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WO1991018535A1 - Dispositif applicateur - Google Patents

Dispositif applicateur Download PDF

Info

Publication number
WO1991018535A1
WO1991018535A1 PCT/AU1991/000225 AU9100225W WO9118535A1 WO 1991018535 A1 WO1991018535 A1 WO 1991018535A1 AU 9100225 W AU9100225 W AU 9100225W WO 9118535 A1 WO9118535 A1 WO 9118535A1
Authority
WO
WIPO (PCT)
Prior art keywords
liquid
container
wick
application device
absorbent
Prior art date
Application number
PCT/AU1991/000225
Other languages
English (en)
Inventor
Kaye Lynette Howell
Original Assignee
Kalumburu Pty. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kalumburu Pty. Ltd. filed Critical Kalumburu Pty. Ltd.
Publication of WO1991018535A1 publication Critical patent/WO1991018535A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D34/00—Containers or accessories specially adapted for handling liquid toiletry or cosmetic substances, e.g. perfumes
    • A45D34/04—Appliances specially adapted for applying liquid, e.g. using roller or ball
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D2200/00—Details not otherwise provided for in A45D
    • A45D2200/10—Details of applicators
    • A45D2200/1009—Applicators comprising a pad, tissue, sponge, or the like
    • A45D2200/1018—Applicators comprising a pad, tissue, sponge, or the like comprising a pad, i.e. a cushion-like mass of soft material, with or without gripping means

