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WO1991010364A1 - Utter or teat care substance with mastitis preventing effect - Google Patents

Utter or teat care substance with mastitis preventing effect Download PDF

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Publication number
WO1991010364A1
WO1991010364A1 PCT/DK1991/000015 DK9100015W WO9110364A1 WO 1991010364 A1 WO1991010364 A1 WO 1991010364A1 DK 9100015 W DK9100015 W DK 9100015W WO 9110364 A1 WO9110364 A1 WO 9110364A1
Authority
WO
WIPO (PCT)
Prior art keywords
oil
tree
tea
substance
utter
Prior art date
Application number
PCT/DK1991/000015
Other languages
French (fr)
Inventor
Niels Erik AAMANN-CHRISTENSEN
Original Assignee
Spindel & Spinnfluegelfab Veb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spindel & Spinnfluegelfab Veb filed Critical Spindel & Spinnfluegelfab Veb
Priority to DE19914190064 priority Critical patent/DE4190064T/de
Priority to DE4190064A priority patent/DE4190064C2/en
Priority to FI923258A priority patent/FI923258A7/en
Publication of WO1991010364A1 publication Critical patent/WO1991010364A1/en
Priority to DK92920A priority patent/DK92092D0/en
Priority to NO19922859A priority patent/NO313171B1/en
Priority to GB9215391A priority patent/GB2257629B/en
Priority to SE9202205A priority patent/SE9202205L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0041—Mammary glands, e.g. breasts, udder; Intramammary administration
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A01N65/28—Myrtaceae [Myrtle family], e.g. teatree or clove

