbei spi el with liquid inlets, liquid channels and slides. The slides are in the "standby" position.
  • Figure 4 switching unit of Figure 3 with sliders in the
  • Figure 5 switching unit of Figure 3 with the slider in the "flushing" position.
  • Figure 6 switching unit of Figure 3 with the slide in the "calibration" position.
  • Figure 7 Structure of the measuring chamber
  • FIG. 1 shows a block diagram of the entire measuring device with the measuring head (10), the liquid conveying device (90), the liquid supply lines for the measuring liquid (40), for the calibration solution (50) and for the rinsing solution (60), the latter being able to be shut off by a flush valve (18).
  • the measuring head (10) consists of the switching unit (20), the measuring unit (30) and the liquid connection line (70 and 75) between the two. Depending on the switching state of the switching unit (20), measuring liquid, rinsing solution or calibration solution can be used with the
  • Liquid delivery device (90) is sucked through the measuring chamber (34) over the liquid outlet (80) and conveyed into the waste via the liquid outlet supports (95).
  • the up to 15 micro sensors (100) receive their operating voltages via the supply lines (110) from the electrical supply unit (130).
  • the Measurement signals go via the signal lines (120) to the measured value acquisition and processing unit, in which the signals are appropriately amplified and digitized before they are sent to the control unit via the signal lines (151) to get redirected.
  • the digital control unit (150) takes over the further evaluation of the measurement signals according to predetermined criteria, stores the data in the mass memory (170), displays them in a suitable manner on the display unit (160) and, if necessary, solves when the limit values are exceeded or undershot issued corresponding alarms.
  • the control unit (150) also monitors and controls the entire measuring sequence. It triggers a measuring cycle periodically or as required and ensures a perfect sequence of the individual measuring phases.
  • the electronic elements can be actuated directly by a corresponding interface card.
  • the measuring head according to FIG. 2 consists of a three-part plastic cuboid.
  • the edge lengths of this cuboid are in the range of 2.5 - 4.0 cm x 3.0 - 5.0 cm x 0.8 - 2.0 cm.
  • the dimensions 3.5 cm ⁇ 5.0 cm ⁇ 1.2 cm are particularly favorable.
  • the lower part (20) forms the switching unit and is separated from the upper part (30) forming the measuring unit by a thin partition plate (32).
  • the cuboidal switching unit (20) has two main surfaces (20a and 20b), two transverse surfaces (20c and 20d) and two longitudinal surfaces (20e and 20f).
  • the switching unit is in contact with the separating plate (32) with the main surface (20a).
  • the liquid supply lines (40, 50, 60) are fastened to the transverse surfaces (20c) and (20d) of the switching unit via standardized connections according to DIN (Luer lock).
  • FIG 3 shows a plan view of the main surface (20a) of the switching unit (20) with the liquid inlets (40, 50, 60) and the liquid channels located in the switching unit.
  • Three slides (25s, 26s, 27s) are used to switch the liquid flows, which are slidably arranged in corresponding guide grooves. While the liquid channels lie in the plane of the plate and run essentially parallel to the longitudinal surfaces (20e) and (20f) or in curves, the guide grooves are machined transversely thereto and cut the liquid channels.
  • the guide grooves (25) and (27) both start from the longitudinal surfaces (20e), while the groove (26) is machined into the switching unit (20) from the opposite longitudinal surface (20f).
  • the three guide grooves (25, 26, 27) are offset with respect to one another along the longitudinal surfaces, so that the groove (26) is arranged approximately centrally to the longitudinal surface (20f) and the two grooves (25) and (27) by approximately one fifth of the longitudinal extent the switching unit are removed from the transverse surfaces (20c) or (20d).
  • the slides (25s, 26s, 27s) each have two
  • the slide is actuated via the adjusting elements (22, 23, 24), which preferably operate on an electromagnetic or electro-pneumatic basis and are actuated by the control unit can be.
  • the adjusting elements are push buttons which are operated by hand. In this case, the necessary counter forces are supplied by the springs (21).
  • the connection to the measuring chamber (34) is made from the blind bore (71) through the partition plate (32).
  • the liquid channel (42) emanating from the measuring line (40) opens into the blind bore (71) and is divided into the sections (42a, 42b, 42c) by the grooves (25) and (26).
  • the liquid channel (52) emanating from the flushing line (50) lies between the channel (42) and the longitudinal surface (20f) and ends in the guide groove (27) for slides (27s).
  • the liquid channel running near the longitudinal surface (20e) and coming from the flushing line (60), coming from the transverse surface (20d), is divided into two parallel channels (62) and (64) in front of the groove (27) the grooves (25, 27) are divided into the sections (62a, 62b) and (64a, 64b).
  • the extension of the two channels (62, 64) beyond the guide groove (25) merges into the first legs (66a, 68a) of two nested U-shaped channel pieces (66, 68). These U-shaped channel pieces are oriented so that their
  • Figure 3 shows the slide (25s, 26s, 27s) in the "ready” state. All three slides are in basic position A. To switch the liquid flows, the slides have corresponding through bores transverse to the direction of displacement and partially U-shaped channel pieces for deflecting the liquid flows.
  • the slide (25s) has three through bores (25a, 25b) and (25c).
