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WO1992000759A3 - Complexes radiopharmaceutiques therapeutiques stabilises - Google Patents

Complexes radiopharmaceutiques therapeutiques stabilises Download PDF

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Publication number
WO1992000759A3
WO1992000759A3 PCT/US1991/004749 US9104749W WO9200759A3 WO 1992000759 A3 WO1992000759 A3 WO 1992000759A3 US 9104749 W US9104749 W US 9104749W WO 9200759 A3 WO9200759 A3 WO 9200759A3
Authority
WO
WIPO (PCT)
Prior art keywords
radionuclide
stable
therapeutic radiopharmaceutical
stabilized therapeutic
radiopharmaceutical complexes
Prior art date
Application number
PCT/US1991/004749
Other languages
English (en)
Other versions
WO1992000759A2 (fr
Inventor
Robert F Wolfangel
Original Assignee
Mallinckrodt Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Medical Inc filed Critical Mallinckrodt Medical Inc
Priority to AU84242/91A priority Critical patent/AU656915B2/en
Priority to EP91915301A priority patent/EP0660722A1/fr
Publication of WO1992000759A2 publication Critical patent/WO1992000759A2/fr
Publication of WO1992000759A3 publication Critical patent/WO1992000759A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

Procédé de préparation d'une composition radiopharmaceutique thérapeutique stable composée d'un radionuclide alpha ou bêta-radiateur et d'un ligand, en lyophilisant une solution dudit complexe. Le radionuclide a de préférence une demi-vie d'au moins douze heures. L'invention concerne également des compositions radiopharmaceutiques lyophilisées stables préparées selon ce procédé. Elle convient particulièrement à la préparation d'anticorps marqués par radionuclides sous une forme stable, qui requiert simplement une reconstitution au moment de l'usage.
PCT/US1991/004749 1990-07-09 1991-07-03 Complexes radiopharmaceutiques therapeutiques stabilises WO1992000759A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU84242/91A AU656915B2 (en) 1990-07-09 1991-07-03 Stabilized therapeutic radiopharmaceutical complexes
EP91915301A EP0660722A1 (fr) 1990-07-09 1991-07-03 Complexes radiopharmaceutiques therapeutiques stabilises

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US549,981 1990-07-09
US07/549,981 US5219556A (en) 1990-07-09 1990-07-09 Stabilized therapeutic radiopharmaceutical complexes

Publications (2)

Publication Number Publication Date
WO1992000759A2 WO1992000759A2 (fr) 1992-01-23
WO1992000759A3 true WO1992000759A3 (fr) 1992-02-20

Family

ID=24195225

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/004749 WO1992000759A2 (fr) 1990-07-09 1991-07-03 Complexes radiopharmaceutiques therapeutiques stabilises

Country Status (5)

Country Link
US (1) US5219556A (fr)
EP (1) EP0660722A1 (fr)
AU (1) AU656915B2 (fr)
CA (1) CA2087009A1 (fr)
WO (1) WO1992000759A2 (fr)

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MC2260A1 (fr) * 1990-06-18 1993-04-26 Dow Chemical Co Formulations de produits radiopharmaceutiques,leur methode d'administration et leur procede de preparation
ES2150916T3 (es) * 1991-08-29 2000-12-16 Mallinckrodt Medical Inc Utilizacion del acido gentisico o del alcohol gentisilico para estabilizar peptidos y proteinas radiomarcados.
US6066309A (en) 1996-02-02 2000-05-23 Rhomed Incorporated Post-labeling stabilization of radiolabeled proteins and peptides
US20010055563A1 (en) 1999-09-09 2001-12-27 Rhomed Incorporated Post-labeling stabilization of radiolabeled proteins and peptides
CA2259343C (fr) * 1996-06-24 2002-12-03 The Dupont Merck Pharmaceutical Company Compositions et supports radiopharmaceutiques de type nouveau et leurs utilisations
US6027710A (en) * 1996-09-18 2000-02-22 Nihon Medi-Physiscs Co., Ltd. Radiation-protecting agent
IL122094A (en) 1997-11-03 2003-07-06 Israel Atomic Energy Comm In situ-generated solid radiation source based on tungsten<188>/rhenium<188> and the use thereof
MY133346A (en) 1999-03-01 2007-11-30 Biogen Inc Kit for radiolabeling ligands with yttrium-90
US20020102208A1 (en) * 1999-03-01 2002-08-01 Paul Chinn Radiolabeling kit and binding assay
AU5871000A (en) * 1999-06-11 2001-01-02 Paul G. Abrams High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
DE60041713D1 (de) 1999-11-30 2009-04-16 Scott Schenter Verfahren zur erzeugung von actinium-225 und töchtern
DE10016559A1 (de) * 2000-04-03 2001-10-18 Eucro Europe Contract Res Gmbh System für den Transport von Aktivstoffen in einem biologischen System
WO2002022615A1 (fr) * 2000-09-14 2002-03-21 Merck & Co., Inc. Antagonistes du recepteur de l'alpha v integrine
KR20030043931A (ko) * 2000-09-18 2003-06-02 에프. 에이취. 펄딩 앤드 컴파니 리미티드 디포스포네이트 용액
ATE445418T1 (de) * 2000-10-19 2009-10-15 Bracco Imaging Spa Radiopharmazeutische formulierungen
US7850947B2 (en) 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
US7611692B2 (en) * 2003-01-13 2009-11-03 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US8420050B2 (en) * 2003-01-13 2013-04-16 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US20070269375A1 (en) * 2003-07-24 2007-11-22 Bracco Imaging S.P.A. Stable Radiopharmaceutical Compositions and Methods for Preparation
US7229603B2 (en) * 2004-06-17 2007-06-12 Anazaohealth Corporation Stablilized and lyophilized radiopharmaceutical agents
US20070189965A1 (en) * 2004-06-17 2007-08-16 Kuperus John H Copper-complex isonitrile positron emission tomography (pet) imaging agent and method
JP2008503493A (ja) * 2004-06-17 2008-02-07 アナザオヘルス コーポレーション 腫瘍を破壊するための安定化され凍結乾燥された放射性薬剤
JP5264500B2 (ja) 2005-12-22 2013-08-14 デューク ユニバーシティー 薬剤をα−粒子エミッターによって放射標識するための安定化組成物および方法
US20080206879A1 (en) * 2007-02-28 2008-08-28 The Lubrizol Corporation Analysis of Functional Fluids Using a Redox Indicator
CN113385118A (zh) * 2020-03-12 2021-09-14 益诺思生物技术海门有限公司 一种125i药物标记及纯化装置及其方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0081193A2 (fr) * 1981-12-03 1983-06-15 Nihon Medi-Physics Co., Ltd. Agent diagnostique radioactif stable et support non radioactif pour celui-ci
US4515766A (en) * 1980-06-23 1985-05-07 The Massachusetts General Hospital Labeled phosphonic acid compositions for investigations of in vivo deposits of calcium
EP0164843A2 (fr) * 1984-06-04 1985-12-18 The Dow Chemical Company Complexes organiques d'acide aminophosphonique pour le traitement de tumeurs calcifiantes
EP0173424A1 (fr) * 1984-06-25 1986-03-05 University Of Utah Research Foundation Chélates de technétium radioactif marqués pour usage dans la détermination de la fonction rénale
EP0174853A2 (fr) * 1984-09-13 1986-03-19 Mallinckrodt, Inc. (a Delaware corporation) Fragments d'anticorps marqués
EP0196669A2 (fr) * 1985-04-03 1986-10-08 The Du Pont Merck Pharmaceutical Company Procédé de conjugaison de la métallothionéine avec des molécules biologiquement actives
EP0250966A1 (fr) * 1986-06-13 1988-01-07 University Of Cincinnati Procédé pour isoler et purifier des médicaments contenant du rhénium radioactif lié par coordination, leur usage et équipement

