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WO1990013643A3 - Molecules receptrices d'hormone de glycoproteine - Google Patents

Molecules receptrices d'hormone de glycoproteine Download PDF

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Publication number
WO1990013643A3
WO1990013643A3 PCT/US1990/002488 US9002488W WO9013643A3 WO 1990013643 A3 WO1990013643 A3 WO 1990013643A3 US 9002488 W US9002488 W US 9002488W WO 9013643 A3 WO9013643 A3 WO 9013643A3
Authority
WO
WIPO (PCT)
Prior art keywords
hormone receptor
receptor molecules
glycoprotein hormone
molecules
stimulating hormone
Prior art date
Application number
PCT/US1990/002488
Other languages
English (en)
Other versions
WO1990013643A2 (fr
Inventor
Karoly Nikolics
Keith C Mcfarland
Deborah L Segaloff
Peter H Seeburg
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Priority to EP90908349A priority Critical patent/EP0471030B1/fr
Priority to DE69015175T priority patent/DE69015175T2/de
Publication of WO1990013643A2 publication Critical patent/WO1990013643A2/fr
Publication of WO1990013643A3 publication Critical patent/WO1990013643A3/fr
Priority to US08/207,814 priority patent/US6261800B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Reproductive Health (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Cette invention porte sur la purification et sur le clonage de récepteurs de la lutéinostimuline, de la choriogonadotrophine, de la folliculostimuline et de la thyrotrophine. Elle porte en outre sur l'utilisation de ces molécules pour diagnostiquer et soigner des affections chez l'homme.
PCT/US1990/002488 1989-05-05 1990-05-04 Molecules receptrices d'hormone de glycoproteine WO1990013643A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP90908349A EP0471030B1 (fr) 1989-05-05 1990-05-04 Molecules receptrices d'hormone de glycoproteine
DE69015175T DE69015175T2 (de) 1989-05-05 1990-05-04 Glykoprotein-hormonrezeptor-moleküle.
US08/207,814 US6261800B1 (en) 1989-05-05 1994-03-07 Luteinizing hormone/choriogonadotropin (LH/CG) receptor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34768389A 1989-05-05 1989-05-05
US347,683 1989-05-05

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US34768389A Continuation-In-Part 1989-05-05 1989-05-05

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US78115391A Continuation 1989-05-05 1991-10-31
US07781153 A-371-Of-International 1991-10-31
US08/207,814 Continuation US6261800B1 (en) 1989-05-05 1994-03-07 Luteinizing hormone/choriogonadotropin (LH/CG) receptor

Publications (2)

Publication Number Publication Date
WO1990013643A2 WO1990013643A2 (fr) 1990-11-15
WO1990013643A3 true WO1990013643A3 (fr) 1991-01-10

Family

ID=23364795

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1990/002488 WO1990013643A2 (fr) 1989-05-05 1990-05-04 Molecules receptrices d'hormone de glycoproteine

Country Status (9)