Definitions

  • APPLICATION DEVICE THIS INVENTION relates to a device for dermal or transdermal application of liquids or creams.
  • the application device of this invention is particularly, but not solely, suitable for the topical application of liquids and creams which are inherently toxic and must therefore be administered in controlled dosages.
  • Cortisone creams provide further examples of substances whose transdermal application must be controlled. There are many ailments which are treated topically with cortisone. Due to the high transdermal absorption of cortisone in liquid form, it is important that the cortisone be applied with a controlled maximum dosage.
  • MINOXIDIL is another drug which can be applied transdermally, for promoting hair growth. This drug however, increases blood pressure and its usage must be carefully controlled. As users anxious to accelerate hair growth may be likely to apply it in excess of prescribed doses, the maximum available dosage must be limited.
  • nicotine Yet another example of a substance whose transdermal application must be controlled and limited is nicotine. It is now common practice to administer nicotine topically in order to satiate nicotine craving, to thereby assist in treatment for reducing or
  • SUBSTITUTE SHEET eliminating the need to smoke.
  • the transdermal dosage of nicotine must be carefully controlled since nicotine is easily absorbed transdermally, and is extremely toxic, even in relatively small doses.
  • the patient applies a nicotine-coated bandage or plaster which contains a known quantity of nicotine.
  • This dermal patch is changed at regular intervals, typically every 24 hours.
  • the dermal patches have achieved limited success in smoking therapy, they do not cater for the large variation in nicotine requirements of individual users.
  • the patches could be made in varying dosage strengths, the different dosage versions would pose a marketing problem.
  • the same user may require different dosages at different times.
  • a roll-on device similar to a conventional deodorant roll- on applicator.
  • This device contains liquid nicotine solution of desired strength and can be applied to the skin at desired intervals in desired dosages. For example, larger doses may be administered after a meal, while smaller doses may administered in the evening when nicotine requirements are less.
  • Such a roll-on device therefore permits far more variable dosing than the dermal patch system as the dosage is entirely in the hands of the patient.
  • a nicotine application device should permit different doses to be applied to meet the varying nicotine needs of the individual patient at different times, the device should limit the maximum dosage available to the patient at any particular time or at least not allow total control of the dosage by the patient.
  • the known application devices do not meet the requirements.
  • swab applicators which comprise a wad of absorbent material adjacent a tube containing liquid medicament. Examples of such swab applicators can be found in Australian patent applications nos. 35535/89 and 67905/87, as well as U.S. patents nos. 3,958,571; 3,519,364; 4,430,013; 4,218,155 and 3,757,782.
  • Such known swab applicators normally require the breaking or rupturing of a seal between the tube and the wad, or a seal at the other end of the tube, or the breaking of the tube itself, to permit the liquid medicament in the tube to flow into the swab and saturate it.
  • Such known swab applicators are designed to be used once only and thereafter discarded. That is, substantially all of the medicament in the tube is absorbed by the applicator on first absorption. Such known swab applicators are therefore unsuitable for continued treatment by a patient. In addition, those swab applicators which rely on the rupturing of a capillary tube have the inherent disadvantage of a jagged edge which may cause "stick" injuries.
  • T be applied at intervals in varying dosages, but limits maximum dosage.
  • the present invention provides an application device suitable for applying a liquid to the skin of the user, comprising: a container adapted to hold a quantity of the liquid; a liquid transport member having one end within the container and another end outside it, the liquid transport member permitting the liquid to flow through it at a restricted flow rate; and an absorbent member for topical application of the liquid, the absorbent member having a predetermined liquid absorption capacity, whereby in use the absorbent member is placed in contact with the other end of the liquid transport member to be charged to a predetermined maximum quantity with liquid from the container through the liquid transport member over a predetermined minimum period of time.
  • liquid where the context permits, is to be interpreted to include semi-liquid or liquescent materials such as creams, ointments, gels and the like.
  • the container is a sealed container and may suitably be a closed tube or vial.
  • the liquid transport member is typically a wick, capillary tube, or similar device through which liquid passes by capillary action, osmosis, diffusion or other wicking effect.
  • wick includes fibrous rods or similar devices made from foraminous ceramics, woven or non-woven fibrous materials, or particular materials.
  • One end of the liquid transport member is located within the container in contact with the liquid in that container, while the other end has an end surface outside the container for contact with the absorbent member.
  • the absorbent member may suitably be a sponge, pad, wad, swab, packing or similar absorbent material.
  • the absorbent member In use, the absorbent member is placed in contact with the outer end of the liquid transport member. Liquid within the container passes through the liquid transport member at a restricted rate and is absorbed by the absorbent member. However, the absorbent member has a finite liquid absorption capacity. Once the absorbent member has been charged to its capacity with liquid, no further liquid will be absorbed. Moreover, the charging of the absorbent member with the liquid will take at least a predetermined minimum period of time due to the restricted flow rate through the liquid transport member. The charged absorbent member may then be used to apply the liquid topically, for example by wiping over a selected portion of the patient's skin. The absorbent member is then replaced in contact with the other end of the liquid transport member to be recharged to its capacity. Typically, the absorbent member is located on a cap designed to fit on the container so that the absorbent member will be recharged automatically whenever the cap is replaced.
