WO1991007193A1 - Methode de sterilisation a l'aide de sterilisants sous faible pression de vapeur - Google Patents
Methode de sterilisation a l'aide de sterilisants sous faible pression de vapeur Download PDFInfo
- Publication number
- WO1991007193A1 WO1991007193A1 PCT/US1990/006610 US9006610W WO9107193A1 WO 1991007193 A1 WO1991007193 A1 WO 1991007193A1 US 9006610 W US9006610 W US 9006610W WO 9107193 A1 WO9107193 A1 WO 9107193A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- enclosure
- vapor phase
- sterilant
- vapor
- vapor pressure
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 18
- 239000012808 vapor phase Substances 0.000 claims abstract description 57
- 230000008016 vaporization Effects 0.000 claims abstract description 22
- 239000007788 liquid Substances 0.000 claims abstract description 19
- 230000001954 sterilising effect Effects 0.000 claims abstract description 18
- 238000009834 vaporization Methods 0.000 claims abstract description 17
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 14
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 61
- 238000001816 cooling Methods 0.000 claims description 2
- 229920006395 saturated elastomer Polymers 0.000 description 10
- 239000003795 chemical substances by application Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 238000009792 diffusion process Methods 0.000 description 6
- 230000036961 partial effect Effects 0.000 description 6
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 4
- 239000000243 solution Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000011358 absorbing material Substances 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000004377 microelectronic Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000006200 vaporizer Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/20—Gaseous substances, e.g. vapours
Definitions
- Saturated sterilant vapors are generated at a high temperature. That may be achieved through the use of a vaporization chamber 12 which receives a liquid to be vaporized from a liquid reservoir 14.
- That pressure differential (48.2 mm Hg - 6.0 mm Hg) can act as a driving force to propel the vapors from the vaporizer to the enclosure. When the vapors reach the enclosure, they will expand to fill the available volume. That expansion cools the vapors.
- vapor phase hydrogen peroxide Comparing vapor phase hydrogen peroxide to ethylene oxide, the 12% ethylene oxide 88% freon sterilant used in many ethylene oxide sterilizers is typically introduced into a chamber evacuated to 90 mm Hg absolute and controlled at 1,174 mm Hg. Thus, the total vapor pressure which is used to deliver the sterilant is 1084 mm Hg. The concentration of ethylene oxide sterilant is approximately 350,000 ppm. 30% vapor phase hydrogen peroxide at 20°C has a vapor pressure of only 4.3 mm Hg and a concentration in dry air of approximately 5,660 ppm (1047 ppm hydrogen peroxide, 4613 ppm water) .
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
Méthode de stérilisation utilisant des stérilisants sous faible pression de vapeur comprenant les étapes de vaporisation d'un liquide de façon à produire un stérilisant en phase vapeur possèdant une faible pression de vapeur. Le stérilisant en phase vapeur est chauffé au-delà de la température de vaporisation de manière à en augmenter la pression de vapeur. La pression de vapeur accrue est utilisée afin d'acheminer le stérilisant en phase vapeur chauffé vers une enceinte. Le stérilisant en phase vapeur chauffé est refroidi jusqu'à la température de l'enceinte. La chaleur dégagée par le stérilisant en phase vapeur lorsqu'il refroidit est absorbée par l'enceinte sans en augmenter de façon sensible la température. La concentration de stérilisant en phase vapeur dans l'enceinte est maintenue jusqu'à ce que l'on obtienne la stérilisation.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43771689A | 1989-11-16 | 1989-11-16 | |
| US437,716 | 1989-11-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1991007193A1 true WO1991007193A1 (fr) | 1991-05-30 |
