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WO1990012577A3 - Anti-angiogenique topique a usage d'inhibiteur de croissance capillaire - Google Patents

Anti-angiogenique topique a usage d'inhibiteur de croissance capillaire Download PDF

Info

Publication number
WO1990012577A3
WO1990012577A3 PCT/US1990/000812 US9000812W WO9012577A3 WO 1990012577 A3 WO1990012577 A3 WO 1990012577A3 US 9000812 W US9000812 W US 9000812W WO 9012577 A3 WO9012577 A3 WO 9012577A3
Authority
WO
WIPO (PCT)
Prior art keywords
angiogenic
hair growth
growth inhibitors
topical anti
formula
Prior art date
Application number
PCT/US1990/000812
Other languages
English (en)
Other versions
WO1990012577A2 (fr
Inventor
J Michael Holland
Duane B Lakings
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Priority to KR1019900702637A priority Critical patent/KR920700035A/ko
Publication of WO1990012577A2 publication Critical patent/WO1990012577A2/fr
Publication of WO1990012577A3 publication Critical patent/WO1990012577A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A61Q7/02—Preparations for inhibiting or slowing hair growth

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Birds (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

Est décrit un procédé pour inhiber la croissance capillaire chez des mammifères, qui comporte l'administration topique d'une composition renfermant une quantité efficace anti-angiogénique d'un composé angiostatique de formule (I). Ce composé est présent dans une quantité d'au moins 1 mg/ml, de préférence comprise entre environ 1 mg/ml et environ 10 mg/ml.
PCT/US1990/000812 1989-04-18 1990-02-20 Anti-angiogenique topique a usage d'inhibiteur de croissance capillaire WO1990012577A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019900702637A KR920700035A (ko) 1989-04-18 1990-02-20 털 성장 억제제로서의 국소 항-맥관형성제

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33983689A 1989-04-18 1989-04-18
US339,836 1989-04-18

Publications (2)

Publication Number Publication Date
WO1990012577A2 WO1990012577A2 (fr) 1990-11-01
WO1990012577A3 true WO1990012577A3 (fr) 1992-03-19

Family

ID=23330825

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1990/000812 WO1990012577A2 (fr) 1989-04-18 1990-02-20 Anti-angiogenique topique a usage d'inhibiteur de croissance capillaire

Country Status (5)

Country Link
EP (1) EP0468969A1 (fr)
JP (1) JPH04504572A (fr)
KR (1) KR920700035A (fr)
AU (1) AU5154990A (fr)
WO (1) WO1990012577A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9198921B2 (en) 2010-04-05 2015-12-01 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-κB for treatment of disease
US11690853B2 (en) 2015-06-29 2023-07-04 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-κβ for treatment of disease

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9607060A (pt) * 1995-02-28 1998-12-15 Handelman Joseph H Processos para inibição de crescimento de pelos em mamíferos uso de um inibidor não esteroidal de angiogénese processo para produção de uma composição para inibir o crescimento de pelos em mamíferos composição quando usada para inibir o crescimento de pelos em mamíferos
US6596703B1 (en) 1997-07-11 2003-07-22 Jagotec Ag Promotion of wound healing utilizing steroids having reduced deteriorous systemic side effects typical of glucocorticoids, mineralocorticoids and sex steroids
FR2872040B1 (fr) * 2004-06-23 2006-09-22 Centre Nat Rech Scient Cnrse Utilisation cosmetique d'au moins un tetrapeptide naturel ac-n-ser-asp-lys-pro- ou un de ses analogues en tant qu'agent antivieillissement et restructurant de la peau
ES2350583T3 (es) * 2005-05-23 2011-01-25 Reckitt Benckiser (Uk) Limited Composición que comprende wortmanina y uso tópico de la misma para reducir el crecimiento del vello humano.
WO2009155056A2 (fr) 2008-05-28 2009-12-23 Validus Genetics Modulateurs stéroïdiens non hormonaux de nf-kb pour le traitement d’une maladie
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Acta Physiol. Latinoam., Volume 28, 1978, (Buenos Aires, AR), A.B. HOUSSAY et al.: "Effects of Halogenated Analogues of Cortisol and Progesterone Upon Hair Growth in Castrated Mice", pages 11-16 *
Arch. of Dermatological Research, Volume 277, No. 1, 1985, Springer-Verlag, (Berlin, DE), S. MAJEWSKI et al.: " Relationship Between the Hair Growth Cycle and the Intensity of Lymphocyte-Induced Angiogenesis in Mouse Skin", pages 77-78 *
Endocrinology, Volume 119, No. 4, 1986, The Endocrine Society, (Baltimore, US), D.E. INGBER et al.: "A Possible Mechanism for Inhibition of Angiogenesis by Angiostatic Steroids: Induction of Capillary Basement Membrane Dissolution", pages 1768-1775 *
Laboratory Investigation, Volume 59, No. 1, 1988, The United States and Canadian Academy of Pathology, Inc., (Washington, US), D. INGBER et al.: "Inhibition of Angiogenesis Through Modulation of Collagen Metabolism", pages 44-51 *
Proceedngs of AACR, Volume 26, March 1985, J. FOLKMAN: "How is Blood Vessel Growth Regulated in Normal and Neoplastic Tissue", pages 384-385 *
The Journal of Investigative Dermatology, Volume 90, No. 3, 198, The Society for Investigative Dermatology, Inc., (Baltimor, US), K.S. STENN eet al.: "The Angiongenic Properties of the Rat Vibrissa Hair Follicle Associate with the Bulb", Pages 409-411 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9198921B2 (en) 2010-04-05 2015-12-01 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-κB for treatment of disease
US11690853B2 (en) 2015-06-29 2023-07-04 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-κβ for treatment of disease

Also Published As

Publication number Publication date
JPH04504572A (ja) 1992-08-13
EP0468969A1 (fr) 1992-02-05
AU5154990A (en) 1990-11-16
WO1990012577A2 (fr) 1990-11-01
KR920700035A (ko) 1992-02-19

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