  • the application device has several advantages. First, as the absorbent member has a limited capacity, the maximum dosage at any one time is limited to the predetermined capacity. The capacity limit therefore prevents excessive single doses being applied.
  • the absorbent member will require a minimum period to recharge. This time delay prevents overdosing by too frequent repetitive application.
  • the application device permits flexibility of application.
  • the device can be used as required by the patient, with the security of a controlled maximum dosage and minimum period between
  • the device can therefore cater to the varying needs of different patients, yet minimises the potential for patient abuse.
  • FIG. 1 is a partial sectional elevation of the application device of the preferred embodiment
  • Fig. 2 is an exploded perspective view of the application device of Fig. 1;
  • Fig. 3 is a graph illustrating typical absorption characteristics of the sponge pad of the device of Fig. 1.
  • the application device illustrated in Figs. 1 and 2 is suitable for topical transdermal application of a liquid or semi-liquid substance.
  • the illustrated device 10 is particularly suitable for transdermal application of nicotine solution.
  • the device 10 comprises an open-top vial-like container 11 which typically is made of plastic, glass, metal or other suitable material, and is designed to hold the liquid to be applied, for example a nicotine solution.
  • an insert 12 After filling the container 11 with the desired quantity of liquid, the top opening of the container 11 is closed by an insert 12.
  • An internal bead 13 around the top rim of container 11 engages into an annular channel 14 around the top rim of the insert 12 to thereby snap-lock the insert 12 in container 11 and prevent tampering.
  • the base of insert 12 is recessed below the top of the container 11 and has a socket formation 15 formed therein as can be seen more clearly in Fig. 1.
  • a wick holder 16 is snap fitted into the socket formation 15 as also illustrated in Fig. 1.
  • the wick holder 16 comprises
  • HEET two half-sections 16A, 16B having opposing vertical channels (see Fig. 2).
  • the opposing channels form a through bore in which a wick 17 is located in use.
  • the diameter of the through bore is preferably less than the diameter of the wick so that when the wick holder assembly 16 is snap fitted into socket 15, and thereby held together, the wick 17 will be held in a tight fit within the composite bore in the wick holder 16.
  • a tooth 18 may protrude laterally within a channel in at least one of the halves 16A, 16B to engage the wick 17 and prevent the wick from being pulled out of container 11.
  • the container 11, insert 12 and wick holder 16 are of moulded plastics construction. However, any other known suitable material may be used.
  • wick 17 extends into the liquid within container 11, while the upper end of wick 17 protrudes above the wick holder 16. However, the upper end of the wick 17 is located below the upper rim of the container 11 to thereby prevent the wick 17 being rubbed directly on the skin.
  • the wick may be of any known suitable material which has a restricted liquid flow rate therethrough. In this manner, the liquid within the container 11 will not flow out in the event that the container is knocked over or up-ended.
  • a capillary tube may be used as an alternative to the wick 17, and the term "wick” is intended to cover similar devices which operate by capillary action, osmosis, diffusion or equivalent “slow" transport action.
  • the insert 12 may be glued to the container 11, and the wick holder 16 may be glued into the insert 12, to increase the security of the device.
  • a narrow passage is provided between the insert 12 and the container 11 so as to vent the interior of the container 11 to the atmosphere but not readily permit passage of
  • the application device 10 also includes a threaded or bayonet cap or top 20 as shown in the drawings.
  • the top 20 preferably has a pair of side wings 21 to assist in gripping.
  • An absorbent member 22 is held in place against the bottom face of top 20 by a collar 23 which is snap fitted onto the bottom portion of top 20, as can be seen more clearly in the sectional view of Fig. 1.
  • the absorbent member 22 is configured so that a portion thereof protrudes through the bottom aperture in collar 23.
  • the base of insert 12 is also provided on its upper side with an upstanding annular flange 19 within which the protruding portion of absorbent member 22 is received when the top 20 is screwed into insert 12.
  • the annular flange 19 engages in the bottom aperture of collar 23 so as to generally seal the area around the absorbent member 22 and thereby prevent air drying of the absorbent member or leakage of fluid.
  • the absorbent member 22 is a sponge, preferably a cellulose sponge, but any other suitable absorbent pad or wad may be used.
  • the absorption characteristics of a typical preferred sponge 22 are illustrated in Fig. 3.
  • the sponge 22 will absorb liquid at a relatively constant rate until it reaches its absorption capacity, at which time it will not substantially absorb any more liquid.
  • the liquid within container 11 travels up through wick 17 at a slow rate and is absorbed by sponge 22 until the sponge has reached its absorption capacity.
  • the rate of flow through wick 17 can be preselected by appropriate choice of wick material, wick diameter and length.
  • the absorbed liquid can be applied simply by unscrewing top 12 and wiping the sponge 22 on the desired
  • SUBSTITUTE SHEET part of the body The maximum dosage is limited by the absorption capacity of sponge 22.
  • the top 20 is replaced on container 11 so that the sponge 22 will automatically contact the upper end of wick 17, and be recharged with liquid from within the container through the wick.
  • the recharge time, and hence the minimum period between applications, is governed by the rate of flow through wick 17 as well as the absorption rate of sponge 22.
  • the device can also be used for applying other therapeutic or liquid substances generally, particularly toxic substances whose dosages must be restricted.