Definitions

  • the present invention relates to a remedy for fighting the cattle disease summer mastitis and other ⁇ wise for care of teats and utter of milch cows.
  • the invention is based on the observation that a certain substance, which is a purely natural product, exhibits not only a good disinfecting ability, but also a pronounced insect repulsing ability, this being highly important for preventing the diseases such as mastitis which are provoked by insect attacks.
  • the substance in question is a rather expensive one, which was earlier - before the entry of moderen antibiotics - used to a certain extent as a disinfectant in the humane medicine, while due to its high price it would be excluded from use as a daily care substance in herds of cattle.
  • the particular substance is an ethereal oil named tea-tree-oil, which is won from the cultivatedn tea-tree or Melaleucha Alternifolia.
  • This oil is emulsifiable in water, though not particularly easily, and in connection with the invention it has been found that that the emul ⁇ sion has a pronounced insect repulsing effect, which has its maximum for a concentration of only some 2.5%PC%. A noticeable effect is found also at lower concentrations, e.g. down to 0.5%PC%.
  • the substance is effective also in higher concentrations, but for higher concentrations the effect will decrease, and when at the same time the price will increase, then the use of concentrations above 5-6%PC% will not be realistic.
  • the said ethereal oil has a high ability to intrude into the outer skin, from where it will disappear rather slowly, partly by evaporation and partly by admixture into the body liquid.
  • the oil therefore, may remain active during the periods between consecutive milkings, and since it is a completely non-toxic natural product it will show no dangerous side effects whatsoever, neither with respect to assimilation in the body of the animal nor with respect to possible remnants in the teat cups during the next milking; at the highest a certain smell contamination of the milk could be involved, but with the low degree of admixture this contamination will be absolutely imperceptible and totally harmless.
  • the oil is advantageously usable in admixture with pronounced skin friendly oils, e.g. in particular coconut oil, which, as already known, is usable for cleaning the skin and making it supple.
  • the coconut oil does not posses the same ability as the tea-tree-oil of easily intruding into the skin, but it will exhibit another advantageous effect, viz. to be present as a protective layer at the outside of the teat skin, whereby it will cause the evaporation of the tea-tree-oil to be retarded, though without blocking for the degree of evaporation that conditions the insect repulsing effect.
  • the tea-tree-oil is usable in different types of treating agents, viz. either in a viscid teat oinment or in a low viscid liquid adapted for teat dipping or spraying.
  • the preferred basic product is a liquid concen ⁇ trate, which, when diluted with water e.g. in the pro ⁇ portion one part of concentrate to four parts of water, will become a well suited teat dipping or spraying sub ⁇ stance.
  • the concentrate can be a non-aqueous liquid consisting predominantly of coconut oil or, optionally, of another vegetable oil such as sesam or almond oil, in admixture with an emulsifying carrier such as sorbitane-trioleate and the tea-rree-oil as well as a small volume of a preservation agent.
  • Natural coconut oil requires to be heated and violently agitated in order to be emulsified, but if the oil is used in a so-called fractionized state there are no problems in this respect, i.e. the oil should not be heated, neither by the preparation of the concentrate mixture nor by the later dilution with water. This is very important, be ⁇ cause the tea-tree-oil should not be exposed to tempera ⁇ tures above some 40°, as it will otherwise largely loose its special abilities.
  • the said concentrate may be composed as follows
  • sorbitane ester trioleate may be used, but skilled persons will know that also other non-ionic surfactants or emulsifiers may be used for making the substance effective for skin care.
  • the said ingredients can be mixed together in an uncomplicated manner
  • the said ingredients can be mixed together in an uncomplicated manner at ambient tempera ⁇ ture, just as the concentrate may later on be diluted by water in the said proportion by simple stirring, without heating or violent agitation.
  • the substance may of course also be marketed in a diluted state, ready for use.
  • the amount of preservation agent may be kept rela ⁇ tively low, because the tea-tree-oil itself exhibits a preserving effect.
  • the dipping or spraying substance should contain neither more nor less than 1-6%PC% of the tea-tree-oil, preferably 2-3%PC%, as the insect repulsing effect of the substance will other ⁇ wise be noticeably reduced, just as the price of the product will increase quite unnecessarily when a higher admixture percentage of this oil is employed.
  • the diluted liquid can be used in a dipping cup, for dipping of the teats, or in a spray dispenser for being sprayed upon the utter and the teats, whereafter the parts thus treated will be both disinfecting and insect repulsing until the next milk ⁇ ing, with a following, renewed dipping or spraying treatment of the utter or at least the teats and parti ⁇ cularly the lower tip areas thereof, where the insect attacks are normally particularly concentrated.
  • the tea-tree-oil may be mixed into almost any known, suitable ointment sub ⁇ stance, also here with an admixture of only few per- cents; a noticeable insect repulsing effect is achieved with an oil content of only some 0.5%PC%, and the con ⁇ tents of the oil should not exceed 6%PC%. If the oint ⁇ ment is prepared at an increased temperature the tea-tree-oil should not be added until the temperature has fallen to 25-30°, as the oil will not resist tempe ⁇ ratures higher than some 40°. In the ointment may well be used coconut oil which should not necessarily be of the fractionized type.
  • the tea-tree-oil moreover, exhibits both fungicide and bactericidal abilities, which are fully active by the discussed, relatively weak concentrations.
  • the oil holding preparations should contain a preservation agent, e.g. the said methylparaoxy-benzonate.
  • the discussed substance is used preferably for milch cows, as it can be applied centrally in connection with the cows being assembled for milking. It will be relevant to use the substance also on heifers to the extent this is practically possible, that is in the instances the heifers are not entirely freely held.
  • the methodic use of the skin friendly substance has the additional effect that milking can be accomplished with the use of a reduced vacuum on the teat cups compared with normal practice, this adding to the care of the teats.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Botany (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

For the prevention of mastitis a demonstrated insect repulsing effect of the so-called tea-tree-oil is exploited, this oil being won from the Australian tea-tree or Melaleucha Alternifolia. The oil can be used with a quite low concentration in a teat dip (teat spray) or an ointment.

