+

WO1992000721A1 - Compositions antitartre/antiplaque utilisant des diphosphonates d'azacycloalcane - Google Patents

Compositions antitartre/antiplaque utilisant des diphosphonates d'azacycloalcane Download PDF

Info

Publication number
WO1992000721A1
WO1992000721A1 PCT/US1991/004850 US9104850W WO9200721A1 WO 1992000721 A1 WO1992000721 A1 WO 1992000721A1 US 9104850 W US9104850 W US 9104850W WO 9200721 A1 WO9200721 A1 WO 9200721A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition according
compositions
oral
oral care
calculus
Prior art date
Application number
PCT/US1991/004850
Other languages
English (en)
Inventor
Dennis George Anthony Nelson
Herbert Charles Smitherman
Original Assignee
The Procter & Gamble Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24205160&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1992000721(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by The Procter & Gamble Company filed Critical The Procter & Gamble Company
Priority to DE69114708T priority Critical patent/DE69114708T2/de
Priority to EP91913575A priority patent/EP0539480B1/fr
Priority to SK10193A priority patent/SK10193A3/sk
Publication of WO1992000721A1 publication Critical patent/WO1992000721A1/fr
Priority to CZ93215A priority patent/CZ21593A3/cs
Priority to GR950403080T priority patent/GR3018102T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to oral care compositions such as dentifrices, mouthwashes, lozenges, chewing gums, and the like, which are designed to prevent the accumulation of calculus, or
  • Dental calculus is a deposit which forms on the surfaces of the teeth at the gingival margin. Supragingival calculus appears principally in the areas near the orifices of the salivary ducts; e.g., on the lingual surfaces of the lower anterior teeth and on the buccal surfaces of the upper first and second molars, and on the distal surfaces of the posterior molars.
  • Mature calculus consists of an inorganic material which is largely calcium phosphate arranged in a hydroxyapatite crystal lattice structure similar to bone, enamel and dentine.
  • An organic portion is also present and consists of desquamated epithelial cells, leukocytes, salivary sediment, food debris and various types of microorganisms.
  • the mature calculus As the mature calculus develops, it becomes visibly white or yellowish in color unless stained or discolored by some extraneous agent. In addition to being unsightly and undesirable from an aesthetic standpoint, the mature calculus deposits are constant sources of irritation of the gingiva.
  • the chemical approach to calculus inhibition generally involves crystal growth inhibition and/or chelation of calcium ion which prevents the calculus from forming and/or breaks down mature calculus by removing calcium.
  • Dental plaque comprises an accumulation of bacteria and bacterial by-products on teeth. Plaque adheres tenaciously at points of irregularity or discontinuity, e.g., on rough calculus surfaces, at the gum line, and the like.
  • the chemical approach to c plaque inhibition generally involves the use of antibacterials. o
  • the present invention provides a new solution to the problem of dental calculus and dental plaque by means of the compositions disclosed hereinafter.
  • U.S. Patent 4,244,931, January 13, 1981 and 4,247,5226, January 27, 1981 to Jarvis, et al . disclose pyrophosphate salts in dicalcium phosphate systems.
  • Japanese Patent Application Disclosure No. 4945-1974 discloses soluble pyrophosphates in a variety of dentifrice systems.
  • U.S. Patent 4,333,551, April 6, 1982 to Parran discloses tetraalkali metal salts in mouthwash composi ⁇ tions. Draus, Lesniewski and Miklos, Pyrophosphate and Hexametaphosphate Effects In Vitro Calculus Formation, Arch. Oral Biol., Vol. 15, pp.
  • U.S. Patent 4,847,070, July 11, 1989 to Pyrz et al relates to oral compositions which are effective against calculus contain ⁇ ing a chelating agent which is an acrylic acid polymer or copolymer or EDTA, together with a strontium source, a fluoride ion source and a pyrophosphate ion source.
  • U.S. Patent 4,661,341, April 28, 1987 to Benedict et al relates to oral compositions containing an anticalculus agent which is an acrylic acid polymer or copolymer.
  • U.S. Patent 4,022,880, May 10, 1977 to Vinson et al relates to compositions for inhibiting dental plaque and calculus forma ⁇ tion comprising zinc ions and a nontoxic, organoleptically accept ⁇ able antibacterial agent.
  • U.S. Patent 4,656,031, April 7, 1987 to Lane et al relates to a dentifrice which includes a surfactant and an antiplaque agent comprising a substantially water-insoluble noncationic antimicrobial agent or a zinc salt or a mixture thereof.
  • European Patent Application 0,251,591, Jackson et al., filed June 19, 1987 relates to oral hygiene compositions comprising specified pyrophosphates and antibacterials.
  • U.S. Patent 4,885,155, December 5, 1989 to Parran, Jr. et al. relates to oral compositions containing partic ⁇ ular pyrophosphate salts which provide an anticalculus benefit.
  • compositions comprising:
  • an effective amount generally, at least about 0.05%) of an antimicrobial agent
  • a toxicologically acceptable oral carrier preferably, the oral care compositions herein additionally comprise a course of an effective amount of fluoride ions.
  • Other oral care adjunct materials such as pyrophosphate, various metal cations, and the like, can optionally be used in the compositions and methods herein.
  • An oral care composition in the form of dentifrices, mouthwashes, lozenges, chewing gums, and the like, are provided by this invention.
  • Typical oral care compositions according to this invention comprise:
  • Preferred oral carriers assist in the e ulsification or solubilization of the 5-chloro-2-(2,4-dichlorophenoxy)phenol . This can be achieved, for example, by inclusion of surfactants in the oral carrier.
  • compositions herein additionally comprise a source which will provide from about 100 ppm to about 1500 ppm of fluoride ions.
  • This invention also encompasses a method for preventing the accumulation of calculus and plaque on dental enamel comprising contacting said dental enamel with a composition as disclosed above. Said method is assisted by brushing said dental enamel with a toothpaste which contains an abrasive.
  • Highly preferred oral care compositions according to this invention additionally comprise a source of an effective amount of fluoride ions.
  • sources can include, for example, sodium fluoride, stannous fluoride, sodium monofluorophosphate, and the like.
  • the oral care compositions according to this invention can also additionally comprise an effective amount of a source of pyrophosphate ions to provide additional calculus- controlling benefits.
  • oral care compositions herein can additionally comprise an effective amount of zinc citrate as an adjunct calcu- lus-controlling agent.
  • compositions according to this inven ⁇ tion can additionally comprise an effective amount of a source of a cation selected from the group consisting of zinc, indium, strontium and stannous cations, and mixtures thereof.
  • a source of a cation selected from the group consisting of zinc, indium, strontium and stannous cations, and mixtures thereof.
  • Such compositions, or compositions which additionally comprise an effective amount of a member selected from the group consisting of sodium nitrate and potassium nitrate are useful when treating c sensitive teeth, e.g., in older patients.
  • compositions herein are intended for oral use, toxicologically-acceptable materials are used in the various compositions and methods disclosed hereinafter.
  • azacycl oal kane-2,2-diphosphonates have the formula
  • the antimicrobials used herein can be any of the known c materials which control oral bacterial species. Such materials include cetyl pyridiniu chloride (“CPC”), N-tetradecyl-4-ethyl- pyridinium chloride (“TDEPC”), peroxides such as sodium peroxide, H 2 0 2 and magnesium onoperphthalate (“PAM”; U.S. Patent 4,670,252).
  • CPC cetyl pyridiniu chloride
  • TDEPC N-tetradecyl-4-ethyl- pyridinium chloride
  • PAM magnesium onoperphthalate
  • a highly preferred antimicrobial herein is 10 TRICLOSAN (especially at levels of 0.3-0.6%) which is the trade name of 5-chloro-2-(2,4-dichlorophenoxy)phenol, also known as 2,4,4'-trichloro-2'-hydroxydiphenyl ether; see U.S. Patent 3,506,720.
  • compositions and processes herein are designed to deliver an effective amount of the func ⁇ tional ingredients to the oral cavity safely and conveniently so
  • 25 tooth brushing and/or use of mouthwash will provide the desired benefits. Lesser or greater degrees of anticalculus benefits can be achieved by modifying the regimen. For example, use of a lozenge or chewing gum provides prolonged contact of the teeth with the functional ingredients.
  • compositions in the manner of this invention employs otherwise conventional ingredients such as well-known dentifrice abrasives, flavorants, thickening agents, fluid carriers (especially water-ethanol), sweetening agents, especially noncariogenic sweeteners such as the aspartic acid ⁇ i c derived sweeteners, saccharin and/or cyclamate, standard dental grade sources of fluoride ions such as sodium fluoride, stannous fluoride, and sodium onofluorophosphate (which are noted herein by way of exemplification, and not by way of limitation) and like materials which have come into broad usage in the dental arts. Various formularies are available and can be referred to for details of such materials.
  • the oral care compositions of this invention can comprise an effective amount of fluoride ions.
  • effective amount is meant sufficient fluoride ions to provide a dental enamel-strengthening or anticaries effect.
  • composi ⁇ tions comprising from about 0.0025% to about 2%, preferably from about 0.01% to about 1% by weight of said fluoride ion source will provide sufficient fluoride ions for these desired benefits.
  • compositions herein comprise effective amounts of AHP plus TRICLOSAN plus fluoride.
  • oral care adjunct materials can also be used herein.
  • Such materials are, for example, pyrophosphate, zinc citrate, metal cations, and the like.
