WO1992003168A1 - Utilisation nouvelle de sels complexes - Google Patents
Utilisation nouvelle de sels complexes Download PDFInfo
- Publication number
- WO1992003168A1 WO1992003168A1 PCT/EP1991/001534 EP9101534W WO9203168A1 WO 1992003168 A1 WO1992003168 A1 WO 1992003168A1 EP 9101534 W EP9101534 W EP 9101534W WO 9203168 A1 WO9203168 A1 WO 9203168A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- salts
- contrast
- complex
- pancreas
- imaging
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title claims description 19
- 210000000496 pancreas Anatomy 0.000 claims abstract description 20
- 239000002872 contrast media Substances 0.000 claims description 25
- 239000011572 manganese Substances 0.000 claims description 18
- 238000003384 imaging method Methods 0.000 claims description 14
- 229910052748 manganese Inorganic materials 0.000 claims description 11
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims description 10
- 229940039231 contrast media Drugs 0.000 claims description 10
- 239000003446 ligand Substances 0.000 claims description 8
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- 159000000007 calcium salts Chemical class 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 239000000654 additive Substances 0.000 claims 1
- SQKUFYLUXROIFM-UHFFFAOYSA-N 2-[2-[carboxymethyl-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)pyridin-4-yl]methyl]amino]ethyl-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)pyridin-4-yl]methyl]amino]acetic acid Chemical compound CC1=NC=C(COP(O)(O)=O)C(CN(CCN(CC(O)=O)CC=2C(=C(C)N=CC=2COP(O)(O)=O)O)CC(O)=O)=C1O SQKUFYLUXROIFM-UHFFFAOYSA-N 0.000 abstract description 8
- 230000003321 amplification Effects 0.000 description 5
- 238000003199 nucleic acid amplification method Methods 0.000 description 5
- 238000001802 infusion Methods 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 150000002696 manganese Chemical class 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- -1 3-hydroxy-2-methyl-5-phosphonomethyl-4-pyridylmethyl Chemical group 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 238000013421 nuclear magnetic resonance imaging Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 238000000264 spin echo pulse sequence Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
Definitions
- the invention relates to the new application of a known complex salt in de NMR diagnostics.
- N N, N'-bis (py ⁇ doxal-5-phosphate) -ethylenediamine-N, N'-diacetic acid or N, N'-bis- (3-hydroxy-2-methyl-5-phosphonomethyl-4-pyridylmethyl) -ethylenediamine- N, N'-diacetic acid is called.
- This manganese complex is referred to in the European patent application 290047 and also in the text below as Mn (DPDP).
- the invention thus relates to the use of manganese complexes with the complex ligand of the formula I and their salts for the production of contrast media for the imaging of the pancreas.
- the invention also relates to contrast media for imaging the pancreas containing a manganese complex with the complex ligand of the formula I and / or its salts.
- the invention furthermore relates to the use of contrast media containing a manganese complex with the complex ligand of the formula I and / or its salts in the imaging of the pancreas.
- the invention comprises a method for producing a contrast agent for imaging the pancreas, which contains a manganese complex with the complex ligand of the formula I and / or its salts, and also conventional auxiliaries, which is characterized in that it is prepared in a known manner Manganese complex and / or its salts are mixed with customary auxiliaries and converted into a contrast medium for imaging the pancreas.
- Possible salts are the salts mentioned in European patent application 290047, and here in particular the sodium / calcium salt. Contrast agents in the sense of the invention are to be understood in particular as NMR contrast agents.
- Figures 1 and 2 below show the signal amplifications in the head and tail of the pancreas (in%) as a function of time ( Figure 1: 0-100 min; Figure 2: 0-400 min). The signal amplification in the liver is given for comparison.
Landscapes
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
L'invention concerne l'utilisation nouvelle du complexe Mn(DPDP) lors de la représentation graphique du pancréas.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH2653/90-7 | 1990-08-15 | ||
| CH265390 | 1990-08-15 | ||
| DE19904026103 DE4026103A1 (de) | 1990-08-17 | 1990-08-17 | Neue verwendung von komplexsalzen |
| DEP4026103.4 | 1990-08-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1992003168A1 true WO1992003168A1 (fr) | 1992-03-05 |
Family
ID=25691060
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP1991/001534 WO1992003168A1 (fr) | 1990-08-15 | 1991-08-13 | Utilisation nouvelle de sels complexes |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0543872A1 (fr) |
| JP (1) | JPH06500090A (fr) |
| AU (1) | AU8325491A (fr) |
| WO (1) | WO1992003168A1 (fr) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0290047A2 (fr) * | 1987-05-08 | 1988-11-09 | Nycomed Salutar, Inc. | Phosphate de dipyridoxyle comme agents de contraste en imagerie par résonance magnétique nucléaire |
| WO1990003975A1 (fr) * | 1988-09-27 | 1990-04-19 | Salutar, Inc. | Chelates de manganese (ii) |
-
1991
- 1991-08-13 WO PCT/EP1991/001534 patent/WO1992003168A1/fr not_active Application Discontinuation
- 1991-08-13 EP EP19910914512 patent/EP0543872A1/fr not_active Withdrawn
- 1991-08-13 AU AU83254/91A patent/AU8325491A/en not_active Abandoned
- 1991-08-13 JP JP3513878A patent/JPH06500090A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0290047A2 (fr) * | 1987-05-08 | 1988-11-09 | Nycomed Salutar, Inc. | Phosphate de dipyridoxyle comme agents de contraste en imagerie par résonance magnétique nucléaire |
| WO1990003975A1 (fr) * | 1988-09-27 | 1990-04-19 | Salutar, Inc. | Chelates de manganese (ii) |
Non-Patent Citations (4)
| Title |
|---|
| Magnetic Resonance in Medicine, Band 10, 1989, Academic Press, Inc., S.W. Young et al.: "MRI measurement of hepatocyte toxicity using the new MRI contrast agent manganese dipyridoxal diphosphate, a manganese/pyridoxal 5-phosphate chelate", Seiten 1-13, siehe Seite 3, Absatz 3 * |
| STN (Karlsruhe) File Server, File Medline, Nr. 91075010, G. Elizondo et al.: "Preclinical evaluation of MnDPDP: new paramagnetic hepatobiliary", Seiten 73-78, & Radiology, (1991 Jan) 178 (1) 73-8, siehe Zusammenfassung * |
| STN (Karlsruhe) File Server, File Medline, Nr. 91075011, K.O. Lim et al.: "Hepatobiliary, MR imaging: first human experience with MnDPDP", Seiten 79-82, & Radiology, (1991 Jan) 178 (1) 79-82, siehe Zusammenfassung * |
| STN (Karlsruhe) File Server, File Medline, Nr. 91297063, H.B. Gehl et al.: "Pancreatic enhancement after low-dose infusion of Mn-DPDP", Seiten 337-339, & Radiology, (1991 Aug) 180 (2) 337-9, siehe Zusammenfassung * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0543872A1 (fr) | 1993-06-02 |
| JPH06500090A (ja) | 1994-01-06 |
| AU8325491A (en) | 1992-03-17 |
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