Description

Utter or teat care substance with mastitis prevent¬ ing effect.
The present invention relates to a remedy for fighting the cattle disease summer mastitis and other¬ wise for care of teats and utter of milch cows.
As well known the summer mastitis is an extremely costly disease in agriculture. Endavours are done to reduce it, but so far without much success. It is a common and widespread practice that the teats are kept disinfected by a so-called teat dipping after each milk¬ ing, this referring to a treatment of the teats - not necessarily by real dipping - with a disinfectant, which, almost as a standard, consists of chlorohexidine and iodine. Thus, chemicals are involved, which should be isolated from the milk product, so the teats should be washed before each milking or the preparation should be dosed so sparingly that by the next milking it has almost entirely disappeard.
It is unquestionable that a disinfection of the teats will be essential in the attempts of fighting the said disease and certain other diseases, too, and it is the purpose of the invention to provide a treating sub¬ stance which is in more respects advantageous over the prior art.
The invention is based on the observation that a certain substance, which is a purely natural product, exhibits not only a good disinfecting ability, but also a pronounced insect repulsing ability, this being highly important for preventing the diseases such as mastitis which are provoked by insect attacks. The substance in question is a rather expensive one, which was earlier - before the entry of moderen antibiotics - used to a certain extent as a disinfectant in the humane medicine, while due to its high price it would be excluded from use as a daily care substance in herds of cattle. It is, therefore, an additional and both essential and surpris¬ ing finding according to the invention that the relevant effects of this substance are in fact improved by a dilution of the substance down to a concentration of only a few percents, whereby the substance may then anyway - even with an improved result - be economically applied in practice for the discussed purpose.
The particular substance is an ethereal oil named tea-tree-oil, which is won from the Australien tea-tree or Melaleucha Alternifolia. This oil is emulsifiable in water, though not particularly easily, and in connection with the invention it has been found that that the emul¬ sion has a pronounced insect repulsing effect, which has its maximum for a concentration of only some 2.5%PC%. A noticeable effect is found also at lower concentrations, e.g. down to 0.5%PC%. The substance is effective also in higher concentrations, but for higher concentrations the effect will decrease, and when at the same time the price will increase, then the use of concentrations above 5-6%PC% will not be realistic.
By the said low concentrations the inherent dis- infectory effect still remains to a degree sufficient for the purpose.
The said ethereal oil has a high ability to intrude into the outer skin, from where it will disappear rather slowly, partly by evaporation and partly by admixture into the body liquid. The oil, therefore, may remain active during the periods between consecutive milkings, and since it is a completely non-toxic natural product it will show no dangerous side effects whatsoever, neither with respect to assimilation in the body of the animal nor with respect to possible remnants in the teat cups during the next milking; at the highest a certain smell contamination of the milk could be involved, but with the low degree of admixture this contamination will be absolutely imperceptible and totally harmless.
In addition the oil is advantageously usable in admixture with pronounced skin friendly oils, e.g. in particular coconut oil, which, as already known, is usable for cleaning the skin and making it supple. The coconut oil does not posses the same ability as the tea-tree-oil of easily intruding into the skin, but it will exhibit another advantageous effect, viz. to be present as a protective layer at the outside of the teat skin, whereby it will cause the evaporation of the tea-tree-oil to be retarded, though without blocking for the degree of evaporation that conditions the insect repulsing effect.
The tea-tree-oil is usable in different types of treating agents, viz. either in a viscid teat oinment or in a low viscid liquid adapted for teat dipping or spraying.
The preferred basic product is a liquid concen¬ trate, which, when diluted with water e.g. in the pro¬ portion one part of concentrate to four parts of water, will become a well suited teat dipping or spraying sub¬ stance. The concentrate can be a non-aqueous liquid consisting predominantly of coconut oil or, optionally, of another vegetable oil such as sesam or almond oil, in admixture with an emulsifying carrier such as sorbitane-trioleate and the tea-rree-oil as well as a small volume of a preservation agent. Natural coconut oil requires to be heated and violently agitated in order to be emulsified, but if the oil is used in a so-called fractionized state there are no problems in this respect, i.e. the oil should not be heated, neither by the preparation of the concentrate mixture nor by the later dilution with water. This is very important, be¬ cause the tea-tree-oil should not be exposed to tempera¬ tures above some 40°, as it will otherwise largely loose its special abilities. The said concentrate may be composed as follows
1-3%PC% preservation agent such as methyle paraoxy- benzoase,
10-15%PC% tea-tree-oil,
20-30%PC% sorbitane ester, and
50-70%PC% fractionized coconut oil.
As sorbitane ester trioleate may be used, but skilled persons will know that also other non-ionic surfactants or emulsifiers may be used for making the substance effective for skin care.
The said ingredients can be mixed together in an uncomplicated manner The said ingredients can be mixed together in an uncomplicated manner at ambient tempera¬ ture, just as the concentrate may later on be diluted by water in the said proportion by simple stirring, without heating or violent agitation. However, the substance may of course also be marketed in a diluted state, ready for use.
The amount of preservation agent may be kept rela¬ tively low, because the tea-tree-oil itself exhibits a preserving effect.
In its ready for use condition the dipping or spraying substance should contain neither more nor less than 1-6%PC% of the tea-tree-oil, preferably 2-3%PC%, as the insect repulsing effect of the substance will other¬ wise be noticeably reduced, just as the price of the product will increase quite unnecessarily when a higher admixture percentage of this oil is employed.
After each milking the diluted liquid can be used in a dipping cup, for dipping of the teats, or in a spray dispenser for being sprayed upon the utter and the teats, whereafter the parts thus treated will be both disinfecting and insect repulsing until the next milk¬ ing, with a following, renewed dipping or spraying treatment of the utter or at least the teats and parti¬ cularly the lower tip areas thereof, where the insect attacks are normally particularly concentrated.
For the use of an ointment the tea-tree-oil may be mixed into almost any known, suitable ointment sub¬ stance, also here with an admixture of only few per- cents; a noticeable insect repulsing effect is achieved with an oil content of only some 0.5%PC%, and the con¬ tents of the oil should not exceed 6%PC%. If the oint¬ ment is prepared at an increased temperature the tea-tree-oil should not be added until the temperature has fallen to 25-30°, as the oil will not resist tempe¬ ratures higher than some 40°. In the ointment may well be used coconut oil which should not necessarily be of the fractionized type.
The tea-tree-oil, moreover, exhibits both fungicide and bactericidal abilities, which are fully active by the discussed, relatively weak concentrations.
Preferably the oil holding preparations should contain a preservation agent, e.g. the said methylparaoxy-benzonate.
The discussed substance is used preferably for milch cows, as it can be applied centrally in connection with the cows being assembled for milking. It will be relevant to use the substance also on heifers to the extent this is practically possible, that is in the instances the heifers are not entirely freely held.
It is the found insect repulsive effect of the low concentrated, particular oil product, which is the main aspect of the invention, but of course it is a particu¬ larly lucky coincidence that the relevant oil is advan¬ tageous in so to speak all other respects, except for its high price, which, however, is neutralized by the oil proving to be effective in a low concentration. This repulsing effect will occur, even without noticeable smell nuisances for humans, irrespective of whether the oil is used in combination with particularly skin friendly agents, and it will be a possibility of the invention, therefore, that the tea-tree-oil in its low concentrated edition may be used e.g for spraying onto stable surfaces or for application onto surfaces adja¬ cent to admission openings into stables.
The basic insect repulsing effect and the disin¬ fecting effect combined therewith has been demonstrated for the low concentrated tea-tree-oil from Melaleucha Alternifolia, but it will be understood that similar abilities can be expected for oils won from closely related trees. By now, however, no further details on this matter are available.
It should be mentioned that the methodic use of the skin friendly substance has the additional effect that milking can be accomplished with the use of a reduced vacuum on the teat cups compared with normal practice, this adding to the care of the teats.