  • compositions can comprise from about 0.1% to about 10% by weight of pyrophosphate ions, which can be sourced from pyrophosphate salt such as tetrasodium, tetrapotassium, and disodium dihydrogen pyrophosphates.
  • an “effective amount” of zinc citrate herein is meant an amount sufficient to provide adjunct anticalculus benefits. Typically, an amount of zinc citrate of from about 0.1% to about 5% by weight of the compositions herein is sufficient.
  • an “effective amount" of a source of cation especially cations selected from zinc, indium, strontium and stannous cations, and mixtures thereof, herein is meant a sufficient amount of said cations to provide the benefits which are normally associ- ated with the use of these particular materials in oral composi ⁇ tions.
  • the stannous cation has been associated with an anticaries benefit, as has the indium cation.
  • Zinc and stron ⁇ tium cations have been noted for use in, for example, dentifrice compositions which are used in situations where the tee+h have been made "sensitive" to pain, particularly in older teeth which have undergone serious erosion of the dental enamel.
  • Typical usage levels to provide the aforesaid effective amount of such cations generally ranges from about 0.01% to about 3% by weight of the compositions.
  • Materials such as indium chloride, stannous fluoride, strontium chloride, zinc chloride, and the like can be used for such purposes.
  • an “effective amount” of sodium nitrate and potassium c nitrate (preferred) herein is meant sufficient amounts of such materials to provide desensitization of otherwise sensitive teeth (as noted above). Typically, such amounts can comprise from about 0.01% to about 5% of the compositions herein.
  • abrasives that are safe for use on teeth.
  • abrasives useful herein include calcium carbonate, hydrated alumina, urea-formaldehyde resins (see U.S. Patent 3,070,510) and, as noted, the silica abrasives (see U.S. Patents 3,538,230 and 3,862,307).
  • "Syloid" silica xerogels, available from W. R. Grace 5 and Company and precipitated silicas, e.g., "Zeodent 119" from J. M. Humber Corporation are a preferred class of abrasives used herein.
  • Abrasives are typically in the 0.1 to 30 micron size, and are typically used in toothpastes at the 6% to about 80% level and in toothpowders at levels up to 99%. Silica abrasives are pre- 0 ferred herein.
  • Mouthwashes generally comprise from about 20:1 to about 2:1 of a water/ethyl alcohol solution and preferably other ingredients such as flavoring agents, sweeteners, humectants and sudsing agents such as those described above.
  • the humectants such as glycerin and sorbitol, give a moist feel to the mouth.
  • the mouthwashes of the invention comprise from about 0 5% to about 60%, preferably from about 10% to about 25%, of ethyl alcohol; from 0% to about 20%, preferably from about 5% to about 20%, of a humectant, from 0% to about 2%, preferably from about 0.01% to about 0.15%, of an emulsifying agent; from 0% to about 0.5% of a sweetening agent; from about 0.03% to about 0.3% of a 5 flavoring agent; and the above-specified levels of AHP, TRICLOSAN, fluoride, and the like.
  • Suitable lozenge and chewing gum components are disclosed in U.S. Patent 4,083,955, issued April 11, 1978 to Grabenstetter et al.
  • Suitable topical dental gels generally comprise a base of a humectant such as glycerin thickened with a suitable agent. Such gels generally do not contain an abrasive.
  • Flavoring agents can also be added to the compositions of the present invention. Suitable flavoring agents include oil of wintergreen, oil of peppermint, oil of spearmint, oil of sassafras and oil of clove. Sweetening agents are also useful and include aspartame, acesulfame, saccharin, dextrose, levulose and sodium cyclamate. Flavoring and sweetening agents are generally used in the compositions herein at levels of from about 0.005% to about 2% by weight.
  • compositions of this invention may also contain emulsify- ing agents.
  • Suitable emulsifying agents are those which are reasonably stable and foam throughout a wide pH range, and include non-soap anionic, nonionic, cationic, zwitterionic and amphoteric organic synthetic detergents. Many of these suitable surfactants are disclosed by Gieske et al . in U.S. Patent 4,051,234, issued September 27, 1977, which is incorporated herein by reference. It is preferred that the dentifrice compositions herein contain at least about 0.2%, preferably about 0.5% to about 6%, by weight of a surfactant, especially sodium C 12 -C 18 alkyl sulfate, to help emulsify or partly dissolve TRICLOSAN.
  • a surfactant especially sodium C 12 -C 18 alkyl sulfate
  • Water may also be present in the compositions of this inven ⁇ tion.
  • Water employed in the preparation of commercially suitable compositions should preferably be deionized and free of organic impurities.
  • Water generally comprises from about 10% to about 50% by weight, preferably from about 20% to about 40% by weight, of the toothpaste compositions herein. These amounts of water include the free water which is added plus that which is intro ⁇ quizd with other materials, such as with sorbitol. In preparing toothpastes, it is common to add some thickening material to provide a desirable consistency.