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
US4062933A (en) * 1975-05-27 1977-12-13 Mallinckrodt, Inc. Colloidal compositions with protective agents suitable for radioactive labeling
USRE32417E (en) * 1979-10-29 1987-05-12 Summa Medical Corporation Radiolabeled antibody to anti-tumor associated antigen and process
US4341755A (en) * 1980-07-15 1982-07-27 Immuno Nuclear Corporation Parathyroid radioimmunoassay
US4485086A (en) * 1983-04-11 1984-11-27 Wong Dennis W Radiolabeled tumor imaging agent and method of preparation
US4636380A (en) * 1984-04-23 1987-01-13 Wong Dennis W Novel physiologic chemical method of labeling protein substances with the radionuclides of indium
US4652440A (en) * 1984-05-03 1987-03-24 Paik Chang H Method of stably radiolabeling antibodies with technetium and rhenium
US5001072A (en) * 1984-05-23 1991-03-19 Icn Biomedicals Inc. Compositions and methods for multiple simultaneous immunoradiometric assay (IRMA) of analytes using radioisotope chelate labels
US4898724A (en) * 1984-06-04 1990-02-06 The Dow Chemical Company Organis amine phosphonic acid complexes for the treatment of calcific tumors
US4897255A (en) * 1985-01-14 1990-01-30 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
GB8510726D0 (en) * 1985-04-26 1985-06-26 Amersham Int Plc Stabilised radio-labelled compounds
US4778672A (en) * 1985-11-27 1988-10-18 University Of Cincinnati Method of isolating radioactive perrhenate or pertechnetate from an aqueous solution

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515766A (en) * 1980-06-23 1985-05-07 The Massachusetts General Hospital Labeled phosphonic acid compositions for investigations of in vivo deposits of calcium
EP0081193A2 (fr) * 1981-12-03 1983-06-15 Nihon Medi-Physics Co., Ltd. Agent diagnostique radioactif stable et support non radioactif pour celui-ci
EP0164843A2 (fr) * 1984-06-04 1985-12-18 The Dow Chemical Company Complexes organiques d'acide aminophosphonique pour le traitement de tumeurs calcifiantes
EP0173424A1 (fr) * 1984-06-25 1986-03-05 University Of Utah Research Foundation Chélates de technétium radioactif marqués pour usage dans la détermination de la fonction rénale
EP0174853A2 (fr) * 1984-09-13 1986-03-19 Mallinckrodt, Inc. (a Delaware corporation) Fragments d'anticorps marqués
EP0196669A2 (fr) * 1985-04-03 1986-10-08 The Du Pont Merck Pharmaceutical Company Procédé de conjugaison de la métallothionéine avec des molécules biologiquement actives
EP0250966A1 (fr) * 1986-06-13 1988-01-07 University Of Cincinnati Procédé pour isoler et purifier des médicaments contenant du rhénium radioactif lié par coordination, leur usage et équipement

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. NUCL. MED., vol. 18, no. 5, 1977, (New York, US), B.W. WISTOW et al.: "An evaluation of 99mTc-labeled hepatobiliary agents", pages 455-461, see whole article (cited in the application) *

Also Published As

Publication number Publication date
US5219556A (en) 1993-06-15
AU8424291A (en) 1992-02-04
CA2087009A1 (fr) 1992-01-10
WO1992000759A2 (fr) 1992-01-23
AU656915B2 (en) 1995-02-23
EP0660722A1 (fr) 1995-07-05

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