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WO1991015498A3 - Nucleoside derivatives - Google Patents

Nucleoside derivatives Download PDF

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Publication number
WO1991015498A3
WO1991015498A3 PCT/EP1991/000639 EP9100639W WO9115498A3 WO 1991015498 A3 WO1991015498 A3 WO 1991015498A3 EP 9100639 W EP9100639 W EP 9100639W WO 9115498 A3 WO9115498 A3 WO 9115498A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleoside
nucleoside derivatives
compounds
purine
acyl
Prior art date
Application number
PCT/EP1991/000639
Other languages
French (fr)
Other versions
WO1991015498A2 (en
Inventor
Jo Klaveness
Kjell Undheim
Original Assignee
Holmes Michael John
Nycomed As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909007650A external-priority patent/GB9007650D0/en
Priority claimed from GB909007651A external-priority patent/GB9007651D0/en
Priority claimed from GB909007566A external-priority patent/GB9007566D0/en
Application filed by Holmes Michael John, Nycomed As filed Critical Holmes Michael John
Priority to JP91506841A priority Critical patent/JPH05505815A/en
Priority to CA002079796A priority patent/CA2079796A1/en
Publication of WO1991015498A2 publication Critical patent/WO1991015498A2/en
Publication of WO1991015498A3 publication Critical patent/WO1991015498A3/en
Priority to NO92923849A priority patent/NO923849L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Nucleoside compounds of formula (I): Y1O-G-X wherein Y1 is a hydrogen atom or an acyl or acyloxymethyl group; G is the residue of the glycone moiety of the nucleoside; and X is a purine or pyrimidine base or an ester, amide or acyloxyalkyl derivative thereof. The compounds have antiviral activity.
PCT/EP1991/000639 1990-04-04 1991-04-04 Nucleoside derivatives WO1991015498A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP91506841A JPH05505815A (en) 1990-04-04 1991-04-04 nucleoside derivatives
CA002079796A CA2079796A1 (en) 1990-04-04 1991-04-04 Nucleoside derivatives
NO92923849A NO923849L (en) 1990-04-04 1992-10-02 Nucleoside derivative

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB9007566.4 1990-04-04
GB9007651.4 1990-04-04
GB909007650A GB9007650D0 (en) 1990-04-04 1990-04-04 Nucleoside derivatives
GB909007651A GB9007651D0 (en) 1990-04-04 1990-04-04 Nucleoside derivatives
GB9007650.6 1990-04-04
GB909007566A GB9007566D0 (en) 1990-04-04 1990-04-04 Nucleoside derivatives

Publications (2)

Publication Number Publication Date
WO1991015498A2 WO1991015498A2 (en) 1991-10-17
WO1991015498A3 true WO1991015498A3 (en) 1992-06-11

Family

ID=27265029

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1991/000639 WO1991015498A2 (en) 1990-04-04 1991-04-04 Nucleoside derivatives

Country Status (6)

Country Link
EP (1) EP0523110A1 (en)
JP (1) JPH05505815A (en)
AU (1) AU7558491A (en)
CA (1) CA2079796A1 (en)
OA (1) OA09677A (en)
WO (1) WO1991015498A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE45288E1 (en) 2008-04-18 2014-12-09 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring
US9102681B2 (en) 2008-04-18 2015-08-11 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
US9233998B2 (en) 2008-04-18 2016-01-12 Reata Pharmaceuticals, Inc. Natural product analogs including an anti-inflammatory cyanoenone pharmacore and methods of use
US9249089B2 (en) 2008-04-18 2016-02-02 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: C-17 homologated oleanolic acid derivatives