  • Preferred thickening agents are carboxyvinyl polymers, carrageenan, hydroxyethyl cellulose and water soluble salts of cellulose ethers such as sodium carboxymethyl cellulose and sodium carboxymethyl hydroxy ⁇ ethyl cellulose.
  • Natural gums such as gum karaya, gum arabic and gum tragacanth, and polysaccharide gums such as xanthan gum can also be used.
  • Colloidal magnesium aluminum silicate can be used as part of the thickening agent to further improve texture.
  • Thickening agents in an amount from about 0.5% to about 5.0% by weight of the total composition may be used.
  • a hu ectant in a toothpaste to keep it from hardening.
  • Suitable humectants include glycerin, sorbitol and other edible polyhydric alcohols at a level of from about 10% to about 70% by weight.
  • the pH of the present compositions and/or their pH in the mouth can be any pH which is safe for the mouth's hard and soft tissues. Such pH's are generally from about 3 to about 10, preferably from about 7 to about 9.
  • a toothpaste composition is as follows. Ingredient Percent fwt.)
  • a mouthwash composition is- as follows.
  • a toothpowder composition is prepared by dry-blending ingre ⁇ washers, as follows:
  • a toothpaste composition is prepared according to Example I, but with the addition of 0.5% by weight of TDEPC in place of an equivalent weight of TRICLOSAN.
  • the resulting for 'ilation provides anticalculus, antiplaque and anticaries benefits.
  • a lozenge comprising 80% maltose, 2% azacyclopentane-2,2- diphosphonic acid (triethanolammonium salt form), 1% sodium monofluorophosphate, 1.5% gum arabic, 0.1% strontium chloride, 0.1% flavorant, 0.05% magnesium stearate (tableting aid), the balance comprising corn starch, is prepared in a standard tablet press. In use, the lozenge is allowed to dissolve slowly in the mouth to bathe the teeth in the combination of active ingredients.
  • a chewing gum comprises 99.0% standard chewing gum base (chicle), 0.5% flavorant and 0.1% AHP, 0.1% NaF and 0.3% CPC.
  • a dentifrice powder comprises the following mixture of o ingredients.
  • Example VII can be modified by replacing the tetrasodium pyrophosphate with an equivalent amount of 0 tetrapotassium pyrophosphate.
  • a mild toothpowder for sensitive teeth comprises 90% silica abrasive, 0.2% stannous fluoride, 0.1% potassium nitrate, 0.15% zinc sulfate, 1% sodium alkyl sulfate, 1% AHP (K salt), 1% TRICLOSAN, 0.25% CPC, the balance, corn starch, (per Reaction B, herein), the balance comprising flavorant.
  • An oral gel dentifrice comprises 3% AHP with 1.5% TRICLOSAN and 1.5% sodium lauryl sulfate, 1.5% Veegum, 1.5% carboxymethyl cellulose, 1.0% NaF, the balance comprising water.
  • Base toothpaste compositions comprising standard amounts and types of abrasives, thickeners, humectants, surfactants and flavorants and prepared and blended with the following combina- tions of ingredients to provide dentifrice compositions A through
  • adjunct oral care agents can be used in such compositions, including materials such as: the ethylenediamine tetraacetates (EDTA) generally at effec ⁇ tive levels of 0.1%, or less; peroxides, especially 1% aqueous hydrogen peroxide; sodium tripolyphosphate (STPP), typically at 0.5%-10% levels, and the like.
  • EDTA ethylenediamine tetraacetates
  • STPP sodium tripolyphosphate
  • Base mouthwash compositions comprising water, 15% ethanol, standard flavorants and dyes are prepared and blended with the following combinations of ingredients to provide mouthwash compositions A, B and C, as follows.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Des diphosphonates d'azacycloalcane sont utilisés en combinaison avec des agents antimicrobiens, en particulier du 5-chloro-2-(2,4-dichloro-phénoxy) phénol, afin de protéger les dents contre le tartre et la plaque. Des compositions destinées aux soins buccaux, telles que des dentifrices, des bains de bouche et produits analogues, sont décrites.
PCT/US1991/004850 1990-07-13 1991-07-11 Compositions antitartre/antiplaque utilisant des diphosphonates d'azacycloalcane WO1992000721A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE69114708T DE69114708T2 (de) 1990-07-13 1991-07-11 Mittel gegen zahnstein und zahnbelag, die azacycloalkan-diphosphonsäurederivate enthalten.
EP91913575A EP0539480B1 (fr) 1990-07-13 1991-07-11 Compositions antitartre/antiplaque utilisant des diphosphonates d'azacycloalcane
SK10193A SK10193A3 (en) 1990-07-13 1991-07-11 Anticalculus antiplaque compositions using azacycloalkane diphosphonates
CZ93215A CZ21593A3 (en) 1990-07-13 1993-02-17 Mixtures preventing the formation of tartar and bacterial plaque on teeth and containing azacycloalkane diphosphonates
GR950403080T GR3018102T3 (en) 1990-07-13 1995-11-16 Anticalculus/antiplaque compositions using azacycloalkane diphosphonates.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55239990A 1990-07-13 1990-07-13
US552,399 1990-07-13