  • the bore (25a) connects the first U-leg (66a) with the channel piece (64b) and the bore (25b) connects the first U-leg (68a) with the channel piece (62b). Bore (65c) connects the second U-leg (68b) with the leg (69a) of a further U-shaped channel piece (69).
  • the slide (25s) contains two U-shaped channel pieces, which are arranged at the same height in relation to one another and, in the basic position A, divert the liquid flow from the second U-leg (66b) into the measuring channel (42a) and connect the second leg (69b) of the U-piece (69) to the channel piece (42b), so that a connection from channel (62b) to channel (42b) is created.
  • the slide (25s) also has a blind bore (76) which, coming from the direction of the main surface (20a) of the switching unit (20), is inserted in the slide and in the basic position A of the slide (25s) the U-shaped channel piece ( 25d) connects to the connecting line (75) and thus creates a passage from the micro pressure sensor (105) to the measuring line (40).
  • the slide (27s) contains only one through hole (27a), which connects the channel piece (64a) with the channel piece (64b) in the basic position A. In this position, a connection from the flushing line (60) to the measuring line (40) is thus created.
  • the slide (26s) contains a through hole (26a) and a U-shaped channel piece (26b). In the basic position, the through hole (26a) connects the two channel pieces (42b) and (42c) to one another. In the "standby" position, there is therefore only a continuous liquid connection from the flushing line (60) to the measuring line (40). All other channels are blocked, in particular the measuring chamber (34) is separated from the outer inlets (40, 50, 60).
  • FIG. 4 shows the plan view given in FIG. 3 of the main surface of the switching unit in the position of the slide for "sampling". Only slide (25s) is in position B, so that the bore (25c) connects the duct section (42a) to the duct section (42b). A continuous connection is thus created from the measuring line (40) via duct pieces 42a-42c and pocket hole 71 to the measuring chamber and measuring liquid can be sucked into the measuring chamber.
  • the measurement is carried out after sampling.
  • the position of the slide in the "measurement” state is identical to the position of the slide shown in FIG. 3 in the “ready” state, so that the measuring chamber is again separated from all external inlets. At the same time, however, flushing from the flushing line (60) into the measuring line (40) is possible.
  • FIG. 5 shows the top view shown in FIG. 3 with the slide position for the “flushing” state.
  • the measuring chamber (30) there is only slide (27s) in position B, so that the flushing solution through the flushing line has the flushing channel 62, the through hole 27a in the slide 27s, the U-shaped channels 68, 69, Through hole 25c and the u-shaped channel 25e in the slide 25s, the measuring channel 42 and the blind hole 71 can be sucked into the measuring chamber.
  • the other channels are blocked by the positions of the discs 25, 26, 27.
  • FIG. 6 shows the slide position for the "calibration" state.
  • the slide (26s) is in position B.
  • the U-shaped channel piece (26b) of the slide (26s) connects the liquid channel (52) to the channel piece (42c), thus connecting the calibration line to the measuring chamber is created.
  • the construction of the slide (26) prevents calibration liquid from entering the measuring line (42c).
  • the separating plate (32) between the switching unit (20) and the measuring unit (30) is provided with two through bores which form the liquid connection lines (70 and 75).
  • Line (70) connects the blind bore (71) of the switching unit (20) with its corresponding one
  • the measuring chamber itself is preferably designed as a liquid channel, along which the various micro sensors (100) are distributed. In order to enable a sufficient number of micro sensors, the measuring channel can be designed in a meandering manner.
  • the total volume V of the measuring channel is typically less than 1 ml.
  • Switching unit (20) and measuring unit (30) are made of a transparent plastic, such as polymethyl methacrylate.
  • the Tre ⁇ nplatte is made of a white plastic, so that the liquid channels in the switching unit (20) and in the measuring unit (30) can be checked very easily visually for cleanliness.
  • FIG. 7 schematically shows the measuring chamber (34) with the micro sensors (100) arranged therein, the micro pressure sensor (105) and the outlet (80) from the measuring chamber (34).
  • the inlet is through the end of the blind bore (71).
  • the sensors (100, 105) are arranged spatially within the measuring chamber so that the measuring solutions and calibration solutions flow around them sufficiently and do not interfere with each other.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Ecology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Physiology (AREA)
  • Food Science & Technology (AREA)
  • Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Dispositif pour la mesure simultanée de différents paramètres physiques et chimiques dans un liquide de mesure, comportant une tête de mesure, une unité d'alimentation électrique pour les microcapteurs, une unité de saisie des valeurs de mesure et une unité de commande et d'analyse, ainsi qu'une unité de mémoire pour la mémorisation des valeurs de mesure. Le dispositif passe, lors de l'opération de mesure, par plusieurs états de fonctionnement: 'Prélèvement d'échantillon', 'Mesure', 'Rinçage' et éventuellement 'Etalonnage', jusqu'à ce que l'état 'En attente' soit atteint.
PCT/EP1991/001755 1990-09-20 1991-09-14 Dispositif pour la mesure simultanee de differents parametres physiques et chimiques d'un liquide WO1992005449A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19904029746 DE4029746A1 (de) 1990-09-20 1990-09-20 Vorrichtung und verfahren zur gleichzeitigen messung verschiedener physikalischer und chemischer parameter einer fluessigkeit
DEP4029746.2 1990-09-20

