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WO1992001794A3 - Ancrod-like proteins, their preparation and their use - Google Patents

Ancrod-like proteins, their preparation and their use Download PDF

Info

Publication number
WO1992001794A3
WO1992001794A3 PCT/EP1991/001361 EP9101361W WO9201794A3 WO 1992001794 A3 WO1992001794 A3 WO 1992001794A3 EP 9101361 W EP9101361 W EP 9101361W WO 9201794 A3 WO9201794 A3 WO 9201794A3
Authority
WO
WIPO (PCT)
Prior art keywords
ancrod
proteins
preparation
amino
glycosylated
Prior art date
Application number
PCT/EP1991/001361
Other languages
German (de)
French (fr)
Other versions
WO1992001794A2 (en
Inventor
Alfred Bach
Heinz Hillen
Siegfried Bialojan
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Priority to DE59106997T priority Critical patent/DE59106997D1/en
Priority to CA002083286A priority patent/CA2083286C/en
Priority to JP91512191A priority patent/JPH05508771A/en
Priority to EP91912909A priority patent/EP0540560B1/en
Publication of WO1992001794A2 publication Critical patent/WO1992001794A2/en
Publication of WO1992001794A3 publication Critical patent/WO1992001794A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6418—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals from snakes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Described are glycosylated, partially glycosylated or unglycosylated polypeptides with the amino-acid sequence given in the sequence protocol and in which up to 10 amino acid groups can be replaced by other, naturally occurring, amino acids. The peptides are suitable for use in treating illnesses.
PCT/EP1991/001361 1990-07-26 1991-07-19 Ancrod-like proteins, their preparation and their use WO1992001794A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE59106997T DE59106997D1 (en) 1990-07-26 1991-07-19 ANCROD SIMILAR PROTEINS, THEIR PRODUCTION AND USE.
CA002083286A CA2083286C (en) 1990-07-26 1991-07-19 Recombinant fibrinogenases, preparation and use thereof
JP91512191A JPH05508771A (en) 1990-07-26 1991-07-19 ANCROD-like proteins, their production and use
EP91912909A EP0540560B1 (en) 1990-07-26 1991-07-19 Ancrod-like proteins, their preparation and their use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4023699.4 1990-07-26
DE4023699A DE4023699A1 (en) 1990-07-26 1990-07-26 NEW PROTEINS, THEIR PRODUCTION AND USE

Publications (2)

Publication Number Publication Date
WO1992001794A2 WO1992001794A2 (en) 1992-02-06
WO1992001794A3 true WO1992001794A3 (en) 1992-03-05

Family

ID=6411021

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1991/001361 WO1992001794A2 (en) 1990-07-26 1991-07-19 Ancrod-like proteins, their preparation and their use

Country Status (8)

Country Link
EP (1) EP0540560B1 (en)
JP (1) JPH05508771A (en)
AT (1) ATE130872T1 (en)
CA (1) CA2083286C (en)
DE (2) DE4023699A1 (en)
DK (1) DK0540560T3 (en)
ES (1) ES2080326T3 (en)
WO (1) WO1992001794A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3841736A1 (en) * 1988-12-10 1990-07-05 Basf Ag ANCROD PROTEINS, THEIR PREPARATION AND USE
KR0127776B1 (en) * 1994-10-11 1997-12-29 허영섭 CDNA sequences of novel proteases and proteins derived therefrom
US5955306A (en) * 1996-09-17 1999-09-21 Millenium Pharmaceuticals, Inc. Genes encoding proteins that interact with the tub protein

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4585653A (en) * 1984-02-27 1986-04-29 Robert L. Letcher Neuraminidase treated ancrod
US4610879A (en) * 1984-01-06 1986-09-09 University Of Southern California Fibrinolytic enzyme from snake vernom
WO1990006362A1 (en) * 1988-12-10 1990-06-14 Basf Aktiengesellschaft Ancrod proteins, their production and use
EP0395375A1 (en) * 1989-04-26 1990-10-31 Knoll Ag Novel DNA sequences which encode ancrod-like polypeptides and compositions comprising the expression products thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4610879A (en) * 1984-01-06 1986-09-09 University Of Southern California Fibrinolytic enzyme from snake vernom
US4585653A (en) * 1984-02-27 1986-04-29 Robert L. Letcher Neuraminidase treated ancrod
WO1990006362A1 (en) * 1988-12-10 1990-06-14 Basf Aktiengesellschaft Ancrod proteins, their production and use
EP0395375A1 (en) * 1989-04-26 1990-10-31 Knoll Ag Novel DNA sequences which encode ancrod-like polypeptides and compositions comprising the expression products thereof

Also Published As

Publication number Publication date
ATE130872T1 (en) 1995-12-15
EP0540560A1 (en) 1993-05-12
ES2080326T3 (en) 1996-02-01
JPH05508771A (en) 1993-12-09
CA2083286C (en) 2001-11-27
WO1992001794A2 (en) 1992-02-06
DK0540560T3 (en) 1995-12-27
CA2083286A1 (en) 1992-01-27
DE59106997D1 (en) 1996-01-11
EP0540560B1 (en) 1995-11-29
DE4023699A1 (en) 1992-01-30

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