Publications (1)

Publication Number Publication Date
WO1992000721A1 true WO1992000721A1 (fr) 1992-01-23

Family

ID=24205160

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/004850 WO1992000721A1 (fr) 1990-07-13 1991-07-11 Compositions antitartre/antiplaque utilisant des diphosphonates d'azacycloalcane

Country Status (14)

Country Link
EP (1) EP0539480B1 (fr)
AT (1) ATE130185T1 (fr)
AU (1) AU8231191A (fr)
CA (1) CA2086620C (fr)
CZ (1) CZ21593A3 (fr)
DE (1) DE69114708T2 (fr)
DK (1) DK0539480T3 (fr)
ES (1) ES2079673T3 (fr)
GR (1) GR3018102T3 (fr)
HU (1) HUT63323A (fr)
IE (1) IE71649B1 (fr)
PT (1) PT98309A (fr)
SK (1) SK10193A3 (fr)
WO (1) WO1992000721A1 (fr)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0480811A3 (en) * 1990-10-09 1993-01-27 Colgate-Palmolive Company (A Delaware Corporation) Non-staining anti-bacterial oral composition
US5256401A (en) * 1987-01-30 1993-10-26 Colgate-Palmolive Company Antibacterial antiplaque mouthwash composition
US5283057A (en) * 1992-04-24 1994-02-01 The Procter & Gamble Company Risedronate in oral compositions
US5318772A (en) * 1991-12-10 1994-06-07 The Dow Chemical Company Oral compositions for inhibiting calculus formation
US5320829A (en) * 1991-12-10 1994-06-14 The Dow Chemical Company Oral compositions for inhibiting plaque formation
FR2700118A1 (fr) * 1993-01-07 1994-07-08 Colgate Palmolive Co Composition à usage buccal contre la plaque dentaire et son procédé d'utilisation.
US5338537A (en) * 1993-10-05 1994-08-16 The Procter & Gamble Company Oral compositions
WO1994023691A3 (fr) * 1993-04-08 1995-01-12 Procter & Gamble Compositions orales de traitement de la plaque dentaire et de la gingivite, contenant un agent antibacterien non cationique et un sel de bicarbonate
US5486350A (en) * 1991-10-17 1996-01-23 Colgate Palmolive Company Desensitizing anti-tartar dentifrice
US5505933A (en) * 1994-06-27 1996-04-09 Colgate Palmolive Company Desensitizing anti-tartar dentifrice
WO1999002539A1 (fr) * 1997-07-09 1999-01-21 Geange Limited Sels d'acide diphosphonique pour le traitement de l'osteoporose
EP0875238A3 (fr) * 1997-04-22 2000-04-05 The Procter & Gamble Company Compositions dentifrices
US6214320B1 (en) * 1990-10-09 2001-04-10 Colgate-Palmolive Company Oral compositions containing anticalculus and antiplaque agents
RU2170079C2 (ru) * 1995-09-22 2001-07-10 Колгейт-Палмолив Компани Антимикробная композиция для перорального применения и предотвращения образования зубного налета и соединение
RU2183453C2 (ru) * 1996-06-07 2002-06-20 Колгейт-Палмолив Компани Пероральная композиция, предназначенная для ингибирования скопления бактериальных бляшек на дентине
WO2004080434A1 (fr) * 2003-03-12 2004-09-23 Henkel Kommanditgesellschaft Auf Aktien Agents de soin bucco-dentaire