Publications (1)

Publication Number Publication Date
WO1992005449A1 true WO1992005449A1 (fr) 1992-04-02

Family

ID=6414588

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1991/001755 WO1992005449A1 (fr) 1990-09-20 1991-09-14 Dispositif pour la mesure simultanee de differents parametres physiques et chimiques d'un liquide

Country Status (2)

Country Link
DE (1) DE4029746A1 (fr)
WO (1) WO1992005449A1 (fr)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995027201A1 (fr) * 1994-04-04 1995-10-12 Via Medical Corporation Procede permettant de distribuer et de recueillir des fluides
FR2730565A1 (fr) * 1995-11-14 1996-08-14 Rybak Boris Sondes miniatures multi-parametriques physico-chimiques
GB2311614A (en) * 1996-03-29 1997-10-01 Byk Gulden Italia Spa Automatic diagnostic apparatus
EP0809966A1 (fr) * 1996-05-31 1997-12-03 Siemens Aktiengesellschaft Cellule d'écoulement destinée à la mesure extracorporelle de paramètres sanguins
EP0724152A3 (fr) * 1995-01-25 1998-09-23 Przedsiebiorstwo Zagraniczne Htl Dispositif, procédé et électrode de mesure pour déterminer des paramètres d'un liquide
US6866821B2 (en) 1996-03-29 2005-03-15 Byk Gulden Italia S.P.A. Automatic diagnostic apparatus
DE19821903B4 (de) * 1997-06-04 2007-08-30 Sphere Medical Ltd., Cambridge Blutanalysesystem zum Verfahren zum Steuern eines Blutanalysesystems
CN111239375A (zh) * 2020-03-25 2020-06-05 云南华联锌铟股份有限公司 一种pH测量仪探头及冲洗水喷头支架组合装置
CN114646679A (zh) * 2020-12-21 2022-06-21 豪夫迈·罗氏有限公司 传感器设备和使用方法
CN114646678A (zh) * 2020-12-21 2022-06-21 豪夫迈·罗氏有限公司 传感器组件
CN116106525A (zh) * 2023-04-13 2023-05-12 深圳市帝迈生物技术有限公司 血液分析仪

