WO1990012009A1 - Nouveaux derives d'imidazole, leur production, et leurs emplois comme medicaments - Google Patents

Nouveaux derives d'imidazole, leur production, et leurs emplois comme medicaments Download PDF

Info

Publication number: WO1990012009A1
Authority: WO; WIPO (PCT)
Prior art keywords: inhibition; imidazole derivatives; medicines; production; new imidazole
Prior art date: 1989-03-31

Application number

PCT/JP1990/000409

Other languages

English (en)

French (fr)

Inventor

Hiroshi Matsui

Syouzi Kamiya

Hiroaki Shirahase

Rika Morihisa

Ken-Ichi Nishimura

Nobuharu Kakeya

Original Assignee

Kyoto Pharmaceutical Industries, Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-31

Filing date

1990-03-27

Publication date

1990-10-18

1990-03-27 Application filed by Kyoto Pharmaceutical Industries, Ltd. filed Critical Kyoto Pharmaceutical Industries, Ltd.

1990-03-27 Priority to KR1019900702541A priority Critical patent/KR920700210A/ko

1990-10-18 Publication of WO1990012009A1 publication Critical patent/WO1990012009A1/ja

Links

150000002460 imidazoles Chemical class 0.000 title abstract 2
229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title abstract 2
229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
230000005764 inhibitory process Effects 0.000 abstract 3
206010003210 Arteriosclerosis Diseases 0.000 abstract 1
206010008190 Cerebrovascular accident Diseases 0.000 abstract 1
206010012289 Dementia Diseases 0.000 abstract 1
208000005189 Embolism Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
206010061216 Infarction Diseases 0.000 abstract 1
208000006011 Stroke Diseases 0.000 abstract 1
208000007536 Thrombosis Diseases 0.000 abstract 1
108010069102 Thromboxane-A synthase Proteins 0.000 abstract 1
230000004520 agglutination Effects 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
230000000747 cardiac effect Effects 0.000 abstract 1
230000002490 cerebral effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
150000002148 esters Chemical group 0.000 abstract 1
201000005577 familial hyperlipidemia Diseases 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 abstract 1
230000007574 infarction Effects 0.000 abstract 1
-1 lipid peroxide Chemical class 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000024883 vasodilation Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

PCT/JP1990/000409 1989-03-31 1990-03-27 Nouveaux derives d'imidazole, leur production, et leurs emplois comme medicaments WO1990012009A1 (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
KR1019900702541A KR920700210A (ko)	1989-03-31	1990-03-27	신규 이미다졸 유도체, 그의 제법 및 그의 의약용도

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP1/81694		1989-03-31
JP8169489		1989-03-31

Publications (1)

Publication Number	Publication Date
WO1990012009A1 true WO1990012009A1 (fr)	1990-10-18

Family

ID=13753475

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PCT/JP1990/000409 WO1990012009A1 (fr)	1989-03-31	1990-03-27	Nouveaux derives d'imidazole, leur production, et leurs emplois comme medicaments

Country Status (5)

Country	Link
EP (1)	EP0427860A1 (ja)
KR (1)	KR920700210A (ja)
AU (1)	AU5279390A (ja)
CA (1)	CA2030557A1 (ja)
WO (1)	WO1990012009A1 (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995029163A1 (fr) *	1994-04-27	1995-11-02	Nippon Soda Co., Ltd.	Derive d'imidazole et procede de production de ce derive
JP3720395B2 (ja)	1994-09-20	2005-11-24	京都薬品工業株式会社	新規ヘテロ環誘導体、その製造方法およびその医薬用途
US6060496A (en)	1995-12-27	2000-05-09	Yoshitomi Pharmaceutical Industires, Ltd.	Prophylaxis and treatment of diabetic complications with 4-[α-hydroxy-2-methyl-5-(1-imidazolyl) benzyl]-3,5-dimethylbenzoic acid
OA11622A (en)	1998-03-31	2004-09-16	Inst For Pharm Discovery Inc	Substituted indolealkanoic acids.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0003901A2 (en) *	1978-02-24	1979-09-05	Pfizer Limited	3-(Imidazol-1-ylalkyl)indoles as selective inhibitors of thromboxane synthetase,pharmaceutical compositions thereof, and methods for preparing them
US4273782A (en) *	1979-03-07	1981-06-16	Pfizer Inc.	Inhibition of thromboxane synthetase by 3-(1-Imidazolylalkyl) indoles
EP0069513A2 (en) *	1981-07-07	1983-01-12	Pfizer Limited	Indole thromboxane synthetase inhibitors, processes for their preparation, and pharmaceutical compositions containing them
EP0073663A2 (en) *	1981-08-26	1983-03-09	Pfizer Limited	Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them

1990
- 1990-03-27 EP EP90904929A patent/EP0427860A1/en not_active Withdrawn
- 1990-03-27 KR KR1019900702541A patent/KR920700210A/ko not_active Ceased
- 1990-03-27 AU AU52793/90A patent/AU5279390A/en not_active Abandoned
- 1990-03-27 WO PCT/JP1990/000409 patent/WO1990012009A1/ja not_active Application Discontinuation
- 1990-03-27 CA CA002030557A patent/CA2030557A1/en not_active Abandoned

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0003901A2 (en) *	1978-02-24	1979-09-05	Pfizer Limited	3-(Imidazol-1-ylalkyl)indoles as selective inhibitors of thromboxane synthetase,pharmaceutical compositions thereof, and methods for preparing them
US4273782A (en) *	1979-03-07	1981-06-16	Pfizer Inc.	Inhibition of thromboxane synthetase by 3-(1-Imidazolylalkyl) indoles
EP0069513A2 (en) *	1981-07-07	1983-01-12	Pfizer Limited	Indole thromboxane synthetase inhibitors, processes for their preparation, and pharmaceutical compositions containing them
EP0073663A2 (en) *	1981-08-26	1983-03-09	Pfizer Limited	Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them

Also Published As

Publication number	Publication date
KR920700210A (ko)	1992-02-19
EP0427860A1 (en)	1991-05-22
AU5279390A (en)	1990-11-05
CA2030557A1 (en)	1990-10-01

Legal Events

Date	Code	Title	Description
1990-10-18	AK	Designated states	Kind code of ref document: A1 Designated state(s): AU CA KR SU US
1990-10-18	AL	Designated countries for regional patents	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB IT LU NL SE
1990-11-29	WWE	Wipo information: entry into national phase	Ref document number: 2030557 Country of ref document: CA
1990-11-30	WWE	Wipo information: entry into national phase	Ref document number: 1990904929 Country of ref document: EP
1991-04-17	WWW	Wipo information: withdrawn in national office	Ref document number: 1990904929 Country of ref document: EP
1991-05-22	WWP	Wipo information: published in national office	Ref document number: 1990904929 Country of ref document: EP
2000-01-01	ENP	Entry into the national phase	Ref country code: CA Ref document number: 2030557 Kind code of ref document: A Format of ref document f/p: F

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