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WO1991010645A3 - Agents de chelation - Google Patents

Agents de chelation

Info

Publication number
WO1991010645A3
WO1991010645A3 PCT/EP1991/000126 EP9100126W WO9110645A3 WO 1991010645 A3 WO1991010645 A3 WO 1991010645A3 EP 9100126 W EP9100126 W EP 9100126W WO 9110645 A3 WO9110645 A3 WO 9110645A3
Authority
WO
WIPO (PCT)
Prior art keywords
chelants
radiotherapeutic
preparation
chelating agents
agents useful
Prior art date
Application number
PCT/EP1991/000126
Other languages
English (en)
Other versions
WO1991010645A2 (fr
Inventor
Joan F Carvalho
Shaun P Crofts
Scott M Rocklage
Original Assignee
Cockbain Julian R M
Salutar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cockbain Julian R M, Salutar Inc filed Critical Cockbain Julian R M
Priority to FI923286A priority Critical patent/FI923286A7/fi
Priority to CA002074171A priority patent/CA2074171A1/fr
Priority to JP91502458A priority patent/JPH05506426A/ja
Publication of WO1991010645A2 publication Critical patent/WO1991010645A2/fr
Publication of WO1991010645A3 publication Critical patent/WO1991010645A3/fr
Priority to NO92922849A priority patent/NO922849L/no

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/228—Host-guest complexes, clathrates, chelates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Acoustics & Sound (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

L'invention se rapporte à de nouveaux agents de chélation utilisables dans la préparation d'agents de contraste pour des techniques de formation d'images diagnostiques ou dans la préparation de compositions radiothérapeutiques ou de détoxification.
PCT/EP1991/000126 1990-01-19 1991-01-18 Agents de chelation WO1991010645A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
FI923286A FI923286A7 (fi) 1990-01-19 1991-01-18 Kelatointiaineita
CA002074171A CA2074171A1 (fr) 1990-01-19 1991-01-18 Agents chelateurs
JP91502458A JPH05506426A (ja) 1990-01-19 1991-01-18 キレート化剤
NO92922849A NO922849L (no) 1990-01-19 1992-07-17 Chelateringsmidler

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909001245A GB9001245D0 (en) 1990-01-19 1990-01-19 Compounds
GB9001245.1 1990-01-19

Publications (2)

Publication Number Publication Date
WO1991010645A2 WO1991010645A2 (fr) 1991-07-25
WO1991010645A3 true WO1991010645A3 (fr) 1991-12-26

Family

ID=10669570

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1991/000126 WO1991010645A2 (fr) 1990-01-19 1991-01-18 Agents de chelation

Country Status (10)