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3988443A (en) * 1973-08-27 1976-10-26 Henkel & Cie G.M.B.H. Azacycloalkane-2,2-diphosphonic acids
FR2361865A1 (fr) * 1976-08-16 1978-03-17 Colgate Palmolive Co Composition pour l'hygiene buccale et son procede de preparation
US4575456A (en) * 1984-11-30 1986-03-11 Colgate-Palmolive Company Gel dentifrice of desirable consistency

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3988443A (en) * 1973-08-27 1976-10-26 Henkel & Cie G.M.B.H. Azacycloalkane-2,2-diphosphonic acids
FR2361865A1 (fr) * 1976-08-16 1978-03-17 Colgate Palmolive Co Composition pour l'hygiene buccale et son procede de preparation
US4575456A (en) * 1984-11-30 1986-03-11 Colgate-Palmolive Company Gel dentifrice of desirable consistency

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256401A (en) * 1987-01-30 1993-10-26 Colgate-Palmolive Company Antibacterial antiplaque mouthwash composition
US6214320B1 (en) * 1990-10-09 2001-04-10 Colgate-Palmolive Company Oral compositions containing anticalculus and antiplaque agents
EP0480811A3 (en) * 1990-10-09 1993-01-27 Colgate-Palmolive Company (A Delaware Corporation) Non-staining anti-bacterial oral composition
US5486350A (en) * 1991-10-17 1996-01-23 Colgate Palmolive Company Desensitizing anti-tartar dentifrice
US5318772A (en) * 1991-12-10 1994-06-07 The Dow Chemical Company Oral compositions for inhibiting calculus formation
US5320829A (en) * 1991-12-10 1994-06-14 The Dow Chemical Company Oral compositions for inhibiting plaque formation
US5283057A (en) * 1992-04-24 1994-02-01 The Procter & Gamble Company Risedronate in oral compositions
FR2700118A1 (fr) * 1993-01-07 1994-07-08 Colgate Palmolive Co Composition à usage buccal contre la plaque dentaire et son procédé d'utilisation.
GB2274247A (en) * 1993-01-07 1994-07-20 Colgate Palmolive Co Oral antiplaque compositions
US5368845A (en) * 1993-01-07 1994-11-29 Colgate Palmolive Company Oral composition
WO1994023691A3 (fr) * 1993-04-08 1995-01-12 Procter & Gamble Compositions orales de traitement de la plaque dentaire et de la gingivite, contenant un agent antibacterien non cationique et un sel de bicarbonate
WO1995009602A1 (fr) * 1993-10-05 1995-04-13 The Procter & Gamble Company Compositions orales
TR27989A (tr) * 1993-10-05 1995-11-13 Procter & Gamble Antitartar ve antigingivitis yararlari temin eden oral bilesimler.
US5338537A (en) * 1993-10-05 1994-08-16 The Procter & Gamble Company Oral compositions
US5505933A (en) * 1994-06-27 1996-04-09 Colgate Palmolive Company Desensitizing anti-tartar dentifrice
RU2170079C2 (ru) * 1995-09-22 2001-07-10 Колгейт-Палмолив Компани Антимикробная композиция для перорального применения и предотвращения образования зубного налета и соединение
RU2183453C2 (ru) * 1996-06-07 2002-06-20 Колгейт-Палмолив Компани Пероральная композиция, предназначенная для ингибирования скопления бактериальных бляшек на дентине
EP0875238A3 (fr) * 1997-04-22 2000-04-05 The Procter & Gamble Company Compositions dentifrices
WO1999002539A1 (fr) * 1997-07-09 1999-01-21 Geange Limited Sels d'acide diphosphonique pour le traitement de l'osteoporose
US6410782B1 (en) 1997-07-09 2002-06-25 Geange Ltd. Diphosphonic acid salts for the treatment of osteoporosis
WO2004080434A1 (fr) * 2003-03-12 2004-09-23 Henkel Kommanditgesellschaft Auf Aktien Agents de soin bucco-dentaire