Country Link
EP (3) EP0614975B1 (fr)
JP (1) JPH04505103A (fr)
AT (2) ATE115409T1 (fr)
AU (1) AU5732190A (fr)
DE (2) DE69015175T2 (fr)
DK (2) DK0614975T3 (fr)
ES (2) ES2068388T3 (fr)
HK (1) HK1046429A1 (fr)
WO (1) WO1990013643A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614363A (en) * 1990-01-25 1997-03-25 New England Medical Center Hospitals, Inc. TSH receptor
WO1991003483A1 (fr) * 1989-09-08 1991-03-21 New England Medical Center Hospitals, Inc. Recepteur de thyrotropine
JPH05504683A (ja) * 1989-12-20 1993-07-22 ニコルス　インスティテュート　ダイアグノスティックス 組み換えチロトロピン受容体
DE69131393T2 (de) 1990-09-10 1999-11-04 Takeda Chemical Industries, Ltd. Menschlicher Rezeptor für luteinisierendes Hormon und Choriongonadotropin
ES2183806T3 (es) * 1991-03-15 2003-04-01 Applied Research Systems Receptor de la hormona estimuladora de foliculo humano.
WO1993020199A1 (fr) * 1992-03-30 1993-10-14 Akzo Nobel N.V. Recepteur de gonadotrophine humaine (recepteur hfs)
US6033903A (en) * 1995-06-02 2000-03-07 Applied Research Systems, ARS Holding N.V. Method of expressing and secreting soluble extracellular domains of human gonadotropin hormone receptors
AU2728297A (en) * 1996-04-15 1997-11-07 Board Of Trustees Of The Leland Stanford Junior University Soluble 7-transmembrane domain G-protein-coupled receptor compositions and me thods
US5858716A (en) 1997-05-30 1999-01-12 Smithkline Beecham Corporation H2CAA71 polynucleotides
EP1049779A2 (fr) * 1998-01-20 2000-11-08 Wilex Biotechnology GmbH Promoteur du gene du recepteur de la lh servant pour l'expression de genes specifiques de tissus
GB9909661D0 (en) 1998-06-06 1999-06-23 Rsr Ltd Assays for TSH receptor autoantibodies
US8298769B2 (en) 2001-08-23 2012-10-30 Rsr Limited Epitope regions of a thyrotrophin (TSH) receptor, uses thereof and antibodies thereto

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0108633A2 (fr) * 1982-11-09 1984-05-16 Cornell Research Foundation, Inc. Essai de détermination qualitative ou quantitative de hLH ou hCG dans les fluides du corps et réactifs utilisés pour cet essai
EP0192392A2 (fr) * 1985-02-12 1986-08-27 Genentech, Inc. Récepteur d'insuline, sa purification, sa production dans des cellules recombinantes, ADN pour ce but, anticorps de récepteur d'insuline et leur préparation, et compositions pharmaceutiques contenant lesdits anticorps
US4921808A (en) * 1986-06-25 1990-05-01 The Albany Medical College Of Union University Method for determining follicle stimulating hormone
WO1991003483A1 (fr) * 1989-09-08 1991-03-21 New England Medical Center Hospitals, Inc. Recepteur de thyrotropine
WO1991009121A2 (fr) * 1989-12-14 1991-06-27 Henning Berlin Gmbh Chemie- Und Pharmawerk Polypeptides possedant de recepteurs actifs de thyrotropine, sequences d'acide nucleique codant pour ces recepteurs et polypetides, et applications de ces polypeptides
WO1991009137A1 (fr) * 1989-12-20 1991-06-27 Basil Rapoport Recepteur de thyrotropine recombinant
WO1991010735A2 (fr) * 1990-01-15 1991-07-25 Institut National De La Sante Et De La Recherche Medicale Recepteur humain de la tsh. sequence codant pour ce recepteur

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0108633A2 (fr) * 1982-11-09 1984-05-16 Cornell Research Foundation, Inc. Essai de détermination qualitative ou quantitative de hLH ou hCG dans les fluides du corps et réactifs utilisés pour cet essai
EP0192392A2 (fr) * 1985-02-12 1986-08-27 Genentech, Inc. Récepteur d'insuline, sa purification, sa production dans des cellules recombinantes, ADN pour ce but, anticorps de récepteur d'insuline et leur préparation, et compositions pharmaceutiques contenant lesdits anticorps
US4921808A (en) * 1986-06-25 1990-05-01 The Albany Medical College Of Union University Method for determining follicle stimulating hormone
WO1991003483A1 (fr) * 1989-09-08 1991-03-21 New England Medical Center Hospitals, Inc. Recepteur de thyrotropine
WO1991009121A2 (fr) * 1989-12-14 1991-06-27 Henning Berlin Gmbh Chemie- Und Pharmawerk Polypeptides possedant de recepteurs actifs de thyrotropine, sequences d'acide nucleique codant pour ces recepteurs et polypetides, et applications de ces polypeptides
WO1991009137A1 (fr) * 1989-12-20 1991-06-27 Basil Rapoport Recepteur de thyrotropine recombinant
WO1991010735A2 (fr) * 1990-01-15 1991-07-25 Institut National De La Sante Et De La Recherche Medicale Recepteur humain de la tsh. sequence codant pour ce recepteur

