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WO1990010709A3 - Anticorps monoclonaux pour cations metalliques sur petites molecules - Google Patents

Anticorps monoclonaux pour cations metalliques sur petites molecules Download PDF

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Publication number
WO1990010709A3
WO1990010709A3 PCT/US1990/001401 US9001401W WO9010709A3 WO 1990010709 A3 WO1990010709 A3 WO 1990010709A3 US 9001401 W US9001401 W US 9001401W WO 9010709 A3 WO9010709 A3 WO 9010709A3
Authority
WO
WIPO (PCT)
Prior art keywords
monoclonal antibodies
fragments
small molecules
directed
metallic cations
Prior art date
Application number
PCT/US1990/001401
Other languages
English (en)
Other versions
WO1990010709A2 (fr
Inventor
Fred W Wagner
Dwane E Wylie
Sheldon M Schuster
Thomas R Coolidge
Pill-Soon Song
William Parker
Original Assignee
Univ Nebraska
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23263379&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1990010709(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Nebraska filed Critical Univ Nebraska
Priority to DE69031909T priority Critical patent/DE69031909T2/de
Priority to CA002047717A priority patent/CA2047717C/fr
Priority to EP90905954A priority patent/EP0463110B1/fr
Priority to AU54114/90A priority patent/AU648022B2/en
Publication of WO1990010709A2 publication Critical patent/WO1990010709A2/fr
Publication of WO1990010709A3 publication Critical patent/WO1990010709A3/fr
Priority to FI914298A priority patent/FI100472B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Inorganic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Endoscopes (AREA)
  • Pressure Sensors (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne des anticorps monoclonaux, leurs fragments, des chaînes individuelles et des imitateurs polypeptidiques de leurs régions hypervariables immuniréagissant avec des petites fractions simples telles que des cations métalliques et des petites molécules organiques, les hybridomes permettant la production des anticorps monoclonaux, des composés immunogènes permettant de développer les hybridomes, ainsi que des procédés d'utilisation des anticorps monoclonaux.
PCT/US1990/001401 1989-03-14 1990-03-14 Anticorps monoclonaux pour cations metalliques sur petites molecules WO1990010709A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE69031909T DE69031909T2 (de) 1989-03-14 1990-03-14 Monoklonale antikörper für metall kationen
CA002047717A CA2047717C (fr) 1989-03-14 1990-03-14 Anticorps monoclonaux contre de petites molecules et methodes pour les preparer
EP90905954A EP0463110B1 (fr) 1989-03-14 1990-03-14 Anticorps monoclonaux contre des cations metalliques
AU54114/90A AU648022B2 (en) 1989-03-14 1990-03-14 Monoclonal antibodies for metallic cations on small molecules
FI914298A FI100472B (fi) 1989-03-14 1991-09-12 Monoklonaalisia vasta-aineita metallikationeille

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32439289A 1989-03-14 1989-03-14
US324,392 1989-03-14

Publications (2)

Publication Number Publication Date
WO1990010709A2 WO1990010709A2 (fr) 1990-09-20
WO1990010709A3 true WO1990010709A3 (fr) 1990-11-15

Family

ID=23263379

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1990/001401 WO1990010709A2 (fr) 1989-03-14 1990-03-14 Anticorps monoclonaux pour cations metalliques sur petites molecules

Country Status (9)

Country Link
US (1) US5503987A (fr)
EP (2) EP0589487A1 (fr)
JP (1) JPH05504464A (fr)
AT (1) ATE161852T1 (fr)
AU (1) AU648022B2 (fr)
CA (1) CA2047717C (fr)
DE (1) DE69031909T2 (fr)
FI (1) FI100472B (fr)
WO (1) WO1990010709A2 (fr)