Landscapes

  • Media Introduction/Drainage Providing Device (AREA)

Abstract

Dispositif applicateur permettant l'application locale d'un liquide et comportant un récipient fermé (11, 12) renfermant une réserve de liquide. Une mèche (17) fait saillie du récipient (11, 12) et son extrémité intérieure se trouve en contact avec le liquide. Le dessous du couvercle (20) du récipient possède une éponge absorbante (22) qui se trouve en contact avec l'extrémité extérieure de la mèche (17) lorsque le couvercle (20), est vissé sur le récipient, et permet donc à l'éponge (22) d'absorber du liquide de l'intérieur du récipient par l'intermédiaire de la mèche (17). Pour appliquer le liquide absorbé, on enlève le couvercle (20) et l'on passe l'éponge (22) sur la peau. L'éponge (22) présente un pouvoir absorbant prédéterminé, ce qui limite la dose maximale reçue par un malade. L'écoulement lent du liquide dans la mèche retarde la saturation en liquide de l'éponge et assure ainsi un délai minimum entre deux applications du liquide.
PCT/AU1991/000225 1990-05-29 1991-05-23 Dispositif applicateur WO1991018535A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPK037190 1990-05-29
AUPK0371 1990-05-29

Publications (1)

Publication Number Publication Date
WO1991018535A1 true WO1991018535A1 (fr) 1991-12-12

Family

ID=3774716

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU1991/000225 WO1991018535A1 (fr) 1990-05-29 1991-05-23 Dispositif applicateur

Country Status (3)

Country Link
IE (1) IE911795A1 (fr)
WO (1) WO1991018535A1 (fr)
ZA (1) ZA914029B (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007054723A1 (fr) * 2005-11-12 2007-05-18 Unilever Plc Distributeur capillaire
WO2008083423A1 (fr) * 2007-01-11 2008-07-17 Acrux Dds Pty Ltd Instrument d'étalement
USD749225S1 (en) 2013-11-26 2016-02-09 Acrux Dds Pty Ltd Topical spreading applicator
USD750788S1 (en) 2013-11-26 2016-03-01 Acrux Dds Pty Ltd Topical spreading applicator
FR3144747A1 (fr) * 2023-01-10 2024-07-12 Chanel Parfums Beaute Flacon pour le conditionnement et l’application d’un produit cosmétique comportant un embout d’application poreux

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB407061A (en) * 1932-07-27 1934-02-27 Max Neumann Device for applying and spreading non-solid substances for cosmetic or similar purposes
US2610769A (en) * 1949-08-30 1952-09-16 Goetz Carlos Cudell Dispensing container having an absorbing layer for dispensing by capillary action
US4452262A (en) * 1981-09-21 1984-06-05 A. W. Faber-Castell Method of applying cosmetics and medium and device for performing the method

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB407061A (en) * 1932-07-27 1934-02-27 Max Neumann Device for applying and spreading non-solid substances for cosmetic or similar purposes
US2610769A (en) * 1949-08-30 1952-09-16 Goetz Carlos Cudell Dispensing container having an absorbing layer for dispensing by capillary action
US4452262A (en) * 1981-09-21 1984-06-05 A. W. Faber-Castell Method of applying cosmetics and medium and device for performing the method

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007054723A1 (fr) * 2005-11-12 2007-05-18 Unilever Plc Distributeur capillaire
US8807861B2 (en) 2007-01-11 2014-08-19 Acrux Dds Pty Ltd. Spreading implement
EA015473B1 (ru) * 2007-01-11 2011-08-30 АКРУКС ДиДиЭс ПиТиУай ЭлТиДи Инструмент для нанесения объема жидкости на обрабатываемую поверхность, система и способ трансдермального введения физиологически активного вещества в организм больного
US8177449B2 (en) 2007-01-11 2012-05-15 Acrux Dds Pty Ltd. Spreading implement
US8419307B2 (en) 2007-01-11 2013-04-16 Acrux Dds Pty Ltd. Spreading implement
KR101301116B1 (ko) 2007-01-11 2013-09-03 애크럭스 디디에스 피티와이 리미티드 분산 기구
WO2008083423A1 (fr) * 2007-01-11 2008-07-17 Acrux Dds Pty Ltd Instrument d'étalement
US9289586B2 (en) 2007-01-11 2016-03-22 Acrux Dds Pty Ltd Spreading implement
USD749225S1 (en) 2013-11-26 2016-02-09 Acrux Dds Pty Ltd Topical spreading applicator
USD750788S1 (en) 2013-11-26 2016-03-01 Acrux Dds Pty Ltd Topical spreading applicator
FR3144747A1 (fr) * 2023-01-10 2024-07-12 Chanel Parfums Beaute Flacon pour le conditionnement et l’application d’un produit cosmétique comportant un embout d’application poreux
EP4399995A1 (fr) * 2023-01-10 2024-07-17 Chanel Parfums Beauté Flacon pour le conditionnement et l'application d'un produit cosmétique comportant un embout d'application poreux
US12268289B2 (en) 2023-01-10 2025-04-08 Chanel Parfums Beaute Bottle for packaging and applying a cosmetic product including a porous application tip

Also Published As

Publication number Publication date
IE911795A1 (en) 1991-12-04
ZA914029B (en) 1992-02-26

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