Claims

C L A I M S :
1. An utter or teat care substance with mastitis preventing effect, characterized in that the substance is an ointment or a dip/spray agent having a low content of tea-tree-oil or a corresponding skin friendly and insect repulsing oil.
2. A substance according to claim 1, characterized in that it contains 1-6%PC% tea-tree-oil, preferably 2-3%PC%.
3. A substance according to claim 1, characterized in that it is made as a concentrate for dilution with water, said concentrate comprising, in addition to the tea-tree-oil, a fractionized coconut oil or a corre¬ sponding vegetable oil and a non-ionic surfactant with emulsifier effect, e.g. a sorbitane ester such as sorbi¬ tane trioleate, and preferably a small amount of a pre¬ servative such as methyl paraoxybenzonate.
4. A substance according to claim 3, characterized in that it contains 10-15%PC% tea-tree-oil, 20-30%PC% surfactant such as sorbitane trioleate and 50-75%PC% fractionized vegetable oil, and, optionally, 1-3%PC% preservative.
5. A substance according to claim 1, characterized in that it is prepared as an ointment holding 0.6-6%PC% tea-tree-oil.
PCT/DK1991/000015 1990-01-19 1991-01-21 Utter or teat care substance with mastitis preventing effect WO1991010364A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE19914190064 DE4190064T (en) 1990-01-19 1991-01-21
DE4190064A DE4190064C2 (en) 1990-01-19 1991-01-21 Use an ointment or a bath / spray for udder and teat care
FI923258A FI923258A7 (en) 1990-01-19 1991-01-21 A substance intended for the treatment of the udder or nipples that has an anti-mastitis effect
DK92920A DK92092D0 (en) 1990-01-19 1992-07-15 OVERSEAS OR PATIENTS WITH MASTITIC PREVENTIONAL EFFECT
NO19922859A NO313171B1 (en) 1990-01-19 1992-07-17 Use of a preparation for udder or teat care and prevention of mastitis
GB9215391A GB2257629B (en) 1990-01-19 1992-07-20 Tea-tree oil containing composition for preventing mastitis
SE9202205A SE9202205L (en) 1990-01-19 1992-07-20 JEWELERY OR EXPENDITURE WITH MASTITIVE PREVENTIONAL EFFECTS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK162/90 1990-01-19
DK016290A DK16290D0 (en) 1990-01-19 1990-01-19 PATTERN TREATMENT NAME NECESSARY TO FIGHT MASTITIS

