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WO1990015592A1 - Dentifrice anti-plaque - Google Patents

Dentifrice anti-plaque Download PDF

Info

Publication number
WO1990015592A1
WO1990015592A1 PCT/AU1990/000255 AU9000255W WO9015592A1 WO 1990015592 A1 WO1990015592 A1 WO 1990015592A1 AU 9000255 W AU9000255 W AU 9000255W WO 9015592 A1 WO9015592 A1 WO 9015592A1
Authority
WO
WIPO (PCT)
Prior art keywords
gel according
dentifrice
weight
amount
dentifrice gel
Prior art date
Application number
PCT/AU1990/000255
Other languages
English (en)
Inventor
Patrick John Shanahan
Original Assignee
Patrick John Shanahan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Patrick John Shanahan filed Critical Patrick John Shanahan
Publication of WO1990015592A1 publication Critical patent/WO1990015592A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A61K8/416—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/54—Polymers characterized by specific structures/properties
    • A61K2800/542—Polymers characterized by specific structures/properties characterized by the charge
    • A61K2800/5422—Polymers characterized by specific structures/properties characterized by the charge nonionic

Definitions

  • This invention relates to an anti-plaque dentifrice, and in particular it relates to a dentifrice in the form of a non-abrasive gel containing active anti- plaque agents which maximises the recognised anti-plaque and anti-bacterial properties of the active components, and utilises the oral physiology in the mouth to assist in destroying dental plaque.
  • Dental plaque is the major cause of dental disease affecting both tooth and gum tissues. Therefore, its effective removal is critical to maintaining optimal oral health. Plaque consists of food breakdown products, food debris, and harmful pathogenic bacterial. In the presence of plaque, sugars create acids which cause loss of calcium from the tooth enamel eventually forming cavities. Due to the introduction of fluoride into community water supplies and toothpastes dental decay has been significantly reduced. Today, the major dental problem in all age groups is periodontal (gum) disease. It will increase markedly in the future because better dental care is resulting in more people keeping their teeth. Gum disease is initiated by the release of harmful toxin by-products from plaque. These result from the reaction between food breakdown products and the bacteria in the plaque.
  • the toxins cause inflammation of the gum margins (gingivitis), and if the plaque is retained it becomes calcified to form calculus. This calcification results from the deposition of calcium salts which are contained in the saliva reacting with plaque. If this process continues, infection follows and with it destruction of tooth support and bone, eventually resulting in tooth loss.
  • the most widely accepted method of removing plaque is with the use of a toothbrush assisted by a toothpaste.
  • a toothbrush assisted by a toothpaste Prior to the present invention, it has always been the toothbrush alone which has determined how effectively plaque has been removed.
  • the toothpaste assists the toothbrush through its detergent action.
  • All conventional toothpastes are cosmetic products because the manufacturers believe a toothpaste must contain an abrasive which acts as a polishing agent.
  • the basic composition of a conventional toothpaste then is the abrasive or polishing agent, a chemically inert carrier acting as a binder, a foaming agent, fluoride, flavouring, and the like.
  • the composition also contains other additive(s) for which certain benefits are claimed.
  • abrasive As described above, to date it has been considered mandatory to incorporate an abrasive in any commercially available dentifrice, however, there are several reasons why an abrasive is not advised, especially in combination with a cationic anti-plaque agent.
  • the use of abrasives is contraindicated with cationic agents because the commonly used dentifrice abrasives are anionic. They are therefore, ionically incompatible with the anti-plaque agent.
  • Another reason why the use of abrasives is disadvantageous is that the dental pellicle - the protein layer coating the tooth surface - is part of the normal physiology of the mouth, and is a protective layer.
  • abrasives removes the pellicle, but it is reconstituted shortly afterwards by the salivary proteins.
  • Anti-plaque agents are attracted to the glycoproteins in the saliva, the soft tissues, and in the pellicle on the tooth surfaces. Accordingly, when the dental pellicle is not removed, there is enhancement of the anti-plaque activity of the anti-plaque agent.
  • U.S. Patent Specification No. 4,022,880 discloses an oral composition capable of retarding the development of plaque and dental calculus consisting essentially of zinc ions and an antibacterial agent such as a quaternary ammonium compound in an orally acceptable medium.
  • Particular formulations of the oral composition disclosed in U.S. Patent Specification No. 4,022,880 include toothpastes incorporating abrasive polishing agents, typically in the range of from 40% to 50% by weight, or tooth powders incorporating such abrasive polishing agents in typical amounts of from 90% to 95%.
  • Alternative formulations disclosed are mouthwash or rinse formulations in which the orally acceptable medium is water optionally containing ethanol.
