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WO1992004464A3 - Monoclonal antibodies against tenascin - Google Patents

Monoclonal antibodies against tenascin Download PDF

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Publication number
WO1992004464A3
WO1992004464A3 PCT/US1991/006433 US9106433W WO9204464A3 WO 1992004464 A3 WO1992004464 A3 WO 1992004464A3 US 9106433 W US9106433 W US 9106433W WO 9204464 A3 WO9204464 A3 WO 9204464A3
Authority
WO
WIPO (PCT)
Prior art keywords
monoclonal antibodies
antibodies against
tenascin
against tenascin
melanomas
Prior art date
Application number
PCT/US1991/006433
Other languages
French (fr)
Other versions
WO1992004464A2 (en
Inventor
Meenhard Herlyn
Original Assignee
Wistar Inst
Meenhard Herlyn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wistar Inst, Meenhard Herlyn filed Critical Wistar Inst
Publication of WO1992004464A2 publication Critical patent/WO1992004464A2/en
Publication of WO1992004464A3 publication Critical patent/WO1992004464A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053—Skin, nerves, brain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

This invention provides monoclonal antibodies that bind to four non-overlapping epitopes on human tenascin. This invention also provides an improved method for determining metastatic potential of melanomas, based on the discovery that metastatic melanomas secrete tenascin.
PCT/US1991/006433 1990-09-05 1991-09-05 Monoclonal antibodies against tenascin WO1992004464A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57773290A 1990-09-05 1990-09-05
US577,732 1990-09-05

Publications (2)

Publication Number Publication Date
WO1992004464A2 WO1992004464A2 (en) 1992-03-19
WO1992004464A3 true WO1992004464A3 (en) 2004-05-13

Family

ID=24309942

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/006433 WO1992004464A2 (en) 1990-09-05 1991-09-05 Monoclonal antibodies against tenascin

Country Status (2)

Country Link
AU (1) AU8547291A (en)
WO (1) WO1992004464A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5436132A (en) * 1993-02-13 1995-07-25 Amano Pharmaceutical Co., Ltd. Quantitative determination of tenascin as glioma marker
US6482410B1 (en) * 1994-09-16 2002-11-19 The Scripps Research Institute Cytotactin derivatives that stimulate attachment and neurite outgrowth, and methods of making same
IT1307864B1 (en) * 1999-04-20 2001-11-19 Istituto Naz Per La Ricerca Su DIAGNOSTIC METHOD FOR THE RECOGNITION OF HUMAN NEOPLASIA THROUGH THE DETERMINATION OF THE CTN-C ISOFORM OF TN-C, FRAGMENTS OF
US20020187100A1 (en) * 2000-12-21 2002-12-12 David Rizzieri Anti-tenascin monoclonal antibody therapy for lymphoma
GB0207224D0 (en) 2002-03-27 2002-05-08 Novartis Forschungsstiftung Tenascin-W compositions and uses thereof

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CANCER RESEARCH, Vol. 47, August 1987 R.G. Blasberg et al.: "Regional localization of a glioma-associated antigen defined by monoclonal antibody 81C6 in Vivo: Kinetics and implications for diagnosis and therapy ", *
CANCER RESEARCH, Vol. 50, July 1990 Michael R. Zalutsky et al.: "Monoclonal antibody and F(ab')2 fragment delivery to tumor in patients with glioma: comparison of intracarotid and intravenous administration ", *
Cell, Vol. 47, October 1986 Ruth Chiquet-Ehrismann et al.: "Tenascin: an extracellular matrix protein involved in tissue interactions during fetal development and oncogenesis ", *
Cell, Vol. 59, October 1989 J~rg Spring et al.: "Two contrary functions of tenascin: dissection of the active sites by recombinant tenascin fragments ", *
Dialog Informational Service, File 155, Medline 66-90/May, accession no. 06639065, medline accesssion no. 88284065, Inaguma Y et al: "Epithelial induction of stromal "tenascin" in the mouse mammary gland from embryogenesis to carcino- genesis", & Dev Biol (UNITED STATES) Aug 1988, 128, (2) p245-55. *
Int. J. Cancer: Supplement 4, Vol., 1989 Pier Giorgio Natali et al.: "Tenascin: A hexameric adhesive glycoprotein ", *
Journal of Neurochemistry, Vol., 1990 John R. Harper et al.: "Human neuroectoderm-derived cell line secretes fibronectin that shares the HNK-1/10C5 carbohydrate epitope with Neural cell adhesion molecules ", *
Proc. Natl. Acad. Sci., Vol. 84, July 1987 Eleanor J. Mackie et al.: "Tenascin is a stromal marker for epithelial malignancy in the mammary gland ", *
The Journal of Cell Biology, Vol. 108, June 1989 Virginia A. Lightner et al.: "Tenascin/Hexabrachion in Human Skin: Biochemical Identification and Localization by Light and Electron Microscopy ", *

Also Published As

Publication number Publication date
AU8547291A (en) 1992-03-30
WO1992004464A2 (en) 1992-03-19

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