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WO1992003421A3 - Pyrazolines, pyrazolidines et hydrazines arthropodicides - Google Patents

Pyrazolines, pyrazolidines et hydrazines arthropodicides Download PDF

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Publication number
WO1992003421A3
WO1992003421A3 PCT/US1991/005334 US9105334W WO9203421A3 WO 1992003421 A3 WO1992003421 A3 WO 1992003421A3 US 9105334 W US9105334 W US 9105334W WO 9203421 A3 WO9203421 A3 WO 9203421A3
Authority
WO
WIPO (PCT)
Prior art keywords
arthropodicidal
pyrazolidines
pyrazolines
hydrazines
compounds
Prior art date
Application number
PCT/US1991/005334
Other languages
English (en)
Other versions
WO1992003421A2 (fr
Inventor
Charles Richard Harrison
Renee Marie Lett
Stephen Frederick Mccann
Rafael Shapiro
Thomas Martin Stevenson
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Priority to US07/971,974 priority Critical patent/US5474998A/en
Publication of WO1992003421A2 publication Critical patent/WO1992003421A2/fr
Publication of WO1992003421A3 publication Critical patent/WO1992003421A3/fr

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0803Compounds with Si-C or Si-Si linkages
    • C07F7/081Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/561,2-Diazoles; Hydrogenated 1,2-diazoles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/34Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/38Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/06Compounds containing any of the groups, e.g. semicarbazides
    • C07C281/08Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones
    • C07C281/12Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones the carbon atom being part of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/75Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06Peri-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18Fluorenes; Hydrogenated fluorenes

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Health & Medical Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)

Abstract

Composés de pyrazoline, de pyrazolidine et d'hydrazine arthropodicides, y compris pour leurs isomères géométriques et stéréo-isomères, sels desdits composés appropriés à l'utilisation agricole et compositions les contenant, ainsi qu'un procédé de lutte contre les arthropodes à l'aide desdits composés qui présentent les formules (I) et (II), dans lesquelles Q, X, X1, Y et G sont tels qu'ils ont été définis dans le texte.
PCT/US1991/005334 1990-08-17 1991-08-01 Pyrazolines, pyrazolidines et hydrazines arthropodicides WO1992003421A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US07/971,974 US5474998A (en) 1990-08-17 1991-08-01 Arthropodicidal pyrazolines, pyrazolidines and hydrazines

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US56904490A 1990-08-17 1990-08-17
US569,044 1990-08-17
US57395490A 1990-08-27 1990-08-27
US573,954 1990-08-27
US59515190A 1990-10-09 1990-10-09
US595,151 1990-10-09

Publications (2)

Publication Number Publication Date
WO1992003421A2 WO1992003421A2 (fr) 1992-03-05
WO1992003421A3 true WO1992003421A3 (fr) 1992-10-29

Family

ID=27416068

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/005334 WO1992003421A2 (fr) 1990-08-17 1991-08-01 Pyrazolines, pyrazolidines et hydrazines arthropodicides

Country Status (4)

Country Link
US (1) US5474998A (fr)
EP (1) EP0543930A1 (fr)
JP (1) JPH06500333A (fr)
WO (1) WO1992003421A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8895556B2 (en) 2007-12-26 2014-11-25 Critical Outcome Technologies Inc. Compounds and method for treatment of cancer
US8987272B2 (en) 2010-04-01 2015-03-24 Critical Outcome Technologies Inc. Compounds and method for treatment of HIV
US9284275B2 (en) 2007-01-11 2016-03-15 Critical Outcome Technologies Inc. Inhibitor compounds and cancer treatment methods