  • a non-abrasive gel comprising a zinc salt (such as zinc chloride), a quaternary ammonium compound (such as cetyl pyridinium chloride - CPC) and a gelling agent is an effective anti- plaque dentifrice when used with a toothbrush, in the manner of a traditional toothpaste.
  • a non-abrasive dentifrice gel which comprises an effective antibacterial amount of the combination of a zinc salt and a quaternary ammonium compound, and a gelling agent.
  • zinc chloride has been shown to be anti-bacterial, and reduce plaque and calculus formation.
  • the reason for the increased effectiveness of CPC in combination with zinc chloride is unknown at present, but a suggested theory is that zinc chloride may retard the calcification of plaque allowing optimal activity of the recognised anti-plaque agent. Since the anti-calculus properties of zinc chloride continue to remain effective over long periods of use, this may be used to maintain the efficacy of CPC over greater periods of time.
  • the zinc salts which may be used in the gel composition of this invention include any water soluble zinc salt such as zinc chloride, zinc acetate, zinc sulphate, and the like. Other less soluble zinc salts such as zinc fluoride and zinc citrate may also be used.
  • the zinc salt is zinc chloride.
  • the zinc salt may be included in the gel composition in an amount of from about 0.1 to 5% by weight.
  • zinc chloride is added in an amount of from 0.2 to 0.25% by weight, more preferably an amount of about 0.22% by weight.
  • Suitable quaternary ammonium compounds for inclusion in the gel composition of the present invention include (C ⁇ .- ⁇ g) alkyl pyridinium chlorides and (C ⁇ _i8) alkyl pyridinium bromides. Particularly preferred is cetyl pyridinium chloride (CPC) .
  • the quaternary ammonium compound may be incorporated in the gel composition in amounts in the range of 0.01 to 0.5% by weight.
  • the gel composition includes CPC in an amount of 0.01 to 0.1% by weight, more preferably an amount of about 0.05% by weight.
  • the gel composition of this invention also includes a gelling agent.
  • this gelling agent is a non-ionic gelling or thickening agent such as the natural or synthetic gums including hydroxyethyl cellulose, hydroxymethyl cellulose, and the like.
  • the gelling agent may be used in amounts in the range of 0.5 to 5% by weight.
  • the gelling agent is hydroxyethyl cellulose in an amount of 2 to 4% by weight, more preferably an amount of about 2.5 to 3% by weight.
  • the gel composition may also include suitable fluoride-providing compounds including, by way of example, soluble inorganic fluoride salts such as sodium or potassium fluoride and sodium monofluorphosphate.
  • suitable fluoride-providing compounds including, by way of example, soluble inorganic fluoride salts such as sodium or potassium fluoride and sodium monofluorphosphate.
  • the fluoride-providing compound is incorporated in amounts of 0.005 to 2% by weight.
  • the gel composition also incorporates a surfactant to enhance the foaming action of the quaternary ammonium compound.
  • Suitable surfactants include the non-ionic surfactants and betaine surfactants such as cocoamidopropyl betaine, lauramidopropylbetaine and cocobetaine.
  • cocobetaine Cocobetaine (Gafamox) is particularly preferred.
  • the surfactant may be used in amounts of from 0.1 to 5% by weight, preferably from 0.2 to 0.5% by weight.
  • humectants such as polyethylene glycol, sorbitol or glycerol, sweeteners such as saccharin, and colouring and flavouring agents.
  • the gel composition may also include charged and uncharged polysaccharides and other polymers, particularly chitosan and alginates, which are used in food products and which are gel-forming agents. These can assist in binding the active anti-plaque agents such as zinc chloride and cetyl pyridinium chloride to the teeth by establishment of a polysaccharide or other polymer film layer to which the active agents will bind, thereby resulting in more effective antibacterial and anti-plaque performance.
  • the gel composition of the present invention differs essentially from a traditional toothpaste formulation in that it is non- abrasive. Nevertheless, by applying it in a gel form on a toothbrush, the plaque massis broken up by the brushing action allowing easier penetration of the remaining plaque. A mouth rinse will not dislodge plaque as effectively as a gel applied with a toothbrush, even if the mouth rinse is agitated vigorously.
  • the following Example illustrates the non-abrasive dentifrice gel composition of the present invention, and the method of preparation thereof. It is to be understood, however, that this invention is not limited to the particular formulation set out in this Example.
  • An anti-plaque dentifrice gel composition is made up as follows:

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

Un gel dentifrice non-abrasif comprend une quantité efficace pour combattre des bactéries d'une combinaison d'un sel de zinc tel que le chlorure de zinc et d'un composé d'ammonium quaternaire tel que le chlorure de cétylpyridinium, ainsi qu'un agent gélifiant.
PCT/AU1990/000255 1989-06-12 1990-06-12 Dentifrice anti-plaque WO1990015592A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPJ4645 1989-06-12
AUPJ464589 1989-06-12