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2073063A1 (en) * 1989-11-06 1991-05-07 Jo Klaveness Nucleoside derivatives
YU43193A (en) * 1992-06-22 1997-01-08 Eli Lilly And Company 2'-DEOXY-2 ', 2'-DIFLUORO (4-SUBSTITUTED) PYRIMIDINE NUCLEOSIDS OF ANTIVIRUS AND ANTICANCEROGENIC ACTIVITY AND INTERMEDIATES
UA41261C2 (en) * 1992-06-22 2001-09-17 Елі Ліллі Енд Компані METHOD OF OBTAINING BETA-ANOMER-ENRICHED NUCLEOSIDES
JPH0692987A (en) * 1992-09-17 1994-04-05 Tanabe Seiyaku Co Ltd Uridine derivative and process for producing the same
JPH11217396A (en) * 1998-01-30 1999-08-10 Ajinomoto Co Inc Production of nucleoside derivative
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US7435755B2 (en) 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
CA2472581C (en) 2002-01-15 2012-06-26 Trustees Of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
WO2004041203A2 (en) 2002-11-04 2004-05-21 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
CN1693309A (en) * 2005-04-18 2005-11-09 成都正开生物科技发展有限公司 N4 (substituted oxycarbonyl) 2',2'-bifluoro-2'-deoxycytidine derivate and application thereof
US7714012B2 (en) 2006-11-17 2010-05-11 Trustees Of Dartmouth University Synthesis and biological activities of new tricyclic-bis-enones (TBEs)
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
US8299046B2 (en) 2006-11-17 2012-10-30 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
TWI621624B (en) 2008-01-11 2018-04-21 瑞塔醫藥有限責任公司 Synthetic triterpenoid compounds and methods for treating diseases thereof
TW201004627A (en) 2008-04-18 2010-02-01 Reata Pharmaceuticals Inc Antioxidant inflammation modulators: novel derivatives of oleanolic acid
EA031986B1 (en) 2012-04-04 2019-03-29 Галозим, Инк. Method and combination for treating solid tumor cancer and kit comprising the combination
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
WO2016078397A1 (en) * 2014-11-17 2016-05-26 常州方圆制药有限公司 New type of cytidine derivative and application thereof
WO2016078160A1 (en) * 2014-11-17 2016-05-26 常州方圆制药有限公司 Cytidine derivative and application thereof
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
GR1009958B (en) * 2019-04-24 2021-03-18 ΕΝΟΡΑΣΙΣ ΑΝΩΝΥΜΗ ΕΜΠΟΡΙΚΗ ΕΤΑΙΡΕΙΑ ΦΑΡΜΑΚΕΥΤΙΚΩΝ ΚΑΙ ΙΑΤΡΙΚΩΝ ΥΛΙΚΩΝ ΚΑΙ ΜΗΧΑΝΗΜΑΤΩΝ με δ.τ. "ΕΝΟΡΑΣΙΣ Α.Ε." Gemcitabine derivatives and methods of forming gemcotabine derivatives

Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3651045A (en) * 1968-10-21 1972-03-21 Parke Davis & Co 9-(beta-d-arabinofuranosyl)adenine esters and methods for their production
EP0042596A1 (en) * 1980-06-23 1981-12-30 The Regents Of The University Of Minnesota Novel adenine nucleoside derivatives, their preparation and pharmaceutical compositions containing them
EP0056265A2 (en) * 1981-01-09 1982-07-21 Dr. Thilo & Co. GmbH Pyrimidinenucleosides esterified in position 5' having antiviral activity, method for their preparation and medicinal compositions containing them
EP0104857A1 (en) * 1982-09-28 1984-04-04 Beecham Group Plc Deoxyuridine compounds, methods for preparing them and their use in medicine
US4495180A (en) * 1982-06-21 1985-01-22 Merck & Co., Inc. Prodrugs of Ara-A an antiviral agent
EP0151189A1 (en) * 1983-07-20 1985-08-14 Teijin Limited Antineoplastic agent
EP0217580A2 (en) * 1985-09-17 1987-04-08 The Wellcome Foundation Limited Therapeutic nucleosides
EP0219829A2 (en) * 1985-10-18 1987-04-29 Sloan-Kettering Institute For Cancer Research 2-Fluoro-arabinofuranosyl purine nucleosides
EP0260852A2 (en) * 1986-09-08 1988-03-23 The Wellcome Foundation Limited Nucleoside Analogues
WO1988007532A1 (en) * 1987-03-24 1988-10-06 Nycomed A.S. 2',3' dideoxyribofuranoxide derivatives
EP0329348A2 (en) * 1988-02-16 1989-08-23 Eli Lilly And Company 2',3'-Dideoxy-2',2'-difluoronucleosides
EP0340778A2 (en) * 1988-05-06 1989-11-08 Bristol-Myers Squibb Company Prodrugs of 2',3'- Didehydro-2',3'-Dideoxynucleosides
EP0341704A2 (en) * 1988-05-12 1989-11-15 F. Hoffmann-La Roche Ag Process for the preparation of 2',3'-dideoxycytidines
EP0346108A2 (en) * 1988-06-09 1989-12-13 The Wellcome Foundation Limited Anti-infective nucleosides
EP0355031A2 (en) * 1988-08-17 1990-02-21 MATTHES, Eckart, Dr. Substituted pyrimidine nucleosides, process for their preparation and pharmaceutical compounds containing them
EP0362967A1 (en) * 1988-10-05 1990-04-11 Nycomed Imaging As Nucleoside derivatives
EP0366171A1 (en) * 1988-10-05 1990-05-02 Nycomed As Nucleoside derivatives
EP0417999A1 (en) * 1989-09-11 1991-03-20 The Wellcome Foundation Limited Antiviral compounds

