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WO1991009961A3 - Nouveaux produits - Google Patents

Nouveaux produits Download PDF

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Publication number
WO1991009961A3
WO1991009961A3 PCT/GB1990/001997 GB9001997W WO9109961A3 WO 1991009961 A3 WO1991009961 A3 WO 1991009961A3 GB 9001997 W GB9001997 W GB 9001997W WO 9109961 A3 WO9109961 A3 WO 9109961A3
Authority
WO
WIPO (PCT)
Prior art keywords
novel products
paraherquamide
imi
oxides
preparing
Prior art date
Application number
PCT/GB1990/001997
Other languages
English (en)
Other versions
WO1991009961A2 (fr
Inventor
Rhona Mary Banks
Simon Edward Blanchflower
Christopher Reading
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898928844A external-priority patent/GB8928844D0/en
Priority claimed from GB909024716A external-priority patent/GB9024716D0/en
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of WO1991009961A2 publication Critical patent/WO1991009961A2/fr
Publication of WO1991009961A3 publication Critical patent/WO1991009961A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/80—Penicillium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Composés apparentés à la paraherquamide préparés par culture de Penicillium sp. IMI 332995. La présente invention décrit en outre une méthode synthétique de préparation des N-oxydes de dérivés de paraherquamide.
PCT/GB1990/001997 1989-12-21 1990-12-20 Nouveaux produits WO1991009961A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB898928844A GB8928844D0 (en) 1989-12-21 1989-12-21 Novel compounds
GB8928844.3 1989-12-21
GB909024716A GB9024716D0 (en) 1990-11-14 1990-11-14 Novel products
GB9024716.4 1990-11-14

Publications (2)

Publication Number Publication Date
WO1991009961A2 WO1991009961A2 (fr) 1991-07-11
WO1991009961A3 true WO1991009961A3 (fr) 1991-10-31

Family

ID=26296401

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1990/001997 WO1991009961A2 (fr) 1989-12-21 1990-12-20 Nouveaux produits

Country Status (6)

Country Link
EP (1) EP0506814A1 (fr)
JP (1) JPH05502163A (fr)
CA (1) CA2071982A1 (fr)
IE (1) IE904606A1 (fr)
PT (1) PT96298A (fr)
WO (1) WO1991009961A2 (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
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JP3134936B2 (ja) * 1992-10-16 2001-02-13 沖電気工業株式会社 衝撃センサ
TW410227B (en) * 1993-06-16 2000-11-01 Upjohn Co 14-substituted marcfortines and derivatives useful as antiparasitic agents
TW334436B (en) * 1995-07-21 1998-06-21 Upjohn Co Antiparasitic marcfortines and paraherquamides
ZA976761B (en) * 1996-09-09 1999-01-29 Upjohn Co 25 Methylene and 24,25-epoxy marcfortines and paraherquamides
WO1998021211A1 (fr) * 1996-11-15 1998-05-22 Pharmacia & Upjohn Company Marcfortines et paraherquamides substitues en position 1 et 2 utilises comme antiparasitaires
MX2011005011A (es) 2008-11-14 2011-07-29 Merial Ltd Compuestos de arilazol-2-il-cianoetilamino enantiomericamente enriquecidos, metodo de elaboracion y de uso de los mismos.
PL396375A1 (pl) 2008-11-19 2012-04-23 Merial Limited Kompozycje obejmujące arylopirazol i/lub formamidynę, sposoby i zastosowania je obejmujące
EP2376513B1 (fr) 2008-12-04 2015-02-25 Merial Limited Dérivés dimères d'avermectine et de milbémycine
CA2782902C (fr) 2009-12-04 2017-10-17 Merial Limited Composes pesticides bis-organosulfures
BR112012014921B1 (pt) 2009-12-17 2020-11-03 Merial, Inc. compostos dihidroazol parasiticidas e composições compreendendo os mesmos
MX2012006921A (es) 2009-12-17 2012-07-10 Merial Ltd Composiciones que comprenden compuestos de lactona macrociclica y espirodioxepinoindoles.
UA108641C2 (uk) 2010-04-02 2015-05-25 Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування
LT2640728T (lt) 2010-11-16 2017-03-27 Merial, Inc. Nauji monenzino dariniai, skirti pirmuonių sukeltų infekcijų gydymui
US20120329832A1 (en) 2011-06-27 2012-12-27 Jean Delaveau Novel Insect-Repellent Coumarin Derivatives, Syntheses, and Methods of Use
ES2618813T3 (es) 2011-06-27 2017-06-22 Merial, Inc. Compuestos y composiciones de éter amido-piridílico y uso contra los parásitos
EP3788874A1 (fr) 2011-09-12 2021-03-10 Boehringer Ingelheim Animal Health USA Inc. Compositions parasiticides comprenant un agent actif d'isoxazoline, procédés et utilisations associés
WO2013044118A2 (fr) 2011-09-23 2013-03-28 Merial Limited Modélisation indirecte de molécules répulsives inédites actives contre les insectes, les acariens et autres arthropodes
WO2013074892A1 (fr) 2011-11-17 2013-05-23 Merial Limited Compositions comprenant un aryl pyrazole et un imidazole substitué, procédés et utilisations de celles-ci
EP3351546B9 (fr) 2011-12-02 2024-07-10 Boehringer Ingelheim Vetmedica GmbH Formulations de moxidectine injectables à action prolongée
GB2514951C (en) 2012-02-06 2020-11-04 Boehringer Ingelheim Animal Health Usa Inc Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
PT2895465T (pt) 2012-04-20 2019-01-16 Boehringer Ingelheim Animal Health Usa Inc Composições parasiticidas compreendendo derivados de benzimidazoles, os seus métodos e as suas utilizações
NZ723198A (en) 2012-11-20 2018-11-30 Boehringer Ingelheim Animal Health Usa Inc Anthelmintic compounds and compositions and methods of using thereof
PT3063144T (pt) 2013-11-01 2021-10-28 Boehringer Ingelheim Animal Health Usa Inc Compostos de isoxazolina antiparasitários e pesticidas
JP6682719B2 (ja) 2014-04-17 2020-04-15 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 寄生生物から動物を保護するためのマロノニトリル化合物の使用
MX361606B (es) 2014-05-19 2018-12-11 Merial Inc Compuestos antihelmínticos.
AU2015276941B2 (en) 2014-06-19 2018-07-19 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal compositions comprising indole derivatives, methods and uses thereof
NZ731446A (en) 2014-10-31 2018-09-28 Boehringer Ingelheim Animal Health Usa Inc Parasiticidal composition comprising fipronil
UY36570A (es) 2015-02-26 2016-10-31 Merial Inc Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas
KR20180002886A (ko) 2015-05-20 2018-01-08 메리얼 인코포레이티드 구충성 뎁시펩티드 화합물
UY37137A (es) 2016-02-24 2017-09-29 Merial Inc Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos
WO2018039508A1 (fr) 2016-08-25 2018-03-01 Merial, Inc. Procédé de réduction d'effets indésirables dans des traitements antiparasitaires
CN110381738B (zh) 2016-10-14 2021-07-16 勃林格殷格翰动物保健美国公司 农药的和杀寄生物的乙烯基异噁唑啉化合物
US11382949B2 (en) 2016-11-16 2022-07-12 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic depsipeptide compounds
CN111194316A (zh) 2017-08-14 2020-05-22 勃林格殷格翰动物保健美国公司 农药的和杀寄生物的吡唑-异噁唑啉化合物
EP3749096A1 (fr) 2018-02-08 2020-12-16 Boehringer Ingelheim Animal Health USA Inc. Compositions parasiticides comprenant de l'éprinomectine et du praziquantel, procédés et utilisations associés
MX2021000293A (es) 2018-07-09 2021-07-15 Boehringer Ingelheim Animal Health Usa Inc Compuestos heterociclicos antihelminticos.
EP3883648A1 (fr) 2018-11-20 2021-09-29 Boehringer Ingelheim Animal Health USA Inc. Composé indazolylcyanoéthylamino, compositions associées, procédé de fabrication et procédés d'utilisation de celui-ci
BR112021016196A2 (pt) 2019-03-01 2021-10-05 Boehringer Ingelheim Animal Health USA Inc. Composições injetáveis de clorsulon, métodos e usos das mesmas
WO2020191091A1 (fr) 2019-03-19 2020-09-24 Boehringer Ingelheim Animal Health USA Inc. Composés d'aza-benzothiophène et d'aza-benzofurane anthelminthiques
AU2021278889A1 (en) 2020-05-29 2023-02-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anthelmintic heterocyclic compounds
AU2021410052B2 (en) 2020-12-21 2025-01-09 Boehringer Ingelheim Vetmedica Gmbh Parasiticidal collar comprising isoxazoline compounds
JP2025507585A (ja) 2022-02-17 2025-03-21 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー 流体製品メーラーを提供する方法及びシステム