Publications (1)

Publication Number Publication Date
WO1990015592A1 true WO1990015592A1 (fr) 1990-12-27

Family

ID=3773977

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU1990/000255 WO1990015592A1 (fr) 1989-06-12 1990-06-12 Dentifrice anti-plaque

Country Status (1)

Country Link
WO (1) WO1990015592A1 (fr)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993011754A1 (fr) * 1991-12-11 1993-06-24 The Procter & Gamble Company Chlorure de cetylpyridinium et bromure de domiphene incorpores dans un solvant organique
WO1997046217A1 (fr) * 1996-05-31 1997-12-11 Smithkline Beecham Plc Composition pour bains de bouche comprenant du chlorure de pyridinium ainsi qu'un tensioactif amphotere
WO1999020238A1 (fr) * 1997-10-23 1999-04-29 Warner-Lambert Company Produits oraux contenant un ion metallique a astringence reduite
ES2132033A1 (es) * 1997-11-06 1999-08-01 Dentaid Sa Composicion oral para el tratamiento de la halitosis.
WO2000051559A1 (fr) * 1999-03-01 2000-09-08 Orix As Composition orale contre la mauvaise haleine
WO2001070183A1 (fr) * 2000-03-22 2001-09-27 Church & Dwight Co., Inc. Compositions de dentifrice contenant du chlorure de pyridinium
US6355229B1 (en) 2001-06-27 2002-03-12 Church & Dwight Co., Inc. Oral composition containing cetylpyridinium chloride and guar hydroxypropyltrimonium chloride and method of using the same
WO2003075865A1 (fr) * 2002-03-04 2003-09-18 Colgate-Palmolive Company Bain de rinçage de bouche antimicrobien rafraichissant l'haleine
EP1393710A1 (fr) * 2002-08-21 2004-03-03 The Procter & Gamble Company Méthode d'application d'une composition orale
EP1562615A1 (fr) * 2002-07-29 2005-08-17 SHANAHAN, Patrick, John Composition buccale et dentaire
GB2436463A (en) * 2006-03-21 2007-09-26 Biofilm Ltd Breath deodoriser
WO2007134335A2 (fr) * 2006-05-15 2007-11-22 Zicare, Llc Méthode destiné à améliorer de façon mesurée la santé buccale
WO2008145475A1 (fr) * 2007-05-31 2008-12-04 Unilever Plc Composition pour l'hygiène buccale
US20100221196A1 (en) * 2007-05-07 2010-09-02 Koninklijke Philips Electronics N.V. Method for cleaning dental plaque from teeth using an adherent peelable gel
US8871183B2 (en) 2006-05-15 2014-10-28 Zicare, Llc Composition for promoting and maintaining oral health
US9554976B2 (en) 2002-09-11 2017-01-31 The Procter & Gamble Company Tooth whitening product
US10555880B2 (en) 2015-12-18 2020-02-11 Colgate-Palmolive Company Sodium zinc alginate structurant and methods for making and using the same

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3124512A (en) * 1958-05-29 1964-03-10 Compositions for use in caries
US3235459A (en) * 1962-02-15 1966-02-15 Procter & Gamble Oral compositions for caries prophylaxis
US4022880A (en) * 1973-09-26 1977-05-10 Lever Brothers Company Anticalculus composition
US4118473A (en) * 1976-08-16 1978-10-03 Colgate-Palmolive Company Antibacterial oral composition
US4118472A (en) * 1976-08-16 1978-10-03 Colgate-Palmolive Company Antibacterial oral composition
US4256731A (en) * 1978-03-23 1981-03-17 Beecham, Inc. Oral Compositions
EP0026252A1 (fr) * 1979-09-27 1981-04-08 Blendax-Werke R. Schneider GmbH & Co. Composition pour l'hygiène orale
US4370314A (en) * 1975-12-08 1983-01-25 Colgate-Palmolive Company Oral composition containing antibacterial agent
EP0181161A2 (fr) * 1984-10-31 1986-05-14 Stafford-Miller Ltd. Produits pour l'hygiène buccale
US4622220A (en) * 1984-02-20 1986-11-11 Blendax-Werke R. Schneider Preparation for oral hygiene

