WO1990007000A3 - Nucleotides codant la b1,4-galactosyltransferase humaine et leurs utilisations - Google Patents
Nucleotides codant la b1,4-galactosyltransferase humaine et leurs utilisations Download PDFInfo
- Publication number
- WO1990007000A3 WO1990007000A3 PCT/US1989/005128 US8905128W WO9007000A3 WO 1990007000 A3 WO1990007000 A3 WO 1990007000A3 US 8905128 W US8905128 W US 8905128W WO 9007000 A3 WO9007000 A3 WO 9007000A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nucleic acid
- galactosyltransferase
- provides
- encodes
- acid sequence
- Prior art date
Links
- 239000002773 nucleotide Substances 0.000 title 1
- 125000003729 nucleotide group Chemical group 0.000 title 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 4
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 102000005383 human beta1,4-galactosyltransferase Human genes 0.000 abstract 2
- 108010045961 human beta1,4-galactosyltransferase Proteins 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 206010010356 Congenital anomaly Diseases 0.000 abstract 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 1
- 208000007502 anemia Diseases 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La présente invention concerne une séquence d'acides nucléiques isolée qui code β-1,4-galactosyltransférase humaine liée à une membrane purifiée, ou son équivalent fonctionnel. Cette invention concerne également une séquence d'acides nucléiques isolée qui code β-1,4-galactosyltransférase humaine soluble et purifiée ou son équivalent fonctionnel. L'invention concerne en outre des vecteurs comprenant ces séquences d'acides nucléiques et l'expression de protéines recombinantes par l'utilisation d'un système vecteur hôte. L'invention concerne également des anticorps réagissant avec les protéines et des sondes réagissant avec les séquences d'acides nucléiques. Finalement, l'invention décrit une méthode permettant de diagnostiquer une anémie dyserthropoiétique congénitale de type II chez un sujet.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28373288A | 1988-12-13 | 1988-12-13 | |
| US283,732 | 1988-12-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1990007000A2 WO1990007000A2 (fr) | 1990-06-28 |
| WO1990007000A3 true WO1990007000A3 (fr) | 1990-08-09 |
Family
ID=23087318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1989/005128 WO1990007000A2 (fr) | 1988-12-13 | 1989-11-16 | Nucleotides codant la b1,4-galactosyltransferase humaine et leurs utilisations |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU4751990A (fr) |
| CA (1) | CA2003797A1 (fr) |
| WO (1) | WO1990007000A2 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5032519A (en) * | 1989-10-24 | 1991-07-16 | The Regents Of The Univ. Of California | Method for producing secretable glycosyltransferases and other Golgi processing enzymes |
| SE9201544L (sv) * | 1991-05-31 | 1992-12-01 | Ciba Geigy Ag | Saett att framstaella glykosyltransferaser |
| GB2256197B (en) * | 1991-05-31 | 1995-11-22 | Ciba Geigy Ag | Yeast as host for expression of heterologous glycosyl transferase enzymes |
| NZ258525A (en) * | 1992-11-27 | 1997-05-26 | Ciba Geigy Ag | Proteins with glycosyltransferase activity and their recombinant production |
| GB9603256D0 (en) * | 1996-02-16 | 1996-04-17 | Wellcome Found | Antibodies |
| US6558934B1 (en) * | 1998-07-17 | 2003-05-06 | Glycozm Aps | UDP-galactose: β-N-acetyl-glucosamine β-1,4-galactosyl-transferase, β4Gal-T2 |
| WO2001014535A2 (fr) | 1999-08-24 | 2001-03-01 | Glycozym Aps | UDP-N-ACETYLGLUCOSAMINE: GALACTOSE-β1,3-N-ACETYLGALACTOSAMINE-α-R/(GlcNAc - GalNAc) β1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE, C2GnT3 |
| CN1331292A (zh) * | 2000-06-26 | 2002-01-16 | 上海博德基因开发有限公司 | 一种新的多肽——人β－1,4半乳糖苷转运酶13.2和编码这种多肽的多核苷酸 |
-
1989
- 1989-11-16 WO PCT/US1989/005128 patent/WO1990007000A2/fr unknown
- 1989-11-16 AU AU47519/90A patent/AU4751990A/en not_active Abandoned
- 1989-11-24 CA CA002003797A patent/CA2003797A1/fr not_active Abandoned
Non-Patent Citations (3)
| Title |
|---|
| Biochemical and Biophysical Research Communications, vol. 139, no. 1, 29 August 1986, Academic Press, Inc., (Duluth, MN, US), H.E. Appert et al.: "Isolation of a cDNA coding for human galactosyl transferase", pages 163-168, see the whole article (cited in the application) * |
| Biochemical and Biophysical Research Communications, vol. 187, no. 2, 15 December 1988, Academic Press, Inc., (Duluth, MN, US), K.A. Masri et al.: "Identification of the full-lenght coding sequence for human galactosyltransferase (beta-N-acetylglucosaminide: betal, 4-galactosyltransferase)", see pages 657-663 * |
| The Journal of Biological Chemistry, vol. 263, no. 21, 25 July 1988, (Baltimore, ND, US), N.L. Shaper et al.: "Characterization of the full lenght cDNA for murine beta-1,4-Galactosyltransferase", pages 10420-10428, see "Discussion" (cited in the application) * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU4751990A (en) | 1990-07-10 |
| WO1990007000A2 (fr) | 1990-06-28 |
| CA2003797A1 (fr) | 1990-06-13 |
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