Family
ID=23737587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1990/006610 WO1991007193A1 (fr) | 1989-11-16 | 1990-11-13 | Methode de sterilisation a l'aide de sterilisants sous faible pression de vapeur |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0453549A1 (fr) |
| JP (1) | JPH04503026A (fr) |
| WO (1) | WO1991007193A1 (fr) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993017726A1 (fr) * | 1992-03-13 | 1993-09-16 | American Sterilizer Company | Appareil et procede de sterilisation a l'aide d'un agent sterilisateur a multicomposant__________________________________________ |
| WO1994011034A1 (fr) * | 1992-11-12 | 1994-05-26 | American Sterilizer Company | Methode de decontamination de lyophilisateurs |
| EP1764115A1 (fr) * | 2005-09-15 | 2007-03-21 | Shibuya Kogyo Co., Ltd. | Méthode de stérilisation |
| JP2016529025A (ja) * | 2013-08-30 | 2016-09-23 | アメリカン ステリライザー カンパニー | 滅菌サイクルの実行方法 |
| US9731041B2 (en) | 2012-04-19 | 2017-08-15 | Ena Co., Ltd. | Method and apparatus for sterilization with nitrogen oxide |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5688622B2 (ja) * | 2012-04-19 | 2015-03-25 | 株式会社エナ | 滅菌装置及び滅菌法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4512951A (en) * | 1980-12-30 | 1985-04-23 | American Sterilizer Company | Hydrogen peroxide liquid film sterilization method |
| EP0243003A2 (fr) * | 1986-03-24 | 1987-10-28 | Snow Brand Milk Products Co., Ltd. | Procédé et appareil de stérilisation |
| EP0298694A2 (fr) * | 1987-07-06 | 1989-01-11 | American Sterilizer Company | Installation de circulation de vapeur |
| EP0302420A2 (fr) * | 1987-07-30 | 1989-02-08 | JOHNSON & JOHNSON MEDICAL, INC. | Système de stérilisation par la vapeur de peroxyde d'hydrogène à basse pression |
| WO1989010762A1 (fr) * | 1988-05-06 | 1989-11-16 | American Sterilizer Company | Procede de sterilisation au peroxyde d'hydrogene |
-
1990
- 1990-11-13 EP EP19900917243 patent/EP0453549A1/fr not_active Withdrawn
- 1990-11-13 JP JP3500564A patent/JPH04503026A/ja active Pending
- 1990-11-13 WO PCT/US1990/006610 patent/WO1991007193A1/fr not_active Application Discontinuation
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4512951A (en) * | 1980-12-30 | 1985-04-23 | American Sterilizer Company | Hydrogen peroxide liquid film sterilization method |
| EP0243003A2 (fr) * | 1986-03-24 | 1987-10-28 | Snow Brand Milk Products Co., Ltd. | Procédé et appareil de stérilisation |
| EP0298694A2 (fr) * | 1987-07-06 | 1989-01-11 | American Sterilizer Company | Installation de circulation de vapeur |
| EP0302420A2 (fr) * | 1987-07-30 | 1989-02-08 | JOHNSON & JOHNSON MEDICAL, INC. | Système de stérilisation par la vapeur de peroxyde d'hydrogène à basse pression |
| WO1989010762A1 (fr) * | 1988-05-06 | 1989-11-16 | American Sterilizer Company | Procede de sterilisation au peroxyde d'hydrogene |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993017726A1 (fr) * | 1992-03-13 | 1993-09-16 | American Sterilizer Company | Appareil et procede de sterilisation a l'aide d'un agent sterilisateur a multicomposant__________________________________________ |
| US5492672A (en) * | 1992-03-13 | 1996-02-20 | American Sterilizer Company | Sterilization apparatus and method for multicomponent sterilant |
| WO1994011034A1 (fr) * | 1992-11-12 | 1994-05-26 | American Sterilizer Company | Methode de decontamination de lyophilisateurs |
| US5837193A (en) * | 1992-11-12 | 1998-11-17 | American Sterilizer Company | Method of decontaminating freeze dryers |
| EP1764115A1 (fr) * | 2005-09-15 | 2007-03-21 | Shibuya Kogyo Co., Ltd. | Méthode de stérilisation |
| US9731041B2 (en) | 2012-04-19 | 2017-08-15 | Ena Co., Ltd. | Method and apparatus for sterilization with nitrogen oxide |
| JP2016529025A (ja) * | 2013-08-30 | 2016-09-23 | アメリカン ステリライザー カンパニー | 滅菌サイクルの実行方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0453549A1 (fr) | 1991-10-30 |
| JPH04503026A (ja) | 1992-06-04 |
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