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3124512A (en) * 1958-05-29 1964-03-10 Compositions for use in caries
US3235459A (en) * 1962-02-15 1966-02-15 Procter & Gamble Oral compositions for caries prophylaxis
US4022880A (en) * 1973-09-26 1977-05-10 Lever Brothers Company Anticalculus composition
US4370314A (en) * 1975-12-08 1983-01-25 Colgate-Palmolive Company Oral composition containing antibacterial agent
US4118473A (en) * 1976-08-16 1978-10-03 Colgate-Palmolive Company Antibacterial oral composition
US4118472A (en) * 1976-08-16 1978-10-03 Colgate-Palmolive Company Antibacterial oral composition
US4256731A (en) * 1978-03-23 1981-03-17 Beecham, Inc. Oral Compositions
EP0026252A1 (fr) * 1979-09-27 1981-04-08 Blendax-Werke R. Schneider GmbH & Co. Composition pour l'hygiène orale
US4622220A (en) * 1984-02-20 1986-11-11 Blendax-Werke R. Schneider Preparation for oral hygiene
EP0181161A2 (fr) * 1984-10-31 1986-05-14 Stafford-Miller Ltd. Produits pour l'hygiène buccale

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993011754A1 (fr) * 1991-12-11 1993-06-24 The Procter & Gamble Company Chlorure de cetylpyridinium et bromure de domiphene incorpores dans un solvant organique
TR27527A (tr) * 1991-12-11 1995-06-07 Procter & Gamble Nefes koruyucu mikrokapsüller
WO1997046217A1 (fr) * 1996-05-31 1997-12-11 Smithkline Beecham Plc Composition pour bains de bouche comprenant du chlorure de pyridinium ainsi qu'un tensioactif amphotere
US6117417A (en) * 1996-05-31 2000-09-12 Smithkline Beecham P.L.C. Mouthwash composition comprising cetylpyridinium chloride and an amphoteric surfactant
WO1999020238A1 (fr) * 1997-10-23 1999-04-29 Warner-Lambert Company Produits oraux contenant un ion metallique a astringence reduite
ES2132033A1 (es) * 1997-11-06 1999-08-01 Dentaid Sa Composicion oral para el tratamiento de la halitosis.
WO2000051559A1 (fr) * 1999-03-01 2000-09-08 Orix As Composition orale contre la mauvaise haleine
US6344184B1 (en) 1999-03-01 2002-02-05 Orix As Oral composition for inhibiting oral malodor
WO2001070183A1 (fr) * 2000-03-22 2001-09-27 Church & Dwight Co., Inc. Compositions de dentifrice contenant du chlorure de pyridinium
US6471948B1 (en) * 2000-03-22 2002-10-29 Church & Dwight Co. Inc. Toothpaste compositions containing cetylpyridinium chloride
US6355229B1 (en) 2001-06-27 2002-03-12 Church & Dwight Co., Inc. Oral composition containing cetylpyridinium chloride and guar hydroxypropyltrimonium chloride and method of using the same
US6723305B2 (en) 2002-03-04 2004-04-20 Colgate Palmolive Company Anti-microbial breath freshening mouthrinse
WO2003075865A1 (fr) * 2002-03-04 2003-09-18 Colgate-Palmolive Company Bain de rinçage de bouche antimicrobien rafraichissant l'haleine
EP1562615A1 (fr) * 2002-07-29 2005-08-17 SHANAHAN, Patrick, John Composition buccale et dentaire
EP1562615A4 (fr) * 2002-07-29 2007-03-07 Patrick John Shanahan Composition buccale et dentaire
EP1393710A1 (fr) * 2002-08-21 2004-03-03 The Procter & Gamble Company Méthode d'application d'une composition orale
WO2004017933A1 (fr) * 2002-08-21 2004-03-04 The Procter & Gamble Company Technique d'application de composition buccale et composition buccale a cet effet
US10493016B2 (en) 2002-09-11 2019-12-03 The Procter & Gamble Company Tooth whitening product
US9554976B2 (en) 2002-09-11 2017-01-31 The Procter & Gamble Company Tooth whitening product
GB2436463A (en) * 2006-03-21 2007-09-26 Biofilm Ltd Breath deodoriser
WO2007134335A2 (fr) * 2006-05-15 2007-11-22 Zicare, Llc Méthode destiné à améliorer de façon mesurée la santé buccale
WO2007134335A3 (fr) * 2006-05-15 2008-01-24 Zicare Llc Méthode destiné à améliorer de façon mesurée la santé buccale
US8871183B2 (en) 2006-05-15 2014-10-28 Zicare, Llc Composition for promoting and maintaining oral health
US9072673B2 (en) 2006-05-15 2015-07-07 Zicare, Llc Method for measurably improving oral health
US9248079B2 (en) * 2007-05-07 2016-02-02 Koninklijke Philips N.V. Method for cleaning dental plaque from teeth using an adherent peelable gel
US20100221196A1 (en) * 2007-05-07 2010-09-02 Koninklijke Philips Electronics N.V. Method for cleaning dental plaque from teeth using an adherent peelable gel
WO2008145475A1 (fr) * 2007-05-31 2008-12-04 Unilever Plc Composition pour l'hygiène buccale
US10555880B2 (en) 2015-12-18 2020-02-11 Colgate-Palmolive Company Sodium zinc alginate structurant and methods for making and using the same

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