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7884691A (en) * 1990-05-15 1991-12-10 E.I. Du Pont De Nemours And Company Arthropodicidal tetrahydropyridazines
IL105208A0 (en) * 1992-04-23 1993-07-08 Sumitomo Chemical Co Hydrazone derivatives,process for producing same,insecticides and/or acaricides containing same as active ingredient and intermediate compounds thereof
EP0994103A1 (fr) * 1998-10-13 2000-04-19 Rhone Poulenc Agro Procédé de préparation d'intermediaires pesticides
KR20010080147A (ko) * 1998-10-13 2001-08-22 추후제출 화학적 방법
WO2003027099A1 (fr) * 2001-09-21 2003-04-03 E. I. Du Pont De Nemours And Company Anthranilamides arthropodicides
AU2002366278B2 (en) 2001-12-18 2007-07-19 F. Hoffmann-La Roche Ag CIS-2,4,5- triphenyl-imidazolines and their use in the treatment of tumors
ATE397925T1 (de) 2001-12-18 2008-07-15 Hoffmann La Roche Cis-imidazoline als mdm2-hemmer
US7425638B2 (en) 2003-06-17 2008-09-16 Hoffmann-La Roche Inc. Cis-imidazolines
DE602005008555D1 (de) * 2004-01-30 2008-09-11 Solvay Pharm Bv 1,3,5-trisubstituierte 4,5-dihydro-1h-pyrazol-derivative mit cb1-antagonistischer aktivität
TW200533657A (en) * 2004-02-17 2005-10-16 Esteve Labor Dr Substituted pyrazoline compounds, their preparation and use as medicaments
US7897589B2 (en) 2005-07-15 2011-03-01 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds, their preparation and use as medicaments
EP1743890A1 (fr) 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Dérivés 4,5-dihydro-1H-pyrazole, leur, préparation et utilisation comme médicaments.
EP1743892A1 (fr) 2005-07-15 2007-01-17 Laboratorios del Dr. Esteve S.A. Composés pyrazoline substitués, leur préparation et utilisation comme médicaments
CN106631886B (zh) * 2016-11-09 2018-07-03 帕潘纳(北京)科技有限公司 2-硝基-4-三氟甲基苯腈的制备方法

Citations (14)

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US4067872A (en) * 1975-07-02 1978-01-10 Polaroid Corporation Cyclic derivatives of 1,2,3,4 tetrahydroquinoline and indolene
EP0015156A1 (fr) * 1979-02-23 1980-09-03 E.R. Squibb &amp; Sons, Inc. Pyrazoles tricycliques à substitution basique, leur préparation et leur utilisation comme agents anti-inflammatoires
EP0082732A2 (fr) * 1981-12-23 1983-06-29 Konica Corporation Coupleur bloqué formateur de colorant magenta
EP0114002A2 (fr) * 1983-01-06 1984-07-25 Warner-Lambert Company Benzothiopyrano(4,3,2-cd)indazoles, leur compositions pharmaceutiques et méthodes pour leur préparation
DE3314843A1 (de) * 1983-04-23 1984-10-25 Beiersdorf Ag, 2000 Hamburg 1-amidino-2,3,3a,8-tetrahydro-1h-pyrazolo (5,1-a)isoindol, verfahren zu dessen herstellung, diese verbindung enthaltende zubereitungen und zwischenprodukte
EP0163888A1 (fr) * 1984-05-05 1985-12-11 Bayer Ag Amidinohydrazones de dérivés de tétraline, de chromone, de thiachromone et de tétrahydroquinoléine, procédé pour leur préparation et leur utilisation dans des médicaments
EP0215445A2 (fr) * 1985-09-12 1987-03-25 Fujisawa Pharmaceutical Co., Ltd. Dérivés de la pyrazolo-isoquinoléine, leur procédé de préparation et composition pour la régulation de la croissance des plantes
EP0286346A2 (fr) * 1987-04-09 1988-10-12 E.I. Du Pont De Nemours And Company Indazoles substitués insecticides
EP0363051A1 (fr) * 1988-09-22 1990-04-11 E.I. Du Pont De Nemours And Company Indazoles substituées comme arthropodicides
EP0365155A1 (fr) * 1988-09-27 1990-04-25 E.I. Du Pont De Nemours And Company Pyrazolines N-sulfénylées et N-acylées
EP0365201A1 (fr) * 1988-10-11 1990-04-25 E.I. Du Pont De Nemours And Company Indazoles substitués comme arthropodicides
EP0377304A2 (fr) * 1988-12-27 1990-07-11 E.I. Du Pont De Nemours And Company Arthropodicides de semicarbazones substituées
EP0386892A2 (fr) * 1989-03-09 1990-09-12 E.I. Du Pont De Nemours And Company Tetrahydrobenzopyranopyrazoles comme arthropodicides
EP0394043A1 (fr) * 1989-04-19 1990-10-24 Sumitomo Chemical Company, Limited Composés d'amide, leur production et leur usage

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Patent Citations (15)

