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WO1992000977A3 - Derives de 4-alkylimidazole - Google Patents

Derives de 4-alkylimidazole Download PDF

Info

Publication number
WO1992000977A3
WO1992000977A3 PCT/US1991/004826 US9104826W WO9200977A3 WO 1992000977 A3 WO1992000977 A3 WO 1992000977A3 US 9104826 W US9104826 W US 9104826W WO 9200977 A3 WO9200977 A3 WO 9200977A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkylimidazole derivatives
alkylimidazole
derivatives
coumpounds
angiotensin
Prior art date
Application number
PCT/US1991/004826
Other languages
English (en)
Other versions
WO1992000977A2 (fr
Inventor
David John Carini
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE69108913T priority Critical patent/DE69108913T2/de
Priority to CA002087274A priority patent/CA2087274C/fr
Priority to SK3912-92A priority patent/SK279326B6/sk
Priority to RO93-00803A priority patent/RO111270B1/ro
Priority to PL91297616A priority patent/PL168311B1/pl
Priority to HU9204058A priority patent/HU223530B1/hu
Priority to CS923912A priority patent/CZ280018B6/cs
Application filed by Du Pont filed Critical Du Pont
Priority to EP91914167A priority patent/EP0539509B1/fr
Publication of WO1992000977A2 publication Critical patent/WO1992000977A2/fr
Publication of WO1992000977A3 publication Critical patent/WO1992000977A3/fr
Priority to NO930088A priority patent/NO303015B1/no
Priority to FI930109A priority patent/FI102752B1/fi
Priority to BG97438A priority patent/BG61341B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Lubricants (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Composés antihypertenseurs d'antagoniste d'angiotensine II, tel que représentés par la formule (I), dans lesquels R2 représente -CHO ou -COOH et R1 représente éthyle. Ces composés ont une remarquable efficacité par voie orale.
PCT/US1991/004826 1990-07-13 1991-07-15 Derives de 4-alkylimidazole WO1992000977A2 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
EP91914167A EP0539509B1 (fr) 1990-07-13 1991-07-15 Derives de 4-alkylimidazole
SK3912-92A SK279326B6 (sk) 1990-07-13 1991-07-15 Antihypertenzívne zlúčeniny a farmaceutický prostr
RO93-00803A RO111270B1 (ro) 1990-07-13 1991-07-15 Derivati de 4-alchilimidazol
PL91297616A PL168311B1 (pl) 1990-07-13 1991-07-15 Sposób wytwarzania terapeutycznie czynnych zwiazków imidazolowych PL
HU9204058A HU223530B1 (hu) 1990-07-13 1991-07-15 4-Alkil-imidazol-származékok
DE69108913T DE69108913T2 (de) 1990-07-13 1991-07-15 4-alkylimidazolderivate.
CA002087274A CA2087274C (fr) 1990-07-13 1991-07-15 Derives 4-alkylimidazole
CS923912A CZ280018B6 (cs) 1990-07-13 1991-07-15 4-alkylimidazolové deriváty
NO930088A NO303015B1 (no) 1990-07-13 1993-01-11 AnalogifremgangsmÕte for fremstilling av terapeutisk aktive 4-alkylimidazolderivater
FI930109A FI102752B1 (fi) 1990-07-13 1993-01-12 Menetelmä verenpainetta alentavien 4-alkyyli-imidatsolijohdannaisten valmistamiseksi
BG97438A BG61341B1 (en) 1990-07-13 1993-02-11 4- alkylimidazole derivatives

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US55263790A 1990-07-13 1990-07-13
US552,637 1990-07-13
US650,258 1991-02-04
US07/650,258 US5137902A (en) 1990-07-13 1991-02-04 4-alkylimidazole derivatives and anti-hypertensive use thereof

Publications (2)

Publication Number Publication Date
WO1992000977A2 WO1992000977A2 (fr) 1992-01-23
WO1992000977A3 true WO1992000977A3 (fr) 1992-02-20

Family

ID=27070086

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/004826 WO1992000977A2 (fr) 1990-07-13 1991-07-15 Derives de 4-alkylimidazole

Country Status (23)