Country Link
EP (1) EP0527131A1 (fr)
JP (1) JPH05506426A (fr)
AU (1) AU7060291A (fr)
CA (1) CA2074171A1 (fr)
FI (1) FI923286A7 (fr)
GB (1) GB9001245D0 (fr)
HU (1) HUT61306A (fr)
IE (1) IE910189A1 (fr)
NO (1) NO922849L (fr)
WO (1) WO1991010645A2 (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5334371A (en) * 1988-07-20 1994-08-02 Schering Aktiengesellschaft Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI
FR2644785B1 (fr) * 1989-03-24 1991-07-05 Guerbet Sa Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant
US5367080A (en) * 1990-11-08 1994-11-22 Sterling Winthrop Inc. Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods
CA2072934C (fr) * 1991-07-19 2007-08-28 Karl William Aston Complexes de manganese et de ligands macrocycliques contenant de l'azote, efficaces comme catalyseurs de la dismutation de superoxydes
US5739294A (en) * 1991-12-10 1998-04-14 The Dow Chemical Company Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents
AU3324193A (en) * 1991-12-10 1993-07-19 Dow Chemical Company, The Oral compositions for inhibiting plaque and calculus formation
WO1994026313A1 (fr) * 1993-05-06 1994-11-24 The Dow Chemical Company Complexes et conjugues de complexes d'acides bicyclopolyazamacrocyclocarboxyliques, procedes de preparation de ces derniers et d'utilisation en tant qu'agents de contraste
US5428139A (en) * 1991-12-10 1995-06-27 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
SG46598A1 (en) * 1991-12-10 1998-02-20 Dow Chemical Co Bicycloazamacroyclophosphonic acid conjugates contrast agents and preparation
WO1994026754A1 (fr) * 1993-05-06 1994-11-24 The Dow Chemical Company Acides bicyclopolyazamacrocyclophosphoniques, leurs complexes et conjugues, destines a etre utilises en tant qu'agents de contraste, et leurs procedes de preparation
HUT67602A (en) * 1991-12-10 1995-04-28 Dow Chemical Co Process for producing bicyclo-polyaza-macrocyclo-carboxylic acid complexes, their conjugates and contrast materials containing them
AU672951B2 (en) * 1992-05-07 1996-10-24 Ge Healthcare As Complexing agents and targeting immunoreagents
WO1994026315A1 (fr) * 1993-05-06 1994-11-24 The Dow Chemical Company Complexes et conjugues de complexes d'acides bicyclopolyazamacrocyclocarboxyliques, procedes de preparation de ces derniers et d'utilisation en tant que produits radiopharmaceutiques
WO1994026755A1 (fr) * 1993-05-06 1994-11-24 The Dow Chemical Company Complexes d'acides bicyclopolyazamacrocyclophosphoniques, conjugues de ces derniers, procede de preparation associe et d'utilisation en tant que produits radiopharmaceutiques
US5476644A (en) * 1994-04-13 1995-12-19 Sterling Winthrop Inc. Cyclic triamine chelating agents
US6207826B1 (en) 1995-03-27 2001-03-27 Isis Pharmaceuticals, Inc. Macrocyclic compounds having nitrogen-containing linkages
AU5375896A (en) * 1995-03-27 1996-10-16 Isis Pharmaceuticals, Inc. Nitrogenous macrocyclic compounds
US6525041B1 (en) 1995-06-06 2003-02-25 Pharmacia Corporation Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
US5976498A (en) * 1995-08-17 1999-11-02 Neumann; William L. Methods of diagnostic image analysis using metal complexes of nitrogen-containing macrocyclic ligands
BR9610241A (pt) 1995-08-17 1999-06-29 Monsanto Co Processos para análise de imagem de diagnóstico utilizando bioconjgados de complexos de metal de ligandos macrocíclicos contendo nitrogênio
GB9702978D0 (en) * 1997-02-13 1997-04-02 Ciba Geigy Compounds
US6214817B1 (en) 1997-06-20 2001-04-10 Monsanto Company Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity
EP2056675B1 (fr) 2006-10-12 2019-01-09 Galera Labs, LLC Procédés de traitement de mucosites orales
US20090208421A1 (en) * 2008-02-19 2009-08-20 Dominique Meyer Process for preparing a pharmaceutical formulation of contrast agents
EP2760874A4 (fr) 2011-09-26 2015-04-08 Galera Therapeutics Llc Méthodes de traitement de maladies
US10918743B2 (en) * 2013-04-26 2021-02-16 Guerbet Contrast medium formulation and related preparation method
PH12018500296B1 (en) 2015-08-11 2024-04-12 Galera Labs Llc Pentaaza macrocyclic ring complexes possessing oral bioavailability
KR20230075528A (ko) 2016-05-03 2023-05-31 갈레라 랩스, 엘엘씨 암 치료를 위한 조합 요법
GB201610738D0 (en) 2016-06-20 2016-08-03 Ge Healthcare As Chelate compounds
CN109906081A (zh) 2016-09-01 2019-06-18 加莱拉实验室有限责任公司 利用五氮杂大环络合物和抗坏血酸类化合物的联合癌症疗法
IL269915B (en) 2017-04-13 2022-09-01 Galera Labs Llc Combination cancer immunotherapy with pentaaza macrocyclic ring complex

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2751390A (en) * 1950-09-02 1956-06-19 Dow Chemical Co Di-pyridyl aliphatic alkylene polyamine poly acids
WO1986006605A1 (fr) * 1985-05-08 1986-11-20 The General Hospital Corporation Agents de contraste hepatobiliaire pour resonance magnetique nucleaure
WO1989011868A1 (fr) * 1988-05-31 1989-12-14 Coulter Electronics, Inc. Composes macrocycliques d'yttrium, de lanthanides et d'actinides a fonctions peripheriques de liaison
EP0352218A2 (fr) * 1988-07-20 1990-01-24 Schering Aktiengesellschaft Composés polyaza macrocycliques, leur procédé de préparation et compositions pharmaceutiques les contenant
WO1990011282A1 (fr) * 1989-03-24 1990-10-04 Guerbet S.A. Ligands macrocycliques azotes et leurs complexes metalliques

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2751390A (en) * 1950-09-02 1956-06-19 Dow Chemical Co Di-pyridyl aliphatic alkylene polyamine poly acids
WO1986006605A1 (fr) * 1985-05-08 1986-11-20 The General Hospital Corporation Agents de contraste hepatobiliaire pour resonance magnetique nucleaure
WO1989011868A1 (fr) * 1988-05-31 1989-12-14 Coulter Electronics, Inc. Composes macrocycliques d'yttrium, de lanthanides et d'actinides a fonctions peripheriques de liaison
EP0352218A2 (fr) * 1988-07-20 1990-01-24 Schering Aktiengesellschaft Composés polyaza macrocycliques, leur procédé de préparation et compositions pharmaceutiques les contenant
WO1990011282A1 (fr) * 1989-03-24 1990-10-04 Guerbet S.A. Ligands macrocycliques azotes et leurs complexes metalliques