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH684554A5 (de) * 1992-09-22 1994-10-14 Sotax Ag Probensammler.
DE4306184A1 (de) * 1993-02-27 1994-09-01 Joerg Doerpinghaus Vorrichtung zum kontinuierlichen Erfassen physikalischer und/oder chemischer Parameter von Flüssigkeiten
DE4440580A1 (de) * 1994-11-14 1996-05-15 Kurt Schwabe Inst Fuer Mes Und Meß- und Kalibrierzelle zur Adaption von Sensoren an Rohrströmungen
DE19507638C2 (de) * 1995-03-04 1997-09-25 Danfoss As Analysenvorrichtung
DE19627587C2 (de) * 1996-07-09 1999-02-04 Hydac Filtertechnik Gmbh Vorrichtung zur Überwachung von Gebrauchseigenschaften von Fluiden, insbesondere von Druckflüssigkeiten in fluidtechnischen Anlagen
DE19651489A1 (de) * 1996-12-11 1998-06-25 Bioskin Inst Fuer Dermatologis Verfahren zur Messung von Körperausscheidungen
DE19704237B4 (de) * 1997-02-05 2006-11-23 Micronas Gmbh Meßeinrichtung
DE29703788U1 (de) * 1997-03-03 1997-06-26 Bürkert Werke GmbH & Co., 74653 Ingelfingen Modularer Steuerblock für die Analysentechnik
DE10057895B4 (de) * 2000-11-22 2009-06-18 peS Gesellschaft für medizinische Diagnosesysteme mbH Vorrichtung und Verfahren zur Probenvorbereitung flüssiger Proben
DE10116614C5 (de) * 2001-04-03 2008-10-16 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Automatisierbare Meß-, Reinigungs- und Kalibriereinrichtung für pH-Elektroden oder Elektroden zur Messung von Redoxpotentialen
DE10135237A1 (de) * 2001-07-24 2003-02-06 Mettler Toledo Gmbh Vorrichtung zur Behandlung einer Messsonde sowie deren Verwendungen
DE10228089A1 (de) * 2002-06-19 2004-01-15 Filt Lungen- Und Thoraxdiagnostik Gmbh Verfahren und Anordnung zur Bestimmung von Parametern des Atemkondensates
DE112004002936B4 (de) * 2004-08-18 2008-12-11 Agilent Technologies, Inc. (n.d.Ges.d. Staates Delaware), Santa Clara Mikrofluidische Anordnung mit einem Ventilschieber für ein mikrofluidisches Kopplungsgerät
DE102009001157B4 (de) * 2009-02-25 2014-10-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung und Verfahren zumm Prüfen des Verhaltens von Fluiden, insbesondere polymeren Flüssigkeiten
EP3120928A1 (fr) * 2015-07-24 2017-01-25 Centre National De La Recherche Scientifique Dispositifs fluidiques avec au moins une fibre activable

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3884640A (en) * 1972-10-26 1975-05-20 Gen Electric Apparatus to analyze fluids
US4013413A (en) * 1975-07-10 1977-03-22 The United States Of America As Represented By The Secretary Of Agriculture Apparatus and method for rapid analyses of plurality of samples
EP0189316A2 (fr) * 1985-01-25 1986-07-30 Mallinckrodt Sensor Systems, Inc. Dispositif de détection ou de mesure de composants chimiques
US4734184A (en) * 1985-08-29 1988-03-29 Diamond Sensor Systems, Inc. Self-activating hydratable solid-state electrode apparatus
DE3818148A1 (de) * 1987-06-30 1989-01-12 Avl Ag Analysegeraet