Country Link
US (1) US5137902A (fr)
EP (1) EP0539509B1 (fr)
JP (1) JP2550455B2 (fr)
KR (1) KR0162669B1 (fr)
AT (1) ATE121087T1 (fr)
AU (1) AU639400B2 (fr)
BG (1) BG61341B1 (fr)
CA (1) CA2087274C (fr)
CZ (1) CZ280018B6 (fr)
DE (1) DE69108913T2 (fr)
DK (1) DK0539509T3 (fr)
ES (1) ES2071325T3 (fr)
FI (1) FI102752B1 (fr)
HU (2) HUT63411A (fr)
IE (1) IE69849B1 (fr)
IL (1) IL98794A (fr)
MY (1) MY140243A (fr)
NO (1) NO303015B1 (fr)
NZ (1) NZ238920A (fr)
PL (1) PL168311B1 (fr)
RO (1) RO111270B1 (fr)
SK (1) SK279326B6 (fr)
WO (1) WO1992000977A2 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
DE4132633A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Cyclisch substituierte imidazolyl-propensaeurederivate
US5250558A (en) * 1992-01-28 1993-10-05 Merck & Co., Inc. Substituted triazolinones, triazolinethiones, and triazolinimines as neurotensin antagonists used to treat psychosis
WO1993017681A1 (fr) * 1992-03-02 1993-09-16 Abbott Laboratories Antagonistes du recepteur d'angiotensine ii
GB9218449D0 (en) 1992-08-29 1992-10-14 Boots Co Plc Therapeutic agents
US5310929A (en) * 1992-08-06 1994-05-10 E. I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
CA2111662C (fr) * 1992-12-17 2004-11-23 Hiroaki Yanagisawa Derives de biphenyles, leur preparation et leur utilisation pour le traitement de l'hypertension et des maladies cardiaques
US5338740A (en) * 1993-07-13 1994-08-16 Pfizer Inc. Angiotensin II receptor antagonists
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
WO2001082858A2 (fr) * 2000-05-04 2001-11-08 Ipf Pharmaceuticals Gmbh Nouveaux composes pour le traitement de maladies inflammatoires et cardiovasculaires
ATE493973T1 (de) 2004-06-04 2011-01-15 Teva Pharma Irbesartan enthaltende pharmazeutische zusammensetzung
KR20090102883A (ko) * 2004-09-02 2009-09-30 테바 파마슈티컬 인더스트리즈 리미티드 올메살탄 메독소밀의 정제
US20070054948A1 (en) * 2004-09-02 2007-03-08 Lilach Hedvati Purification of olmesartan medoxomil
DK2170930T3 (da) 2007-06-04 2012-11-05 Synergy Pharmaceuticals Inc Agonister af guanylatcyclase, anvendelige til behandlingen af gastrointestinale sygdomme, inflammation, cancer og andre sygdomme
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2522968T3 (es) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
EP3241839B1 (fr) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonistes de guanylate cyclase utiles pour le traitement de troubles gastro-intestinaux, inflammatoires, cancéreux et autres
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2905438A1 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase et leurs utilisations
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
KR102272746B1 (ko) 2013-06-05 2021-07-08 보슈 헬스 아일랜드 리미티드 구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
EP0324377A2 (fr) * 1988-01-07 1989-07-19 E.I. Du Pont De Nemours And Company Imidazoles à activité bloquante de récepteur de l'angiotensine II et leurs combinaisons avec des agents diurétiques et NSaids
EP0401030A2 (fr) * 1989-06-01 1990-12-05 Merck & Co. Inc. Antagonistes de l'angiotensine II
WO1991000277A1 (fr) * 1989-06-30 1991-01-10 E.I. Du Pont De Nemours And Company Imidazoles substitues
WO1991000281A2 (fr) * 1989-06-30 1991-01-10 E.I. Du Pont De Nemours And Company Imidazoles a substitution aryle a anneau fusionne

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
DE4132633A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Cyclisch substituierte imidazolyl-propensaeurederivate

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
EP0324377A2 (fr) * 1988-01-07 1989-07-19 E.I. Du Pont De Nemours And Company Imidazoles à activité bloquante de récepteur de l'angiotensine II et leurs combinaisons avec des agents diurétiques et NSaids
EP0401030A2 (fr) * 1989-06-01 1990-12-05 Merck & Co. Inc. Antagonistes de l'angiotensine II
WO1991000277A1 (fr) * 1989-06-30 1991-01-10 E.I. Du Pont De Nemours And Company Imidazoles substitues
WO1991000281A2 (fr) * 1989-06-30 1991-01-10 E.I. Du Pont De Nemours And Company Imidazoles a substitution aryle a anneau fusionne

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BIOCHEM. BIOPHYS. RES. COMMUN. vol. 177, no. 1, 31 May 1991, SAN DIEGO pages 209 - 217; ANDREW T. CHIU, A.O.: 'DuP 532 : A Second Generation of Nonpeptide Angiotensin II Receptor Antagonists.' *
THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. vol. 258, no. 1, July 1991, USA pages 49 - 57; PANCRAS C. WONG AND PIETER B. M.W. M. TIMMERMANS: 'Nonpeptide Angiotensin II Receptor Antagonists : Insurmountable Angiotensin II Antagonism of EXP3892 is Reversed by the Surmountable Antagonist DuP 753.' *

Also Published As

Publication number Publication date
RO111270B1 (ro) 1996-08-30
PL168311B1 (pl) 1996-02-29
NO930088D0 (no) 1993-01-11
BG97438A (bg) 1994-03-24
FI930109L (fi) 1993-01-12
ATE121087T1 (de) 1995-04-15
ES2071325T3 (es) 1995-06-16
MY140243A (en) 2009-12-31
FI102752B (fi) 1999-02-15
IL98794A (en) 1995-11-27
NO930088L (no) 1993-01-11
FI930109A0 (fi) 1993-01-12
IL98794A0 (en) 1992-07-15
IE69849B1 (en) 1996-10-02
BG61341B1 (en) 1997-06-30
WO1992000977A2 (fr) 1992-01-23
JP2550455B2 (ja) 1996-11-06
CA2087274A1 (fr) 1992-01-14
HUT63411A (en) 1993-08-30
DE69108913D1 (de) 1995-05-18
DE69108913T2 (de) 1995-08-24
EP0539509B1 (fr) 1995-04-12
HU9204058D0 (en) 1993-03-29
KR0162669B1 (ko) 1998-12-01
PL297616A1 (fr) 1992-07-13
EP0539509A1 (fr) 1993-05-05
HU223530B1 (hu) 2004-08-30
CZ391292A3 (en) 1993-12-15
JPH05508415A (ja) 1993-11-25
NO303015B1 (no) 1998-05-18
US5137902A (en) 1992-08-11
FI102752B1 (fi) 1999-02-15
IE912438A1 (en) 1992-01-15
AU639400B2 (en) 1993-07-22
CZ280018B6 (cs) 1995-09-13
AU8311691A (en) 1992-02-04
SK391292A3 (en) 1993-07-07
SK279326B6 (sk) 1998-10-07
DK0539509T3 (da) 1995-07-03
CA2087274C (fr) 2002-02-19
NZ238920A (en) 1993-07-27

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