Publications (1)

Publication Number Publication Date
WO1991010364A1 true WO1991010364A1 (en) 1991-07-25

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK1991/000015 WO1991010364A1 (en) 1990-01-19 1991-01-21 Utter or teat care substance with mastitis preventing effect

Country Status (8)

Country Link
AU (1) AU7181591A (en)
DE (1) DE4190064C2 (en)
DK (1) DK16290D0 (en)
FI (1) FI923258A7 (en)
GB (1) GB2257629B (en)
NO (1) NO313171B1 (en)
SE (1) SE9202205L (en)
WO (1) WO1991010364A1 (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19511429A1 (en) * 1995-03-29 1996-10-02 Gerhard Linnhoff Care products for pets and their applications
DE19537782A1 (en) * 1995-10-11 1997-04-17 Foerster Karl Heinz Disinfectant for use in surgeries or clinics
US5826546A (en) * 1997-04-23 1998-10-27 Miraclecorp Of Australia Method for shampooing a pet using a foam-dispensed pet shampoo composition
WO1999013892A1 (en) * 1997-09-12 1999-03-25 Laboratorios Pisa, S.A. De C.V. Antimastitic pharmaceutical composition and preparation process
WO1999038521A1 (en) * 1998-02-02 1999-08-05 Boehringer Ingelheim Vetmedica Gmbh The use of combinations of active agents consisting of antimicrobially active substances and plant extracts containing terpene in veterinary medicine
DE19729852A1 (en) * 1997-07-11 1999-09-09 Feil Mosquito repellant comprising beer, effective against malarial mosquitos
WO2000025724A3 (en) * 1998-11-03 2000-07-27 Safe N Sound Solutions Inc COMPOSITIONS COMPRISING OLEUM $i(MELALEUCA)
EP1230927A1 (en) * 2001-02-12 2002-08-14 Allegrini S.p.a. Phyto-derivative disinfectant solution for veterinary use in the endo-mammary anti-mastitis treatment of milk-producing animals
EP2138171A1 (en) * 2008-06-18 2009-12-30 Istituto Superiore Di Sanita' Veterinarian compositions containing terpinen-4-ol for the treatment and prevention of mastitis

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2329583A (en) * 1997-09-25 1999-03-31 Marilyn Rydstrom Use of tea-tree oil for prophylaxis against cystitis

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EP0027623A1 (en) * 1979-10-20 1981-04-29 Henkel Kommanditgesellschaft auf Aktien Composition for the control of suckling mastitis and pyogenes mastitis in cattle
AU559001B2 (en) * 1980-09-05 1987-02-19 Sedgewick, S.E. Skin cream containing tea tree oil
WO1988010122A1 (en) * 1987-06-22 1988-12-29 The Commonwealth Industrial Gases Limited Treatment of air conditioning system

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CA1052697A (en) * 1974-03-29 1979-04-17 Upjohn Company (The) Composition for treating mastitis in animals
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JPH02145502A (en) * 1988-11-29 1990-06-05 Ube Ind Ltd Agent for controlling crop diseases

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EP0027623A1 (en) * 1979-10-20 1981-04-29 Henkel Kommanditgesellschaft auf Aktien Composition for the control of suckling mastitis and pyogenes mastitis in cattle
AU559001B2 (en) * 1980-09-05 1987-02-19 Sedgewick, S.E. Skin cream containing tea tree oil
WO1988010122A1 (en) * 1987-06-22 1988-12-29 The Commonwealth Industrial Gases Limited Treatment of air conditioning system