Patent Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3651045A (en) * 1968-10-21 1972-03-21 Parke Davis & Co 9-(beta-d-arabinofuranosyl)adenine esters and methods for their production
EP0042596A1 (en) * 1980-06-23 1981-12-30 The Regents Of The University Of Minnesota Novel adenine nucleoside derivatives, their preparation and pharmaceutical compositions containing them
EP0056265A2 (en) * 1981-01-09 1982-07-21 Dr. Thilo & Co. GmbH Pyrimidinenucleosides esterified in position 5' having antiviral activity, method for their preparation and medicinal compositions containing them
US4495180A (en) * 1982-06-21 1985-01-22 Merck & Co., Inc. Prodrugs of Ara-A an antiviral agent
EP0104857A1 (en) * 1982-09-28 1984-04-04 Beecham Group Plc Deoxyuridine compounds, methods for preparing them and their use in medicine
EP0151189A1 (en) * 1983-07-20 1985-08-14 Teijin Limited Antineoplastic agent
EP0217580A2 (en) * 1985-09-17 1987-04-08 The Wellcome Foundation Limited Therapeutic nucleosides
EP0219829A2 (en) * 1985-10-18 1987-04-29 Sloan-Kettering Institute For Cancer Research 2-Fluoro-arabinofuranosyl purine nucleosides
EP0260852A2 (en) * 1986-09-08 1988-03-23 The Wellcome Foundation Limited Nucleoside Analogues
WO1988007532A1 (en) * 1987-03-24 1988-10-06 Nycomed A.S. 2',3' dideoxyribofuranoxide derivatives
EP0329348A2 (en) * 1988-02-16 1989-08-23 Eli Lilly And Company 2',3'-Dideoxy-2',2'-difluoronucleosides
EP0340778A2 (en) * 1988-05-06 1989-11-08 Bristol-Myers Squibb Company Prodrugs of 2',3'- Didehydro-2',3'-Dideoxynucleosides
EP0341704A2 (en) * 1988-05-12 1989-11-15 F. Hoffmann-La Roche Ag Process for the preparation of 2',3'-dideoxycytidines
EP0346108A2 (en) * 1988-06-09 1989-12-13 The Wellcome Foundation Limited Anti-infective nucleosides
EP0355031A2 (en) * 1988-08-17 1990-02-21 MATTHES, Eckart, Dr. Substituted pyrimidine nucleosides, process for their preparation and pharmaceutical compounds containing them
EP0362967A1 (en) * 1988-10-05 1990-04-11 Nycomed Imaging As Nucleoside derivatives
EP0366171A1 (en) * 1988-10-05 1990-05-02 Nycomed As Nucleoside derivatives
EP0417999A1 (en) * 1989-09-11 1991-03-20 The Wellcome Foundation Limited Antiviral compounds

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE45288E1 (en) 2008-04-18 2014-12-09 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring
USRE45325E1 (en) 2008-04-18 2015-01-06 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring
US9102681B2 (en) 2008-04-18 2015-08-11 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
US9233998B2 (en) 2008-04-18 2016-01-12 Reata Pharmaceuticals, Inc. Natural product analogs including an anti-inflammatory cyanoenone pharmacore and methods of use
US9249089B2 (en) 2008-04-18 2016-02-02 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: C-17 homologated oleanolic acid derivatives

Also Published As

Publication number Publication date
CA2079796A1 (en) 1991-10-05
OA09677A (en) 1993-05-15
EP0523110A1 (en) 1993-01-20
WO1991015498A2 (en) 1991-10-17
JPH05505815A (en) 1993-08-26
AU7558491A (en) 1991-10-30

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