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts, vol. 113, no. 7, 13 August 1990, (Columbus, Ohio, US), K.I. Dhont et al: "Metal ion template synthesis of the macrocyclic multidentate polyamine ligand: 3,6,14,17,23,24-hexa azatricyclo(17.3.1.1 8,12)tetraeicosa-1(22),8(9), 10,12,19,20-hexaene", abstract 59129d & Bull. Soc. Chim. Belg. 1989, 98(8),575-6, see reg no 127503-08-6 *
Helvetica Chimica Acta, vol. 72, August 1989, M.W. Hosseini et al: "Synthesis of polyaza macrocyclic ligands incorporating pyridine units", pages 1066-1077, see especially compounds 4, 5, 21 and 22 *
Inorg. Chem., vol. 25, no. 4, 1986, E.K. Barefield et al: "Electrochemical and Structural Studies of Nickel(II) Complexes of N-Alkylated Cyclam Ligands: X-ray Structures of trans-/Ni(C14H32N4)(OH2)2/ Cl2.2H2O and /Ni(C14H32N4)/(O3SCF3)2", pages 552-558, see compound D *
J. Am. Chem. Soc., vol. 110, no. 9, 1988, R.D. Hancock et al: "More rigid Macrocyclic Ligands That Show Metal Ion Size-Based Selectivity. A Crystallographic, Molecular Mechanics, and Formation Constant Study of the Complexes of BridgedCyclen", pages 2788-2794, see tables I and VI *
J. Am. Chem. Soc., vol. 111, September 1989, P.H. Smith et al: "Solution and solid-state characterization of Europium and Gadolinium schiff base complexes and assessment of their potential as contrast agents in magnetic resonance imaging", pages 7437-7443, see the whole article *
J. Am. Chem. Soc., vol.87, 1965, R.G. Lacoste et al: "New Multidentate Ligands. II. Amino Acids Containing alfa-Pyridyl Groups", pages 2385-2388, see the whole document *
J. Chem. Soc. Dalton Trans., December 1988, N.W. Alcock et al:"Synthesis and Co-ordination Chemistry of Two Penta-azamacrocycles containing a 1,4-Piperazine Backbone. Crystal Structure Determinations of 6,12-Dioxo-1,5,13,17,22-penta- -azatricyclo/15.2.2.1 7,11/docosa-7(22),8,10- -triene and 1,5,13,17,22-Penta-azatricyclo /15.2.2.1 7,11/docosa-7(22),8,10-trienenickel(II) Perchlorate", pages 2959-2963, see compound L2 and tables 1 and 2 *
J. Chem. Soc., Chem. Commun., 1982, A. Ramasubbu et al: "Structurally Reinforced Cyclen: A Rigidly trans-Co-ordinating Twelve-membered Macrocycle", pages 277-278, see compound 2 *
J. Chem. Soc., Chem. Commun., 1985, N.W. Alcock et al: "Co-ordination to Copper(II) by OnlyThree Nitrogen Atoms of a Tetra-azamacro- cyclic Ligand functionalised with Two Pendant Acetate-arms. X-Ray Structure of /Cu(L1H2)Cl/Cl, where L1 is 3,11-Diacetato-7-methyl-3,7,11,17- -tetraazabicyclo/11.3.1/heptadeca-1(17),13,15- -triene", pages 1058-1059, see compound L1 *
J. Phys. Chem., vol. 91, no. 18, 1987, N. Sabbatini et al: "Radiative and Nonradiative Transitions in the Eu(III) Hexaaza Macrocyclic Complex /Eu(C22H26N6)(CH3COO)/(CH3COO)Cl.2H2O pages 4681-4685, see the whole document *
Tetrahedron, vol. 37, 1981, H. Stetter et al: "Darstellung und Komplexbildung von Polyazacyclo- alkan-N-Essigs{uren, pages 767-772, see especially compounds 19 and 31 *

Also Published As

Publication number Publication date
JPH05506426A (ja) 1993-09-22
WO1991010645A2 (fr) 1991-07-25
FI923286A0 (fi) 1992-07-17
NO922849L (no) 1992-09-04
EP0527131A1 (fr) 1993-02-17
GB9001245D0 (en) 1990-03-21
FI923286L (fi) 1992-07-17
CA2074171A1 (fr) 1991-07-20
HU9202347D0 (en) 1992-10-28
HUT61306A (en) 1992-12-28
IE910189A1 (en) 1991-07-31
NO922849D0 (no) 1992-07-17
FI923286A7 (fi) 1992-07-17
AU7060291A (en) 1991-08-05

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