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US4067872A (en) * 1975-07-02 1978-01-10 Polaroid Corporation Cyclic derivatives of 1,2,3,4 tetrahydroquinoline and indolene
EP0015156A1 (fr) * 1979-02-23 1980-09-03 E.R. Squibb &amp; Sons, Inc. Pyrazoles tricycliques à substitution basique, leur préparation et leur utilisation comme agents anti-inflammatoires
EP0082732A2 (fr) * 1981-12-23 1983-06-29 Konica Corporation Coupleur bloqué formateur de colorant magenta
EP0114002A2 (fr) * 1983-01-06 1984-07-25 Warner-Lambert Company Benzothiopyrano(4,3,2-cd)indazoles, leur compositions pharmaceutiques et méthodes pour leur préparation
DE3314843A1 (de) * 1983-04-23 1984-10-25 Beiersdorf Ag, 2000 Hamburg 1-amidino-2,3,3a,8-tetrahydro-1h-pyrazolo (5,1-a)isoindol, verfahren zu dessen herstellung, diese verbindung enthaltende zubereitungen und zwischenprodukte
EP0163888A1 (fr) * 1984-05-05 1985-12-11 Bayer Ag Amidinohydrazones de dérivés de tétraline, de chromone, de thiachromone et de tétrahydroquinoléine, procédé pour leur préparation et leur utilisation dans des médicaments
EP0215445A2 (fr) * 1985-09-12 1987-03-25 Fujisawa Pharmaceutical Co., Ltd. Dérivés de la pyrazolo-isoquinoléine, leur procédé de préparation et composition pour la régulation de la croissance des plantes
EP0286346A2 (fr) * 1987-04-09 1988-10-12 E.I. Du Pont De Nemours And Company Indazoles substitués insecticides
WO1988007994A1 (fr) * 1987-04-09 1988-10-20 E.I. Du Pont De Nemours And Company Indazoles substitues insecticides
EP0363051A1 (fr) * 1988-09-22 1990-04-11 E.I. Du Pont De Nemours And Company Indazoles substituées comme arthropodicides
EP0365155A1 (fr) * 1988-09-27 1990-04-25 E.I. Du Pont De Nemours And Company Pyrazolines N-sulfénylées et N-acylées
EP0365201A1 (fr) * 1988-10-11 1990-04-25 E.I. Du Pont De Nemours And Company Indazoles substitués comme arthropodicides
EP0377304A2 (fr) * 1988-12-27 1990-07-11 E.I. Du Pont De Nemours And Company Arthropodicides de semicarbazones substituées
EP0386892A2 (fr) * 1989-03-09 1990-09-12 E.I. Du Pont De Nemours And Company Tetrahydrobenzopyranopyrazoles comme arthropodicides
EP0394043A1 (fr) * 1989-04-19 1990-10-24 Sumitomo Chemical Company, Limited Composés d'amide, leur production et leur usage

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Bulletin of the Chemical Society of Japan, vol. 55, no. 8, 1982, (Tokyo, JP), T. SHIMIZU et al.: "Intramolecular 1,3-dipolar cycloadditions and intramolecular ene reactions of 2-(alkenyloxy)benzaldehyde arylhydrazones", pages 2450-2455 (cited in the application) *
Journal of Organic Chemistry, vol. 52, no. 11, 1987, (Easton, US), T. SHIMIZU et al.: "Reactions of aldehydes with hydrazine hydrochlorides in the presence of dipolarophiles; intra- and intermolecular [3+ + 2] cycloadditions", pages 2277-2284 (cited in the application) *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9284275B2 (en) 2007-01-11 2016-03-15 Critical Outcome Technologies Inc. Inhibitor compounds and cancer treatment methods
US8895556B2 (en) 2007-12-26 2014-11-25 Critical Outcome Technologies Inc. Compounds and method for treatment of cancer
US8987272B2 (en) 2010-04-01 2015-03-24 Critical Outcome Technologies Inc. Compounds and method for treatment of HIV
US9422282B2 (en) 2010-04-01 2016-08-23 Critical Outcome Technologies Inc. Compounds and method for treatment of HIV

Also Published As

Publication number Publication date
JPH06500333A (ja) 1994-01-13
EP0543930A1 (fr) 1993-06-02
US5474998A (en) 1995-12-12
WO1992003421A2 (fr) 1992-03-05

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