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1202536B (de) * 1961-06-26 1965-10-07 Beckman Instruments Inc Schieberventil fuer gaschromatographische Anordnungen
US3327204A (en) * 1963-04-15 1967-06-20 Beckman Instruments Inc Fluid sample examining apparatus
CA989476A (en) * 1971-03-18 1976-05-18 Edmund E. Buzza Automatic analyzer
US3763422A (en) * 1971-10-21 1973-10-02 Corning Glass Works Method and apparatus for electrochemical analysis of small samples of blood
DE2726771C3 (de) * 1977-06-14 1981-04-16 Dr. Eduard Fresenius Chemisch-Pharmazeutische Industrie Kg Apparatebau Kg, 6380 Bad Homburg Vorrichtung zur elektrochemisch-enzymatischen Analyse strömender Flüssigkeiten
IT1167468B (it) * 1981-07-13 1987-05-13 Instrumentation Lab Spa Cella elettrochimica dotata di elettrodi selettivi ed almeno un reattore chimico, atta alla misura indiretta di parametri chimico-clinici, e metodo di misura impiegante tale cella
JPS595933A (ja) * 1982-07-02 1984-01-12 Hitachi Ltd 液体試料のフロ−分析方法
CA1226036A (fr) * 1983-05-05 1987-08-25 Irving J. Higgins Materiel d'analyse et ses electrodes-sondes
CH674580A5 (fr) * 1983-10-06 1990-06-15 Contraves Ag
US4627893A (en) * 1984-03-28 1986-12-09 Amdev, Inc. Means and methods for quantitative determination of analyte in liquids
US4726237A (en) * 1985-06-19 1988-02-23 Sequoia-Turner Corporation Fluid metering apparatus and method
FI80152C (fi) * 1988-04-15 1990-04-10 Kone Oy Ventilsystem t.ex. foer analysator.

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3884640A (en) * 1972-10-26 1975-05-20 Gen Electric Apparatus to analyze fluids
US4013413A (en) * 1975-07-10 1977-03-22 The United States Of America As Represented By The Secretary Of Agriculture Apparatus and method for rapid analyses of plurality of samples
US4013413B1 (fr) * 1975-07-10 1984-08-28
EP0189316A2 (fr) * 1985-01-25 1986-07-30 Mallinckrodt Sensor Systems, Inc. Dispositif de détection ou de mesure de composants chimiques
US4734184A (en) * 1985-08-29 1988-03-29 Diamond Sensor Systems, Inc. Self-activating hydratable solid-state electrode apparatus
DE3818148A1 (de) * 1987-06-30 1989-01-12 Avl Ag Analysegeraet

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995027201A1 (fr) * 1994-04-04 1995-10-12 Via Medical Corporation Procede permettant de distribuer et de recueillir des fluides
EP0724152A3 (fr) * 1995-01-25 1998-09-23 Przedsiebiorstwo Zagraniczne Htl Dispositif, procédé et électrode de mesure pour déterminer des paramètres d'un liquide
FR2730565A1 (fr) * 1995-11-14 1996-08-14 Rybak Boris Sondes miniatures multi-parametriques physico-chimiques
GB2311614A (en) * 1996-03-29 1997-10-01 Byk Gulden Italia Spa Automatic diagnostic apparatus
GB2311614B (en) * 1996-03-29 2000-04-12 Byk Gulden Italia Spa Automatic diagnostic apparatus
US6866821B2 (en) 1996-03-29 2005-03-15 Byk Gulden Italia S.P.A. Automatic diagnostic apparatus
EP0809966A1 (fr) * 1996-05-31 1997-12-03 Siemens Aktiengesellschaft Cellule d'écoulement destinée à la mesure extracorporelle de paramètres sanguins
DE19821903B4 (de) * 1997-06-04 2007-08-30 Sphere Medical Ltd., Cambridge Blutanalysesystem zum Verfahren zum Steuern eines Blutanalysesystems
CN111239375A (zh) * 2020-03-25 2020-06-05 云南华联锌铟股份有限公司 一种pH测量仪探头及冲洗水喷头支架组合装置
CN114646679A (zh) * 2020-12-21 2022-06-21 豪夫迈·罗氏有限公司 传感器设备和使用方法
CN114646678A (zh) * 2020-12-21 2022-06-21 豪夫迈·罗氏有限公司 传感器组件
EP4016068A1 (fr) * 2020-12-21 2022-06-22 F. Hoffmann-La Roche AG Ensemble capteurs
EP4016069A1 (fr) * 2020-12-21 2022-06-22 F. Hoffmann-La Roche AG Dispositif de capteur et procédé de son utilisation
JP2022098478A (ja) * 2020-12-21 2022-07-01 エフ ホフマン－ラ ロッシュ アクチェン ゲゼルシャフト センサアセンブリ
US11709145B2 (en) 2020-12-21 2023-07-25 Roche Diagnostics Operations, Inc. Sensor assembly
CN114646678B (zh) * 2020-12-21 2024-12-06 豪夫迈·罗氏有限公司 传感器组件
US12163909B2 (en) 2020-12-21 2024-12-10 Roche Diagnostics Operations, Inc. Sensor assembly
CN116106525A (zh) * 2023-04-13 2023-05-12 深圳市帝迈生物技术有限公司 血液分析仪
CN116106525B (zh) * 2023-04-13 2023-09-15 深圳市帝迈生物技术有限公司 血液分析仪