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. vol. 165, no. 3, 29 December 1989, DULUTH, MINNESOTA US pages 1184 - 1190 YUGI NAGAYAMA ET AL 'Molecular cloning , sequence and functionnal expression of the cDNA for the human TSH receptor' *
ENDOCRINOLOGY REVIEWS vol. 10, no. 1, February 1989, pages 27 - 44 M. ASCOLI ET AL 'On the structure of the luteinizing hormone / chorionic gonadotropin receptor' *
ENDOCRINOLOGY vol. 123, no. 8, 1988, SPRINGFIELD ; US. pages 2284 - 2290 N. ROSEMBLIT ET AL 'Characterization of an antiserum to the rat luteal luteinizing hormone / chorionic gonadotropic receptor' *
Endocrinology, Volume 123, No. 5, 1988, The Endocrine Society, (Springfield, US) N. ROSEMBLIT et al.: "Characterization of an Antiserum of the Rat Luteal Luteinizing Hormone/Chorionic Gonadotropin Receptor", pages 2284-2290 see the whole article (cited in the application) *
JOURNAL OF BIOLOGICAL CHEMISTRY. vol. 260, no. 18, 25 August 1985, BALTIMORE US pages 9988 - 9993 A. A. BRANCA ET AL 'the subunit structure of the follitropin receptor' *
JOURNAL OF BIOLOGICAL CHEMISTRY. vol. 263, no. 31, 5 November 1988, BALTIMORE US pages 16341 - 16347 TADASHI YOSHIDA ET AL 'Monoclonal antibodies to the TSH receptor bind to a 56 Kda subunit of the TSH receptor and show heterogeneous bioactivities' *
L. D. KOHN ET AL 'Autoimmune thyroid disease studied with monoclonal antibodies : probes for the study of autoimmunity and immunodeficiency' 1983 , B. F. HAYNES; G.S. EISENBATH , ACADEMIC PRESS ; NEW YORK. *
MOLECULAR ENDOCRINOLOGY vol. 4, no. 4, April 1990, pages 525 - 530 R. SPRENGEL ET AL 'The testicular receptor for follicle stimulating hormone : structure and funtionnal expression of cloned cDNA' *
RADIOIMMUNOASSAYS AND RELATED PROCEDURES IN MEDICINE 1982, pages 297 - 305 P. KOTULA ET AL 'radioligand receptor assay ( RRA ) for thyroid stimulating hormone ( TSH ) using triton X100 solubilized receptor preparation' *
SCIENCE vol. 245, August 1989, LANCASTER, PA US pages 494 - 499 K. C. MAC FARLAND ET AL 'lutropin-choriogonadotropin receptor : an unusual member of the G-protein coupled receptor family' *

Also Published As

Publication number Publication date
ES2068388T3 (es) 1995-04-16
HK1046429A1 (zh) 2003-01-10
DE69033990D1 (de) 2002-08-29
WO1990013643A2 (fr) 1990-11-15
EP0614975B1 (fr) 2002-07-24
EP0471030A1 (fr) 1992-02-19
ATE115409T1 (de) 1994-12-15
EP0614975A1 (fr) 1994-09-14
ATE221123T1 (de) 2002-08-15
JPH04505103A (ja) 1992-09-10
AU5732190A (en) 1990-11-29
ES2180550T3 (es) 2003-02-16
EP1199361A2 (fr) 2002-04-24
EP0471030B1 (fr) 1994-12-14
DE69015175T2 (de) 1995-06-29
EP1199361A3 (fr) 2004-03-10
DK0614975T3 (da) 2002-11-11
DK0471030T3 (da) 1995-05-29
DE69033990T2 (de) 2003-02-13
DE69015175D1 (de) 1995-01-26

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