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AU8499691A (en) * 1990-09-05 1992-03-30 Neurex Corporation Method and composition for detecting bioactive peptides
US5273909A (en) * 1991-06-03 1993-12-28 Quantix Systems, L.P. Immunoassay for the detection of small aliphatic organic compounds
US5532136A (en) * 1993-06-22 1996-07-02 Bionebraska, Inc. Monoclonal antibody assay and kit for detecting metal cations in body fluids
US5459040A (en) * 1993-11-22 1995-10-17 The Regents Of The University Of California Enzyme amplified, complex linked, competitive and non-competitive assays for the detection of metal ions
US5476939A (en) * 1993-12-30 1995-12-19 Abbott Laboratories Certain pyridyl and isoquinolyl carbinolamine derivatives
AU1695795A (en) * 1994-01-27 1995-08-15 Bionebraska, Inc. Mercury binding polypeptides and nucleotides coding therefor
WO1996039518A1 (fr) * 1995-06-05 1996-12-12 Bionebraska, Inc. Polypeptides fixant le plomb et nucleotides codants afferent
US6111079A (en) * 1995-06-05 2000-08-29 Bionebraska, Inc. Lead binding polypeptides and nucleotides coding therefore
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US5962291A (en) * 1996-04-19 1999-10-05 The Regents Of The University Of Colorado Metal dependent catalytic antibodies and method for producing the same
DE69731983T2 (de) * 1996-08-19 2005-10-06 Shaker, Ghassan I. Verwendung von molt4 cd69 expression zur bestimmung der anwesenheit und der aktivität von interferoninhibitoren
US6190923B1 (en) 1997-09-05 2001-02-20 David K. Johnson Diethylenetriamine-N,N′,N″-triacetic acid derivatives
US6962702B2 (en) * 1998-06-22 2005-11-08 Immunomedics Inc. Production and use of novel peptide-based agents for use with bi-specific antibodies
US7833528B2 (en) * 1998-06-22 2010-11-16 Immunomedics, Inc. Use of multispecific, non-covalent complexes for targeted delivery of therapeutics
US7405320B2 (en) 1998-06-22 2008-07-29 Immunomedics, Inc. Therapeutic and diagnostic conjugates for use with multispecific antibodies
US7138103B2 (en) * 1998-06-22 2006-11-21 Immunomedics, Inc. Use of bi-specific antibodies for pre-targeting diagnosis and therapy
US7387772B1 (en) 1999-06-22 2008-06-17 Immunimedics, Inc. Chimeric, human and humanized anti-CSAP monoclonal antibodies
US7074405B1 (en) * 1998-06-22 2006-07-11 Immunomedics, Inc. Use of bi-specific antibodies for pre-targeting diagnosis and therapy
US7070937B1 (en) 1998-10-02 2006-07-04 Ischemia Technologies, Inc. Marker useful for detection and measurement of free radical damage and method
US7449338B2 (en) * 1998-10-02 2008-11-11 Ischemia Technologies, Inc. Tests for the rapid evaluation of ischemic states and kits
US20050142613A1 (en) * 1998-10-02 2005-06-30 David Bar-Or Test for the rapid evaluation of ischemic states and kits
US6475743B1 (en) 1998-10-02 2002-11-05 Ischemia Technologies, Inc. Marker useful for detection and measurement of free radical damage and method
US20030215359A1 (en) * 1998-10-02 2003-11-20 Ischemia Technologies, Inc. Tests for the rapid evaluation of ischemic states and kits
US20030215952A1 (en) * 1998-10-02 2003-11-20 Ischemia Technologies, Inc. Tests for the rapid evaluation of ischemic states and kits
US20020199218A1 (en) * 1999-08-19 2002-12-26 Daphne Goring Proline-rich extensin-like receptor kinases
US20030130185A1 (en) * 2000-09-29 2003-07-10 David Bar-Or Metal-binding compounds and uses therefor
US20030158111A1 (en) * 1999-10-01 2003-08-21 David Bar-Or Methods and products for oral care
US7592304B2 (en) * 1999-10-01 2009-09-22 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
US7632803B2 (en) 1999-10-01 2009-12-15 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
CA2364983A1 (fr) * 2000-12-13 2002-06-13 John R. Coleman Molecules d'acide nucleique et polypeptides pour le catabolisme de l'acide abscisique
US20030049800A1 (en) * 2000-12-15 2003-03-13 Saravis Calvin A. Compositions and methods for producing antibodies to low molecular weight analytes
US7597895B2 (en) * 2001-02-20 2009-10-06 The Governing Council Of The University Of Toronto Signal peptides, nucleic acid molecules and methods for treatment of caries
US7556807B2 (en) 2001-02-20 2009-07-07 Kane Biotech, Inc. Signal peptides, nucleic acid molecules and methods for treatment of caries
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AU2002366640A1 (en) * 2001-12-11 2003-06-23 Expressive Constructs, Inc. Detection and removal of lead using lead-binding proteins
CN101921338A (zh) * 2004-03-31 2010-12-22 佳能株式会社 一种靶物质俘获体
US8021849B2 (en) * 2004-11-05 2011-09-20 Siemens Healthcare Diagnostics Inc. Methods and kits for the determination of sirolimus in a sample
US20090075342A1 (en) * 2005-04-26 2009-03-19 Sharon Cload Metabolic profile directed aptamer medicinal chemistry
US7189582B2 (en) * 2005-04-27 2007-03-13 Dade Behring Inc. Compositions and methods for detection of sirolimus
US20100329983A1 (en) 2009-06-26 2010-12-30 Soricimed Biopharma Inc. Compounds and methods for the detection of trpv-6 cancers and drug delivery
CN113801220B (zh) * 2021-09-18 2023-07-07 青岛普瑞邦生物工程有限公司 一种米酵菌酸复合抗原、米酵菌酸抗体及其制备方法和酶联免疫试剂盒
CN114014934B (zh) * 2021-10-14 2023-05-05 江苏省农业科学院 多氯联苯单克隆抗体及其应用

Citations (2)

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Publication number Priority date Publication date Assignee Title
EP0235457A2 (fr) * 1985-12-13 1987-09-09 Syngene International N.V. Anticorps monoclonaux
US4722892A (en) * 1984-08-31 1988-02-02 Meares Claude F Monoclonal antibodies against metal chelates

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EP0235457A2 (fr) * 1985-12-13 1987-09-09 Syngene International N.V. Anticorps monoclonaux

Also Published As

Publication number Publication date
CA2047717A1 (fr) 1990-09-15
WO1990010709A2 (fr) 1990-09-20
EP0589487A1 (fr) 1994-03-30
EP0463110A1 (fr) 1992-01-02
FI100472B (fi) 1997-12-15
DE69031909D1 (de) 1998-02-12
AU648022B2 (en) 1994-04-14
DE69031909T2 (de) 1998-04-16
US5503987A (en) 1996-04-02
AU5411490A (en) 1990-10-09
EP0463110B1 (fr) 1998-01-07
FI914298A0 (fi) 1991-09-12
CA2047717C (fr) 2000-08-01
ATE161852T1 (de) 1998-01-15
JPH05504464A (ja) 1993-07-15

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