Also Published As

Publication number Publication date
DE4029746C2 (fr) 1992-10-22
DE4029746A1 (de) 1992-04-02

Similar Documents

Publication Publication Date Title
WO1992005449A1 (fr) Dispositif pour la mesure simultanee de differents parametres physiques et chimiques d'un liquide
EP0938383B1 (fr) Dispositif pour effectuer des analyses d'echantillons cellulaires ou similaires
DE102012205171B3 (de) Integriertes Einweg-Chipkartuschensystem für mobile Multiparameteranalysen chemischer und/oder biologischer Substanzen
DE69526364T2 (de) Patch-clamp-vorrichtung und -technik mit hohem durchfluss und niedrigen flüssigkeitsvolumenanforderungen
EP2340432B1 (fr) Procédé d'analyse d'un analyte dans un échantillon d'eau à l'aide d'un dispositif d'analyse d'eau mobile
DE60309104T2 (de) Automatische Analysevorrichtung
DE68907344T2 (de) Verfahren und Vorrichtung zur Anzeige von Urinbestandteilen.
DE69434438T2 (de) Biosensor mit ausfallgesichertem betriebsverfahren zur vermeidung von falschen anzeigen
EP2062643B1 (fr) Système d'analyse et procédé d'analyse d'un échantillon de liquide corporel sur un analyte contenu dans celui-ci
DE2927048C2 (de) Vorrichtung zur Durchführung analytischer Messungen an einer Flüssigkeit
DE10013242B4 (de) Chemisches Analysegerät
EP0722567B1 (fr) Dispositif de mesure destine a l'analyse de fluides
DE10112507C2 (de) Vorrichtung und System zur Untersuchung von biologischen Flüssigkeiten
DE19546535C2 (de) Meßkartusche für flüssige oder gasförmige Proben, Verfahren zu deren Betreiben und deren Verwendung
EP1035918A1 (fr) Dispositif de mesure de parametres physiologiques
DE19903704C1 (de) Aufnahmeeinheit für Lösungen, insbesondere Lösungen zur Kalibrierung von Sensoren zur Messung physiologisch relevanter Parameter
EP0460343A2 (fr) Elément de mesure à usage unique pour l'analyse d'un échantillon liquide ou gazeux
WO2008128534A1 (fr) Cuvette pour l'analyse optique de petits volumes
EP1541986A1 (fr) Dispositif d'échantillonage pour l'analyse d'un échantillon fluide
EP1343011A2 (fr) Dispositif de détection des séquences de nucléotides, cassette d'analyse accessoire et procédé de fabrication de la cassette d'analyse
EP0366645B1 (fr) Appareil de mesure pour déterminer un paramètre chimique dans un échantillon aqueux
DE102005017364B4 (de) Analysegerät mit auswechselbarem Testfeldträger
EP0335859B1 (fr) Dispositif de mesure de composants présents dans un échantillon
EP0724152A2 (fr) Dispositif, procédé et électrode de mesure pour déterminer des paramètres d'un liquide
DE69803943T2 (de) Automatische hämatologische zähl-und messvorrichtung

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): CA JP US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IT LU NL SE

NENP Non-entry into the national phase

Ref country code: CA

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载