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WO1992002819A3 - Assay for ulcerative colitis and primary sclerosing cholangitis - Google Patents

Assay for ulcerative colitis and primary sclerosing cholangitis Download PDF

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Publication number
WO1992002819A3
WO1992002819A3 PCT/US1991/005276 US9105276W WO9202819A3 WO 1992002819 A3 WO1992002819 A3 WO 1992002819A3 US 9105276 W US9105276 W US 9105276W WO 9202819 A3 WO9202819 A3 WO 9202819A3
Authority
WO
WIPO (PCT)
Prior art keywords
ulcerative colitis
sclerosing cholangitis
primary sclerosing
assay
patient
Prior art date
Application number
PCT/US1991/005276
Other languages
French (fr)
Other versions
WO1992002819A2 (en
Inventor
Stephan R Targan
Fergus L J Shanahan
Carol J Landers
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of WO1992002819A2 publication Critical patent/WO1992002819A2/en
Publication of WO1992002819A3 publication Critical patent/WO1992002819A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/554—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Physiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides a method for detecting the presence of diseases including ulcerative colitis or primary sclerosing cholangitis in a patient. The method consists of contacting a body sample of the patient with immobilized neutrophils so as to allow the antineutrophilic cytoplasmic antibodies to bind to the neutrophils. Further, the method provides detecting bound anti-neutrophilic cytoplasmic antibodies, the presence of the antibodies indicative of the disease state.
PCT/US1991/005276 1990-08-10 1991-07-25 Assay for ulcerative colitis and primary sclerosing cholangitis WO1992002819A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56605190A 1990-08-10 1990-08-10
US566,051 1990-08-10

Publications (2)

Publication Number Publication Date
WO1992002819A2 WO1992002819A2 (en) 1992-02-20
WO1992002819A3 true WO1992002819A3 (en) 1992-03-19

Family

ID=24261265

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/005276 WO1992002819A2 (en) 1990-08-10 1991-07-25 Assay for ulcerative colitis and primary sclerosing cholangitis

Country Status (1)

Country Link
WO (1) WO1992002819A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211176D0 (en) * 1992-05-27 1992-07-08 Central Blood Lab Authority Assay
US5830675A (en) * 1993-03-10 1998-11-03 Cedars-Sinai Medical Center Methods for selectively detecting perinuclear anti-neutrophil cytoplasmic antibody of ulcerative colitis, primary sclerosing cholangitis, or type 1 autoimmune hepatitis
DK0615129T3 (en) * 1993-03-10 2000-08-07 Cedars Sinai Medical Center Methods for selective detection of perinuclear anti-neutrophil cytoplasmic antibody from ulcerative colitis or
US5681699A (en) * 1994-02-11 1997-10-28 Cedars-Sinai Medical Center Methods of diagnosing ulcerative colitis and Crohn's disease
US6884590B1 (en) 1994-02-11 2005-04-26 Cedars-Sinai Medical Center Methods of screening for ulcerative colitis and crohn's disease
US5738847A (en) * 1994-09-19 1998-04-14 The Regents Of The University Of California Anti-VH3-15 reagents and methods for their use
US5691151A (en) * 1994-10-07 1997-11-25 Regents Of University Of California Methods of screening for ulcerative colitis and crohn's disease by detecting VH3-15 autoantibody and panca
RU2141661C1 (en) * 1998-11-18 1999-11-20 Московский медицинский стоматологический институт Method of treatment of peptic ulcer
US20110229471A1 (en) 2008-11-26 2011-09-22 Cedars-Sinai Medical Center Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease
US9580752B2 (en) 2008-12-24 2017-02-28 Cedars-Sinai Medical Center Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy
AU2014241162A1 (en) 2013-03-27 2015-10-22 Cedars-Sinai Medical Center Mitigation and reversal of fibrosis and inflammation by inhibition of TL1A function and related signaling pathways
WO2015010108A1 (en) 2013-07-19 2015-01-22 Cedars-Sinai Medical Center Signature of tl1a (tnfsf15) signaling pathway
EP3121289A1 (en) 2015-07-22 2017-01-25 Humanitas Mirasole S.p.A. Micrornas as biomarkers of bile duct diseases
KR20240095481A (en) 2016-03-17 2024-06-25 세다르스-신나이 메디칼 센터 Methods of diagnosing inflammatory bowel disease through rnaset2

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CLINICAL AND EXPERIMENTAL IMMUNOLOGY vol. 76, 1989, OXFORD UK pages 30 - 33; J.A. SNOOK ET AL.: 'Anti-neutrophil nuclear antibody in ulcerative colitis, Crohns disease and primary sclerosing cholangitis.' See whole article. *
GASTROENTEROLOGY vol. 100, no. 6, 1 September 1991, WASHINGTON DC USA pages 1590 - 1599; R.H. DUERR ET AL.: 'Anti-neutrophil cytoplasmic antibodies in ulcerative colitis.' See whole article., *
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY vol. 86, no. 2, 1 August 1990, PHILADELPHIA PA USA pages 202 - 210; A. SAXON ET AL.: 'A distinct subset of antineutrophil cytoplasmic antibodies is assiciated with inflammatory bowel disease.' See whole article. *

Also Published As

Publication number Publication date
WO1992002819A2 (en) 1992-02-20

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