Also Published As

Publication number Publication date
DE69114708D1 (de) 1995-12-21
DE69114708T2 (de) 1996-05-02
ATE130185T1 (de) 1995-12-15
ES2079673T3 (es) 1996-01-16
EP0539480B1 (fr) 1995-11-15
CZ21593A3 (en) 1993-07-14
IE912450A1 (en) 1992-01-15
EP0539480A1 (fr) 1993-05-05
DK0539480T3 (da) 1996-03-11
IE71649B1 (en) 1997-02-26
HUT63323A (en) 1993-08-30
AU8231191A (en) 1992-02-04
HU9300066D0 (en) 1993-04-28
GR3018102T3 (en) 1996-02-29
CA2086620C (fr) 1997-10-14
CA2086620A1 (fr) 1992-01-14
SK10193A3 (en) 1993-10-06
PT98309A (pt) 1992-05-29

Similar Documents

Publication Publication Date Title
US5015466A (en) Anticalculus compositions using tartrate-succinates
US5015467A (en) Combined anticalculus and antiplaque compositions
US5096701A (en) Oral compositions
CA2097493C (fr) Compositions orales
US5208009A (en) Anticalculus oral compositions
EP0180435B1 (fr) Compositions orales
EP0609215B1 (fr) Dentifrices anti-tartre
US5188820A (en) Method of inhibiting plaque on teeth by applying an oral composition
US5338537A (en) Oral compositions
US5096699A (en) Anticalculus oral compositions
CA2086620C (fr) Compositions anticalcul et antiplaque a base de diphosphonates d'azacylcloalcane
WO1994014406A1 (fr) Compositions de soins bucco-dentaires contenant des agents anti-plaque et anti-tartre
US5578295A (en) Oral care compositions comprising certain substituted diphenyl ethers
JPH062657B2 (ja) 口腔用組成物
EP0697855A1 (fr) Compositions orales
US20220401321A1 (en) Oral Care Compositions
CA2026906C (fr) Compositions pour usage buccal
EP0483111A2 (fr) Composition contre les calculs
US5068100A (en) Anticalculus compositions
EP0265186A2 (fr) Compositions contre le tartre dentaire
US3894147A (en) Method and composition for inhibiting calculus
US5011830A (en) Oral compositions having improved anticalculus properties containing pyrophosphate and an acrylic acid polymer
CA2754213C (fr) Dentifrice desensibilisant presentant une absorption d'agent antibacterien pour tissu dentaire
US4990328A (en) Anticalculus compositions
WO1994000102A1 (fr) Compositions agissant contre le tartre dentaire

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AT AU BB BG BR CA CH CS DE DK ES FI GB HU JP KP KR LK LU MC MG MW NL NO PL RO SD SE SU

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE BF BJ CF CG CH CI CM DE DK ES FR GA GB GN GR IT LU ML MR NL SE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2086620

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 1991913575

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 10193

Country of ref document: SK

Ref document number: PV1993-215

Country of ref document: CZ

WWP Wipo information: published in national office

Ref document number: 1991913575

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: PV1993-215

Country of ref document: CZ

ENP Entry into the national phase

Ref document number: 2101336

Country of ref document: CA

Kind code of ref document: A

Ref document number: 2101336

Country of ref document: CA

WWG Wipo information: grant in national office

Ref document number: 1991913575

Country of ref document: EP

WWR Wipo information: refused in national office

Ref document number: PV1993-215

Country of ref document: CZ

WWW Wipo information: withdrawn in national office

Ref document number: 1991913575

Country of ref document: EP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载