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CHEMICAL ABSTRACTS, Volume 70, No. 2, 13 January 1969, (Columbus, Ohio, US), LAAKSO P.V.: "Fractionation of Tea-Tree Oil, 'Melaleuca Alternifolia'", see page 629, Abstract 6513m; & SCI. PHARM. PROC., 25th 1965, 1966, 1, 485-492. *
DIALOG INFORMATION SERVICES, File 351, WORLD PATENT INDEX 81-90, Dialog Accession No. 5670859, (UBE INDUSTRIES KK), "Non-Noxious Pesticide - is Applicalbe to Agricultural Crops, is Prepd. from Melaleuca Tea-Tree Oil"; & JP,A,2 145 502, 05-06-1990, 9028, (Basic). *
GOULD'S MEDICAL DICTIONARY, Fifth Revised Edition, 1941, C.V. BROWNLOW et al.: see page 252, "Cajuput Oil". *
ROEMPPS CHEMIE-LEXIKON, Achte, Neubearbeitete und Erweiterte Auflage, Band 3, H-Z, 1983, OTTO-ALBRECHT NEUMUELLER: see page 2003, "Kajeputoel". *
THE MERCK INDEX, Eleventh Edition, 1989, SUSAN BUDAVARI et al.: see page 1072, No. 6700, "Oil of Cajeput". *

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19511429A1 (en) * 1995-03-29 1996-10-02 Gerhard Linnhoff Care products for pets and their applications
EP0734727A3 (en) * 1995-03-29 1998-11-11 Gerhard Linnhoff Use of tea tree oil for the manufacture of medicaments or personal care preparations, medicaments or personal care preparation containing tea tree oil
DE19537782A1 (en) * 1995-10-11 1997-04-17 Foerster Karl Heinz Disinfectant for use in surgeries or clinics
US5826546A (en) * 1997-04-23 1998-10-27 Miraclecorp Of Australia Method for shampooing a pet using a foam-dispensed pet shampoo composition
DE19729852A1 (en) * 1997-07-11 1999-09-09 Feil Mosquito repellant comprising beer, effective against malarial mosquitos
WO1999013892A1 (en) * 1997-09-12 1999-03-25 Laboratorios Pisa, S.A. De C.V. Antimastitic pharmaceutical composition and preparation process
WO1999038521A1 (en) * 1998-02-02 1999-08-05 Boehringer Ingelheim Vetmedica Gmbh The use of combinations of active agents consisting of antimicrobially active substances and plant extracts containing terpene in veterinary medicine
AU749923B2 (en) * 1998-02-02 2002-07-04 Boehringer Ingelheim Vetmedica Gmbh The use of combinations of active agents consisting of antimicrobially active substances and plant extracts containing terpene in veterinary medicine
AU749923C (en) * 1998-02-02 2003-01-30 Boehringer Ingelheim Vetmedica Gmbh The use of combinations of active agents consisting of antimicrobially active substances and plant extracts containing terpene in veterinary medicine
WO2000025724A3 (en) * 1998-11-03 2000-07-27 Safe N Sound Solutions Inc COMPOSITIONS COMPRISING OLEUM $i(MELALEUCA)
US6168794B1 (en) 1998-11-03 2001-01-02 Safe 'n Sound Solutions, Inc. Compositions comprising oleum Melaleuca
US6458391B1 (en) 1998-11-03 2002-10-01 Safe ′N Sound Solutions, Inc. Compositions comprising oleum Melaleuca
EP1126861A4 (en) * 1998-11-03 2003-05-02 Safe N Sound Solutions Inc Compositions comprising oleum melaleuca
EP1230927A1 (en) * 2001-02-12 2002-08-14 Allegrini S.p.a. Phyto-derivative disinfectant solution for veterinary use in the endo-mammary anti-mastitis treatment of milk-producing animals
EP2138171A1 (en) * 2008-06-18 2009-12-30 Istituto Superiore Di Sanita' Veterinarian compositions containing terpinen-4-ol for the treatment and prevention of mastitis

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Publication number Publication date
FI923258L (en) 1992-07-16
DE4190064C2 (en) 2002-10-10
FI923258A0 (en) 1992-07-16
GB2257629A (en) 1993-01-20
FI923258A7 (en) 1992-07-16
DK16290D0 (en) 1990-01-19
AU7181591A (en) 1991-08-05
GB2257629B (en) 1994-08-17
SE9202205D0 (en) 1992-07-20
NO922859D0 (en) 1992-07-17
SE9202205L (en) 1992-07-20
NO313171B1 (en) 2002-08-26
GB9215391D0 (en) 1992-09-16
NO922859L (en) 1992-09-10

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