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0301742A2 (fr) * 1987-07-28 1989-02-01 Merck & Co. Inc. Paraherquamide et dihydroparaherquamide comme agents antiparasitaires
EP0322937A2 (fr) * 1987-11-27 1989-07-05 Merck & Co. Inc. Dérivés de la paraherquamide isolés à partir d'un bouillon de fermentation et actifs comme agents antiparasitaires
US4866060A (en) * 1988-08-19 1989-09-12 Merck & Co., Inc. Use of the natural product marcfortines as antiparasitic agents
EP0354615A1 (fr) * 1988-08-12 1990-02-14 Merck & Co. Inc. Dérivés synthétiques de paraherquamide
US4923867A (en) * 1988-08-24 1990-05-08 Merck & Co., Inc. Synthetic marcfortine derivatives useful as antiparasitic agents

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0301742A2 (fr) * 1987-07-28 1989-02-01 Merck & Co. Inc. Paraherquamide et dihydroparaherquamide comme agents antiparasitaires
EP0322937A2 (fr) * 1987-11-27 1989-07-05 Merck & Co. Inc. Dérivés de la paraherquamide isolés à partir d'un bouillon de fermentation et actifs comme agents antiparasitaires
EP0354615A1 (fr) * 1988-08-12 1990-02-14 Merck & Co. Inc. Dérivés synthétiques de paraherquamide
US4866060A (en) * 1988-08-19 1989-09-12 Merck & Co., Inc. Use of the natural product marcfortines as antiparasitic agents
US4923867A (en) * 1988-08-24 1990-05-08 Merck & Co., Inc. Synthetic marcfortine derivatives useful as antiparasitic agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J. Am. Chem. Soc., vol. 110, No. 17, August 1988, R.M. Williams et al: "Facial selectivity of the intramolecular SN2' cyclization: Stereocontrolled total synthesis of brevianamide B", pages 5927-5929, see compound 6 *
J. Am. Chem. Soc., vol. 111, April 1989, R.M. Williams et al: "Remarkable, enantiodivergent biogenesis of brevianamide A and B", pages 3064-3065, see compound 7 *

Also Published As

Publication number Publication date
EP0506814A1 (fr) 1992-10-07
JPH05502163A (ja) 1993-04-22
WO1991009961A2 (fr) 1991-07-11
CA2071982A1 (fr) 1991-06-22
PT96298A (pt) 1991-09-30
IE904606A1 (en) 1991-07-03

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